Pub Date : 2024-10-03DOI: 10.1109/JSEN.2024.3469544
Silu Feng;Kongjin Mo;Xin Song
Osteoporosis, characterized by reduced bone strength and density, poses a significant health threat, especially to the elderly, impacting their quality of life. Osteoprotegerin (OPG) acts as a decoy receptor in the RANK/RANKL/OPG system, inhibiting bone resorption. The existing methods, such as dual X-ray absorptiometry (DXA) and enzyme-linked immunosorbent assay (ELISA), have limitations, making them unsuitable for point-of-care testing (POCT). This highlights the need for molecular-level OPG testing, where microfluidic paper-based analytical devices ( $mu $