Pub Date : 2023-01-27DOI: 10.1142/s1793984423300017
R. J. Thomson, A. K. Limberg, D. V. Van Citters
{"title":"Nanoparticles in Joint Arthroplasties","authors":"R. J. Thomson, A. K. Limberg, D. V. Van Citters","doi":"10.1142/s1793984423300017","DOIUrl":"https://doi.org/10.1142/s1793984423300017","url":null,"abstract":"","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41690455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-12DOI: 10.1142/s1793984423500046
S. Kanimozhi, M. Hariram, V. Ganesan, S. Muthuramkumar, S. Vivekanandhan
{"title":"Exploring Azadirachta indica Gum as the Sustainable Fuel in Combustion Process for the Synthesis of ZnO Nanoparticles with Antimicrobial and Antioxidant Potentials","authors":"S. Kanimozhi, M. Hariram, V. Ganesan, S. Muthuramkumar, S. Vivekanandhan","doi":"10.1142/s1793984423500046","DOIUrl":"https://doi.org/10.1142/s1793984423500046","url":null,"abstract":"","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42533712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-22DOI: 10.1142/s1793984423500022
Aaysha Pandey, V. Sharma
{"title":"Electrochemical, Antimicrobial, and Theoretical Investigations of Synthetic Tetra-aza/Penta-aza-Macrocyclic Complexes","authors":"Aaysha Pandey, V. Sharma","doi":"10.1142/s1793984423500022","DOIUrl":"https://doi.org/10.1142/s1793984423500022","url":null,"abstract":"","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44262079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-15DOI: 10.1142/s1793984423500010
L. Kuriakose, V. V. Ison
{"title":"On the synthesis of novel AgInZn2Te4 quantum dots employing a green route","authors":"L. Kuriakose, V. V. Ison","doi":"10.1142/s1793984423500010","DOIUrl":"https://doi.org/10.1142/s1793984423500010","url":null,"abstract":"","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43737219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-25DOI: 10.1142/s1793984422500131
Shanshan Niu, Lei-Lei Qian, Pan Du, Nan Si, Dawei Jiang, Yan Feng, Bin Huang, X. Gu, Qiang Zhao, Jiao Ji, Hua Zhu
{"title":"Enhanced Ammonia Synthesis by Mo2+-rich Graphene-based Nanocomposite","authors":"Shanshan Niu, Lei-Lei Qian, Pan Du, Nan Si, Dawei Jiang, Yan Feng, Bin Huang, X. Gu, Qiang Zhao, Jiao Ji, Hua Zhu","doi":"10.1142/s1793984422500131","DOIUrl":"https://doi.org/10.1142/s1793984422500131","url":null,"abstract":"","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43253615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-18DOI: 10.1142/s1793984422500118
Sheba Goklany, Earl Brown, Lauryn De La Torre, K. Rege
Engineered three-dimensional (3D) cell culture models can accelerate drug discovery, and lead to new fundamental insights in cell–cell, cell–extracellular matrix (ECM), and cell–biomolecule interactions. Existing hydrogel or scaffold-based approaches for generating 3D tumor models do not possess significant tunability and possess limited scalability for high throughput drug screening. We have developed a new library of hydrogels, called Amikagels, which are derived from the crosslinking of amikacin hydrate (AH) and poly(ethylene glycol) diglycidyl ether (PEGDE). Here we describe the use of Amikagels for generating 3D tumor microenvironments (3DTMs) of breast cancer cells. Biological characteristics of these breast cancer 3DTMs, such as drug resistance and hypoxia were evaluated and compared to those of two-dimensional (2D) monolayer cultures. Estrogen receptor (ER) positive breast cancer 3DTMs formed on Amikagels were more dormant compared to their respective 2D monolayer cultures. Relative to their respective 2D cultures, breast cancer 3DTMs were resistant to cell death induced by mitoxantrone and doxorubicin, which are commonly used chemotherapeutic drugs in cancer, including breast cancer. The drug resistance seen in 3DTMs was correlated with hypoxia seen in these cultures but not in 2D monolayer cultures. Inhibition of Mucin 1 (MUC1), which is overexpressed in response to hypoxia, resulted in nearly complete cell death of 2D monolayer and 3DTMs of breast cancer. Combination of an ER stress inducer and MUC1 inhibition further enhanced cell death in 2D monolayer and 3DTMs. Taken together, this study shows that the Amikagel platform represents a novel technology for the generation of physiologically relevant 3DTMs in vitro and can serve as a platform to discover novel treatments for drug-resistant breast cancer.
{"title":"Generation and Evaluation of Hydrogel-Facilitated 3D Tumor Microenvironments of Breast Cancer","authors":"Sheba Goklany, Earl Brown, Lauryn De La Torre, K. Rege","doi":"10.1142/s1793984422500118","DOIUrl":"https://doi.org/10.1142/s1793984422500118","url":null,"abstract":"Engineered three-dimensional (3D) cell culture models can accelerate drug discovery, and lead to new fundamental insights in cell–cell, cell–extracellular matrix (ECM), and cell–biomolecule interactions. Existing hydrogel or scaffold-based approaches for generating 3D tumor models do not possess significant tunability and possess limited scalability for high throughput drug screening. We have developed a new library of hydrogels, called Amikagels, which are derived from the crosslinking of amikacin hydrate (AH) and poly(ethylene glycol) diglycidyl ether (PEGDE). Here we describe the use of Amikagels for generating 3D tumor microenvironments (3DTMs) of breast cancer cells. Biological characteristics of these breast cancer 3DTMs, such as drug resistance and hypoxia were evaluated and compared to those of two-dimensional (2D) monolayer cultures. Estrogen receptor (ER) positive breast cancer 3DTMs formed on Amikagels were more dormant compared to their respective 2D monolayer cultures. Relative to their respective 2D cultures, breast cancer 3DTMs were resistant to cell death induced by mitoxantrone and doxorubicin, which are commonly used chemotherapeutic drugs in cancer, including breast cancer. The drug resistance seen in 3DTMs was correlated with hypoxia seen in these cultures but not in 2D monolayer cultures. Inhibition of Mucin 1 (MUC1), which is overexpressed in response to hypoxia, resulted in nearly complete cell death of 2D monolayer and 3DTMs of breast cancer. Combination of an ER stress inducer and MUC1 inhibition further enhanced cell death in 2D monolayer and 3DTMs. Taken together, this study shows that the Amikagel platform represents a novel technology for the generation of physiologically relevant 3DTMs in vitro and can serve as a platform to discover novel treatments for drug-resistant breast cancer.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49665971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-11-11DOI: 10.1142/s179398442250012x
P. Garg
The current review article explores the binding empathy of carbon nanotubes (CNTs) for different molecular targets, in the context of their potential use to fight against severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). CNTs are touted as one of the most impending theranostic tools, owing to their exceptional mechanical, thermal and optical properties. Furthermore, their structural reliability and functional group flexibility make them especially useful for the design of advanced biosensing devices both for diagnostic and therapeutic applications against SARS-CoV-2. In addition, CNTs could also function both as an antigen carrier and an adjuvant when used concurrently with current and upcoming COVID-19 vaccines. [ FROM AUTHOR]
{"title":"Carbon nanotubes (CNTs): Smart theranostic tools for the recognition and preclusion of SARS-CoV-2 variants","authors":"P. Garg","doi":"10.1142/s179398442250012x","DOIUrl":"https://doi.org/10.1142/s179398442250012x","url":null,"abstract":"The current review article explores the binding empathy of carbon nanotubes (CNTs) for different molecular targets, in the context of their potential use to fight against severe acute respiratory syndrome corona virus-2 (SARS-CoV-2). CNTs are touted as one of the most impending theranostic tools, owing to their exceptional mechanical, thermal and optical properties. Furthermore, their structural reliability and functional group flexibility make them especially useful for the design of advanced biosensing devices both for diagnostic and therapeutic applications against SARS-CoV-2. In addition, CNTs could also function both as an antigen carrier and an adjuvant when used concurrently with current and upcoming COVID-19 vaccines. [ FROM AUTHOR]","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41994949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-05DOI: 10.1142/s1793984422300047
Jiménez-Chávez Ángel de Jesús, Moreno-Fierros Leticia
{"title":"Non-Enveloped Virus-Like Particles: A promising Antigen-Delivery strategy for the Induction of Antitumor Immune Responses","authors":"Jiménez-Chávez Ángel de Jesús, Moreno-Fierros Leticia","doi":"10.1142/s1793984422300047","DOIUrl":"https://doi.org/10.1142/s1793984422300047","url":null,"abstract":"","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41943843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-05DOI: 10.1142/s1793984422500106
Qianqian Zhang, Mingjie Zhang, Wenhui Wang
{"title":"Construction of shikonin-loaded mammaglobin-modified liposomes for breast cancer targeted therapy","authors":"Qianqian Zhang, Mingjie Zhang, Wenhui Wang","doi":"10.1142/s1793984422500106","DOIUrl":"https://doi.org/10.1142/s1793984422500106","url":null,"abstract":"","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2022-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43142403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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