Pub Date : 2025-10-01DOI: 10.1016/j.wjam.2025.08.004
Ye-tong CHEN (陈烨彤) , Feng-lin ZHU (朱凤林) , Yang ZHU (朱洋) , Yu-cheng DUAN (段玉丞) , Zhen-min BAI (白震民)
This review summarizes the clinical applications and mechanisms of action of motion-style acupuncture (MSAT) in rehabilitation medicine. Patients are required to perform active or passive movements while the acupuncture needles are inserted. Owing to its effectiveness, MSAT is progressively applied in clinical settings, including musculoskeletal and neurological diseases. Acupuncture and exercise generate synergistic effects through interactive mechanisms. From the perspective of the Traditional Chinese Medicine (TCM) theory, needling with movement can trigger the propagation of the needling sensation, thereby enhancing its efficacy in dredging meridians and regulating qi-blood circulation. In modern medicine, these mechanisms include neural inhibition, ischemia/reperfusion, and fascial stimulation propagation. Although the clinical applications and mechanism research of MSAT in rehabilitation medicine have advanced, the mechanisms of MSAT in treating various diseases and the scope of applicable diseases warrant deeper exploration. This will provide novel therapeutic strategies for clinical applications, thereby advancing the integration and application of TCM therapies with exercise-based interventions.
{"title":"Clinical utility of motion style acupuncture treatment in rehabilitation medicine","authors":"Ye-tong CHEN (陈烨彤) , Feng-lin ZHU (朱凤林) , Yang ZHU (朱洋) , Yu-cheng DUAN (段玉丞) , Zhen-min BAI (白震民)","doi":"10.1016/j.wjam.2025.08.004","DOIUrl":"10.1016/j.wjam.2025.08.004","url":null,"abstract":"<div><div>This review summarizes the clinical applications and mechanisms of action of motion-style acupuncture (MSAT) in rehabilitation medicine. Patients are required to perform active or passive movements while the acupuncture needles are inserted. Owing to its effectiveness, MSAT is progressively applied in clinical settings, including musculoskeletal and neurological diseases. Acupuncture and exercise generate synergistic effects through interactive mechanisms. From the perspective of the Traditional Chinese Medicine (TCM) theory, needling with movement can trigger the propagation of the needling sensation, thereby enhancing its efficacy in dredging meridians and regulating <em>qi</em>-blood circulation. In modern medicine, these mechanisms include neural inhibition, ischemia/reperfusion, and fascial stimulation propagation. Although the clinical applications and mechanism research of MSAT in rehabilitation medicine have advanced, the mechanisms of MSAT in treating various diseases and the scope of applicable diseases warrant deeper exploration. This will provide novel therapeutic strategies for clinical applications, thereby advancing the integration and application of TCM therapies with exercise-based interventions.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 303-311"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.wjam.2025.07.003
Hong-yu LU (卢宏玉), Bao-jin WANG (王宝金), Cui MA (马翠), An-guo LIU (刘安国), Xing-ke YAN (严兴科)
Pain-induced emotions are the negative moods caused by pain, such as depression and anxiety. Acupuncture can effectively relieve pain-induced emotions, and its mechanism is closely related to the regulation of neuroplasticity. Neuroplasticity is composed of two types, functional neuroplasticity and structural neuroplasticity. (1) Acupuncture improves functional neuroplasticity by inhibiting the activation of microglia and astrocytes, regulating the expression of neurotransmitters and receptors, modulating cellular signal transduction pathways, and optimizing synaptic transmission efficiency. (2) Acupuncture improves structural neuroplasticity by modulating neuronal synaptic plasticity, inhibiting neuronal apoptosis, and up-regulating the expression of the BDNF/TrKB/CREB signaling pathway. Additionally, acupuncture up-regulates the expression of brain-derived neurotrophic factors to improve both the functional and structural neuroplasticity, thus relieves pain-induced emotions. The above discovery provides an approach to the mechanism research of acupuncture for pain-induced emotions.
{"title":"Neuroplasticicity mechanism of acupuncture for pain-induced emotions: From function to structure","authors":"Hong-yu LU (卢宏玉), Bao-jin WANG (王宝金), Cui MA (马翠), An-guo LIU (刘安国), Xing-ke YAN (严兴科)","doi":"10.1016/j.wjam.2025.07.003","DOIUrl":"10.1016/j.wjam.2025.07.003","url":null,"abstract":"<div><div>Pain-induced emotions are the negative moods caused by pain, such as depression and anxiety. Acupuncture can effectively relieve pain-induced emotions, and its mechanism is closely related to the regulation of neuroplasticity. Neuroplasticity is composed of two types, functional neuroplasticity and structural neuroplasticity. (1) Acupuncture improves functional neuroplasticity by inhibiting the activation of microglia and astrocytes, regulating the expression of neurotransmitters and receptors, modulating cellular signal transduction pathways, and optimizing synaptic transmission efficiency. (2) Acupuncture improves structural neuroplasticity by modulating neuronal synaptic plasticity, inhibiting neuronal apoptosis, and up-regulating the expression of the BDNF/TrKB/CREB signaling pathway. Additionally, acupuncture up-regulates the expression of brain-derived neurotrophic factors to improve both the functional and structural neuroplasticity, thus relieves pain-induced emotions. The above discovery provides an approach to the mechanism research of acupuncture for pain-induced emotions.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 276-282"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.wjam.2025.08.001
Yu ZHOU (周宇), Zhong-chao WU (吴中朝), Peng WU (吴鹏)
This paper exhibits the construction and development of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences (CACMS), based on Lian ZHU’s acupuncture academic thought, focusing on the practice of the hospital development during the past 74 years, from 1951 to 2025, and by analyzing the development trajectory and elaborating the four-dimensional collaborative development mode guided by Lian ZHU’s thought, grounded in clinical evidence, driven by scientific innovation, guided by international standards, and rooted in educational inheritance. (1) After more than 70 years of development, Acupuncture and Moxibustion Hospital of CACMS has developed into the typical small-scaled general hospital of traditional Chinese medicine (TCM) with acupuncture-moxibustion as the main intervention, and has obtained a fruitful achievement in academic research. (2) The Hospital has led and participated in the formulation of a number of clinical practice guidelines of China Association of Acupuncture and Moxibustion, is entitled as the World Health Organization Collaborating Centre for traditional medicine, and has been ranked among the top in the outpatient visits of acupuncture-moxibustion department of TCM hospitals in Beijing for years. (3) There is a well-known professional team of acupuncture-moxibustion of TCM in the Hospital, and with the characteristic modes of acupuncture-moxibustion diagnosis and treatment delivered, the remarkable curative effects have been obtained in treatment of diseases in neurological, gynecological diseases, orthopedic departments, as well as pain disorders, allergic diseases. (4) In the future, facing the opportunities and challenges in the development of global healthcare, it is necessary to deepen the research on “intelligent acupuncture and moxibustion”, integrating modern technologies such as artificial intelligence and big data, exploring the potential value of acupuncture and moxibustion, discovering and innovating theoretical research on acupuncture and moxibustion, establishing scientific methods, standardizing clinical operation techniques, and driving the creative transformation of TCM. (5) The hospital lays the great consideration to the cultivation of acupuncture-moxibustion talents by means of multiple approaches, in order to deeply grasp the essence of TCM and improve the comprehensive quality of talents. (6) The hospital keeps on the leading role of international communication, advancing the international exchange and cooperation of acupuncture and moxibustion, and contributes more eastern wisdom to global health governance, and promote acupuncture and moxibustion of TCM, the treasure of the Chinese nation to display its importance in the world.
{"title":"Inheritance and development of Lian ZHU’s acupuncture academic thought in the construction of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences","authors":"Yu ZHOU (周宇), Zhong-chao WU (吴中朝), Peng WU (吴鹏)","doi":"10.1016/j.wjam.2025.08.001","DOIUrl":"10.1016/j.wjam.2025.08.001","url":null,"abstract":"<div><div>This paper exhibits the construction and development of Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences (CACMS), based on Lian ZHU’s acupuncture academic thought, focusing on the practice of the hospital development during the past 74 years, from 1951 to 2025, and by analyzing the development trajectory and elaborating the four-dimensional collaborative development mode guided by Lian ZHU’s thought, grounded in clinical evidence, driven by scientific innovation, guided by international standards, and rooted in educational inheritance. (1) After more than 70 years of development, Acupuncture and Moxibustion Hospital of CACMS has developed into the typical small-scaled general hospital of traditional Chinese medicine (TCM) with acupuncture-moxibustion as the main intervention, and has obtained a fruitful achievement in academic research. (2) The Hospital has led and participated in the formulation of a number of clinical practice guidelines of China Association of Acupuncture and Moxibustion, is entitled as the World Health Organization Collaborating Centre for traditional medicine, and has been ranked among the top in the outpatient visits of acupuncture-moxibustion department of TCM hospitals in Beijing for years. (3) There is a well-known professional team of acupuncture-moxibustion of TCM in the Hospital, and with the characteristic modes of acupuncture-moxibustion diagnosis and treatment delivered, the remarkable curative effects have been obtained in treatment of diseases in neurological, gynecological diseases, orthopedic departments, as well as pain disorders, allergic diseases. (4) In the future, facing the opportunities and challenges in the development of global healthcare, it is necessary to deepen the research on “intelligent acupuncture and moxibustion”, integrating modern technologies such as artificial intelligence and big data, exploring the potential value of acupuncture and moxibustion, discovering and innovating theoretical research on acupuncture and moxibustion, establishing scientific methods, standardizing clinical operation techniques, and driving the creative transformation of TCM. (5) The hospital lays the great consideration to the cultivation of acupuncture-moxibustion talents by means of multiple approaches, in order to deeply grasp the essence of TCM and improve the comprehensive quality of talents. (6) The hospital keeps on the leading role of international communication, advancing the international exchange and cooperation of acupuncture and moxibustion, and contributes more eastern wisdom to global health governance, and promote acupuncture and moxibustion of TCM, the treasure of the Chinese nation to display its importance in the world.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 388-392"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-01DOI: 10.1016/j.wjam.2025.09.001
Pei-ming ZHANG (张培铭) , Dan-chun LAN (蓝丹纯) , Ting-ting GU (谷婷婷) , Jia-hua WU (吴佳华) , Rui-rui TAO (陶睿睿) , Chun-zhi TANG (唐纯志) , Zi-yong LI (李子勇) , Li-ming LU (陆丽明)
Overeating is a risk factor and a management challenge in adiposity-based chronic disease (ABCD). Acupuncture has shown high safety and reliable clinical evidence in addressing overeating, and it is the promising potential non-pharmacological intervention. However, the mechanism underlying its effects has not been sufficiently summarized. The addiction model offers a framework to elucidate the mechanism of this aberrant eating behavior and provides novel perspectives and breakthrough points for optimizing clinical acupuncture strategies in ABCD management. In the paper, through analyzing domestic and international relevant findings, the characteristics of overeating based on food addiction, the relationship between overeating and ABCD, and the potential effect mechanisms of acupuncture for FA have been reviewed and summarized. Including adaptive balance of transmitters and hormones, functional networks, periphery-central connection, and cross-system interaction. In future studies, the maturely-developed addiction research methods should be adopted to deepen the exploration on the mechanism of acupuncture effect, addiction medicine should be leveraged to shatter the cognitive barriers surrounding acupuncture's role in mind-body regulation for ABCD treatment, and the prevention and treatment of overeating via acupuncture should be organically integrated into multidisciplinary management strategies.
{"title":"Potential mechanism of acupuncture on overeating and the significance in preventing and treating adiposity-based chronic disease: A new perspective based on the addiction model","authors":"Pei-ming ZHANG (张培铭) , Dan-chun LAN (蓝丹纯) , Ting-ting GU (谷婷婷) , Jia-hua WU (吴佳华) , Rui-rui TAO (陶睿睿) , Chun-zhi TANG (唐纯志) , Zi-yong LI (李子勇) , Li-ming LU (陆丽明)","doi":"10.1016/j.wjam.2025.09.001","DOIUrl":"10.1016/j.wjam.2025.09.001","url":null,"abstract":"<div><div>Overeating is a risk factor and a management challenge in adiposity-based chronic disease (ABCD). Acupuncture has shown high safety and reliable clinical evidence in addressing overeating, and it is the promising potential non-pharmacological intervention. However, the mechanism underlying its effects has not been sufficiently summarized. The addiction model offers a framework to elucidate the mechanism of this aberrant eating behavior and provides novel perspectives and breakthrough points for optimizing clinical acupuncture strategies in ABCD management. In the paper, through analyzing domestic and international relevant findings, the characteristics of overeating based on food addiction, the relationship between overeating and ABCD, and the potential effect mechanisms of acupuncture for FA have been reviewed and summarized. Including adaptive balance of transmitters and hormones, functional networks, periphery-central connection, and cross-system interaction. In future studies, the maturely-developed addiction research methods should be adopted to deepen the exploration on the mechanism of acupuncture effect, addiction medicine should be leveraged to shatter the cognitive barriers surrounding acupuncture's role in mind-body regulation for ABCD treatment, and the prevention and treatment of overeating via acupuncture should be organically integrated into multidisciplinary management strategies.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 312-319"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Microneedles (MNs), as a key component of third-generation transdermal drug delivery systems, show strong potential for obesity treatment. This study aimed to integrate traditional Chinese medicine (TCM) therapies, including Chinese patent medicine (CPM) injections and patches, with MN technology to identify commonly used administration sites and Chinese medicinal material (CMM) constituents suitable for MN-based weight loss interventions.
Methods
Literature was retrieved from PubMed, Web of Science, Google Scholar, CNKI, and Google Patents. First, existing studies on MN-based weight loss were narratively reviewed. Then, studies on CPM injections or patches were analyzed to extract intervention elements, including administration sites, CMM constituents, and symptoms. Acupoint–symptom and CMM constituent–symptom pairs were compiled, and key nodes were identified through complex network analysis using eigenvector centrality, PageRank, and betweenness centrality.
Results
Forty-four studies and thirteen patents were included. The review indicated that MN-based interventions demonstrated significant weight loss effects; however, current research remains limited by a focus on fat-deposition sites and insufficient development of CMM carriers. Network analysis identified Guanyuan (CV4) and Poria cocos (Fuling) as central nodes across all metrics, suggesting their strong potential as key elements in MN-based therapies.
Conclusion
CV4 and Poria cocos represent promising candidates for delivery sites and CMM constituents in MN-mediated obesity treatment. By integrating TCM principles with modern MN technology, these findings provide a theoretical basis for developing more targeted, efficient, and integrative anti-obesity interventions.
目的微针（MNs）作为第三代经皮给药系统的重要组成部分，在治疗肥胖方面具有很大的潜力。本研究旨在将中药（包括中成药（CPM）注射剂和贴片）与MN技术相结合，以确定适合基于MN的减肥干预的常用给药部位和中药材（CMM）成分。方法文献检索：PubMed、Web of Science、b谷歌Scholar、CNKI、谷歌Patents。首先，对现有的基于mn的减肥研究进行了综述。然后，分析中药注射剂或贴片的研究，提取干预元素，包括给药部位、中药成分和症状。编制穴位-症状和CMM成分-症状对，利用特征向量中心性、PageRank和中间度中心性进行复杂网络分析，确定关键节点。结果共纳入44项研究和13项专利。综述表明，基于神经网络的干预措施显示出显著的减肥效果；然而，目前的研究仍然局限于脂肪沉积部位的关注和CMM载体的开发不足。网络分析确定冠元（CV4）和茯苓（涪陵）是所有指标的中心节点，表明它们作为MN-based治疗的关键要素具有强大的潜力。结论cv4和茯苓在mn介导的肥胖治疗中具有潜在的递送位点和CMM成分。通过将中医原理与现代MN技术相结合，这些发现为开发更有针对性、更高效、更综合的抗肥胖干预措施提供了理论基础。
{"title":"Microneedle for weight loss: Most commonly used administration site and Chinese medicinal materials constituent","authors":"Lin-zhi WU (邬林芝) , Shi-jia HAN (韩诗佳) , Shuai-yan WANG (王帅研) , Zi-wen ZHOU (周梓雯) , Ke-ran CHEN (陈可然) , Zhi-qiang JING (景志强) , Bin XU (徐斌) , Tian-cheng XU (徐天成)","doi":"10.1016/j.wjam.2025.09.006","DOIUrl":"10.1016/j.wjam.2025.09.006","url":null,"abstract":"<div><h3>Objective</h3><div>Microneedles (MNs), as a key component of third-generation transdermal drug delivery systems, show strong potential for obesity treatment. This study aimed to integrate traditional Chinese medicine (TCM) therapies, including Chinese patent medicine (CPM) injections and patches, with MN technology to identify commonly used administration sites and Chinese medicinal material (CMM) constituents suitable for MN-based weight loss interventions.</div></div><div><h3>Methods</h3><div>Literature was retrieved from PubMed, Web of Science, Google Scholar, CNKI, and Google Patents. First, existing studies on MN-based weight loss were narratively reviewed. Then, studies on CPM injections or patches were analyzed to extract intervention elements, including administration sites, CMM constituents, and symptoms. Acupoint–symptom and CMM constituent–symptom pairs were compiled, and key nodes were identified through complex network analysis using eigenvector centrality, PageRank, and betweenness centrality.</div></div><div><h3>Results</h3><div>Forty-four studies and thirteen patents were included. The review indicated that MN-based interventions demonstrated significant weight loss effects; however, current research remains limited by a focus on fat-deposition sites and insufficient development of CMM carriers. Network analysis identified Guanyuan (CV4) and <em>Poria cocos</em> (Fuling) as central nodes across all metrics, suggesting their strong potential as key elements in MN-based therapies.</div></div><div><h3>Conclusion</h3><div>CV4 and <em>Poria cocos</em> represent promising candidates for delivery sites and CMM constituents in MN-mediated obesity treatment. By integrating TCM principles with modern MN technology, these findings provide a theoretical basis for developing more targeted, efficient, and integrative anti-obesity interventions.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 283-289"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145500439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Objective</h3><div>Acupuncture can effectively alleviate neuronal damage following traumatic brain injury (TBI); however, the underlying mechanisms remain unclear. This study aimed to investigate the putative mechanisms of acupuncture by examining the expression of Toll-like receptor 4 (TLR4), inhibitor of κB kinase (IKK) complex, nuclear factor κB (NF-κB) p65, and microglial polarization.</div></div><div><h3>Methods</h3><div>Specific pathogen-free (SPF) male Sprague-Dawley (SD) rats were divided into normal, TBI, and acupuncture groups, with 10 rats per group. Except for the normal group, the rat TBI model was established using Feeney's free-fall impact method. The acupuncture group received acupuncture intervention at the acupoints “Yamen (GV15)”, “Fengfu (GV16)”, “Baihui (GV20)”, “Shuigou (GV26)”, and “Hegu (LI4)”, once daily for 15 min per session for 5 days. The normal and TBI groups received no treatment, but were restrained for 15 min. Neurological dysfunction was assessed using the modified Neurological Severity Score (mNSS) on Days 1 and 5. Nissl staining and immunohistochemical staining for microglial M1 (CD86) and M2 (CD206) markers were used to observe the histopathological changes in the cortical tissue of TBI rats. Western blotting was employed to detect the expression of TLR4, IKKα+IKKβ, p-IKKα/β, p-IκBα, and NF-κB p65.</div></div><div><h3>Results</h3><div>(1) Compared to the normal group, the TBI group showed a significant increase in the mNSS score (<em>P</em> < 0.01). Nissl staining revealed disorganized neuronal cells, pyknotic nuclei, and fragmented and significantly decreased Nissl bodies. Immunohistochemistry demonstrated significantly increased expression of both CD86+ and CD206+ cells in the injured area (<em>P</em> < 0.01). Protein expression of TLR4, IKKα+IKKβ, p-IKKα/β, and p-IκBα in the cerebral cortex was significantly upregulated (<em>P</em> < 0.05 or <em>P</em> < 0.01), and NF-κB p65 expression in the nuclear protein fraction was increased (<em>P</em> < 0.01). (2) Compared to the TBI group, the acupuncture group exhibited a significant decrease in the mNSS score (<em>P</em> < 0.01). Nissl staining revealed improved neuronal structure, reduced number of pyknotic nuclei, and a significant increase in Nissl bodies. Immunohistochemistry indicated significantly decreased CD86+ cell expression (<em>P</em> < 0.01) and significantly increased CD206+ cell expression (<em>P</em> < 0.01). Protein expression of TLR4, IKKα+IKKβ, p-IKKα, and p-IκBα in the cerebral cortex was significantly reduced (<em>P</em> < 0.05), and NF-κB p65 expression in the nuclear protein fraction was significantly decreased (<em>P</em> < 0.01).</div></div><div><h3>Conclusions</h3><div>Acupuncture downregulates the expression of TLR4 and IKKα+IKKβ, inhibits the phosphorylation of IKKα/β and IκBα, reduces the nuclear expression of NF-κB p65, suppresses microglial M1 polarization, indirectly promotes M2 polarization,
{"title":"Manual acupuncture alleviates neuronal damage condition after traumatic brain injury by inhibiting the NF-κB pathway","authors":"Min-an CHEN (陈玟安) , Jia-yan CHEN (陈家燕) , Ke-ren ZHAO (赵可人) , Hai ZENG (曾海) , Lu-xi CAO (曹露西) , Xiao-wen CHEN (陈晓文) , Yi-min ZHANG (张毅敏) , Peng QING (卿鹏) , Yu GUO (郭郁) , Ming-min ZHU (朱明敏)","doi":"10.1016/j.wjam.2025.07.002","DOIUrl":"10.1016/j.wjam.2025.07.002","url":null,"abstract":"<div><h3>Objective</h3><div>Acupuncture can effectively alleviate neuronal damage following traumatic brain injury (TBI); however, the underlying mechanisms remain unclear. This study aimed to investigate the putative mechanisms of acupuncture by examining the expression of Toll-like receptor 4 (TLR4), inhibitor of κB kinase (IKK) complex, nuclear factor κB (NF-κB) p65, and microglial polarization.</div></div><div><h3>Methods</h3><div>Specific pathogen-free (SPF) male Sprague-Dawley (SD) rats were divided into normal, TBI, and acupuncture groups, with 10 rats per group. Except for the normal group, the rat TBI model was established using Feeney's free-fall impact method. The acupuncture group received acupuncture intervention at the acupoints “Yamen (GV15)”, “Fengfu (GV16)”, “Baihui (GV20)”, “Shuigou (GV26)”, and “Hegu (LI4)”, once daily for 15 min per session for 5 days. The normal and TBI groups received no treatment, but were restrained for 15 min. Neurological dysfunction was assessed using the modified Neurological Severity Score (mNSS) on Days 1 and 5. Nissl staining and immunohistochemical staining for microglial M1 (CD86) and M2 (CD206) markers were used to observe the histopathological changes in the cortical tissue of TBI rats. Western blotting was employed to detect the expression of TLR4, IKKα+IKKβ, p-IKKα/β, p-IκBα, and NF-κB p65.</div></div><div><h3>Results</h3><div>(1) Compared to the normal group, the TBI group showed a significant increase in the mNSS score (<em>P</em> < 0.01). Nissl staining revealed disorganized neuronal cells, pyknotic nuclei, and fragmented and significantly decreased Nissl bodies. Immunohistochemistry demonstrated significantly increased expression of both CD86+ and CD206+ cells in the injured area (<em>P</em> < 0.01). Protein expression of TLR4, IKKα+IKKβ, p-IKKα/β, and p-IκBα in the cerebral cortex was significantly upregulated (<em>P</em> < 0.05 or <em>P</em> < 0.01), and NF-κB p65 expression in the nuclear protein fraction was increased (<em>P</em> < 0.01). (2) Compared to the TBI group, the acupuncture group exhibited a significant decrease in the mNSS score (<em>P</em> < 0.01). Nissl staining revealed improved neuronal structure, reduced number of pyknotic nuclei, and a significant increase in Nissl bodies. Immunohistochemistry indicated significantly decreased CD86+ cell expression (<em>P</em> < 0.01) and significantly increased CD206+ cell expression (<em>P</em> < 0.01). Protein expression of TLR4, IKKα+IKKβ, p-IKKα, and p-IκBα in the cerebral cortex was significantly reduced (<em>P</em> < 0.05), and NF-κB p65 expression in the nuclear protein fraction was significantly decreased (<em>P</em> < 0.01).</div></div><div><h3>Conclusions</h3><div>Acupuncture downregulates the expression of TLR4 and IKKα+IKKβ, inhibits the phosphorylation of IKKα/β and IκBα, reduces the nuclear expression of NF-κB p65, suppresses microglial M1 polarization, indirectly promotes M2 polarization, ","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 4","pages":"Pages 376-383"},"PeriodicalIF":1.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145499883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To explore the optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade using data mining.
Methods
Clinical studies of abdominal obesity treated with acupuncture and moxibustion, collected in the past 10 years, were searched from China Biology Medicine disc(CBMdisc), China National knowledge infrastructure (CNKI), Wanfang, China Science and Technology Journal Database(VIP), Pubmed, Embase, Google Scholar, Web of Science, (The Cumulative Index to Nursing and Allied Health Literature)CINAHL, Psyclnfo and Scopus, dated from March 1, 2013 to March 31, 2023. Using IBM SPSS Modeler 18.0 and other software, the frequency analysis, association-rules analysis and cluster analysis were conducted on interventions, traditional Chinese medicine(TCM) patterns, use frequency of acupoint, meridian attribution of acupoint, acupoint location, etc.
Results
A total of 55 articles were included, with 102 prescriptions and 71 acupoints involved. The top 3 interventions were acupoint embedding method, simple electroacupuncture and simple filiform needling. Seventeen patterns/syndromes of TCM differentiation were collected, dominated by spleen deficiency and damp blockage, spleen and kidney yang deficiency and heat accumulation in stomach and intestines. The acupoints in clinical practice were mostly at the foot-yangming stomach meridian, the conception vessel and the foot-taiyin spleen meridian, and located at the abdominal region. The top 5 acupoints of high frequency were Tianshu (ST25), Zhongwan (CV12), Daheng (SP15), Zusanli (ST36), Huaroumen (ST24) and Daimai (GB26). The specific points of the high frequency were the crossing points and front-mu points, of which, ST25 and CV12 were the most prominent. After association-rules analysis on the high-frequency acupoints, 20 groups of associated acupoints were obtained, in which, the core acupoints included ST25, CV12, SP15 and ST36.
Conclusion
In recent 10 years, abdominal obesity is treated by the acupoints of foot-yangming stomach meridian, the conception vessel and the foot-taiyin spleen meridian. Compared with the regimen for simple obesity, the acupoints at the abdominal region are specially selected in treatment of abdominal obesity, such as ST25, CV12, SP15 and ST36. Supplementary acupoints are selected based on syndrome differentiation to simultaneously address both the disease manifestations and root causes.
目的利用数据挖掘技术，探讨近十年来针灸治疗成人腹型肥胖的最佳选穴与配合原则。方法检索2013年3月1日至2023年3月31日中国生物医学数据库（CBMdisc）、中国知网（CNKI）、万方、中国科技期刊数据库（VIP）、Pubmed、Embase、谷歌Scholar、Web of Science、（the Cumulative Index to Nursing and Allied Health Literature）CINAHL、Psyclnfo和Scopus，收集近10年来针灸治疗腹部肥胖的临床研究。采用IBM SPSS Modeler 18.0等软件，对干预措施、中医模式、穴位使用频率、穴位经络归属、穴位位置等进行频率分析、关联规则分析和聚类分析。结果共纳入文献55篇，涉及处方102张，穴位71个。排在前3位的干预措施分别是穴位包埋法、简易电针和简易丝状针。收集了17个中医辨证证型，以脾虚湿阻、脾肾阳虚、肠胃热积为主。临床上的穴位多在足阳明胃经、受孕经脉和足太阴脾经，且位于腹部。高频前5位分别为天枢穴（ST25）、中脘穴（CV12）、大横穴（SP15）、足三里穴（ST36）、花乳门穴（ST24）、代脉穴（GB26）。高频的具体点为交叉点和前mu点，其中ST25和CV12最为突出。对高频穴位进行关联规则分析，得到20组关联穴位，其中核心穴位包括ST25、CV12、SP15、ST36。结论近10年来，通过足阳明胃经、受孕经脉、足太阴脾经等穴位治疗腹部肥胖。与单纯性肥胖方案相比，针对腹部肥胖的治疗，特别选择了腹部的穴位，如ST25、CV12、SP15、ST36。根据辨证选择补穴，既能治本，又能治本。
{"title":"Optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade: A data mining","authors":"Jia-xin SHEN (沈佳欣) , Tian-yun HUANG (黄天韵) , Zhou HAO (郝舟) , Guang-bin PENG (彭广彬) , Yue-ying MA (马玥樱) , Huan-gan WU (吴焕淦) , Chun-hui BAO (包春辉)","doi":"10.1016/j.wjam.2025.06.008","DOIUrl":"10.1016/j.wjam.2025.06.008","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the optimization and principles of acupoint selection and coordination in the treatment of adult abdominal obesity using acupuncture and moxibustion over the past decade using data mining.</div></div><div><h3>Methods</h3><div>Clinical studies of abdominal obesity treated with acupuncture and moxibustion, collected in the past 10 years, were searched from China Biology Medicine disc(CBMdisc), China National knowledge infrastructure (CNKI), Wanfang, China Science and Technology Journal Database(VIP), Pubmed, Embase, Google Scholar, Web of Science, (The Cumulative Index to Nursing and Allied Health Literature)CINAHL, Psyclnfo and Scopus, dated from March 1, 2013 to March 31, 2023. Using IBM SPSS Modeler 18.0 and other software, the frequency analysis, association-rules analysis and cluster analysis were conducted on interventions, traditional Chinese medicine(TCM) patterns, use frequency of acupoint, meridian attribution of acupoint, acupoint location, etc.</div></div><div><h3>Results</h3><div>A total of 55 articles were included, with 102 prescriptions and 71 acupoints involved. The top 3 interventions were acupoint embedding method, simple electroacupuncture and simple filiform needling. Seventeen patterns/syndromes of TCM differentiation were collected, dominated by spleen deficiency and damp blockage, spleen and kidney <em>yang</em> deficiency and heat accumulation in stomach and intestines. The acupoints in clinical practice were mostly at the foot-<em>yangming</em> stomach meridian, the conception vessel and the foot-<em>taiyin</em> spleen meridian, and located at the abdominal region. The top 5 acupoints of high frequency were Tianshu (ST25), Zhongwan (CV12), Daheng (SP15), Zusanli (ST36), Huaroumen (ST24) and Daimai (GB26). The specific points of the high frequency were the crossing points and front-<em>mu</em> points, of which, ST25 and CV12 were the most prominent. After association-rules analysis on the high-frequency acupoints, 20 groups of associated acupoints were obtained, in which, the core acupoints included ST25, CV12, SP15 and ST36.</div></div><div><h3>Conclusion</h3><div>In recent 10 years, abdominal obesity is treated by the acupoints of foot-<em>yangming</em> stomach meridian, the conception vessel and the foot-<em>taiyin</em> spleen meridian. Compared with the regimen for simple obesity, the acupoints at the abdominal region are specially selected in treatment of abdominal obesity, such as ST25, CV12, SP15 and ST36. Supplementary acupoints are selected based on syndrome differentiation to simultaneously address both the disease manifestations and root causes.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 223-231"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.wjam.2025.05.002
Qiu-yi CHEN (陈秋怡), Quan MIAO (苗荃), Fei-yu FU (付飞羽), Ying LIN (林颖), Chen-xi ZENG (曾晨曦), Pei-yue PENG (彭佩玥), Yi-xin ZHANG (张艺馨), Lu LIU (刘璐), Bin LI (李彬)
<div><h3>Background</h3><div>A temporomandibular disorders (TMDs) is a musculoskeletal and neuromuscular condition that affects the temporomandibular joint, masticatory muscles, and associated tissues. Non-pharmacological interventions are currently considered as potential therapies for TMDs. However, high-quality systematic reviews and meta-analyses evaluating their clinical efficacy are lacking.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the clinical efficacy of non-pharmacological interventions for TMDs, focusing on their impact on pain relief, jaw mobility, and functional improvement. Specifically, we aimed to compare the effectiveness of four non-pharmacological interventions, including acupuncture, exercise, occlusal splinting, and laser therapy, for treating TMDs.</div></div><div><h3>Methods</h3><div>Comprehensive searches for randomized controlled trials (RCTs) were conducted in PubMed, Web of Science, Scopus, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, China Biomedical Literature Database (SinoMed), VIP, and Wanfang databases. The primary outcome was visual analog scale (VAS) score. The secondary outcomes included pain-free mouth opening, maximum assisted and unassisted mouth opening, and occurrence of adverse events. We used the Cochrane Risk of Bias tool and the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the risk of bias and the quality of evidence. The meta-analysis was performed using RevMan 5.4 software.</div></div><div><h3>Results</h3><div>A total of 22 RCTs involving 717 patients with TMDs were included. Non-pharmacological interventions significantly reduced VAS scores (n=19; mean difference [MD]= –1.86, 95 % confidence interval [CI] –2.40 to –1.31; <em>Z</em>=6.68; <em>P</em><0.05) and improved the pain-free mouth opening (n=6; MD=6.92, 95 % CI 4.91 to 8.94; <em>Z</em>=6.73; <em>P</em><0.05) and maximum unassisted mouth opening (n=10; MD=4.05, 95 % CI 2.08 to 6.02; <em>Z</em>=4.04; <em>P</em><0.05) in patients with TMDs. However, non-pharmacological interventions did not show a significant effect on maximum assisted mouth opening (n=2; MD=0.33, 95 % CI –4.16 to 4.82; <em>Z</em>=0.15; <em>P</em>=0.88). Only one RCT reported the occurrence of adverse events. Subgroup analysis showed that acupuncture (n=6; MD= –1.52, 95 % CI –2.86 to –0.18; <em>Z</em>=2.22; <em>P</em>=0.03), exercise (n=4; MD= –1.12, 95 % CI –1.94 to –0.31, <em>Z</em>=2.70; <em>P</em><0.05), occlusal splint (n=5; MD= –2.00, 95 % CI –2.67 to –1.33, <em>Z</em>=5.88; <em>P</em><0.05), and laser therapy (n=4; MD= –2.81, 95 % CI –3.89 to –1.73, <em>Z</em>=5.10, <em>P</em><0.05) were significantly superior to control treatments in reducing VAS scores. In addition, acupuncture (n=2; MD=6.50, 95 % CI 3.87 to 9.13; <em>Z</em>=4.85; <em>P</em><0.05), occlusal splint (n=2; MD=8.33, 95 % CI 4.41 to 12.24; <em>Z</em>=4.17; <em>P</em><0
颞下颌疾病（TMDs）是一种影响颞下颌关节、咀嚼肌和相关组织的肌肉骨骼和神经肌肉疾病。非药物干预目前被认为是tmd的潜在治疗方法。然而，缺乏高质量的系统评价和评估其临床疗效的荟萃分析。目的评价非药物干预治疗颞下颌关节痛的临床疗效，重点关注其对疼痛缓解、下颌活动能力和功能改善的影响。具体来说，我们的目的是比较四种非药物干预措施的有效性，包括针灸，运动，咬合夹板和激光治疗，治疗颞下颌关节病。方法综合检索PubMed、Web of Science、Scopus、Embase、Cochrane中央对照试验库、中国国家知识基础设施、中国生物医学文献数据库、维普数据库和万方数据库，检索随机对照试验（RCTs）。主要观察指标为视觉模拟评分（VAS）。次要结果包括无痛张嘴，最大辅助和非辅助张嘴，以及不良事件的发生。我们使用Cochrane偏倚风险工具和分级推荐评估、发展和评价方法来评估偏倚风险和证据质量。meta分析采用RevMan 5.4软件进行。结果共纳入22项随机对照试验，共纳入717例tmd患者。非药物干预显著降低VAS评分(n=19；平均差[MD]= -1.86, 95%置信区间[CI] -2.40 ~ -1.31；Z = 6.68;P<0.05)，改善无痛开口(n=6；MD=6.92, 95% CI 4.91 ~ 8.94；Z = 6.73;P<0.05)和最大无辅助张嘴量(n=10；MD=4.05, 95% CI 2.08 ~ 6.02；Z = 4.04;p < 0.05)。然而，非药物干预对最大辅助张嘴没有显着影响(n=2；MD=0.33, 95% CI -4.16 ~ 4.82；Z = 0.15;P = 0.88)。只有一项随机对照试验报告了不良事件的发生。亚组分析显示，针灸(n=6；MD= -1.52, 95% CI -2.86 ~ -0.18；Z = 2.22;P=0.03)，运动(n=4；MD= -1.12, 95% CI -1.94 ~ -0.31， Z=2.70；p < 0.05)，咬合夹板(n=5；MD= -2.00, 95% CI -2.67 ~ -1.33， Z=5.88；p < 0.05)，激光治疗(n=4；MD= -2.81, 95% CI -3.89 ~ -1.73， Z=5.10, P<0.05)在降低VAS评分方面显著优于对照治疗。此外，针灸(n=2；MD=6.50, 95% CI 3.87 ~ 9.13；Z = 4.85;p < 0.05)，咬合夹板(n=2；MD=8.33, 95% CI 4.41 ~ 12.24；Z = 4.17;p < 0.05)，激光治疗(n=2；MD=6.09, 95% CI 0.86 ~ 11.32；Z = 2.28;P=0.02)显著改善无痛张嘴，而运动组(n=2；MD=6.84, 95% CI 3.16 ~ 10.51；Z = 3.65;p < 0.05)和咬合夹板(n=2；MD=4.93, 95% CI 1.66 ~ 8.19；Z = 2.96;（p < 0.05）增加了最大无辅助张嘴。结论非药物干预对缓解疼痛、增强tmd患者无痛张嘴和最大无辅助张嘴有显著疗效。具体来说，针灸、运动、咬合夹板和激光治疗可以显著减轻颞下颌关节病患者的疼痛。咬合夹板改善无痛张嘴和最大无辅助张嘴效果较好，针刺和激光治疗改善无痛张嘴效果较好。运动显著提高最大无辅助张嘴。这些发现支持了这些治疗方法在临床实践中的应用，并为未来的tmd保守治疗指南提供了证据。
{"title":"Non-pharmacological interventions for temporomandibular disorders: A systematic review and meta-analysis","authors":"Qiu-yi CHEN (陈秋怡), Quan MIAO (苗荃), Fei-yu FU (付飞羽), Ying LIN (林颖), Chen-xi ZENG (曾晨曦), Pei-yue PENG (彭佩玥), Yi-xin ZHANG (张艺馨), Lu LIU (刘璐), Bin LI (李彬)","doi":"10.1016/j.wjam.2025.05.002","DOIUrl":"10.1016/j.wjam.2025.05.002","url":null,"abstract":"<div><h3>Background</h3><div>A temporomandibular disorders (TMDs) is a musculoskeletal and neuromuscular condition that affects the temporomandibular joint, masticatory muscles, and associated tissues. Non-pharmacological interventions are currently considered as potential therapies for TMDs. However, high-quality systematic reviews and meta-analyses evaluating their clinical efficacy are lacking.</div></div><div><h3>Objective</h3><div>This study aimed to evaluate the clinical efficacy of non-pharmacological interventions for TMDs, focusing on their impact on pain relief, jaw mobility, and functional improvement. Specifically, we aimed to compare the effectiveness of four non-pharmacological interventions, including acupuncture, exercise, occlusal splinting, and laser therapy, for treating TMDs.</div></div><div><h3>Methods</h3><div>Comprehensive searches for randomized controlled trials (RCTs) were conducted in PubMed, Web of Science, Scopus, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, China Biomedical Literature Database (SinoMed), VIP, and Wanfang databases. The primary outcome was visual analog scale (VAS) score. The secondary outcomes included pain-free mouth opening, maximum assisted and unassisted mouth opening, and occurrence of adverse events. We used the Cochrane Risk of Bias tool and the Grading of Recommendations Assessment, Development, and Evaluation approach to assess the risk of bias and the quality of evidence. The meta-analysis was performed using RevMan 5.4 software.</div></div><div><h3>Results</h3><div>A total of 22 RCTs involving 717 patients with TMDs were included. Non-pharmacological interventions significantly reduced VAS scores (n=19; mean difference [MD]= –1.86, 95 % confidence interval [CI] –2.40 to –1.31; <em>Z</em>=6.68; <em>P</em><0.05) and improved the pain-free mouth opening (n=6; MD=6.92, 95 % CI 4.91 to 8.94; <em>Z</em>=6.73; <em>P</em><0.05) and maximum unassisted mouth opening (n=10; MD=4.05, 95 % CI 2.08 to 6.02; <em>Z</em>=4.04; <em>P</em><0.05) in patients with TMDs. However, non-pharmacological interventions did not show a significant effect on maximum assisted mouth opening (n=2; MD=0.33, 95 % CI –4.16 to 4.82; <em>Z</em>=0.15; <em>P</em>=0.88). Only one RCT reported the occurrence of adverse events. Subgroup analysis showed that acupuncture (n=6; MD= –1.52, 95 % CI –2.86 to –0.18; <em>Z</em>=2.22; <em>P</em>=0.03), exercise (n=4; MD= –1.12, 95 % CI –1.94 to –0.31, <em>Z</em>=2.70; <em>P</em><0.05), occlusal splint (n=5; MD= –2.00, 95 % CI –2.67 to –1.33, <em>Z</em>=5.88; <em>P</em><0.05), and laser therapy (n=4; MD= –2.81, 95 % CI –3.89 to –1.73, <em>Z</em>=5.10, <em>P</em><0.05) were significantly superior to control treatments in reducing VAS scores. In addition, acupuncture (n=2; MD=6.50, 95 % CI 3.87 to 9.13; <em>Z</em>=4.85; <em>P</em><0.05), occlusal splint (n=2; MD=8.33, 95 % CI 4.41 to 12.24; <em>Z</em>=4.17; <em>P</em><0","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 182-196"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.wjam.2025.06.001
Yan LI (李岩) , Shuang LIU (刘双) , Hai-fa QIAO (乔海法)
<div><h3>Background</h3><div>Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurotoxic reaction for patients undergoing anticancer regimens. More and more studies show that acupuncture-moxibustion plays a positive role in the management and prevention of CIPN.</div></div><div><h3>Objective</h3><div>To evaluate the clinical effect of acupuncture-moxibustion in patients with CIPN, with a focus on assessing its effectiveness on improving treatment response rates, alleviating pain, enhancing quality of life (QoL), and improving nerve conduction. Additionally, the study compares the differences in clinical effectiveness among various acupuncture therapies for CIPN management.</div></div><div><h3>Methods</h3><div>Six databases (PubMed, Embase, Cochrane Library, Web of Science, OVID, and China National knowledge infrastructure [CNKI]) were searched from earliest available dates to December 1, 2024, and only randomized controlled trials (RCTs) containing relevant search terms were included. Network meta-analysis of the RCT data were conducted to assess the effective rate of the treatment as the primary outcome. Nerve conduction, pain scores, and QoL were assessed as secondary outcomes. The version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) was used to examine methodological quality, and Stata 15.1 was used to take network meta-analysis.</div></div><div><h3>Results</h3><div>A total of 34 RCTs involving 2039 participants and 9 acupuncture-moxibustion therapies were included. The network meta-analysis evaluated the effect of different acupuncture therapies across four outcomes: effective rate, pain scores, QoL, and nerve conduction. For effective rate, electroacupuncture combined with moxibustion ranked first with a surface under the cumulative ranking curve (SUCRA) value of 62.9 %, followed by acupoint application (56.9 %) and moxibustion (52.3 %). Electroacupuncture combined with moxibustion had the highest effective rate compared to standard of care treatments (odds ratio [OR] = 1.62, 95 % confidence interval [CI] −5.18 to 8.43). For alleviating pain, auricular acupressure had the highest SUCRA value (85.9 %), while electroacupuncture and electroacupuncture combined with three-edged needle ranked second (63.4 %) and third (51.0 %), respectively. Auricular acupressure significantly reduced pain (SMD= −1.73, 95 % CI −3.54 to 0.08). For QoL, warming needle ranked first (SUCRA= 92.0 %), followed by electroacupuncture (48.7 %) and filiform needle (43.0 %). Warming needle significantly improved QoL scores (SMD= −0.75, 95 % CI −1.66 to 0.15). For nerve conduction, electroacupuncture combined with three-edged needle had the highest SUCRA value (100 %), while moxibustion and filiform needle ranked second (65.3 %) and third (39.2 %), respectively. Electroacupuncture combined with three-edged had the best neuroprotective effect (SMD = 1.85, 95 % CI 1.23 to 2.47).</div></div><div><h3>Conclusion</h3><div>Network meta-analysis bas
化疗诱导的周围神经病变（CIPN）是接受抗癌方案的患者常见的神经毒性反应。越来越多的研究表明，针灸对CIPN的管理和预防具有积极作用。目的评价针刺治疗CIPN患者的临床疗效，重点评价其在提高治疗有效率、减轻疼痛、提高生活质量、改善神经传导方面的效果。此外，本研究比较了不同针灸疗法治疗CIPN的临床疗效差异。方法检索PubMed、Embase、Cochrane Library、Web of Science、OVID、中国知网（CNKI） 6个数据库，检索时间为最早可查日期至2024年12月1日，仅纳入包含相关检索词的随机对照试验（RCTs）。对RCT数据进行网络荟萃分析，以评估治疗的有效率作为主要结局。神经传导、疼痛评分和生活质量作为次要指标进行评估。采用Cochrane随机试验风险偏倚工具第2版（RoB 2）检验方法学质量，采用Stata 15.1进行网络荟萃分析。结果共纳入34项随机对照试验，受试者2039人，共纳入9种针灸疗法。网络荟萃分析评估了不同针灸疗法在四个方面的效果：有效率、疼痛评分、生活质量和神经传导。有效率方面，电针联合艾灸以累计排序曲线下曲面（SUCRA）值62.9%居首位，其次为穴位敷贴（56.9%）和艾灸（52.3%）。与标准护理治疗相比，电针联合艾灸的有效率最高（优势比[OR] = 1.62, 95%可信区间[CI] - 5.18 ~ 8.43）。在缓解疼痛方面，耳穴按压的SUCRA值最高（85.9%），其次为电针（63.4%），第三为电针联合三棱针（51.0%）。耳穴压可显著减轻疼痛（SMD= - 1.73, 95% CI = - 3.54 ~ 0.08）。对于生活质量，温针排名第一（SUCRA= 92.0%），其次是电针（48.7%）和丝状针（43.0%）。温针显著提高生活质量评分（SMD= - 0.75, 95% CI = - 1.66 ~ 0.15）。对于神经传导，电针联合三棱针的SUCRA值最高（100%），艾灸次之（65.3%），丝状针次之（39.2%）。电针联合三刃的神经保护效果最好（SMD = 1.85, 95% CI 1.23 ~ 2.47）。结论基于主要转归（有效率）的网络荟萃分析显示，电针联合艾灸是治疗化疗性周围神经病变（CIPN）的最佳针刺疗法。次要结局表现出相当大的异质性：耳穴按压在缓解疼痛方面表现出更好的效果，电针联合三棱针在改善神经传导功能方面表现出更大的优势，而温针在改善生活质量方面表现出更显著的效果。考虑到不同结果测量的干预措施的可变性以及纳入研究的方法学局限性，目前的证据需要谨慎解释。系统评审注册：普洛斯佩罗注册号：CRD42024560017。
{"title":"Acupuncture-moxibustion for chemotherapy-induced peripheral neuropathy: A systematic review and network meta-analysis","authors":"Yan LI (李岩) , Shuang LIU (刘双) , Hai-fa QIAO (乔海法)","doi":"10.1016/j.wjam.2025.06.001","DOIUrl":"10.1016/j.wjam.2025.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Chemotherapy-induced peripheral neuropathy (CIPN) is a common neurotoxic reaction for patients undergoing anticancer regimens. More and more studies show that acupuncture-moxibustion plays a positive role in the management and prevention of CIPN.</div></div><div><h3>Objective</h3><div>To evaluate the clinical effect of acupuncture-moxibustion in patients with CIPN, with a focus on assessing its effectiveness on improving treatment response rates, alleviating pain, enhancing quality of life (QoL), and improving nerve conduction. Additionally, the study compares the differences in clinical effectiveness among various acupuncture therapies for CIPN management.</div></div><div><h3>Methods</h3><div>Six databases (PubMed, Embase, Cochrane Library, Web of Science, OVID, and China National knowledge infrastructure [CNKI]) were searched from earliest available dates to December 1, 2024, and only randomized controlled trials (RCTs) containing relevant search terms were included. Network meta-analysis of the RCT data were conducted to assess the effective rate of the treatment as the primary outcome. Nerve conduction, pain scores, and QoL were assessed as secondary outcomes. The version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) was used to examine methodological quality, and Stata 15.1 was used to take network meta-analysis.</div></div><div><h3>Results</h3><div>A total of 34 RCTs involving 2039 participants and 9 acupuncture-moxibustion therapies were included. The network meta-analysis evaluated the effect of different acupuncture therapies across four outcomes: effective rate, pain scores, QoL, and nerve conduction. For effective rate, electroacupuncture combined with moxibustion ranked first with a surface under the cumulative ranking curve (SUCRA) value of 62.9 %, followed by acupoint application (56.9 %) and moxibustion (52.3 %). Electroacupuncture combined with moxibustion had the highest effective rate compared to standard of care treatments (odds ratio [OR] = 1.62, 95 % confidence interval [CI] −5.18 to 8.43). For alleviating pain, auricular acupressure had the highest SUCRA value (85.9 %), while electroacupuncture and electroacupuncture combined with three-edged needle ranked second (63.4 %) and third (51.0 %), respectively. Auricular acupressure significantly reduced pain (SMD= −1.73, 95 % CI −3.54 to 0.08). For QoL, warming needle ranked first (SUCRA= 92.0 %), followed by electroacupuncture (48.7 %) and filiform needle (43.0 %). Warming needle significantly improved QoL scores (SMD= −0.75, 95 % CI −1.66 to 0.15). For nerve conduction, electroacupuncture combined with three-edged needle had the highest SUCRA value (100 %), while moxibustion and filiform needle ranked second (65.3 %) and third (39.2 %), respectively. Electroacupuncture combined with three-edged had the best neuroprotective effect (SMD = 1.85, 95 % CI 1.23 to 2.47).</div></div><div><h3>Conclusion</h3><div>Network meta-analysis bas","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 197-207"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-07-01DOI: 10.1016/j.wjam.2025.06.004
Shu-juan LI (李蜀娟) , Min XIAO (肖敏) , Chong-bing MA (马重兵) , Xing-ke YAN (严兴科)
Acupuncture has been proven effective in treating depressive disorders, and its neuroelectrophysiological mechanisms have drawn increasing scientific attention. This paper reviews recent neuroelectrophysiological studies on acupuncture in the treatment of depressive disorders. Studies have shown that acupuncture can modulate the Alpha and Theta wave frequencies and amplitudes of electroencephalograms; improve the latency and amplitude of event-related potential such as P300 and mismatch negativity (MMN); enhance the amplitude of motor-evoked potential and short-interval intracortical inhibition as measured by transcranial magnetic stimulation-electromyography (TMS-EMG); regulate both spontaneous and induced rhythmic activities; increase motor cortex excitability; and promote the electrical signal transmission in neuronal clusters. Acupuncture can enhance the long-term potentiation (LTP) detected by PCRT, repair the plasticity of synaptic functions, and promote the transmission of synaptic information; lower the action potential (AP) and population spike (PS) membrane voltage detected by PCRT, inhibit abnormal neuronal excitability, and restore electrical signal transmission across neuronal membranes. These findings, as summarized in this review, may reflect potential neuroelectrical signal transmission mechanisms involved in the acupuncture interventions for depressive disorders.
{"title":"Research progress on the mechanism of neural electrical information transmission in acupuncture intervention of depression","authors":"Shu-juan LI (李蜀娟) , Min XIAO (肖敏) , Chong-bing MA (马重兵) , Xing-ke YAN (严兴科)","doi":"10.1016/j.wjam.2025.06.004","DOIUrl":"10.1016/j.wjam.2025.06.004","url":null,"abstract":"<div><div>Acupuncture has been proven effective in treating depressive disorders, and its neuroelectrophysiological mechanisms have drawn increasing scientific attention. This paper reviews recent neuroelectrophysiological studies on acupuncture in the treatment of depressive disorders. Studies have shown that acupuncture can modulate the Alpha and Theta wave frequencies and amplitudes of electroencephalograms; improve the latency and amplitude of event-related potential such as P300 and mismatch negativity (MMN); enhance the amplitude of motor-evoked potential and short-interval intracortical inhibition as measured by transcranial magnetic stimulation-electromyography (TMS-EMG); regulate both spontaneous and induced rhythmic activities; increase motor cortex excitability; and promote the electrical signal transmission in neuronal clusters. Acupuncture can enhance the long-term potentiation (LTP) detected by PCRT, repair the plasticity of synaptic functions, and promote the transmission of synaptic information; lower the action potential (AP) and population spike (PS) membrane voltage detected by PCRT, inhibit abnormal neuronal excitability, and restore electrical signal transmission across neuronal membranes. These findings, as summarized in this review, may reflect potential neuroelectrical signal transmission mechanisms involved in the acupuncture interventions for depressive disorders.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 3","pages":"Pages 167-172"},"PeriodicalIF":1.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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