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World Federation of Acupuncture-Moxibustion Societies (WFAS) Clinical Practice Guideline on Acupuncture and Moxibustion: Allergic Rhinitis recommendation summaries 世界针灸学会联合会(WFAS)针灸临床实践指南:过敏性鼻炎建议摘要
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-07-01 DOI: 10.1016/j.wjam.2024.06.002
Shi-hao DU (杜世豪) , Jing LIU (刘静) , Sheng CHEN (陈晟) , Shan-ze WANG (王舢泽) , Guan-qun WANG (王冠群) , Shuo DU (杜朔) , Xiao-long XIE (解小龙) , Bi-hui PENG (彭碧辉) , Wei GUO (郭玮) , Chao YANG (杨超) , Ji-ping ZHAO (赵吉平)

Clinical Practice Guideline on Acupuncture and Moxibustion: Allergic Rhinitis was revised and released by the Standards Working Committee of World Federation of Acupuncture-Moxibustion Societies (WFAS) on October 9, 2023. This is the first clinical practice guideline (CPG) on acupuncture and moxibustion for allergic rhinitis approved by an international academic organization, which provides evidence-based recommendations and the practical therapeutic protocols for acupuncture practitioners globally. This CPG was developed by following Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) methodology, and the principles of the World Health Organization Handbook for Guideline Development. The members in the guideline development group (GDG) were from different countries, with different professions, and they played a critical role in the development of clinical questions, recommendations, and therapeutic protocols. Recommendations are the core of a CPG and the direct answers to clinical questions, due to which this article focuses on the recommendations of this CPG. The recommendations were developed by using the modified Delphi method and the GRADE grid rules, based on the updated systematic reviews of clinical evidence. A total of 15 recommendations for 15 clinical questions were developed in this CPG, including one strong recommendation for intervention based on high-quality evidence, three conditional recommendations for either the intervention or the comparison based on very low quality of evidence, and 11 conditional recommendations for the intervention based on very low quality of evidence.

针灸临床实践指南》:世界针灸学会联合会标准工作委员会于2023年10月9日修订并发布了《针灸临床实践指南:过敏性鼻炎》。这是第一部由国际学术组织批准的针灸治疗过敏性鼻炎临床实践指南(CPG),为全球针灸从业者提供循证建议和实用治疗方案。该CPG是按照《推荐、评估、发展和评价分级》(GRADE)方法和世界卫生组织《指南制定手册》的原则制定的。指南制定小组(GDG)的成员来自不同国家,从事不同职业,他们在临床问题、建议和治疗方案的制定过程中发挥了关键作用。建议是 CPG 的核心,也是对临床问题的直接回答,因此本文重点介绍本 CPG 的建议。根据最新的系统性临床证据综述,采用改良德尔菲法和 GRADE 网格规则制定了建议。本 CPG 共针对 15 个临床问题制定了 15 项建议,其中包括 1 项基于高质量证据的干预强力建议,3 项基于极低质量证据的干预或对比有条件建议,以及 11 项基于极低质量证据的干预有条件建议。
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引用次数: 0
World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Electroacupuncture 世界针灸学会联合会(WFAS)针灸技术基准:电针
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-07-01 DOI: 10.1016/j.wjam.2024.03.006
Pei-qi LI (李沛琦) , Si-jie DANG (党思杰) , Fan-lian LI (李凡莲) , Fei-hong CAI (蔡飞鸿) , Yu-chen ZHANG (张宇宸) , Yi-fan WU (吴一凡) , Jia-ni SHI (施嘉旎) , Jia-wei LI (李佳蔚) , Xin FU (傅昕) , Meng-hu GUO (郭梦虎) , Bin XIAO (肖彬) , Hua-yuan YANG (杨华元)

World Federation of Acupuncture-Moxibustion Societies (WFAS) Technical Benchmark of Acupuncture and Moxibustion: Electroacupuncture, developed under the leadership of Shanghai University of Traditional Chinese Medicine, was approved by WFAS. This technical benchmark was issued on October 9, 2023, and implemented on December 31, 2023. The main contents include the scope, normative references, terms and definitions, acupuncture and moxibustion procedures and rules, and safety. This article focuses on the above contents. An outlook on the application, popularization, and update plan of this technical benchmark is proposed.

世界针灸学会联合会(WFAS)针灸技术基准:世界针灸学会联合会批准了由上海中医药大学牵头制定的《电针技术基准》。该技术基准于2023年10月9日发布,2023年12月31日实施。主要内容包括范围、规范性引用文件、术语和定义、针灸操作规程和细则、安全等。本文主要介绍上述内容。对该技术基准的应用、推广和更新计划提出了展望。
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引用次数: 0
The regulatory effects of electroacupuncture on type 2 innate lymphoid cell (ILC2) function and browning of white adipose tissue in obese rats 电针对肥胖大鼠 2 型先天性淋巴细胞(ILC2)功能和白色脂肪组织褐变的调节作用
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.03.004
Jian-kun CHEN (陈剑坤) , Yuan WU (吴苑) , Wen-zhen LI (李文珍) , Meng-fen HUANG (黄梦芬) , Bin HUANG (黄彬) , Chang-cai XIE (谢长才) , Ji-qiang LI (李际强) , Yue LU (卢月) , Yu CHEN (陈裕)
<div><h3>Objective</h3><p>To observe the effects of electroacupuncture (EA) on type 2 innate lymphoid cell (ILC2) function in white adipose tissue (WAT) of high-fat diet (HFD)-induced obese rats to reveal the mechanism underlying weight loss.</p></div><div><h3>Methods</h3><p>Male Winstar rats (n=15) were randomly divided into control, HFD, and HFD+EA groups, with five rats in each group. An obesity model was established by feeding rats with a HFD. EA (2 Hz, 1 mA) was applied to “Zhongwan (CV12)” bilateral “Tianshu (ST25)” “Zusanli (ST36)” and “Sanyinjiao (SP6)” for 15 min, 7 days a week, for a total of 5 weeks. During EA treatment, the HFD group was fed a HFD, whereas rats in the control group were maintained on a normal diet. There was no intervention in either the control or the HFD groups. Body weight was measured weekly. Full-field adipocyte morphology, adipocyte volume, and the number of abdominal WAT were observed under a microscope after sectioning and hematoxylin and eosin staining. The levels of IL-5 (interleukin-5), IL-13 (interleukin-13), IL-33 (interleukin-33), and ST2 (growth stimulating gene 2 protein) in the WAT were assayed using enzyme-linked immunosorbent assay and reverse transcription-polymerase chain reaction (RT-PCR). The expression levels of browning markers including PGC1α(peroxisome proliferator-activated receptor gamma coactivator 1-alpha), PPARγ (peroxisome proliferator-activated receptor gamma), PRDM16 (histone-lysine N-methyltransferase), and UCP1(uncoupling protein 1 in WAT were detected by western blot analysis and RT-PCR.</p></div><div><h3>Results</h3><p>After a 7-week induction period, rats in both the HFD and HFD+EA groups were 20% heavier than their initial weights before modeling (<em>P</em><0.01, <em>P</em><0.001). Following a 5-week EA intervention, the body mass and Lee index of obese rats were significantly reduced (<em>P</em><0.05). The HE results showed that adipocytes in the HFD group displayed a significant increase in diameter and a decrease in number compared to the control group. However, in the HFD+EA group, white adipocytes exhibited reduced diameter and appeared more regular in shape. In the control group, the proportion of ILC2 was (86.53±2.55)%, whereas in the HFD group, it decreased to (73.62±2.52)%, indicating a significant reduction in ILC2 in the WAT of obese rats. Following EA treatment, the proportion of ILC2 was elevated to (80.54±4.25)%. This analysis revealed a significant decrease in the expression levels of IL-5, IL-13, IL-33, and ST2 in the WAT of obese rats in the HFD group; however, these levels increased after EA intervention. The mRNA levels of PPARγ, PGC1α, PRDM16, and protein levels of UCP1 were decreased in the HFD group (<em>P</em><0.01, <em>P</em><0.05, and <em>P</em><0.001), and the trends were significantly reversed with EA manipulation (<em>P</em><0.05). RT-PCR and western blotting results revealed that EA remarkably upregulated the mRNA expression of
方法将雄性Winstar大鼠(n=15)随机分为对照组、HFD组和HFD+EA组,每组5只。给大鼠喂食 HFD,建立肥胖模型。"祖山里(ST36)"和 "三阴交(SP6)",每周 7 天,每次 15 分钟,共 5 周。在 EA 治疗期间,HFD 组大鼠食用高纤维食物,而对照组大鼠则食用普通食物。对照组和 HFD 组均未进行干预。体重每周测量一次。切片和苏木精及伊红染色后,在显微镜下观察全视野脂肪细胞形态、脂肪细胞体积和腹部WAT数量。用酶联免疫吸附试验和反转录聚合酶链反应(RT-PCR)检测了腹部脂肪细胞中 IL-5(白细胞介素-5)、IL-13(白细胞介素-13)、IL-33(白细胞介素-33)和 ST2(促生长基因 2 蛋白)的水平。褐变标记物包括PGC1α(过氧化物酶体增殖体激活受体γ辅激活因子1-α)、PPARγ(过氧化物酶体增殖体激活受体γ)、PRDM16(组蛋白-赖氨酸N-甲基转移酶)和UCP1(解偶联蛋白1)在脂肪中的表达水平通过Western印迹分析和RT-PCR进行了检测。结果经过7周的诱导期后,HFD组和HFD+EA组大鼠的体重都比建模前增加了20%(P<0.01, P<0.001)。经过 5 周的 EA 干预后,肥胖大鼠的体重和 Lee 指数显著降低(P<0.05)。HE 结果显示,与对照组相比,HFD 组脂肪细胞的直径明显增大,数量明显减少。然而,HFD+EA 组的白色脂肪细胞直径减小,形状更加规则。在对照组中,ILC2 的比例为 (86.53±2.55)%,而在 HFD 组中,ILC2 的比例降至 (73.62±2.52)%,这表明肥胖大鼠 WAT 中的 ILC2 显著减少。经 EA 处理后,ILC2 的比例升高至 (80.54±4.25)%。该分析表明,HFD组肥胖大鼠WAT中IL-5、IL-13、IL-33和ST2的表达水平明显下降,但在EA干预后,这些表达水平有所上升。HFD组肥胖大鼠体内PPARγ、PGC1α、PRDM16的mRNA水平和UCP1的蛋白水平均有所下降(P<0.01、P<0.05和P<0.001),EA干预后这些趋势得到了显著逆转(P<0.05)。RT-PCR和Western印迹结果显示,EA能显著上调HFD诱导的PGC1α、PPARγ和PRDM16的mRNA表达以及UCP1的蛋白表达。在高频分解组中,PRDM16的表达与UCP1的表达有很强的相关性,ILC与PGC1α的表达有很强的相关性。然而,这些强相关性在 HFD+EA 组中并未出现。EA治疗后,PPARγ的表达与ILC2s表现出很强的相关性,表明ILC2比例的改变与WAT的棕色化密切相关。ILC2可能在EA治疗效果中发挥了重要作用,但这还需要进一步研究。
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引用次数: 0
Therapeutic effects of electroacupuncture at different sites on rats with neuropathic pain via the spinal Nrf2/HO-1 pathway 不同部位的电针通过脊髓 Nrf2/HO-1 通路对神经性疼痛大鼠的治疗效果
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.03.003
Liu CHEN (陈柳) , Hao-tian PAN (潘昊天) , Ya-nan ZHANG (张衙楠) , Lan DUO (多兰) , Xin DONG (董馨) , Gong-ming WANG (王功命) , Jia ZHOU (周嘉) , Ke WANG (王珂)
<div><h3>Objective</h3><p>This study aimed to assess the effects of electroacupuncture (EA) at the contralateral, ipsilateral, or bilateral “Zusanli (ST36)” and “Yanglingquan(GB34)” on neuropathic pain caused by chronic contractile injury (CCI) and to explore the role of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the effects of EA.</p></div><div><h3>Methods</h3><p>Male Sprague-Dawley rats were subjected to the CCI model to induce neuropathic pain. A total of 45 rats were randomly divided into five groups (n = 9): sham, CCI, EA-Co (CCI + EA at contralateral acupoints), EA-Ip (CCI + EA at ipsilateral acupoints), and EA-Bi (CCI + EA at bilateral acupoints). The rats received EA treatment on day 8 after CCI, once every alternate day, for a total of eight times. The time courses of mechanical pain threshold (MWT), hind paw withdrawal latency (HWL), and sciatic functional index (SFI) were determined. The expression levels of 8-hydroxydeoxyguanosine (8-OHdG), glutathione (GSH), superoxide dismutase (SOD) activity, interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor factor-alpha (TNF-α) in the spinal cord were measured. The distribution of Nrf2, its expression of Nrf2 in both the cytosol and nucleus, and the protein levels of its downstream target genes, NQO1 and HO-1, were detected via double immunofluorescence staining and western blotting, respectively.</p></div><div><h3>Results</h3><p>Following CCI, both MWT and HWL in the CCI group significantly decreased from day 14 after surgery (<em>P</em> < 0.001). EA treatment exhibited significant antinociceptive effects induced by CCI by increasing the MWT and HWL values, especially bilateral EA (<em>P</em> < 0.05). The SFI of the CCI group was significantly lower than that of the sham group (<em>P</em> < 0.001). Only bilateral EA improved the SFI scores compared to the CCI group (<em>P</em> < 0.05). 8-OHdG levels in the spinal cord of the CCI group were significantly higher than those in the sham group (<em>P</em> < 0.05), whereas GSH levels and SOD activity in the spinal cord of the CCI group were significantly lower than those in the sham group (<em>P</em> < 0.001 and <em>P</em> < 0.01, respectively). Bilateral EA administration significantly downregulated 8-OHdG levels (<em>P</em> < 0.01) and upregulated GSH levels and SOD activity in the spinal cord (<em>P</em> < 0.01). CCI significantly enhanced the production of IL-1β, IL-6, and TNF-α in the spinal cord compared with that in the sham group (all <em>P</em> < 0.001). Meanwhile, the effects of EA were also accompanied by markedly decreased expression of IL-1β and IL-6 in the spinal cord (<em>P</em> < 0.05). TNF-α levels were only decreased in the EA-Ip and EA-Bi groups compared with those in the CCI group (<em>P</em> < 0.001). Confocal microscopy revealed that Nrf2 was mainly localized in the neurons of the spinal cord. Notably, EA treatment enhanced nuclear translocation o
方法将雄性Sprague-Dawley大鼠置于CCI模型中诱导神经病理性疼痛,将45只大鼠随机分为五组(n=9):假组、CCI组、EA-Co组(CCI+对侧穴位EA)、EA-Ip组(CCI+对侧穴位EA)。共 45 只大鼠被随机分为五组(n = 9):假组、CCI 组、EA-Co 组(CCI + 对侧穴位 EA)、EA-Ip 组(CCI + 同侧穴位 EA)和 EA-Bi 组(CCI + 双侧穴位 EA)。大鼠在CCI后第8天接受EA治疗,隔天一次,共8次。测定了大鼠机械痛阈值(MWT)、后爪退缩潜伏期(HWL)和坐骨神经功能指数(SFI)的时间进程。测定了脊髓中8-羟基脱氧鸟苷(8-OHdG)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)活性、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)的表达水平。结果CCI后,CCI组的MWT和HWL均从术后第14天开始显著下降(P< 0.001)。EA 治疗通过增加 MWT 和 HWL 值,尤其是双侧 EA,表现出明显的 CCI 引起的抗痛觉效应(P < 0.05)。CCI组的SFI明显低于假组(P< 0.001)。与CCI组相比,只有双侧EA改善了SFI评分(P <0.05)。CCI组脊髓中的8-OHdG水平显著高于假组(P <0.05),而CCI组脊髓中的GSH水平和SOD活性显著低于假组(分别为P <0.001和P <0.01)。双侧EA给药可明显下调脊髓中的8-OHdG水平(P <0.01),上调GSH水平和SOD活性(P <0.01)。与假组相比,CCI能明显增加脊髓中IL-1β、IL-6和TNF-α的产生(P均为0.001)。同时,EA 的作用还伴随着脊髓中 IL-1β 和 IL-6 表达的明显降低(P < 0.05)。与CCI组相比,只有EA-Ip组和EA-Bi组的TNF-α水平有所下降(P <0.001)。共聚焦显微镜显示,Nrf2主要定位于脊髓神经元。值得注意的是,EA 治疗增强了神经元中 Nrf2 的核转位。与假组相比,CCI明显降低了脊髓中Nrf2、HO-1和NQO1的产生(P< 0.001),而双侧EA上调了Nrf2及其靶基因HO-1和NQO1的蛋白水平(均为P< 0.001)。EA对神经病理性疼痛的影响可能是通过恢复脊髓中的Nrf2通路介导的。
{"title":"Therapeutic effects of electroacupuncture at different sites on rats with neuropathic pain via the spinal Nrf2/HO-1 pathway","authors":"Liu CHEN (陈柳) ,&nbsp;Hao-tian PAN (潘昊天) ,&nbsp;Ya-nan ZHANG (张衙楠) ,&nbsp;Lan DUO (多兰) ,&nbsp;Xin DONG (董馨) ,&nbsp;Gong-ming WANG (王功命) ,&nbsp;Jia ZHOU (周嘉) ,&nbsp;Ke WANG (王珂)","doi":"10.1016/j.wjam.2024.03.003","DOIUrl":"https://doi.org/10.1016/j.wjam.2024.03.003","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;This study aimed to assess the effects of electroacupuncture (EA) at the contralateral, ipsilateral, or bilateral “Zusanli (ST36)” and “Yanglingquan(GB34)” on neuropathic pain caused by chronic contractile injury (CCI) and to explore the role of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in the effects of EA.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;Male Sprague-Dawley rats were subjected to the CCI model to induce neuropathic pain. A total of 45 rats were randomly divided into five groups (n = 9): sham, CCI, EA-Co (CCI + EA at contralateral acupoints), EA-Ip (CCI + EA at ipsilateral acupoints), and EA-Bi (CCI + EA at bilateral acupoints). The rats received EA treatment on day 8 after CCI, once every alternate day, for a total of eight times. The time courses of mechanical pain threshold (MWT), hind paw withdrawal latency (HWL), and sciatic functional index (SFI) were determined. The expression levels of 8-hydroxydeoxyguanosine (8-OHdG), glutathione (GSH), superoxide dismutase (SOD) activity, interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor factor-alpha (TNF-α) in the spinal cord were measured. The distribution of Nrf2, its expression of Nrf2 in both the cytosol and nucleus, and the protein levels of its downstream target genes, NQO1 and HO-1, were detected via double immunofluorescence staining and western blotting, respectively.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Following CCI, both MWT and HWL in the CCI group significantly decreased from day 14 after surgery (&lt;em&gt;P&lt;/em&gt; &lt; 0.001). EA treatment exhibited significant antinociceptive effects induced by CCI by increasing the MWT and HWL values, especially bilateral EA (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). The SFI of the CCI group was significantly lower than that of the sham group (&lt;em&gt;P&lt;/em&gt; &lt; 0.001). Only bilateral EA improved the SFI scores compared to the CCI group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). 8-OHdG levels in the spinal cord of the CCI group were significantly higher than those in the sham group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05), whereas GSH levels and SOD activity in the spinal cord of the CCI group were significantly lower than those in the sham group (&lt;em&gt;P&lt;/em&gt; &lt; 0.001 and &lt;em&gt;P&lt;/em&gt; &lt; 0.01, respectively). Bilateral EA administration significantly downregulated 8-OHdG levels (&lt;em&gt;P&lt;/em&gt; &lt; 0.01) and upregulated GSH levels and SOD activity in the spinal cord (&lt;em&gt;P&lt;/em&gt; &lt; 0.01). CCI significantly enhanced the production of IL-1β, IL-6, and TNF-α in the spinal cord compared with that in the sham group (all &lt;em&gt;P&lt;/em&gt; &lt; 0.001). Meanwhile, the effects of EA were also accompanied by markedly decreased expression of IL-1β and IL-6 in the spinal cord (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). TNF-α levels were only decreased in the EA-Ip and EA-Bi groups compared with those in the CCI group (&lt;em&gt;P&lt;/em&gt; &lt; 0.001). Confocal microscopy revealed that Nrf2 was mainly localized in the neurons of the spinal cord. Notably, EA treatment enhanced nuclear translocation o","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 2","pages":"Pages 130-137"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1003525724000138/pdfft?md5=2fa15a4ff2867e50a02754551f58a05c&pid=1-s2.0-S1003525724000138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcutaneous auricular vagus nerve stimulation: Clinical applications and mechanisms 经皮耳廓迷走神经刺激:临床应用和机制
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.03.007
Yu-zhengheng ZHANG (张煜郑姮) , Ning-yi ZOU (邹凝怿) , Pei-jing RONG (荣培晶) , Shao-yuan LI (李少源)
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引用次数: 0
Effect of acupuncture for anisometropic amblyopia: A randomized clinical trial and potential mechanism 针灸治疗异向性弱视的效果:随机临床试验和潜在机制
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.04.005
Cui MA (马翠) , Jing JIA (贾静) , Yu-juan YE (叶钰娟) , Yan SUN (孙燕) , Xing-ke YAN (严兴科)
<div><h3>Objective</h3><p>To evaluate the effect of acupuncture on anisometropic amblyopia (AA) and explore its potential mechanism for children with AA.</p></div><div><h3>Methods</h3><p>Seventy-six children with monocular AA were randomized into a conventional treatment group and a combined treatment group of acupuncture and conventional treatment, with 38 patients in each group. In the conventional treatment group, on the base of patching regimen, the red flashing, grating and visual stimulation were delivered. Each approach lasted for 5 min per session and was given once every two days, three times a week, for 4 consecutive weeks. In the acupuncture-combined treatment group, on the base of the regimen of conventional treatment group, acupuncture was applied to Jingming (BL1), Cuanzhu (BL2), Fengchi (GB20) and Guangming (GB37), with needles retained for 20 min per session, once every two days, three times of intervention a week and for 4 consecutive weeks. Before and after treatment, the best corrected vision acuity (BCVA) was observed to evaluate the clinical effect in the two groups. Before treatment started, 15 patients with AA on left side were randomized selected from each group and the resting-state functional magnetic resonance imaging (rs-fMRI) was operated before and after treatment. Simultaneously, eight healthy children with normal visual acuity were recruited to be the normal control group and received one-time rs-fMRI scanning. Based on the activation likelihood estimation (ALE), the visual “what” pathway network was constructed. By analyzing the amplitude of low frequency fluctuation (ALFF) and the regional homogeneity (ReHo), the differences in the regional autonomous function activities in the key brain areas of the “what” pathway were compared among the three groups.</p></div><div><h3>Results</h3><p>(1) Clinical effect: After treatment, BCVA was (0.6 [0.5, 0.6]), higher than that (0.4 [0.3, 0.5]) before treatment, presenting the statistical difference (<em>P</em> < 0.05) in the conventional treatment group. BCVA was (0.6 [0.6, 0.8]), higher than that (0.4 [0.4, 0.5]) before treatment, presenting the statistical difference (<em>P</em> < 0.05) in the acupuncture-combined treatment group. BCVA in the acupuncture-combined treatment group was higher than that of the conventional treatment group (<em>P</em> < 0.05) after treatment. The total effective rate was 86.1% in the acupuncture-combined treatment group, higher than that (65.8%) of the conventional treatment group (<em>P</em> < 0.05). (2) Mechanism: ① ALFF: In comparison with the healthy control group, the ALFF in the primary visual cortex of the “what” pathway for AA children was reduced significantly (<em>P</em> < 0.05), and ALFF in the right fusiform gyrus and the right inferior temporal gyrus increased significantly when compared with the healthy children (<em>P</em> < 0.05). Compared with that before treatment, there was no significant difference in the b
方法将76名单眼弱视患儿随机分为常规治疗组和针灸与常规治疗联合治疗组,每组38人。常规治疗组在贴敷疗法的基础上,给予红色闪光、光栅和视觉刺激。每种方法每次持续 5 分钟,每两天一次,每周三次,连续 4 周。针灸联合治疗组在常规治疗组的基础上,针刺京明(BL1)、攒竹(BL2)、风池(GB20)和光明(GB37),每次留针 20 分钟,每两天一次,一周三次,连续 4 周。治疗前后,观察两组患者的最佳矫正视力(BCVA),评价临床疗效。治疗开始前,每组随机抽取 15 名左侧 AA 患者,在治疗前后进行静息态功能磁共振成像(rs-fMRI)检查。同时,招募 8 名视力正常的健康儿童作为正常对照组,接受一次性 rs-fMRI 扫描。根据激活似然估计法(ALE),构建了视觉 "什么 "通路网络。通过分析低频波动幅度(ALFF)和区域同质性(ReHo),比较三组患者 "what "通路关键脑区的区域自主功能活动差异:治疗后,常规治疗组 BCVA 为(0.6 [0.5, 0.6]),高于治疗前(0.4 [0.3, 0.5]),差异有统计学意义(P &lt; 0.05)。针灸联合治疗组的 BCVA 为(0.6 [0.6, 0.8]),高于治疗前的(0.4 [0.4, 0.5]),存在统计学差异(P &lt; 0.05)。针灸联合治疗组治疗后 BCVA 高于常规治疗组(P &lt; 0.05)。针刺联合治疗组总有效率为 86.1%,高于常规治疗组的 65.8%(P &lt;0.05)。(2)机理:①ALFF:与健康对照组相比,AA儿童 "什么 "通路初级视皮层的ALFF明显降低(P &lt;0.05),右侧纺锤回和右侧颞下回的ALFF明显升高(P &lt;0.05)。与治疗前相比,常规治疗组治疗后 "什么 "通路的脑区无明显差异(P&gt; 0.05)。在针灸联合治疗组中,治疗后 "什么 "通路的右枕下回和右纺锤回的 ALFF 与治疗前相比有所增加(P &lt;0.05)。针灸联合治疗组治疗后与常规治疗组相比,"什么 "通路脑区无明显差异(P &gt;0.05)。ReHo:与健康对照组相比,AA 儿童 "什么 "通路中的右枕下回、右纺锤回和右颞下回的 ReHo 明显升高(P &lt;0.05)。与治疗前相比,常规治疗组的左枕下回和左纺锤形回的ReHo在治疗后明显增加(P&lt;0.05)。针灸联合治疗组治疗后与治疗前相比,右枕下回、左侧和右侧纺锤回的 ReHo 明显增加(P &lt;0.05)。结论 针灸联合常规治疗可改善AA患儿的BCVA和总有效率。AA儿童枕叶(枕下回)和颞叶(颞下回)自主活动的代偿性增加主导了 "什么 "通路内脑区功能活动的变化。传统治疗和针灸均可增强 "什么 "通路中枕叶(枕下回)和颞叶(纺锤回/颞下回)的自主功能活动强度,从而缓解视力障碍。
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引用次数: 0
Effect of acupuncture and moxibustion as the adjuvant therapy on frozen-thawed embryo transfer: A network meta-analysis 针灸作为辅助疗法对冷冻解冻胚胎移植的影响:网络荟萃分析
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.04.003
Min-hui LUO (罗敏辉) , Yan TAN (谭艳) , Yao-chen ZUO (左耀辰) , Wen-ying SHI (石文英) , Xin WANG (王鑫) , Wei ZHANG (章薇)

Objective

To evaluate the clinical effect of acupuncture- moxibustion as the adjuvant therapy on frozen-thawed embryo transfer (FET) using network meta-analysis.

Methods

In PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Wanfang database (WanFang), VIP database and Chinese Biomedical Literature Database (SinoMed), the randomized controlled trials (RCTs) of the adjuvant therapy of acupuncture-moxibustion for FET were retrieved, from database inception to April 1, 2021. Cochrane risk of bias assessment tool was used to screen and evaluate the quality of the included studies, and RevMan 5.3, GeMTC0.14.3 and Stata16.0 software were adopted to complete the network meta-analysis.

Results

Twenty-nine RCTs comprising 2880 patients were finally included, involving 17 interventions and 4 outcome measures. The results of network meta-analysis showed that the top three therapies under each outcome based on the magnitude of SUCRA values were: ① Clinical pregnancy rate (CPR, %): “transcutaneous electrical acupoint stimulation + herbal medicine” (76.4), “moxibustion + herbal medicine” (74.7), “acupuncture + moxibustion” (73.3); ②Biochemical pregnancy rate (BPR): “moxibustion + herbal medicine” (89.3), “acupuncture + moxibustion” (82.1), “acupuncture + herbal medicine” (78.7); ③Endometrial thickness: “acupoint injection + Western medicine” (87.2), auricular therapy (76.8), “acupuncture + herbal medicine” (73.5); ④Type A endometrial morphology rate: “acupoint injection + Western medicine ”(78.3), “moxibustion + herbal medicine” (58.0) and “acupuncture + moxibustion” (52.6).

Conclusion

The combined treatment of acupuncture-moxibustion was superior to single therapy for FET patients. The combined therapy of transcutaneous electrical acupoint stimulation and herbal medicine had the best effect for improving CPR, “moxibustion + herbal medicine” obtained the best average comprehensive effect, and “acupoint injection + Western medicine” was conductive to ameliorate the endometrial thickness and morphology. Due to the limitations of existing studies, more high-quality RCTs are needed in the future to further verify these conclusions.

目的 通过网络荟萃分析评价针灸作为冻融胚胎移植(FET)辅助治疗的临床效果。方法 在PubMed、Embase、Cochrane图书馆、中国国家知识基础设施(CNKI)、万方数据库(WanFang)、VIP数据库和中国生物医学文献数据库(SinoMed)中,检索自数据库建立至2021年4月1日期间针灸辅助治疗冻融胚胎移植的随机对照试验(RCT)。采用Cochrane偏倚风险评估工具对纳入研究进行筛选和质量评估,并采用RevMan 5.3、GeMTC0.14.3和Stata16.0软件完成网络荟萃分析。网络荟萃分析结果显示,根据 SUCRA 值的大小,每种结局下排名前三的疗法是临床妊娠率(CPR,%):"经皮穴位电刺激+中药"(76.4)、"艾灸+中药"(74.7)、"针灸+艾灸"(73.3);②生化妊娠率(BPR):"艾灸+中药"(89.3)、"针灸+艾灸"(82.1)、"针灸+中药"(78.7);③子宫内膜厚度:穴位注射+西药"(87.2)、"耳穴疗法"(76.8)、"针灸+中药"(73.5);④A 型子宫内膜形态率:"结论 针灸联合治疗 FET 患者的效果优于单一疗法。经皮穴位电刺激和中药联合治疗对改善 CPR 的效果最好,"艾灸+中药 "的平均综合效果最好,"穴位注射+西药 "对改善子宫内膜厚度和形态有传导作用。由于现有研究的局限性,未来需要更多高质量的 RCT 研究来进一步验证这些结论。
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引用次数: 0
Acupuncture for endometriosis-associated infertility: Study protocol for a randomized controlled trial 针灸治疗子宫内膜异位症相关不孕症:随机对照试验研究方案
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.01.001
Chu-ting WU (吴楚婷) , Xiao-yan DONG (董晓燕) , Xin-rong LI (李欣荣) , Yang CAO (曹阳) , Cai-mei HUANG (黄彩梅) , Ming-yang LI (李铭旸) , Jia-wei HU (胡佳玮) , Yuan GAO (高源) , Yu-ran LI (李语然) , Huan-gan WU (吴焕淦) , Chun-yan ZHANG (张春雁)

Background

Acupuncture has been proven to improve the pregnancy rate in infertile women. Endometriosis is a common cause of infertility. So far, there are no studies of the efficacy of acupuncture on endometriosis-associated infertility (EAI). Therefore, we will conduct a randomized controlled trial (RCT) to investigate whether acupuncture could have higher pregnancy rates in patients with EAI compared with sham acupuncture. The study protocol is reported in this paper.

Methods/design

The current trial is a multicenter randomized controlled study undergoing in Shanghai, China. About 224 eligible patients with EAI will be randomly assigned into the acupuncture group and the sham acupuncture group in a 1:1 ratio. In the acupuncture group, patients will be treated with acupuncture on Guanyuan (CV4), Zhongji (CV3), Zigong (EX-CA1), Xuehai (SP10), Zusanli (ST36), Sanyinjiao (SP6), and Taichong (LR3), twice a week, for 3 menstrual cycles, and 12 menstrual cycles will be followed up. The Park sham device will be used to perform non-transdermal acupuncture in the sham acupuncture group. The operation points will be located at 1.5 cm away beside these acupoints in the acupuncture group. The intervention period is the same as that in the acupuncture group. The primary outcome will be pregnancy rate. Secondary outcomes will include ultrasound results, cancer antigen 125 (CA125), anti-Müllerian hormone (AMH), sex hormones, and the Endometriosis Health Profile-5 (EHP-5). Outcomes will be collected at baseline, the end of treatment, and follow-up visits at 3, 6, and 12 menstrual cycles. All data, including major adverse events, will be recorded in electronic case report forms and analyzed using SPSS V.25.0.

Discussion

This study will help to evaluate whether acupuncture is effective in increasing the pregnancy rate of infertile women with endometriosis.

Trial registration

http://www.chictr.org.cn/ Identifier: ChiCTR2100047662. Registered 21 June 2021.

背景经证实,针灸可提高不孕妇女的怀孕率。子宫内膜异位症是导致不孕的常见原因。迄今为止,还没有关于针灸对子宫内膜异位症相关不孕症(EAI)疗效的研究。因此,我们将开展一项随机对照试验(RCT),研究与假针灸相比,针灸是否能提高 EAI 患者的怀孕率。方法/设计本试验是一项在中国上海进行的多中心随机对照研究。约 224 名符合条件的 EAI 患者将按 1:1 的比例随机分配到针刺组和假针刺组。在针刺组,患者将接受关元(CV4)、中极(CV3)、自宫(EX-CA1)、学海(SP10)、足三里(ST36)、三阴交(SP6)和太冲(LR3)的针刺治疗,每周两次,持续3个月经周期,并随访12个月经周期。假针灸组将使用 Park 假针灸仪进行非透皮针灸。针刺组的操作穴位将位于这些穴位旁 1.5 厘米处。干预时间与针灸组相同。主要结果为怀孕率。次要结果包括超声波检查结果、癌抗原 125 (CA125)、抗穆勒氏管激素 (AMH)、性激素和子宫内膜异位症健康档案-5 (EHP-5)。结果将在基线、治疗结束以及 3、6 和 12 个月经周期的随访时收集。包括主要不良事件在内的所有数据将记录在电子病例报告表中,并使用SPSS V.25.0进行分析。讨论本研究将有助于评估针灸是否能有效提高患有子宫内膜异位症的不孕妇女的怀孕率。试验注册http://www.chictr.org.cn/ Identifier:ChiCTR2100047662。注册日期:2021年6月21日。
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引用次数: 0
The rapid antidepressant effect of acupuncture on two animal models of depression by increasing the expression of synaptic proteins in the prefrontal cortex 针灸通过增加前额叶皮层突触蛋白的表达对两种抑郁症动物模型产生快速抗抑郁作用
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.03.002
Bai-le NING (宁百乐) , Zhi-fang WANG (王志芳) , Qing YANG (杨晴) , Qian WU (吴倩) , Qi-yue DENG (邓启粤) , Jing GAO (高静) , Wen FU (傅文) , Ying DENG (邓颖) , Bing-xin WU (吴炳鑫) , Xi-chang HUANG (黄熙畅) , Cong WANG (王聪) , Wen-bin FU (符文彬)
<div><h3>Objective</h3><p>To investigate the effect of acupuncture onset time and synaptic structure in two different models of depression.</p></div><div><h3>Methods</h3><p>A total of 150 healthy male adult SPF C57BL/6J mice were divided into five time-point groups: 1 h, 3 h, 6 h, 12 h and 24 h. Each time-point group was further divided into three groups: the model, scopolamine and acupuncture groups with 10 rats each. Rats were given forced swimming stimulation (15 min, once) before the intervention. A total of 200 healthy male adult specific pathogen-free (SPF) Sprague-Dawley (SD) rats were divided into 30 normal rats, and 170 modelling ones. A total of 90 rats were successfully modeled, and were randomly divided into three time-point groups: 1 h, 6 h and 24 h. And each time-point group was further divided into the normal, model, scopolamine, and acupuncture group. Chronic unpredictable mild stress (CUMS) combined with individual feeding was used to establish the depressed rat model. The sucrose preference test (SPT) and open field test (OFT) were used to evaluate the success of the model. There were 10 rats in each group. The acupuncture intervention was performed once for 20 min on “Baihui (GV20)”, “Yintang (GV29)”, “Hegu (LI4)”, and “Taichong (LR3)” without any other operations for the corresponding animals. Other groups were given corresponding medications. According to different time points, the forced swimming test (FST) was conducted in mice, and the FST and novelty-suppressed feeding test (NSFT) were measured in rats. Monoamine neurotransmitters (NE, DA, DOPAC, 5-HT, 5-HIAA, HVA) in the prefrontal cortex and hippocampus were detected with high performance liquid chromatography (HPLC). The expression of synapsin I, PSD95, p-mTOR, mTOR, and BDNF in the prefrontal cortex and hippocampus was determined by western blot.</p></div><div><h3>Results</h3><p>At the 1 h time point, compared with the model group, the immobility time was significantly decreased in the acupuncture group (<em>P</em> < 0.05). At 3 h, 6 h, 12 h, and 24 h, compared with the model group, the immobility time was significantly reduced in both scopolamine and acupuncture groups (<em>P</em> < 0.05). At the 1 h time point, compared with the normal group, the immobility time of FST and the latency to feed were significantly increased in the model group (<em>P</em> < 0.05). Compared with the model group, the immobility time of FST showed a significant reduction in the acupuncture group (<em>P</em> < 0.05). At the 6 h and 24 h time points, compared with the normal group, the immobility time of FST and the latency to feed were significantly increased in the model group (<em>P</em> < 0.05). Compared with the model group, the immobility time of FST was significantly decreased in the scopolamine and acupuncture groups (<em>P</em> < 0.05). At the 1 h and 24 h time points, compared with the normal group, the expression levels of 5-HT, 5-HIAA, NE, DA, DOPAC, and HVA of
方法将150只健康成年雄性SPF C57BL/6J小鼠分为1 h、3 h、6 h、12 h和24 h五个时间点组,每个时间点组又分为三组:模型组、东莨菪碱组和针刺组,每组10只。干预前对大鼠进行强迫游泳刺激(15 分钟,一次)。200只健康雄性无特定病原体(SPF)Sprague-Dawley(SD)大鼠被分为30只正常大鼠和170只模型大鼠。每个时间点又分为正常组、模型组、东莨菪碱组和针灸组。采用慢性不可预知的轻度应激(CUMS)结合个体喂养建立抑郁大鼠模型。蔗糖偏好试验(SPT)和开阔地试验(OFT)用于评估模型的成功与否。每组 10 只大鼠。针刺 "百会(GV20)"、"印堂(GV29)"、"合谷(LI4)"和 "太冲(LR3)"各一次,每次20分钟。其他组给予相应的药物治疗。根据不同的时间点,对小鼠进行强迫游泳试验(FST),对大鼠进行强迫游泳试验和新奇抑制摄食试验(NSFT)。高效液相色谱法(HPLC)检测了前额叶皮层和海马中的单胺神经递质(NE、DA、DOPAC、5-HT、5-HIAA、HVA)。结果1 h时,与模型组相比,针刺组的静止时间显著缩短(P <0.05)。在3小时、6小时、12小时和24小时,与模型组相比,东莨菪碱组和针刺组的静止时间均显著缩短(P < 0.05)。在1小时时间点,与正常组相比,模型组的FST不动时间和进食潜伏期明显增加(P < 0.05)。与模型组相比,针刺组的FST不动时间明显缩短(P < 0.05)。在 6 h 和 24 h 时间点,与正常组相比,模型组的 FST 不动时间和进食潜伏期显著增加(P < 0.05)。与模型组相比,东莨菪碱组和针刺组的FST不动时间明显缩短(P < 0.05)。在1 h和24 h时点,与正常组相比,模型组前额叶皮质和海马组织中5-HT、5-HIAA、NE、DA、DOPAC和HVA的表达水平明显降低(P < 0.05)。与模型组相比,针刺组前额叶皮层突触素 I、PSD95、p-mTOR 和 BDNF 的表达水平在 1 h 和 24 h 时点均明显升高(P < 0.05)。在 1 h 和 24 h 时点,与正常组相比,模型组前额叶皮层突触素 I、PSD95、p-mTOR 和 BDNF 的表达水平明显降低(P < 0.05)。与模型组相比,针刺组前额叶皮层突触素 I、PSD95、p-mTOR 和 BDNF 的表达水平明显升高(P < 0.05)。在 1 h 和 24 h 时点,与正常组相比,模型组海马组织突触素 I、PSD95、p-mTOR 和 BDNF 的表达水平明显降低(P < 0.05)。与模型组相比,针刺组海马突触素 I、PSD95、p-mTOR 和 BDNF 的表达水平无明显差异(P > 0.05)。
{"title":"The rapid antidepressant effect of acupuncture on two animal models of depression by increasing the expression of synaptic proteins in the prefrontal cortex","authors":"Bai-le NING (宁百乐) ,&nbsp;Zhi-fang WANG (王志芳) ,&nbsp;Qing YANG (杨晴) ,&nbsp;Qian WU (吴倩) ,&nbsp;Qi-yue DENG (邓启粤) ,&nbsp;Jing GAO (高静) ,&nbsp;Wen FU (傅文) ,&nbsp;Ying DENG (邓颖) ,&nbsp;Bing-xin WU (吴炳鑫) ,&nbsp;Xi-chang HUANG (黄熙畅) ,&nbsp;Cong WANG (王聪) ,&nbsp;Wen-bin FU (符文彬)","doi":"10.1016/j.wjam.2024.03.002","DOIUrl":"https://doi.org/10.1016/j.wjam.2024.03.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;p&gt;To investigate the effect of acupuncture onset time and synaptic structure in two different models of depression.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;A total of 150 healthy male adult SPF C57BL/6J mice were divided into five time-point groups: 1 h, 3 h, 6 h, 12 h and 24 h. Each time-point group was further divided into three groups: the model, scopolamine and acupuncture groups with 10 rats each. Rats were given forced swimming stimulation (15 min, once) before the intervention. A total of 200 healthy male adult specific pathogen-free (SPF) Sprague-Dawley (SD) rats were divided into 30 normal rats, and 170 modelling ones. A total of 90 rats were successfully modeled, and were randomly divided into three time-point groups: 1 h, 6 h and 24 h. And each time-point group was further divided into the normal, model, scopolamine, and acupuncture group. Chronic unpredictable mild stress (CUMS) combined with individual feeding was used to establish the depressed rat model. The sucrose preference test (SPT) and open field test (OFT) were used to evaluate the success of the model. There were 10 rats in each group. The acupuncture intervention was performed once for 20 min on “Baihui (GV20)”, “Yintang (GV29)”, “Hegu (LI4)”, and “Taichong (LR3)” without any other operations for the corresponding animals. Other groups were given corresponding medications. According to different time points, the forced swimming test (FST) was conducted in mice, and the FST and novelty-suppressed feeding test (NSFT) were measured in rats. Monoamine neurotransmitters (NE, DA, DOPAC, 5-HT, 5-HIAA, HVA) in the prefrontal cortex and hippocampus were detected with high performance liquid chromatography (HPLC). The expression of synapsin I, PSD95, p-mTOR, mTOR, and BDNF in the prefrontal cortex and hippocampus was determined by western blot.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;At the 1 h time point, compared with the model group, the immobility time was significantly decreased in the acupuncture group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). At 3 h, 6 h, 12 h, and 24 h, compared with the model group, the immobility time was significantly reduced in both scopolamine and acupuncture groups (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). At the 1 h time point, compared with the normal group, the immobility time of FST and the latency to feed were significantly increased in the model group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). Compared with the model group, the immobility time of FST showed a significant reduction in the acupuncture group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). At the 6 h and 24 h time points, compared with the normal group, the immobility time of FST and the latency to feed were significantly increased in the model group (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). Compared with the model group, the immobility time of FST was significantly decreased in the scopolamine and acupuncture groups (&lt;em&gt;P&lt;/em&gt; &lt; 0.05). At the 1 h and 24 h time points, compared with the normal group, the expression levels of 5-HT, 5-HIAA, NE, DA, DOPAC, and HVA of ","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 2","pages":"Pages 117-129"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1003525724000126/pdfft?md5=6c670c5323e0bbcfc187c273ef616d82&pid=1-s2.0-S1003525724000126-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of unilateral oculomotor nerve palsy after arachnoid cyst surgery in a Chinese boy 中国男孩蛛网膜囊肿手术后单侧眼球运动神经麻痹病例
IF 0.7 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2024-04-01 DOI: 10.1016/j.wjam.2024.03.009
Jun WANG (汪军), Xiao-juan SHI (侍孝娟), Dan-dan LUO (骆丹丹)

The paper reports a successful case of unilateral oculomotor palsy treated with acupuncture in a Chinese boy aged 5 years and 3 months. Filiform needles were applied for ptosis, ocular motility impairment and blurred vision of the left oculomotor palsy after arachnoid cyst surgery. Two stages of treatment with acupuncture were composed. Acupuncture in the first stage focused on resolving stasis, unblocking meridians and activating qi and blood circulation, especially at the acupoints around the eye, combined with the distal points (four gate points) to enhance qi movement and activate blood circulation, once daily. Besides, the western medicines for nerve nutrition were added. One month later, all the symptoms were alleviated, and the eyelid could be lifted. Then, the second stage of acupuncture started, during which, the western medicine for nerve nutrition was withdrawal, acupuncture was continued with the same acupoints as the first stage, once every two days. Besides, the thumb-tack needle was used to maintain the effect of filiform needle, and Zusanli (ST36) was added to replenish qi of spleen and stomach and promote circulation of meridians. Another month later, the lift of the left eyelid and the ocular motility were basically symmetrical to the right eye, and the left eye vision returned normal. Follow-up until the time of publication, the motility and function of the affected eye were basically the same as those of the healthy side. This case suggests that the staged intervention with acupuncture could be effective in child with unilateral oculomotor palsy after arachnoid cyst surgery and were acceptable for child. Further studies are needed to confirm the effect and mechanism of acupuncture intervention on postoperative oculomotor palsy.

本文报告了一例针灸治疗单侧眼球运动麻痹的成功病例,患者是一名中国男孩,5 岁零 3 个月。针刺丝状针治疗蛛网膜囊肿术后左侧眼球运动麻痹的上睑下垂、眼球运动障碍和视力模糊。针灸治疗分为两个阶段。第一阶段的针灸以化瘀、通经、活血为主,尤其是眼眶周围的穴位,结合远端穴位(四门穴)加强行气活血,每日一次。此外,还添加了营养神经的西药。一个月后,所有症状都得到了缓解,眼睑也可以抬起来了。然后,开始第二阶段的针灸,在此期间,停用营养神经的西药,继续针灸与第一阶段相同的穴位,每两天一次。此外,为了保持丝线针的效果,使用了拇指扎针,并加入了补脾胃之气、通经络的足三里(ST36)。又一个月后,左眼眼睑上提,眼球运动与右眼基本对称,左眼视力恢复正常。随访至发稿时,患侧眼球运动和功能与健侧基本一致。本病例表明,针灸分期干预对蛛网膜囊肿术后单侧眼球运动麻痹患儿有效,患儿也能接受。针灸干预对术后眼球运动麻痹的效果和机制有待进一步研究证实。
{"title":"A case of unilateral oculomotor nerve palsy after arachnoid cyst surgery in a Chinese boy","authors":"Jun WANG (汪军),&nbsp;Xiao-juan SHI (侍孝娟),&nbsp;Dan-dan LUO (骆丹丹)","doi":"10.1016/j.wjam.2024.03.009","DOIUrl":"https://doi.org/10.1016/j.wjam.2024.03.009","url":null,"abstract":"<div><p>The paper reports a successful case of unilateral oculomotor palsy treated with acupuncture in a Chinese boy aged 5 years and 3 months. Filiform needles were applied for ptosis, ocular motility impairment and blurred vision of the left oculomotor palsy after arachnoid cyst surgery. Two stages of treatment with acupuncture were composed. Acupuncture in the first stage focused on resolving stasis, unblocking meridians and activating <em>qi</em> and blood circulation, especially at the acupoints around the eye, combined with the distal points (four gate points) to enhance <em>qi</em> movement and activate blood circulation, once daily. Besides, the western medicines for nerve nutrition were added. One month later, all the symptoms were alleviated, and the eyelid could be lifted. Then, the second stage of acupuncture started, during which, the western medicine for nerve nutrition was withdrawal, acupuncture was continued with the same acupoints as the first stage, once every two days. Besides, the thumb-tack needle was used to maintain the effect of filiform needle, and Zusanli (ST36) was added to replenish <em>qi</em> of spleen and stomach and promote circulation of meridians. Another month later, the lift of the left eyelid and the ocular motility were basically symmetrical to the right eye, and the left eye vision returned normal. Follow-up until the time of publication, the motility and function of the affected eye were basically the same as those of the healthy side. This case suggests that the staged intervention with acupuncture could be effective in child with unilateral oculomotor palsy after arachnoid cyst surgery and were acceptable for child. Further studies are needed to confirm the effect and mechanism of acupuncture intervention on postoperative oculomotor palsy.</p></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"34 2","pages":"Pages 163-168"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1003525724000199/pdfft?md5=50970bf062f15eab5fc79bf6861ff0f0&pid=1-s2.0-S1003525724000199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141164197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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World Journal of Acupuncture-Moxibustion
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