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Diagnosis and treatment strategy of acupuncture-moxibustion for advanced-age infertility in vitro fertilization and embryo transfer based on the temporal rhythm theory of traditional Chinese medicine 基于中医时间节律理论的针灸治疗高龄不孕症体外受精胚胎移植的诊疗策略
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2025.03.001
Shu Bee CHEN (曾炜美) , Jing LIU (刘静) , Xue-si HOU (侯学思) , Li-kun YANG (杨丽鹍) , Yi-ni SUN (孙旖旎) , Shu-qi MI (米淑琦) , Ji-ping ZHAO (赵吉平)
The ability of natural conception decreases with age, leading many advanced-age women with fertility desire begin to attempt in vitro fertilization and embryo transfer (IVF-ET) technique nowadays. Traditional Chinese medicine (TCM) believes that human body undergoes periodic changes corresponding to the natural rhythms. Women exhibit distinct physiological lunar rhythms of the thoroughfare vessel and the conception vessel, as well as pathological rhythms during the menstrual cycle and IVF-ET cycle. Based on the theory of TCM temporal rhythm, this paper discusses the pathogenesis characteristics of infertility in advanced-age women at different stages. It believes that acupuncture intervention should comply with the following ideas: determining main acupoints based on disease differentiation, with a preference for the acupoints on the thoroughfare vessel, the conception vessel, spleen meridian and kidney meridian, as well as the back-shu points of the liver, spleen and kidney; determining the supplementary acupoints based on syndrome differentiation and symptoms; determining the supplementary acupoints based on time differentiation of lunar rhythm of the thoroughfare vessel and the conception vessel, and integrating both reinforcing and reducing techniques. During the process of intervention, the physical and mental states were balanced simultaneously.
自然受孕能力随着年龄的增长而下降,导致许多有生育愿望的高龄妇女开始尝试体外受精和胚胎移植(IVF-ET)技术。传统中医认为,人体会经历与自然节律相对应的周期性变化。女性在月经周期和IVF-ET周期中表现出不同的经管和受孕管生理节律,以及病理节律。本文以中医时间节律理论为基础,探讨不同阶段高龄妇女不孕的病机特点。认为针灸干预应遵循以下思路:根据疾病辨证确定主要腧穴,优先选择通脉、意脉、脾经、肾经上的腧穴,以及肝、脾、肾的背枢穴;根据辨证论治确定补穴;根据经脉与受孕脉月相节律的时间差确定补穴,补泻并举。在干预过程中,身体和精神状态同时得到平衡。
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引用次数: 0
Nomenclature and location of acupuncture points for laboratory animals Part 3: Mouse 实验动物穴位的命名和定位。第3部分:小鼠
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2024.12.007
China Association of Acupuncture and Moxibustion (中国针灸学会)
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引用次数: 0
Research progress on the mechanism of acupuncture-moxibustion in promoting the rehabilitation of sequelae of ischemic stroke 针灸促进缺血性脑卒中后遗症康复机制的研究进展
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2025.03.004
Chang-long ZHANG (张长龙) , Yang LI (李阳) , Fei XU (徐飞) , Li-li SHANG (尚莉莉)
Acupuncture-moxibustion can promote recovery from the sequelae of ischemic stroke. However, its mechanism of action has not yet been fully elucidated. This paper introduces the mechanism of acupuncture-moxibustion in alleviating rehabilitation of ischemic stroke sequelae. The regulatory mechanism of acupuncture-moxibustion was analyzed for limb movement disorders, cognitive impairment, depression, epilepsy, dysphagia, and insomnia after stroke from four aspects (promoting neuronal growth and cell proliferation, regulating cerebral blood flow, modulating neurochemicals, and suppressing cell apoptosis). This study provides theoretical support for the wide application of acupuncture-moxibustion in rehabilitation after ischemic stroke.
针灸可促进缺血性脑卒中后遗症的恢复。然而,其作用机制尚未完全阐明。本文介绍了针灸缓解缺血性脑卒中后遗症康复的作用机制。从促进神经元生长和细胞增殖、调节脑血流量、调节神经化学物质、抑制细胞凋亡四个方面分析针灸对脑卒中后肢体运动障碍、认知障碍、抑郁、癫痫、吞咽困难、失眠的调节机制。本研究为针灸在缺血性脑卒中后康复中的广泛应用提供了理论支持。
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引用次数: 0
How to generate high-quality clinical evidence: Taking the study of acupuncture for chronic urticaria published in Annals of Internal Medicine as an example 如何产生高质量的临床证据:以《内科医学年鉴》发表的针灸治疗慢性荨麻疹的研究为例
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2025.02.001
Ren-hong WAN (万仁洪) , Wei CAO (曹炜) , Zi-hao ZOU (邹子豪) , Shuai CHEN (陈帅) , Si-jue CHEN (陈思珏) , Hui ZHENG (郑晖) , Ying LI (李瑛)
High-quality clinical evidence is the basis of evidence-based medical practice. Acupuncture is the most widely used complementary and alternative medicine in the world. However, the improvement in the quality of acupuncture clinical research does not match the rapid increase in the number of acupuncture clinical research in recent years. At present, the number of high-quality acupuncture clinical research in the world remains low. Taking the trial of acupuncture for chronic spontaneous urticaria published in Annals of Internal Medicine as an example, this paper discusses the factors that contribute to producing high-quality clinical evidence for acupuncture from the aspects of selecting the topic of study, formulating the study method, designing the study plan, controlling the study process, writing the study report, and selecting the journal in the process of before, during, and after the research. It emphasizes the necessity to start from the benefit of global people's health, take practical clinical problems as guidance, cleverly choose the research entry point, and conduct high-quality research with clinical value. After the accomplishment of the study, the results must be faithfully described, the scientific conclusions accurately sublimated, and appropriate scientific journals selected for publication.
高质量的临床证据是循证医学实践的基础。针灸是世界上使用最广泛的补充和替代医学。然而,针灸临床研究质量的提高与近年来针灸临床研究数量的快速增长并不匹配。目前,世界上高质量的针灸临床研究数量仍然较少。本文以发表在《内科学年鉴》上的针灸治疗慢性自发性荨麻疹试验为例,从研究前、研究中、研究后的研究课题的选择、研究方法的制定、研究计划的设计、研究过程的控制、研究报告的撰写、期刊的选择等方面探讨了产生高质量针灸临床证据的因素。强调要从全球人民健康利益出发,以临床实际问题为导向,巧妙选择研究切入点,开展具有临床价值的高质量研究。在研究完成后,必须忠实地描述结果,准确地升华科学结论,并选择合适的科学期刊发表。
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引用次数: 0
Global trend in the research and development of acupuncture on low back pain during 1997 to 2023: A bibliometric analysis 1997 - 2023年全球针灸治疗腰痛研究发展趋势:文献计量学分析
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2025.01.003
Fang-hua ZHAO (赵芳华), Mei-ling SUN (孙美玲), Wen-yan SHI (石文艳), Hai-yan LI (李海燕)

Objective

This study aims to analyze the current state and emerging trends in research articles related to acupuncture treatment for low back pain (LBP).

Methods

The Web of Science core database was utilized to retrieve relevant literature on acupuncture therapy for LBP from January 1, 1997, to August 29, 2023. Literature metrics analysis was conducted using Microsoft Excel, VOSviewer, SCImago Graphica, and Pajek. The analysis focused on annual publication volume, countries (regions), institutions, authors, journals, keywords, and references.

Results

A total of 1,434 papers on acupuncture treatment for LBP were identified, demonstrating a fluctuating growth trend over the past 25 years. Research in this field has been conducted in 57 countries, with the United States leading in terms of research output. Italy emerged as the country with the highest-quality publications, with an average citation frequency of 205.16 times. A total of 1,781 institutions contributed to research on acupuncture treatment for LBP, with Harvard University having the highest publication volume (cited 77 times). The number of authors contributing to this field reached 5,696, with In-Hyuk Ha having the highest publication count (31 papers) and Claudia-M. Witt is the most influential author (cited 2,699 times). Relevant research was published in 378 journals, with the Journal of Alternative and Complementary Medicine having the highest publication volume (77 papers), and Spine being the most influential journal (cited 3,420 times). A total of 3,854 keywords were identified, forming six main thematic clusters: care management, nerve stimulation, complementary medicine, pregnancy pain, rehabilitation research, and musculoskeletal pain. Twelve highly cited papers with citation frequencies ≥85 times were recognized, predominantly consisting of randomized controlled trials.

Conclusion

Over the past 25 years, the number of articles published on acupuncture for LPB has shown a fluctuating trend of growth; the distribution of countries (regions) and institutions that publish articles is scattered, mainly based on inter-regional cooperation, and international cooperation is still insufficient; Journals in alternative and integrative medicine category provide references for scholars to submit manuscripts and learn about the frontiers; Acupuncture is effective and economical in the treatment of pain, and it has been widely used in the treatment of low back pain. However, the difference in efficacy between acupuncture and sham acupuncture or placebo acupuncture remains controversial. Therefore, in the future, it is necessary to consider the selection of appropriate efficacy evaluation methods in clinical trials that reflect the therapeutic advantages of acupuncture.
目的分析针刺治疗腰痛相关文献的现状及发展趋势。方法利用Web of Science核心数据库检索1997年1月1日至2023年8月29日针灸治疗腰痛的相关文献。使用Microsoft Excel、VOSviewer、SCImago Graphica和Pajek进行文献计量分析。分析的重点是年出版量、国家(地区)、机构、作者、期刊、关键词和参考文献。结果共发现针灸治疗腰痛的论文1434篇,在过去25年中呈波动增长趋势。这一领域的研究在57个国家进行,美国在研究产出方面处于领先地位。意大利成为出版质量最高的国家,平均被引用次数为205.16次。共有1781家机构参与了针灸治疗LBP的研究,其中哈佛大学的论文发表量最高(被引用77次)。在该领域做出贡献的作者共有5696人,其中发表论文最多的是In-Hyuk Ha(31篇)和Claudia-M。威特是最有影响力的作者(被引用2699次)。相关研究发表在378种期刊上,其中《替代与补充医学杂志》(Journal of Alternative and Complementary Medicine)的发表量最高(77篇),《脊柱》(Spine)的影响力最大(被引用3420次)。共识别出3854个关键词,形成6个主要专题集群:护理管理、神经刺激、补充医学、妊娠疼痛、康复研究和肌肉骨骼疼痛。被引频次≥85次的高被引论文12篇,以随机对照试验为主。结论在过去的25年里,针灸治疗LPB的论文发表数量呈波动增长趋势;发表文章的国家(地区)和机构分布分散,以区域间合作为主,国际合作仍不足;替代医学和中西医结合类期刊为学者投稿和了解前沿提供参考;针灸治疗疼痛有效且经济,已广泛应用于腰痛的治疗。然而,针灸与假针灸或安慰剂针灸的疗效差异仍然存在争议。因此,在今后的临床试验中,有必要考虑选择合适的、能体现针灸治疗优势的疗效评价方法。
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引用次数: 0
Nomenclature and location of acupuncture points for laboratory animals Part 2: Rat 实验动物穴位的命名和定位。第2部分:大鼠
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2024.12.003
China Association of Acupuncture and Moxibustion (中国针灸学会)
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引用次数: 0
Analysis of key therapeutic elements in acupuncture therapy and placebo acupuncture controls 针刺治疗与安慰剂对照的关键治疗要素分析
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2025.03.005
Jian-fei NIU (牛舰霏), Guan-qun WANG (王冠群), Xiao-long XIE (解小龙), Shuo DU (杜朔), Bi-hui PENG (彭碧辉), Ji-ping ZHAO (赵吉平)
Identifying key acupuncture elements is essential for optimizing sham acupuncture controls. Based on the characteristics and current state of acupuncture therapy, this paper categorizes key acupuncture elements into types and contents. Taking the former as a clue, it examines the current understanding of key acupuncture elements and underscores the need for further refinement to ensure that sham acupuncture controls more closely approximate physiological inertness. Additionally, it explores strategies and methodologies for advancing the understanding of key acupuncture elements from both the type and content perspectives. Key acupuncture elements should expand the number of included element types. Elements such as acupuncture needles, point selection, point combination, needle insertion, needle manipulation, and needle withdrawal should all be included, and they should be reported in a standardized manner in the trials. Regarding element content, improvements should be made in three key areas to enhance selection accuracy: 1. Strengthening the comprehensiveness of relevant theoretical frameworks. 2. Emphasizing the role of Traditional Chinese Medicine (TCM) diagnosis and acupoint palpation methods in trial application and reporting. 3. Continuously investigating the mechanisms underlying both the specific efficacy and the placebo efficacy of acupuncture.
确定关键的针灸元素对于优化假针灸控制至关重要。本文根据针灸治疗的特点和现状,对针灸的关键要素进行了分类和内容。以前者为线索,它检查了目前对关键针灸元素的理解,并强调需要进一步改进,以确保假针灸更接近生理惰性。此外,它还探讨了从类型和内容角度推进对关键针灸元素的理解的策略和方法。重点针灸要素应扩大纳入要素类型的数量。针刺针、选穴、合穴、插针、手法、退针等要素均应纳入,并在试验中规范报告。对于元素含量,需要在三个关键方面进行改进,以提高选择的准确性:1。加强相关理论框架的综合性。2. 强调中医诊断和穴位触诊方法在临床应用和报告中的作用。3. 持续研究针刺的特异性疗效和安慰剂疗效的机制。
{"title":"Analysis of key therapeutic elements in acupuncture therapy and placebo acupuncture controls","authors":"Jian-fei NIU (牛舰霏),&nbsp;Guan-qun WANG (王冠群),&nbsp;Xiao-long XIE (解小龙),&nbsp;Shuo DU (杜朔),&nbsp;Bi-hui PENG (彭碧辉),&nbsp;Ji-ping ZHAO (赵吉平)","doi":"10.1016/j.wjam.2025.03.005","DOIUrl":"10.1016/j.wjam.2025.03.005","url":null,"abstract":"<div><div>Identifying key acupuncture elements is essential for optimizing sham acupuncture controls. Based on the characteristics and current state of acupuncture therapy, this paper categorizes key acupuncture elements into types and contents. Taking the former as a clue, it examines the current understanding of key acupuncture elements and underscores the need for further refinement to ensure that sham acupuncture controls more closely approximate physiological inertness. Additionally, it explores strategies and methodologies for advancing the understanding of key acupuncture elements from both the type and content perspectives. Key acupuncture elements should expand the number of included element types. Elements such as acupuncture needles, point selection, point combination, needle insertion, needle manipulation, and needle withdrawal should all be included, and they should be reported in a standardized manner in the trials. Regarding element content, improvements should be made in three key areas to enhance selection accuracy: 1. Strengthening the comprehensiveness of relevant theoretical frameworks. 2. Emphasizing the role of Traditional Chinese Medicine (TCM) diagnosis and acupoint palpation methods in trial application and reporting. 3. Continuously investigating the mechanisms underlying both the specific efficacy and the placebo efficacy of acupuncture.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 145-151"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glial cell: Role of the pain modulation in acupuncture analgesia 神经胶质细胞:疼痛调节在针刺镇痛中的作用
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-04-01 DOI: 10.1016/j.wjam.2025.02.002
Mi YUAN (袁咪), Lan YUAN (袁澜), Wei CHEN (陈蔚), Yang-shuai SU (宿杨帅), Meng-yan FAN (范孟妍), Xiang-hong JING (景向红), Wei HE (何伟), Xiao-yu WANG (王晓宇)
The significance of glial cells in the nervous system, particularly in the modulation of pain, has increasingly gained prominence, thereby shifting the traditional neurobiological research paradigm that predominantly focused on neurons. Acupuncture treatment have been shown to influence the functionality of glial cells, enabling them to serve as modulators that significantly contribute to the inhibition of neurogenic inflammation, the restoration of synaptic homeostasis, and the enhancement of the pain modulation system. Furthermore, various molecules and their associated signaling pathways facilitate the biological effects of glial cells in the context of acupuncture-induced analgesia. Notably, P2X receptors (P2X3, P2X4, and P2X7), the MAPK pathway (including p38MAPK and ERK), and the JAK/STAT pathway within glial cells are implicated in the modulation of neuroinflammation and pain regulation through acupuncture. These elucidated mechanisms underscore the potential of acupuncture to modulate neuroimmune signaling for pain alleviation and suggest the prospect of developing more targeted and effective treatments for chronic pain in the future.
神经胶质细胞在神经系统中的重要性,特别是在疼痛的调节中,日益得到重视,从而改变了传统的神经生物学研究范式,主要集中在神经元上。针刺治疗已被证明可以影响神经胶质细胞的功能,使其成为显著有助于抑制神经源性炎症、恢复突触稳态和增强疼痛调节系统的调节剂。此外,各种分子及其相关信号通路促进了针刺镇痛背景下神经胶质细胞的生物学效应。值得注意的是,神经胶质细胞内的P2X受体(P2X3、P2X4和P2X7)、MAPK通路(包括p38MAPK和ERK)和JAK/STAT通路参与了针刺对神经炎症和疼痛的调节。这些阐明的机制强调了针灸在调节神经免疫信号以减轻疼痛方面的潜力,并提示了未来开发更有针对性和更有效的慢性疼痛治疗方法的前景。
{"title":"Glial cell: Role of the pain modulation in acupuncture analgesia","authors":"Mi YUAN (袁咪),&nbsp;Lan YUAN (袁澜),&nbsp;Wei CHEN (陈蔚),&nbsp;Yang-shuai SU (宿杨帅),&nbsp;Meng-yan FAN (范孟妍),&nbsp;Xiang-hong JING (景向红),&nbsp;Wei HE (何伟),&nbsp;Xiao-yu WANG (王晓宇)","doi":"10.1016/j.wjam.2025.02.002","DOIUrl":"10.1016/j.wjam.2025.02.002","url":null,"abstract":"<div><div>The significance of glial cells in the nervous system, particularly in the modulation of pain, has increasingly gained prominence, thereby shifting the traditional neurobiological research paradigm that predominantly focused on neurons. Acupuncture treatment have been shown to influence the functionality of glial cells, enabling them to serve as modulators that significantly contribute to the inhibition of neurogenic inflammation, the restoration of synaptic homeostasis, and the enhancement of the pain modulation system. Furthermore, various molecules and their associated signaling pathways facilitate the biological effects of glial cells in the context of acupuncture-induced analgesia. Notably, P2X receptors (P2X3, P2X4, and P2X7), the MAPK pathway (including p38MAPK and ERK), and the JAK/STAT pathway within glial cells are implicated in the modulation of neuroinflammation and pain regulation through acupuncture. These elucidated mechanisms underscore the potential of acupuncture to modulate neuroimmune signaling for pain alleviation and suggest the prospect of developing more targeted and effective treatments for chronic pain in the future.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 103-108"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcutaneous electrical acupoint stimulation (TEAS): Applications and challenges 经皮穴位电刺激(TEAS):应用和挑战
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-01 DOI: 10.1016/j.wjam.2024.12.002
Wen-lai ZHOU (周文来) , Jing LI (李璟) , Xiao-ning SHEN (沈晓凝) , Xia-tong HUA (华夏童) , Jing XIE (谢静) , Yan-li ZHOU (周艳丽) , Lu ZHU (朱璐)
Transcutaneous electrical acupoint stimulation (TEAS) is a kind of physical therapy that use electric current through the electrodes placed on the surface of acupoints to produce clinical effects in the human body, which is characterized by less adverse reaction and convenient operation. It has been widely used in the treatment of various diseases. This review introduces six major clinical applications of TEAS, named analgesia, regulation of gastrointestinal function, improvement of reproductive function, enhancement of cognitive function, promotion of limb function recovery and relief of fatigue. Besides, TEAS has been applied to the treatment of other chronic diseases such as hypertension and diabetes, achieving satisfactory clinical effects. However, two crucial challenges are encountered in the development of TEAS. One is the lack of standardization in the selection of parameters such as waveform, frequency, intensity and stimulation duration. The other is the limitation on the flexibility in the acupoint selection. This review analyzes key issues that need to be addressed in the current clinical application of TEAS, such as the selection of parameters and acupoints, and this review provides a certain reference value for optimizing regimens of TEAS and promoting its development and application.
经皮穴位电刺激(TEAS)是一种利用电流通过放置在穴位表面的电极在人体内产生临床效果的物理疗法,具有不良反应少、操作方便等特点。它已被广泛应用于各种疾病的治疗。本文综述了tea在镇痛、调节胃肠功能、改善生殖功能、增强认知功能、促进肢体功能恢复和缓解疲劳等方面的主要临床应用。此外,tea已应用于高血压、糖尿病等其他慢性疾病的治疗,取得了满意的临床效果。然而,在tea的发展过程中遇到了两个关键的挑战。一是波形、频率、强度和刺激持续时间等参数的选择缺乏标准化。二是对取穴灵活性的限制。本文分析了目前临床应用中需要解决的关键问题,如参数的选择、穴位的选择等,对优化tea的治疗方案,促进tea的开发和应用具有一定的参考价值。
{"title":"Transcutaneous electrical acupoint stimulation (TEAS): Applications and challenges","authors":"Wen-lai ZHOU (周文来) ,&nbsp;Jing LI (李璟) ,&nbsp;Xiao-ning SHEN (沈晓凝) ,&nbsp;Xia-tong HUA (华夏童) ,&nbsp;Jing XIE (谢静) ,&nbsp;Yan-li ZHOU (周艳丽) ,&nbsp;Lu ZHU (朱璐)","doi":"10.1016/j.wjam.2024.12.002","DOIUrl":"10.1016/j.wjam.2024.12.002","url":null,"abstract":"<div><div>Transcutaneous electrical acupoint stimulation (TEAS) is a kind of physical therapy that use electric current through the electrodes placed on the surface of acupoints to produce clinical effects in the human body, which is characterized by less adverse reaction and convenient operation. It has been widely used in the treatment of various diseases. This review introduces six major clinical applications of TEAS, named analgesia, regulation of gastrointestinal function, improvement of reproductive function, enhancement of cognitive function, promotion of limb function recovery and relief of fatigue. Besides, TEAS has been applied to the treatment of other chronic diseases such as hypertension and diabetes, achieving satisfactory clinical effects. However, two crucial challenges are encountered in the development of TEAS. One is the lack of standardization in the selection of parameters such as waveform, frequency, intensity and stimulation duration. The other is the limitation on the flexibility in the acupoint selection. This review analyzes key issues that need to be addressed in the current clinical application of TEAS, such as the selection of parameters and acupoints, and this review provides a certain reference value for optimizing regimens of TEAS and promoting its development and application.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 1","pages":"Pages 10-16"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture as adjuvant therapy in hospitalized patients with COVID-19: A single-blinded randomized controlled trial 针刺辅助治疗新冠肺炎住院患者:一项单盲随机对照试验
IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE Pub Date : 2025-01-01 DOI: 10.1016/j.wjam.2024.12.006
Amir Hooman Kazemi , Mohammad Sadegh Adel-Mehraban , Ali Vafaie Sefti , Bin Jiang WU (吴滨江) , Reihane Alipour

Objective

Non-pharmacological treatments of traditional medical systems are becoming recognized in management of respiratory diseases, especially COVID-19. This study was designed to evaluate the effectiveness of acupuncture as an adjuvant therapy in hospitalized patients with COVID-19.

Methods

This randomized controlled trial was performed on 70 moderate to severe hospitalized patients with COVID-19. Patients were randomized into two groups, receiving conventional treatment alone or in combination with acupuncture for 7 days. Both groups were followed up for 28 days. Respiratory rate and SpO2 were considered as primary outcomes. Additionally, respiratory symptoms (cough, dyspnea, chest tightness, and oxygen demand) and duration of hospitalization, ICU admission, intubation, and mortality rate were evaluated. The outcome assessor and data analyst were blinded.

Results

Acupuncture significantly improved respiratory rate and SpO2 after 3 days (v.s. 7 days in control group). SpO2 reached 93 % from the third day of conducting acupuncture. Respiratory symptoms were relieved after 7 days in the both groups, but were significant from day 3 in the acupuncture group (P < 0.001). Duration of hospitalization was less in the acupuncture group (3 days v.s. 11 days), with no ICU admission, intubation or death. In contrast, 8 patients in the control group were admitted to ICU, of whom 4 were intubated and died. No adverse effect was reported.

Conclusion

Acupuncture can play a significant role as a safe and effective complementary treatment in the management of COVID-19.

Trial registraion: Iranian Registry of Clinical Trials

IRCT20201 127049504N1.
目的传统医疗系统的非药物治疗在呼吸系统疾病,特别是COVID-19的治疗中得到越来越多的认可。本研究旨在评估针灸作为辅助治疗在COVID-19住院患者中的有效性。方法对70例中重度住院新冠肺炎患者进行随机对照试验。将患者随机分为两组,分别单独或联合针灸治疗7 d。两组均随访28 d。呼吸速率和SpO2被认为是主要结局。此外,对呼吸系统症状(咳嗽、呼吸困难、胸闷和需氧量)、住院时间、ICU入院时间、插管时间和死亡率进行评估。结果评估者和数据分析师采用盲法。结果针刺治疗3 d后呼吸频率和SpO2明显改善(对照组为7 d)。从针灸的第三天开始,SpO2达到93%。两组患者7天后呼吸系统症状均有所缓解,但针刺组患者从第3天起症状明显缓解(P <;0.001)。针刺组住院时间较短(3天vs . 11天),无ICU入院、插管或死亡。对照组8例患者入住ICU, 4例患者插管死亡。无不良反应报告。结论针刺作为一种安全有效的辅助治疗方法在COVID-19治疗中可发挥重要作用。试验注册:伊朗临床试验注册中心sirct20201 127049504N1。
{"title":"Acupuncture as adjuvant therapy in hospitalized patients with COVID-19: A single-blinded randomized controlled trial","authors":"Amir Hooman Kazemi ,&nbsp;Mohammad Sadegh Adel-Mehraban ,&nbsp;Ali Vafaie Sefti ,&nbsp;Bin Jiang WU (吴滨江) ,&nbsp;Reihane Alipour","doi":"10.1016/j.wjam.2024.12.006","DOIUrl":"10.1016/j.wjam.2024.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>Non-pharmacological treatments of traditional medical systems are becoming recognized in management of respiratory diseases, especially COVID-19. This study was designed to evaluate the effectiveness of acupuncture as an adjuvant therapy in hospitalized patients with COVID-19.</div></div><div><h3>Methods</h3><div>This randomized controlled trial was performed on 70 moderate to severe hospitalized patients with COVID-19. Patients were randomized into two groups, receiving conventional treatment alone or in combination with acupuncture for 7 days. Both groups were followed up for 28 days. Respiratory rate and SpO<sub>2</sub> were considered as primary outcomes. Additionally, respiratory symptoms (cough, dyspnea, chest tightness, and oxygen demand) and duration of hospitalization, ICU admission, intubation, and mortality rate were evaluated. The outcome assessor and data analyst were blinded.</div></div><div><h3>Results</h3><div>Acupuncture significantly improved respiratory rate and SpO<sub>2</sub> after 3 days (<em>v.</em>s<em>.</em> 7 days in control group). SpO<sub>2</sub> reached 93 % from the third day of conducting acupuncture. Respiratory symptoms were relieved after 7 days in the both groups, but were significant from day 3 in the acupuncture group (<em>P</em> &lt; 0.001). Duration of hospitalization was less in the acupuncture group (3 days <em>v.</em>s<em>.</em> 11 days), with no ICU admission, intubation or death. In contrast, 8 patients in the control group were admitted to ICU, of whom 4 were intubated and died. No adverse effect was reported.</div></div><div><h3>Conclusion</h3><div>Acupuncture can play a significant role as a safe and effective complementary treatment in the management of COVID-19.</div></div><div><h3>Trial registraion: Iranian Registry of Clinical Trials</h3><div>IRCT20201 127049504N1.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 1","pages":"Pages 41-49"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
World Journal of Acupuncture-Moxibustion
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