Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2025.03.001
Shu Bee CHEN (曾炜美) , Jing LIU (刘静) , Xue-si HOU (侯学思) , Li-kun YANG (杨丽鹍) , Yi-ni SUN (孙旖旎) , Shu-qi MI (米淑琦) , Ji-ping ZHAO (赵吉平)
The ability of natural conception decreases with age, leading many advanced-age women with fertility desire begin to attempt in vitro fertilization and embryo transfer (IVF-ET) technique nowadays. Traditional Chinese medicine (TCM) believes that human body undergoes periodic changes corresponding to the natural rhythms. Women exhibit distinct physiological lunar rhythms of the thoroughfare vessel and the conception vessel, as well as pathological rhythms during the menstrual cycle and IVF-ET cycle. Based on the theory of TCM temporal rhythm, this paper discusses the pathogenesis characteristics of infertility in advanced-age women at different stages. It believes that acupuncture intervention should comply with the following ideas: determining main acupoints based on disease differentiation, with a preference for the acupoints on the thoroughfare vessel, the conception vessel, spleen meridian and kidney meridian, as well as the back-shu points of the liver, spleen and kidney; determining the supplementary acupoints based on syndrome differentiation and symptoms; determining the supplementary acupoints based on time differentiation of lunar rhythm of the thoroughfare vessel and the conception vessel, and integrating both reinforcing and reducing techniques. During the process of intervention, the physical and mental states were balanced simultaneously.
{"title":"Diagnosis and treatment strategy of acupuncture-moxibustion for advanced-age infertility in vitro fertilization and embryo transfer based on the temporal rhythm theory of traditional Chinese medicine","authors":"Shu Bee CHEN (曾炜美) , Jing LIU (刘静) , Xue-si HOU (侯学思) , Li-kun YANG (杨丽鹍) , Yi-ni SUN (孙旖旎) , Shu-qi MI (米淑琦) , Ji-ping ZHAO (赵吉平)","doi":"10.1016/j.wjam.2025.03.001","DOIUrl":"10.1016/j.wjam.2025.03.001","url":null,"abstract":"<div><div>The ability of natural conception decreases with age, leading many advanced-age women with fertility desire begin to attempt in vitro fertilization and embryo transfer (IVF-ET) technique nowadays. Traditional Chinese medicine (TCM) believes that human body undergoes periodic changes corresponding to the natural rhythms. Women exhibit distinct physiological lunar rhythms of the thoroughfare vessel and the conception vessel, as well as pathological rhythms during the menstrual cycle and IVF-ET cycle. Based on the theory of TCM temporal rhythm, this paper discusses the pathogenesis characteristics of infertility in advanced-age women at different stages. It believes that acupuncture intervention should comply with the following ideas: determining main acupoints based on disease differentiation, with a preference for the acupoints on the thoroughfare vessel, the conception vessel, spleen meridian and kidney meridian, as well as the back-<em>shu</em> points of the liver, spleen and kidney; determining the supplementary acupoints based on syndrome differentiation and symptoms; determining the supplementary acupoints based on time differentiation of lunar rhythm of the thoroughfare vessel and the conception vessel, and integrating both reinforcing and reducing techniques. During the process of intervention, the physical and mental states were balanced simultaneously.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 113-118"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2024.12.007
China Association of Acupuncture and Moxibustion (中国针灸学会)
{"title":"Nomenclature and location of acupuncture points for laboratory animals Part 3: Mouse","authors":"China Association of Acupuncture and Moxibustion (中国针灸学会)","doi":"10.1016/j.wjam.2024.12.007","DOIUrl":"10.1016/j.wjam.2024.12.007","url":null,"abstract":"","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 160-162"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2025.03.004
Chang-long ZHANG (张长龙) , Yang LI (李阳) , Fei XU (徐飞) , Li-li SHANG (尚莉莉)
Acupuncture-moxibustion can promote recovery from the sequelae of ischemic stroke. However, its mechanism of action has not yet been fully elucidated. This paper introduces the mechanism of acupuncture-moxibustion in alleviating rehabilitation of ischemic stroke sequelae. The regulatory mechanism of acupuncture-moxibustion was analyzed for limb movement disorders, cognitive impairment, depression, epilepsy, dysphagia, and insomnia after stroke from four aspects (promoting neuronal growth and cell proliferation, regulating cerebral blood flow, modulating neurochemicals, and suppressing cell apoptosis). This study provides theoretical support for the wide application of acupuncture-moxibustion in rehabilitation after ischemic stroke.
{"title":"Research progress on the mechanism of acupuncture-moxibustion in promoting the rehabilitation of sequelae of ischemic stroke","authors":"Chang-long ZHANG (张长龙) , Yang LI (李阳) , Fei XU (徐飞) , Li-li SHANG (尚莉莉)","doi":"10.1016/j.wjam.2025.03.004","DOIUrl":"10.1016/j.wjam.2025.03.004","url":null,"abstract":"<div><div>Acupuncture-moxibustion can promote recovery from the sequelae of ischemic stroke. However, its mechanism of action has not yet been fully elucidated. This paper introduces the mechanism of acupuncture-moxibustion in alleviating rehabilitation of ischemic stroke sequelae. The regulatory mechanism of acupuncture-moxibustion was analyzed for limb movement disorders, cognitive impairment, depression, epilepsy, dysphagia, and insomnia after stroke from four aspects (promoting neuronal growth and cell proliferation, regulating cerebral blood flow, modulating neurochemicals, and suppressing cell apoptosis). This study provides theoretical support for the wide application of acupuncture-moxibustion in rehabilitation after ischemic stroke.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 96-102"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2025.02.001
Ren-hong WAN (万仁洪) , Wei CAO (曹炜) , Zi-hao ZOU (邹子豪) , Shuai CHEN (陈帅) , Si-jue CHEN (陈思珏) , Hui ZHENG (郑晖) , Ying LI (李瑛)
High-quality clinical evidence is the basis of evidence-based medical practice. Acupuncture is the most widely used complementary and alternative medicine in the world. However, the improvement in the quality of acupuncture clinical research does not match the rapid increase in the number of acupuncture clinical research in recent years. At present, the number of high-quality acupuncture clinical research in the world remains low. Taking the trial of acupuncture for chronic spontaneous urticaria published in Annals of Internal Medicine as an example, this paper discusses the factors that contribute to producing high-quality clinical evidence for acupuncture from the aspects of selecting the topic of study, formulating the study method, designing the study plan, controlling the study process, writing the study report, and selecting the journal in the process of before, during, and after the research. It emphasizes the necessity to start from the benefit of global people's health, take practical clinical problems as guidance, cleverly choose the research entry point, and conduct high-quality research with clinical value. After the accomplishment of the study, the results must be faithfully described, the scientific conclusions accurately sublimated, and appropriate scientific journals selected for publication.
{"title":"How to generate high-quality clinical evidence: Taking the study of acupuncture for chronic urticaria published in Annals of Internal Medicine as an example","authors":"Ren-hong WAN (万仁洪) , Wei CAO (曹炜) , Zi-hao ZOU (邹子豪) , Shuai CHEN (陈帅) , Si-jue CHEN (陈思珏) , Hui ZHENG (郑晖) , Ying LI (李瑛)","doi":"10.1016/j.wjam.2025.02.001","DOIUrl":"10.1016/j.wjam.2025.02.001","url":null,"abstract":"<div><div>High-quality clinical evidence is the basis of evidence-based medical practice. Acupuncture is the most widely used complementary and alternative medicine in the world. However, the improvement in the quality of acupuncture clinical research does not match the rapid increase in the number of acupuncture clinical research in recent years. At present, the number of high-quality acupuncture clinical research in the world remains low. Taking the trial of acupuncture for chronic spontaneous urticaria published in <em>Annals of Internal Medicine</em> as an example, this paper discusses the factors that contribute to producing high-quality clinical evidence for acupuncture from the aspects of selecting the topic of study, formulating the study method, designing the study plan, controlling the study process, writing the study report, and selecting the journal in the process of before, during, and after the research. It emphasizes the necessity to start from the benefit of global people's health, take practical clinical problems as guidance, cleverly choose the research entry point, and conduct high-quality research with clinical value. After the accomplishment of the study, the results must be faithfully described, the scientific conclusions accurately sublimated, and appropriate scientific journals selected for publication.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 109-112"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2025.01.003
Fang-hua ZHAO (赵芳华), Mei-ling SUN (孙美玲), Wen-yan SHI (石文艳), Hai-yan LI (李海燕)
Objective
This study aims to analyze the current state and emerging trends in research articles related to acupuncture treatment for low back pain (LBP).
Methods
The Web of Science core database was utilized to retrieve relevant literature on acupuncture therapy for LBP from January 1, 1997, to August 29, 2023. Literature metrics analysis was conducted using Microsoft Excel, VOSviewer, SCImago Graphica, and Pajek. The analysis focused on annual publication volume, countries (regions), institutions, authors, journals, keywords, and references.
Results
A total of 1,434 papers on acupuncture treatment for LBP were identified, demonstrating a fluctuating growth trend over the past 25 years. Research in this field has been conducted in 57 countries, with the United States leading in terms of research output. Italy emerged as the country with the highest-quality publications, with an average citation frequency of 205.16 times. A total of 1,781 institutions contributed to research on acupuncture treatment for LBP, with Harvard University having the highest publication volume (cited 77 times). The number of authors contributing to this field reached 5,696, with In-Hyuk Ha having the highest publication count (31 papers) and Claudia-M. Witt is the most influential author (cited 2,699 times). Relevant research was published in 378 journals, with the Journal of Alternative and Complementary Medicine having the highest publication volume (77 papers), and Spine being the most influential journal (cited 3,420 times). A total of 3,854 keywords were identified, forming six main thematic clusters: care management, nerve stimulation, complementary medicine, pregnancy pain, rehabilitation research, and musculoskeletal pain. Twelve highly cited papers with citation frequencies ≥85 times were recognized, predominantly consisting of randomized controlled trials.
Conclusion
Over the past 25 years, the number of articles published on acupuncture for LPB has shown a fluctuating trend of growth; the distribution of countries (regions) and institutions that publish articles is scattered, mainly based on inter-regional cooperation, and international cooperation is still insufficient; Journals in alternative and integrative medicine category provide references for scholars to submit manuscripts and learn about the frontiers; Acupuncture is effective and economical in the treatment of pain, and it has been widely used in the treatment of low back pain. However, the difference in efficacy between acupuncture and sham acupuncture or placebo acupuncture remains controversial. Therefore, in the future, it is necessary to consider the selection of appropriate efficacy evaluation methods in clinical trials that reflect the therapeutic advantages of acupuncture.
目的分析针刺治疗腰痛相关文献的现状及发展趋势。方法利用Web of Science核心数据库检索1997年1月1日至2023年8月29日针灸治疗腰痛的相关文献。使用Microsoft Excel、VOSviewer、SCImago Graphica和Pajek进行文献计量分析。分析的重点是年出版量、国家(地区)、机构、作者、期刊、关键词和参考文献。结果共发现针灸治疗腰痛的论文1434篇,在过去25年中呈波动增长趋势。这一领域的研究在57个国家进行,美国在研究产出方面处于领先地位。意大利成为出版质量最高的国家,平均被引用次数为205.16次。共有1781家机构参与了针灸治疗LBP的研究,其中哈佛大学的论文发表量最高(被引用77次)。在该领域做出贡献的作者共有5696人,其中发表论文最多的是In-Hyuk Ha(31篇)和Claudia-M。威特是最有影响力的作者(被引用2699次)。相关研究发表在378种期刊上,其中《替代与补充医学杂志》(Journal of Alternative and Complementary Medicine)的发表量最高(77篇),《脊柱》(Spine)的影响力最大(被引用3420次)。共识别出3854个关键词,形成6个主要专题集群:护理管理、神经刺激、补充医学、妊娠疼痛、康复研究和肌肉骨骼疼痛。被引频次≥85次的高被引论文12篇,以随机对照试验为主。结论在过去的25年里,针灸治疗LPB的论文发表数量呈波动增长趋势;发表文章的国家(地区)和机构分布分散,以区域间合作为主,国际合作仍不足;替代医学和中西医结合类期刊为学者投稿和了解前沿提供参考;针灸治疗疼痛有效且经济,已广泛应用于腰痛的治疗。然而,针灸与假针灸或安慰剂针灸的疗效差异仍然存在争议。因此,在今后的临床试验中,有必要考虑选择合适的、能体现针灸治疗优势的疗效评价方法。
{"title":"Global trend in the research and development of acupuncture on low back pain during 1997 to 2023: A bibliometric analysis","authors":"Fang-hua ZHAO (赵芳华), Mei-ling SUN (孙美玲), Wen-yan SHI (石文艳), Hai-yan LI (李海燕)","doi":"10.1016/j.wjam.2025.01.003","DOIUrl":"10.1016/j.wjam.2025.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to analyze the current state and emerging trends in research articles related to acupuncture treatment for low back pain (LBP).</div></div><div><h3>Methods</h3><div>The Web of Science core database was utilized to retrieve relevant literature on acupuncture therapy for LBP from January 1, 1997, to August 29, 2023. Literature metrics analysis was conducted using Microsoft Excel, VOSviewer, SCImago Graphica, and Pajek. The analysis focused on annual publication volume, countries (regions), institutions, authors, journals, keywords, and references.</div></div><div><h3>Results</h3><div>A total of 1,434 papers on acupuncture treatment for LBP were identified, demonstrating a fluctuating growth trend over the past 25 years. Research in this field has been conducted in 57 countries, with the United States leading in terms of research output. Italy emerged as the country with the highest-quality publications, with an average citation frequency of 205.16 times. A total of 1,781 institutions contributed to research on acupuncture treatment for LBP, with Harvard University having the highest publication volume (cited 77 times). The number of authors contributing to this field reached 5,696, with In-Hyuk Ha having the highest publication count (31 papers) and Claudia-M. Witt is the most influential author (cited 2,699 times). Relevant research was published in 378 journals, with the <em>Journal of Alternative and Complementary Medicine</em> having the highest publication volume (77 papers), and Spine being the most influential journal (cited 3,420 times). A total of 3,854 keywords were identified, forming six main thematic clusters: care management, nerve stimulation, complementary medicine, pregnancy pain, rehabilitation research, and musculoskeletal pain. Twelve highly cited papers with citation frequencies ≥85 times were recognized, predominantly consisting of randomized controlled trials.</div></div><div><h3>Conclusion</h3><div>Over the past 25 years, the number of articles published on acupuncture for LPB has shown a fluctuating trend of growth; the distribution of countries (regions) and institutions that publish articles is scattered, mainly based on inter-regional cooperation, and international cooperation is still insufficient; Journals in alternative and integrative medicine category provide references for scholars to submit manuscripts and learn about the frontiers; Acupuncture is effective and economical in the treatment of pain, and it has been widely used in the treatment of low back pain. However, the difference in efficacy between acupuncture and sham acupuncture or placebo acupuncture remains controversial. Therefore, in the future, it is necessary to consider the selection of appropriate efficacy evaluation methods in clinical trials that reflect the therapeutic advantages of acupuncture.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 85-95"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2024.12.003
China Association of Acupuncture and Moxibustion (中国针灸学会)
{"title":"Nomenclature and location of acupuncture points for laboratory animals Part 2: Rat","authors":"China Association of Acupuncture and Moxibustion (中国针灸学会)","doi":"10.1016/j.wjam.2024.12.003","DOIUrl":"10.1016/j.wjam.2024.12.003","url":null,"abstract":"","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 163-165"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2025.03.005
Jian-fei NIU (牛舰霏), Guan-qun WANG (王冠群), Xiao-long XIE (解小龙), Shuo DU (杜朔), Bi-hui PENG (彭碧辉), Ji-ping ZHAO (赵吉平)
Identifying key acupuncture elements is essential for optimizing sham acupuncture controls. Based on the characteristics and current state of acupuncture therapy, this paper categorizes key acupuncture elements into types and contents. Taking the former as a clue, it examines the current understanding of key acupuncture elements and underscores the need for further refinement to ensure that sham acupuncture controls more closely approximate physiological inertness. Additionally, it explores strategies and methodologies for advancing the understanding of key acupuncture elements from both the type and content perspectives. Key acupuncture elements should expand the number of included element types. Elements such as acupuncture needles, point selection, point combination, needle insertion, needle manipulation, and needle withdrawal should all be included, and they should be reported in a standardized manner in the trials. Regarding element content, improvements should be made in three key areas to enhance selection accuracy: 1. Strengthening the comprehensiveness of relevant theoretical frameworks. 2. Emphasizing the role of Traditional Chinese Medicine (TCM) diagnosis and acupoint palpation methods in trial application and reporting. 3. Continuously investigating the mechanisms underlying both the specific efficacy and the placebo efficacy of acupuncture.
{"title":"Analysis of key therapeutic elements in acupuncture therapy and placebo acupuncture controls","authors":"Jian-fei NIU (牛舰霏), Guan-qun WANG (王冠群), Xiao-long XIE (解小龙), Shuo DU (杜朔), Bi-hui PENG (彭碧辉), Ji-ping ZHAO (赵吉平)","doi":"10.1016/j.wjam.2025.03.005","DOIUrl":"10.1016/j.wjam.2025.03.005","url":null,"abstract":"<div><div>Identifying key acupuncture elements is essential for optimizing sham acupuncture controls. Based on the characteristics and current state of acupuncture therapy, this paper categorizes key acupuncture elements into types and contents. Taking the former as a clue, it examines the current understanding of key acupuncture elements and underscores the need for further refinement to ensure that sham acupuncture controls more closely approximate physiological inertness. Additionally, it explores strategies and methodologies for advancing the understanding of key acupuncture elements from both the type and content perspectives. Key acupuncture elements should expand the number of included element types. Elements such as acupuncture needles, point selection, point combination, needle insertion, needle manipulation, and needle withdrawal should all be included, and they should be reported in a standardized manner in the trials. Regarding element content, improvements should be made in three key areas to enhance selection accuracy: 1. Strengthening the comprehensiveness of relevant theoretical frameworks. 2. Emphasizing the role of Traditional Chinese Medicine (TCM) diagnosis and acupoint palpation methods in trial application and reporting. 3. Continuously investigating the mechanisms underlying both the specific efficacy and the placebo efficacy of acupuncture.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 145-151"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01DOI: 10.1016/j.wjam.2025.02.002
Mi YUAN (袁咪), Lan YUAN (袁澜), Wei CHEN (陈蔚), Yang-shuai SU (宿杨帅), Meng-yan FAN (范孟妍), Xiang-hong JING (景向红), Wei HE (何伟), Xiao-yu WANG (王晓宇)
The significance of glial cells in the nervous system, particularly in the modulation of pain, has increasingly gained prominence, thereby shifting the traditional neurobiological research paradigm that predominantly focused on neurons. Acupuncture treatment have been shown to influence the functionality of glial cells, enabling them to serve as modulators that significantly contribute to the inhibition of neurogenic inflammation, the restoration of synaptic homeostasis, and the enhancement of the pain modulation system. Furthermore, various molecules and their associated signaling pathways facilitate the biological effects of glial cells in the context of acupuncture-induced analgesia. Notably, P2X receptors (P2X3, P2X4, and P2X7), the MAPK pathway (including p38MAPK and ERK), and the JAK/STAT pathway within glial cells are implicated in the modulation of neuroinflammation and pain regulation through acupuncture. These elucidated mechanisms underscore the potential of acupuncture to modulate neuroimmune signaling for pain alleviation and suggest the prospect of developing more targeted and effective treatments for chronic pain in the future.
{"title":"Glial cell: Role of the pain modulation in acupuncture analgesia","authors":"Mi YUAN (袁咪), Lan YUAN (袁澜), Wei CHEN (陈蔚), Yang-shuai SU (宿杨帅), Meng-yan FAN (范孟妍), Xiang-hong JING (景向红), Wei HE (何伟), Xiao-yu WANG (王晓宇)","doi":"10.1016/j.wjam.2025.02.002","DOIUrl":"10.1016/j.wjam.2025.02.002","url":null,"abstract":"<div><div>The significance of glial cells in the nervous system, particularly in the modulation of pain, has increasingly gained prominence, thereby shifting the traditional neurobiological research paradigm that predominantly focused on neurons. Acupuncture treatment have been shown to influence the functionality of glial cells, enabling them to serve as modulators that significantly contribute to the inhibition of neurogenic inflammation, the restoration of synaptic homeostasis, and the enhancement of the pain modulation system. Furthermore, various molecules and their associated signaling pathways facilitate the biological effects of glial cells in the context of acupuncture-induced analgesia. Notably, P2X receptors (P2X3, P2X4, and P2X7), the MAPK pathway (including p38MAPK and ERK), and the JAK/STAT pathway within glial cells are implicated in the modulation of neuroinflammation and pain regulation through acupuncture. These elucidated mechanisms underscore the potential of acupuncture to modulate neuroimmune signaling for pain alleviation and suggest the prospect of developing more targeted and effective treatments for chronic pain in the future.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 2","pages":"Pages 103-108"},"PeriodicalIF":0.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transcutaneous electrical acupoint stimulation (TEAS) is a kind of physical therapy that use electric current through the electrodes placed on the surface of acupoints to produce clinical effects in the human body, which is characterized by less adverse reaction and convenient operation. It has been widely used in the treatment of various diseases. This review introduces six major clinical applications of TEAS, named analgesia, regulation of gastrointestinal function, improvement of reproductive function, enhancement of cognitive function, promotion of limb function recovery and relief of fatigue. Besides, TEAS has been applied to the treatment of other chronic diseases such as hypertension and diabetes, achieving satisfactory clinical effects. However, two crucial challenges are encountered in the development of TEAS. One is the lack of standardization in the selection of parameters such as waveform, frequency, intensity and stimulation duration. The other is the limitation on the flexibility in the acupoint selection. This review analyzes key issues that need to be addressed in the current clinical application of TEAS, such as the selection of parameters and acupoints, and this review provides a certain reference value for optimizing regimens of TEAS and promoting its development and application.
{"title":"Transcutaneous electrical acupoint stimulation (TEAS): Applications and challenges","authors":"Wen-lai ZHOU (周文来) , Jing LI (李璟) , Xiao-ning SHEN (沈晓凝) , Xia-tong HUA (华夏童) , Jing XIE (谢静) , Yan-li ZHOU (周艳丽) , Lu ZHU (朱璐)","doi":"10.1016/j.wjam.2024.12.002","DOIUrl":"10.1016/j.wjam.2024.12.002","url":null,"abstract":"<div><div>Transcutaneous electrical acupoint stimulation (TEAS) is a kind of physical therapy that use electric current through the electrodes placed on the surface of acupoints to produce clinical effects in the human body, which is characterized by less adverse reaction and convenient operation. It has been widely used in the treatment of various diseases. This review introduces six major clinical applications of TEAS, named analgesia, regulation of gastrointestinal function, improvement of reproductive function, enhancement of cognitive function, promotion of limb function recovery and relief of fatigue. Besides, TEAS has been applied to the treatment of other chronic diseases such as hypertension and diabetes, achieving satisfactory clinical effects. However, two crucial challenges are encountered in the development of TEAS. One is the lack of standardization in the selection of parameters such as waveform, frequency, intensity and stimulation duration. The other is the limitation on the flexibility in the acupoint selection. This review analyzes key issues that need to be addressed in the current clinical application of TEAS, such as the selection of parameters and acupoints, and this review provides a certain reference value for optimizing regimens of TEAS and promoting its development and application.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 1","pages":"Pages 10-16"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01DOI: 10.1016/j.wjam.2024.12.006
Amir Hooman Kazemi , Mohammad Sadegh Adel-Mehraban , Ali Vafaie Sefti , Bin Jiang WU (吴滨江) , Reihane Alipour
Objective
Non-pharmacological treatments of traditional medical systems are becoming recognized in management of respiratory diseases, especially COVID-19. This study was designed to evaluate the effectiveness of acupuncture as an adjuvant therapy in hospitalized patients with COVID-19.
Methods
This randomized controlled trial was performed on 70 moderate to severe hospitalized patients with COVID-19. Patients were randomized into two groups, receiving conventional treatment alone or in combination with acupuncture for 7 days. Both groups were followed up for 28 days. Respiratory rate and SpO2 were considered as primary outcomes. Additionally, respiratory symptoms (cough, dyspnea, chest tightness, and oxygen demand) and duration of hospitalization, ICU admission, intubation, and mortality rate were evaluated. The outcome assessor and data analyst were blinded.
Results
Acupuncture significantly improved respiratory rate and SpO2 after 3 days (v.s. 7 days in control group). SpO2 reached 93 % from the third day of conducting acupuncture. Respiratory symptoms were relieved after 7 days in the both groups, but were significant from day 3 in the acupuncture group (P < 0.001). Duration of hospitalization was less in the acupuncture group (3 days v.s. 11 days), with no ICU admission, intubation or death. In contrast, 8 patients in the control group were admitted to ICU, of whom 4 were intubated and died. No adverse effect was reported.
Conclusion
Acupuncture can play a significant role as a safe and effective complementary treatment in the management of COVID-19.
Trial registraion: Iranian Registry of Clinical Trials
{"title":"Acupuncture as adjuvant therapy in hospitalized patients with COVID-19: A single-blinded randomized controlled trial","authors":"Amir Hooman Kazemi , Mohammad Sadegh Adel-Mehraban , Ali Vafaie Sefti , Bin Jiang WU (吴滨江) , Reihane Alipour","doi":"10.1016/j.wjam.2024.12.006","DOIUrl":"10.1016/j.wjam.2024.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>Non-pharmacological treatments of traditional medical systems are becoming recognized in management of respiratory diseases, especially COVID-19. This study was designed to evaluate the effectiveness of acupuncture as an adjuvant therapy in hospitalized patients with COVID-19.</div></div><div><h3>Methods</h3><div>This randomized controlled trial was performed on 70 moderate to severe hospitalized patients with COVID-19. Patients were randomized into two groups, receiving conventional treatment alone or in combination with acupuncture for 7 days. Both groups were followed up for 28 days. Respiratory rate and SpO<sub>2</sub> were considered as primary outcomes. Additionally, respiratory symptoms (cough, dyspnea, chest tightness, and oxygen demand) and duration of hospitalization, ICU admission, intubation, and mortality rate were evaluated. The outcome assessor and data analyst were blinded.</div></div><div><h3>Results</h3><div>Acupuncture significantly improved respiratory rate and SpO<sub>2</sub> after 3 days (<em>v.</em>s<em>.</em> 7 days in control group). SpO<sub>2</sub> reached 93 % from the third day of conducting acupuncture. Respiratory symptoms were relieved after 7 days in the both groups, but were significant from day 3 in the acupuncture group (<em>P</em> < 0.001). Duration of hospitalization was less in the acupuncture group (3 days <em>v.</em>s<em>.</em> 11 days), with no ICU admission, intubation or death. In contrast, 8 patients in the control group were admitted to ICU, of whom 4 were intubated and died. No adverse effect was reported.</div></div><div><h3>Conclusion</h3><div>Acupuncture can play a significant role as a safe and effective complementary treatment in the management of COVID-19.</div></div><div><h3>Trial registraion: Iranian Registry of Clinical Trials</h3><div>IRCT20201 127049504N1.</div></div>","PeriodicalId":44648,"journal":{"name":"World Journal of Acupuncture-Moxibustion","volume":"35 1","pages":"Pages 41-49"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}