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Adaptive vaccination and surveillance testing strategies for infectious diseases with diverse strain dynamics. 具有不同菌株动态的传染病的适应性疫苗接种和监测检测策略。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2025-08-05 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2025.2533783
Xilin Zhang, Ozgur M Araz, Zeynep Ertem

The dynamic nature of epidemic diseases presents significant challenges for containment and healthcare resource allocation, particularly as viral strains evolve and outbreak conditions shift over time. While interventions such as testing, vaccination, and quarantine have been widely implemented, most models assess these strategies in isolation. However, we evaluate the combined impact of all aforementioned interventions and optimize resource allocation for maximum effectiveness. This study introduces an adaptive compartmental epidemiological model (SEIR) that integrates dynamic vaccination accessibility and diagnostic surveillance testing strategies, allowing for optimized intervention strategies in response to real-time outbreak progression and demographic variations. Simulation results demonstrate that vaccination effectively reduces infection peaks, while adaptive testing strategies delay peak occurrences and mitigate severity by continuously adjusting to outbreak dynamics and available healthcare resources. By integrating real-time surveillance, strategic testing allocation, and vaccination planning, this model provides a scalable and flexible framework for epidemic preparedness. These findings offer actionable insights for policymakers, guiding the development of robust surveillance systems, optimized resource distribution, and predictive epidemic control measures to mitigate future outbreaks.

流行病的动态性对控制和卫生保健资源分配提出了重大挑战,特别是随着病毒株的演变和爆发条件随时间的变化。虽然检测、疫苗接种和检疫等干预措施已经广泛实施,但大多数模型都是孤立地评估这些战略的。然而,我们评估了所有上述干预措施的综合影响,并优化了资源分配,以获得最大的效果。本研究引入了一种自适应区隔流行病学模型(SEIR),该模型集成了动态疫苗接种可及性和诊断监测测试策略,允许优化干预策略,以应对实时疫情进展和人口变化。仿真结果表明,疫苗接种有效地降低了感染高峰,而自适应测试策略通过不断调整爆发动态和可用医疗资源来延迟峰值发生并减轻严重程度。通过整合实时监测、战略性检测分配和疫苗接种规划,该模型为流行病防范提供了可扩展和灵活的框架。这些发现为政策制定者提供了可行的见解,指导制定健全的监测系统、优化资源分配和预测性流行病控制措施,以减轻未来的疫情。
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引用次数: 0
Revolutionising health monitoring: IOT-Based system with machine learning classification. 革命性的健康监测:基于物联网的系统与机器学习分类。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2025.2507620
Alka Mishra, Aryan Dewangan, Mayank Dewangan

In the pursuit of revolutionising health monitoring, this study introduces an IoT-based smart health monitoring system coupled with a machine learning classification framework. This innovative system tracks five crucial health parameters - Temperature, SPO2, Glucose level, Pulse rate, and Heart rate - providing a comprehensive overview of an individual's health status in real-time. Leveraging these parameters, a dataset is constructed, facilitating the application of four distinct machine learning algorithms: Support Vector Machine (SVM), Decision Tree, Random Forest, and CN2 rule induction. Remarkably, the classification accuracy achieved by these models demonstrates their efficacy, with SVM scoring 0.859, Tree achieving 0.996, Random Forest attaining 0.984, and CN2 rule induction reaching 0.902, respectively. Notably, among these algorithms, the Tree model emerges as the most superior, showcasing its potential for effectively analysing this type of dataset and enhancing the performance of health monitoring systems. Further, ThingSpeak has been utilised as IoT platform within our health monitoring system that facilitates the seamless collection of real-time data from diverse medical devices such as heart rate monitors and glucose metres. With applications in healthcare, home monitoring, sports, fitness, and industrial safety, the system offers versatile solutions for proactive health management and improved well-being.

为了追求革命性的健康监测,本研究引入了基于物联网的智能健康监测系统,并结合了机器学习分类框架。这个创新的系统跟踪五个关键的健康参数——体温、血氧饱和度、血糖水平、脉搏率和心率——实时提供个人健康状况的全面概述。利用这些参数,构建了一个数据集,促进了四种不同机器学习算法的应用:支持向量机(SVM)、决策树、随机森林和CN2规则归纳。值得注意的是,这些模型的分类精度表明了它们的有效性,SVM得分为0.859,Tree得分为0.996,Random Forest得分为0.984,CN2规则归纳得分为0.902。值得注意的是,在这些算法中,树模型是最优越的,展示了它有效分析这类数据集和提高健康监测系统性能的潜力。此外,ThingSpeak已被用作我们健康监测系统中的物联网平台,促进从心率监测仪和血糖仪等各种医疗设备无缝收集实时数据。该系统应用于医疗保健、家庭监控、体育、健身和工业安全等领域,为主动健康管理和改善福祉提供了多种解决方案。
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引用次数: 0
Leveraging quality improvement initiatives to support development of decision support tools in healthcare. 利用质量改进计划来支持医疗保健领域决策支持工具的开发。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2025-05-05 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2025.2500285
Joe Viana, Christos Vasilakis, Neophytos Stylianou

Modelling and simulation studies have been used to inform the choices and development of quality improvement (QI) initiatives in health care, for example, by helping refine the intervention to be implemented or support decisions around the management of demand and capacity. We do not know whether a modelling study can itself be informed by a QI project and what are the associated benefits and challenges. In this research, we sought to investigate the opportunities and challenges associated with an ongoing health service-led QI project in informing the development of a stochastic simulation-based decision support tool to inform decisions around the commissioning of anticoagulation services for patients with atrial fibrillation. We found that the positive synergies offered by the QI project included good access to stakeholders and envisaged end users, co-producing relevant and impactful scenarios for experimentation, as well as access to good quality individual patient level data. On the other hand, substantial effort was required to populate input parameters with values that pertain to the natural history of the disease and the effectiveness of the different treatments. Our findings indicate that, if stakeholders require modelling results to inform aspects of a QI project, upfront investment is needed to ensure timely interaction between the two studies.

建模和模拟研究已用于为卫生保健领域质量改进(QI)举措的选择和制定提供信息,例如,通过帮助改进将要实施的干预措施或支持围绕需求和能力管理的决策。我们不知道一个模型研究本身是否可以由一个质量评估项目提供信息,以及相关的好处和挑战是什么。在这项研究中,我们试图调查与正在进行的卫生服务主导的QI项目相关的机遇和挑战,该项目为基于随机模拟的决策支持工具的开发提供信息,该工具可为心房颤动患者抗凝服务的调试提供决策。我们发现,QI项目提供的积极协同作用包括与利益相关者和设想的最终用户的良好接触,共同生产相关和有影响力的实验场景,以及获得高质量的个体患者水平数据。另一方面,需要大量的努力来填充输入参数,这些参数与疾病的自然历史和不同治疗的有效性有关。我们的研究结果表明,如果利益相关者需要建模结果来告知QI项目的各个方面,则需要前期投资来确保两项研究之间的及时互动。
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引用次数: 0
Towards a solution to the global healthcare crisis: using hierarchical decomposition and theory of constraints (TOC) to address the healthcare supply chain wicked problem. 解决全球医疗保健危机:利用层次分解和约束理论(TOC)解决医疗保健供应链问题。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2025.2460632
James F Cox, Victoria J Mabin

Healthcare is facing a crisis globally, with rising demand and technological advances escalating costs and outpacing supply. The healthcare supply chain (HCSC) encompasses various links, from primary and specialty care to hospitals, which often fail to function quickly, seamlessly, or cost-effectively individually or together. Indeed, the complexities of healthcare make this a "wicked problem" without easy solutions. Research has typically focused on individual links in the supply chain oversimplifying and neglecting their interdependence. Key characteristics - such as the system's hierarchical structure, diverse stakeholder involvement, interdependencies among links, the importance of timeliness, and the need to cope with complexity, change, and uncertainty - are frequently overlooked. Addressing the healthcare crisis requires a pragmatic approach to improving service delivery. This paper advocates for a systems perspective, allowing a breakdown of the problem into manageable units of analysis based on the system hierarchy, viewing each link in the HCSC as integral to the whole. We outline a multimethodology that capitalises on HCSC characteristics to enhance patient flow and provide timely, high-quality, and cost-effective care. It emphasises classifying, prioritising, and synchronising treatment based on urgency. The paper also discusses existing solutions to the system's components and presents a comprehensive strategy for the overall issue.

医疗保健正面临全球危机,不断增长的需求和技术进步使成本不断上升,并超过了供应。医疗保健供应链(HCSC)包含从初级和专科护理到医院的各种链接,这些链接通常无法单独或一起快速、无缝地或经济高效地运行。事实上,医疗保健的复杂性使其成为一个“棘手的问题”,没有简单的解决方案。研究通常集中在供应链中的单个环节上,过度简化并忽视了它们之间的相互依赖性。关键特征——例如系统的层次结构、不同涉众的参与、各环节之间的相互依赖、及时性的重要性以及应对复杂性、变化和不确定性的需要——经常被忽视。解决保健危机需要采取务实的方法来改善服务的提供。本文提倡系统视角,允许将问题分解为基于系统层次结构的可管理的分析单元,将HCSC中的每个链接视为整体的组成部分。我们概述了一种多方法,利用HCSC的特点来提高患者流量,并提供及时、高质量和具有成本效益的护理。它强调根据紧急程度对治疗进行分类、优先排序和同步。本文还讨论了现有的解决方案的系统的组成部分,并提出了一个全面的策略,为整体问题。
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引用次数: 0
A chance-constrained program for the allocation of nurses in acute home healthcare. 急诊家庭保健护士分配的机会限制方案。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2025.2467643
Jedidja Lok-Visser, Hayo Bos, Erwin W Hans, Gréanne Leeftink

Home healthcare capacity is under great pressure due to demographic developments. Existing literature has exclusively focused on the planning, scheduling, and routing of non-acute care activities. However, similar to other healthcare settings, home healthcare also experiences acute care activities that disrupt operational performance. We study the planning and control of an acute care team for dealing with unplanned and urgent home healthcare activities. Particularly, we focus on determining the number of nurses per care level and their standby locations. The primary aim of this study is to introduce this novel problem, which we define as the acute care team location problem. We formulate this problem as a chance-constrained program. We solve the single location problem to optimality, and the multi-location problem with sample average approximation. The results show that our approach enables decision makers to optimally configure their acute care team, to respond quickly to acute care incidents. From a managerial perspective, our research provides a model that supports tactical capacity planning in HHC organisations and presents a benchmark for acute care management policies.

由于人口发展,家庭保健能力面临巨大压力。现有文献专门关注非急性护理活动的计划、调度和路线。然而,与其他医疗保健环境类似,家庭医疗保健也会经历破坏运营绩效的急性护理活动。我们研究计划和控制急症护理小组处理计划外和紧急家庭保健活动。特别是,我们专注于确定每个护理级别的护士数量及其备用位置。本研究的主要目的是引入这个新问题,我们将其定义为急症护理团队定位问题。我们把这个问题表述为一个机会约束程序。我们用最优性来解决单位置问题,用样本平均逼近来解决多位置问题。结果表明,我们的方法使决策者能够优化配置他们的急性护理团队,以快速响应急性护理事件。从管理的角度来看,我们的研究提供了一个支持HHC组织战术能力规划的模型,并为急性护理管理政策提供了基准。
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引用次数: 0
Using routine health care data to develop and validate a system dynamics simulation model of frailty trajectories in an ageing population. 利用常规卫生保健数据开发和验证老龄化人口脆弱轨迹的系统动力学模拟模型。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2025.2459364
Tracey England, Bronagh Walsh, Sally Brailsford, Carole Fogg, Simon de Lusignan, Simon Ds Fraser, Paul Roderick, Scott Harris, Abigail Barkham, Harnish P Patel, Andrew Clegg

Frailty is common in older adults and has a substantial impact on patient outcomes and service use. Information to support service planning, including prevalence in middle-aged adults and patterns of frailty progression at population level, is scarce. This paper presents a system dynamics model describing the dynamics of frailty and ageing within a population of patients aged ≥50, based on linked data for 2.2 million patients from primary care practices in England. The purpose of the model is to estimate the incidence and prevalence of frailty in an ageing population over time. The model was developed in consultation with stakeholders (patients, carers, clinicians, and commissioners) and validated against another large dataset (1.38 million patients) from Wales. It was then scaled up to the population of England, using Office for National Statistics projections (to 2027). The baseline results, subject to the assumption that the frailty transition parameters remain constant over this period, suggest that the number of people living with frailty will increase as the population ages, and that those with mild-moderate frailty are likely to have the greatest impact on demand. This paper focuses on model development and validation, highlighting the benefits and challenges of using large routine health datasets.

虚弱在老年人中很常见,对患者预后和服务使用有重大影响。支持服务规划的资料很少,包括中年人的患病率和人口水平上的衰弱进展模式。本文提出了一个系统动力学模型,描述了年龄≥50岁的患者群体中虚弱和衰老的动态,该模型基于来自英格兰初级保健实践的220万患者的相关数据。该模型的目的是随着时间的推移估计老龄化人口中虚弱的发生率和患病率。该模型是在与利益相关者(患者、护理人员、临床医生和专员)协商后开发的,并在威尔士的另一个大型数据集(138万患者)上进行了验证。然后根据英国国家统计局(Office for National Statistics)的预测(到2027年),将其扩大到英格兰人口。在假定虚弱过渡参数在此期间保持不变的前提下,基线结果表明,随着人口老龄化,生活虚弱的人数将增加,而那些轻度至中度虚弱的人可能对需求产生最大的影响。本文着重于模型的开发和验证,强调了使用大型常规健康数据集的好处和挑战。
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引用次数: 0
A holistic view on the COVID-19 epidemic process: smoking cessation behaviour, epidemic process and precautions. 从整体看新冠肺炎的流行过程:戒烟行为、流行过程和预防措施。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2025-01-11 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2025.2450342
Muammer Albayrak, Ahmet Albayrak

The aim of this study is to investigate the smoking cessation tendencies of people with different levels of smoking addiction during the COVID-19 epidemic process and to investigate the variables that most affect the risk perception of being Covid-19. Data were collected between November 8 and December 20 2021. A total of 898 participants living in the Turkey aged 18 years or older were recruited from Google online form panel. In general, it can be said that the higher the education level and the higher the income, the better the people adapt to the epidemic conditions. During the epidemic, it is seen that people generally (88.2%) get the news about the process from official sources. It is seen that the participants trust the ministry of health and the scientific committee at a rate of 67.1% in the epidemic management. It is possible that those who have chronic diseases and are addicted to cigarettes will experience the COVID-19 process more heavily. However, in this study, it could not be said that those who have a chronic disease and are addicted to smoking are more inclined to quit smoking.

本研究旨在调查不同程度吸烟成瘾人群在COVID-19流行过程中的戒烟倾向,并调查最影响被COVID-19风险感知的变量。数据收集于2021年11月8日至12月20日之间。共有898名18岁以上居住在土耳其的参与者从谷歌在线表格小组中招募。总的来说,可以说受教育程度越高、收入越高的人对疫情的适应能力越强。在疫情期间,人们通常(88.2%)从官方渠道获得有关这一进程的消息。在疫情管理中,参与者对卫生部和科学委员会的信任度为67.1%。患有慢性疾病和吸烟成瘾的人可能会更严重地经历新冠肺炎的过程。然而,在这项研究中,并不能说那些有慢性疾病和吸烟成瘾的人更倾向于戒烟。
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引用次数: 0
Acquisition of patients' EHR information under ED congestion - an empirical investigation. 急诊科拥挤情况下患者电子病历信息获取的实证研究。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2024-12-28 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2024.2444954
Ofir Ben-Assuli, David Gefen, Noam Shamir

We examine the information acquisition process regarding a patient's status under emergency department (ED) congestion conditions. We focus on two key information channels: 1) Electronic Health Record (EHR) that provide the patient's medical history and 2) Medical tests conducted in real-time. Whereas the EHR provides the physician with easily accessible information with little delay, real-time medical tests can provide more current information, but are time-consuming. We examine physicians' decisions in cases of ED congestion, using a dataset that includes more than 1.4 million visits. When congestion is low, the information channels are complementary - acquiring information from the EHR is positively correlated with information acquisition from the medical tests channel, representing an incentive for the physician to acquire all possible information before providing diagnosis. However, as the congestion increases, there is less reliance on medical tests; this effect is amplified when EHR information is used. To avoid excessive congestion, physicians apparently refrain from sending patients for medical tests, and compensate for loss of information using EHR information. The impact of high system workload on the quality of medical service is an essential concern for managers; we show the indirect benefit of investment in EHRs through reduced blood-tests without increasing revisit rates.

我们检查的信息获取过程中,有关病人的状态在急诊科(ED)拥塞条件。我们专注于两个关键的信息渠道:1)提供患者病史的电子健康记录(EHR)和2)实时进行的医学检查。电子健康档案为医生提供了易于获取的信息,几乎没有延迟,而实时医学测试可以提供更多的最新信息,但很耗时。我们使用包含超过140万次就诊的数据集来检查医生在急诊科拥堵情况下的决定。当拥塞较低时,信息渠道是互补的——从电子病历获取信息与从医学测试渠道获取信息正相关,这表明医生在提供诊断之前获取所有可能的信息是一种激励。然而,随着交通拥堵的增加,对医疗检查的依赖减少了;当使用电子病历信息时,这种影响会被放大。为了避免过度拥挤,医生们显然不愿意送病人去做医学检查,而是用电子病历信息来弥补信息的损失。高系统工作量对医疗服务质量的影响是管理人员必须关注的问题;我们通过减少血液检查而不增加复诊率,展示了电子病历投资的间接效益。
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引用次数: 0
Preeclampsia prediction via machine learning: a systematic literature review. 通过机器学习预测子痫前期:系统的文献综述。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2024-12-09 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2024.2435845
Mert Özcan, Serhat Peker

Preeclampsia, a life-threatening condition in late pregnancy, has unclear causes and risk factors. Machine learning (ML) offers a promising approach for early prediction. This systematic review analyzes state-of-the-art studies on preeclampsia prediction using ML approaches. We reviewed articles published between January 1 2013 and December 31 2023, from Google Scholar and PubMed. Of 183 identified studies, 35 were selected based on inclusion and exclusion criteria. Our findings reveal that key predictive features commonly used in machine learning models include age, number of pregnancies, body mass index, diabetes, hypertension, and blood pressure. In contrast, factors such as medications, genetic data, and clinical imaging were considered less frequently. Random Forest, Support Vector Machine, Logistic Regression, Decision Tree, and Naïve Bayes were the most commonly used algorithms. Most studies were conducted in China and the USA, indicating geographic concentration. The field has seen a notable rise in research, especially in the past two years, though many studies rely on small datasets from single hospitals. This review highlights the need for more diverse and comprehensive research to enhance early detection and management of preeclampsia.

先兆子痫是妊娠后期危及生命的疾病,其病因和危险因素尚不清楚。机器学习(ML)为早期预测提供了一种很有前途的方法。本系统综述分析了使用ML方法预测子痫前期的最新研究。我们回顾了谷歌Scholar和PubMed在2013年1月1日至2023年12月31日之间发表的文章。在183项确定的研究中,根据纳入和排除标准选择了35项。我们的研究结果表明,机器学习模型中常用的关键预测特征包括年龄、怀孕次数、体重指数、糖尿病、高血压和血压。相比之下,药物、遗传数据和临床影像等因素被考虑的频率较低。随机森林、支持向量机、逻辑回归、决策树和Naïve贝叶斯是最常用的算法。大多数研究在中国和美国进行,表明地理集中。这一领域的研究有了显著的增长,尤其是在过去的两年里,尽管许多研究依赖于单个医院的小数据集。这篇综述强调需要更多样化和全面的研究来加强子痫前期的早期发现和管理。
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引用次数: 0
From structures to systems: towards a model of ethical healthcare. 从结构到系统:走向道德医疗模式。
IF 1.2 Q4 HEALTH POLICY & SERVICES Pub Date : 2024-12-07 eCollection Date: 2025-01-01 DOI: 10.1080/20476965.2024.2436580
Constantine Manolchev, Marco Campenni, Navonil Mustafee

"Hurt people hurt people" is a phrase which summarises the cyclical nature of painful experiences and harmful actions. Arguably, this cycle of hurt and harm applies to the UK's National Health Service (NHS), where employees are reporting record low levels of physical and mental wellbeing, while experiencing a climate of hostility, bullying and harassment, and pressures to meet targets. Such working environments carry several risks, not only for the employees themselves but also in terms of clinical outcomes for patients. As a result, a range of systemic and targeted infrastructure interventions have been trialled in several NHS hospitals (managed in the UK by independent Trusts), seeking to promote a culture of compassion, and improve the psychological safety of workers. However, the effectiveness of such measures in achieving ethical working environments and preventing unethical behaviours, has been questioned. We join the ongoing debate by proposing the need to go beyond ethical infrastructures and instead consider ethical environments in their systemic complexity. We conclude, by putting forward a model of a complex and ethical health system, which incorporates workplace networks, policy frameworks, and accounts for regional demographics.

“伤人伤人”是一个短语,概括了痛苦经历和有害行为的周期性。可以说,这种伤害和伤害的循环适用于英国国家医疗服务体系(NHS),员工报告的身心健康水平创历史新低,同时经历敌意、欺凌和骚扰的氛围,以及实现目标的压力。这样的工作环境会带来一些风险,不仅对员工本身,而且对患者的临床结果也是如此。因此,一系列系统性和针对性的基础设施干预措施已在几家NHS医院(在英国由独立信托基金管理)进行了试验,旨在促进同情文化,并改善工人的心理安全。然而,这些措施在建立合乎道德的工作环境和防止不道德行为方面的有效性受到质疑。我们加入正在进行的辩论,提出需要超越伦理基础设施,而是考虑伦理环境的系统复杂性。最后,我们提出了一个复杂的道德卫生系统模型,该模型结合了工作场所网络、政策框架和区域人口统计数据。
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引用次数: 0
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