Pub Date : 2021-07-16DOI: 10.1142/S1793984421300065
Y. H. Kang, F. Berthiaume
This review paper presents an overview of periodontal disease, beginning with clinical aspects including prevalence, etiology, disease progression mechanisms and implications for general health, followed by current diagnostic and therapeutic approaches. We then describe experimental models used for in vitro and in vivo investigations of periodontal disease, and emerging therapeutic approaches based on biomedical and tissue engineering concepts, nanotechnology, gene and stem cell therapies. We aim to provide bioengineers, tissue engineers and nanotechnology researchers an overall understanding of the state-of-the-art of periodontal disease to foster technological innovation based on interdisciplinary research and collaboration between physical and medical scientists.
{"title":"Periodontitis: Clinical Aspects, Pathophysiology, Experimental Approaches and Emerging Therapies","authors":"Y. H. Kang, F. Berthiaume","doi":"10.1142/S1793984421300065","DOIUrl":"https://doi.org/10.1142/S1793984421300065","url":null,"abstract":"This review paper presents an overview of periodontal disease, beginning with clinical aspects including prevalence, etiology, disease progression mechanisms and implications for general health, followed by current diagnostic and therapeutic approaches. We then describe experimental models used for in vitro and in vivo investigations of periodontal disease, and emerging therapeutic approaches based on biomedical and tissue engineering concepts, nanotechnology, gene and stem cell therapies. We aim to provide bioengineers, tissue engineers and nanotechnology researchers an overall understanding of the state-of-the-art of periodontal disease to foster technological innovation based on interdisciplinary research and collaboration between physical and medical scientists.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49029697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-28DOI: 10.1142/s1793984421400055
Rahman Moradi, R. Mohammadzadeh, A. Akbari
In this study, the Aspergillus niger L-arginase was expressed in Pichia pastorise and immobilized on Kappa-carrageenan crosslinked magnetic folic acid-conjugated chitosan nanoparticles (magnetic-FA/CTS NPs). L-arginase gene was isolated and cloned in pGAPZ[Formula: see text]A plasmid and transformed in P. pastoris. The purified L-arginase was loaded on magnetic-FA/CTS NPs nanocomposites and the structure of the synthesized nano-carriers was investigated using SEM, FT-IR and DLS techniques. Prepared formulations showed high encapsulation efficiency (91.93%). In vitro release and cytotoxic studies were performed at different pH (pH of 4–8) and against Molt-4 cancer cell line, respectively.
{"title":"Kappa-Carrageenan Crosslinked Magnetic Folic Acid-Conjugated Chitosan Nanocomposites for Arginase Encapsulation, Delivery and Cancer Therapy","authors":"Rahman Moradi, R. Mohammadzadeh, A. Akbari","doi":"10.1142/s1793984421400055","DOIUrl":"https://doi.org/10.1142/s1793984421400055","url":null,"abstract":"In this study, the Aspergillus niger L-arginase was expressed in Pichia pastorise and immobilized on Kappa-carrageenan crosslinked magnetic folic acid-conjugated chitosan nanoparticles (magnetic-FA/CTS NPs). L-arginase gene was isolated and cloned in pGAPZ[Formula: see text]A plasmid and transformed in P. pastoris. The purified L-arginase was loaded on magnetic-FA/CTS NPs nanocomposites and the structure of the synthesized nano-carriers was investigated using SEM, FT-IR and DLS techniques. Prepared formulations showed high encapsulation efficiency (91.93%). In vitro release and cytotoxic studies were performed at different pH (pH of 4–8) and against Molt-4 cancer cell line, respectively.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41584838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-28DOI: 10.1142/s1793984421500021
S. Pramanik, Y. Kumar, P. Karmakar, D. Das
This work deals with the synthesis, characterization of gadolinium ferrite nanoparticles, and its use as an electrochemical sensor for detection of dopamine. For the synthesis of gadolinium ferrite nanoparticles (GdFeO3 NPs), the combustion technique was employed using gadolinium oxide and ferric nitrate as precursor materials with sugar and ethanolamine as fuel. The size, shape and morphology of nanomaterials were determined by field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The crystallite size of synthesized nanoparticles was found to be in the range of 40–45[Formula: see text]nm with a cubic crystal system. The electrochemical sensor, GdFeO3 NPs@graphite paste (GdFeO3/GP), was prepared by using synthesized nanomaterials and graphite powder by mixing in mortar in 1:4 ratio. cyclic voltammetry (CV) and Differential pulse voltammetry (DPV) techniques were employed to assess the electrochemical properties of the developed sensor. The result indicated that the developed sensor possessed better sensing ability, where minimum detection limit of dopamine at GdFeO3/GP electrode was 700[Formula: see text]nM with linearity range from 5[Formula: see text][Formula: see text]M to 160[Formula: see text][Formula: see text]M.
{"title":"Nanosized Gadoliniumorthoferrite-based Electrochemical Sensor for the Determination of Dopamine","authors":"S. Pramanik, Y. Kumar, P. Karmakar, D. Das","doi":"10.1142/s1793984421500021","DOIUrl":"https://doi.org/10.1142/s1793984421500021","url":null,"abstract":"This work deals with the synthesis, characterization of gadolinium ferrite nanoparticles, and its use as an electrochemical sensor for detection of dopamine. For the synthesis of gadolinium ferrite nanoparticles (GdFeO3 NPs), the combustion technique was employed using gadolinium oxide and ferric nitrate as precursor materials with sugar and ethanolamine as fuel. The size, shape and morphology of nanomaterials were determined by field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The crystallite size of synthesized nanoparticles was found to be in the range of 40–45[Formula: see text]nm with a cubic crystal system. The electrochemical sensor, GdFeO3 NPs@graphite paste (GdFeO3/GP), was prepared by using synthesized nanomaterials and graphite powder by mixing in mortar in 1:4 ratio. cyclic voltammetry (CV) and Differential pulse voltammetry (DPV) techniques were employed to assess the electrochemical properties of the developed sensor. The result indicated that the developed sensor possessed better sensing ability, where minimum detection limit of dopamine at GdFeO3/GP electrode was 700[Formula: see text]nM with linearity range from 5[Formula: see text][Formula: see text]M to 160[Formula: see text][Formula: see text]M.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47165695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-09DOI: 10.1142/S1793984421300053
Sheba Goklany
Biofabrication for tissue engineering and regenerative medicine is a rapidly evolving field that incorporates bioprinting or bioassembly for the development of biologically functional products with structural organization using cells, bioactive molecules, and biomaterials. Bioprinting is a biofabrication technology that utilizes biomaterials, living cells, and supporting materials, called bioink, to generate three-dimensional tissue constructs. Bioprinting offers several advantages over traditional scaffolding and microengineering methods such as precise architecture control, high reproducibility, and versatility. The ideal bioink should possess appropriate structural, mechanical, gelation, rheological, chemical, biological, degradation, and biomimetic properties for the desired application of the final product. Several natural and synthetic bioinks have been developed and this review has focused on conductive nanomaterials that have been used in combination with hydrogel materials for bioink synthesis.
{"title":"Conductive Nanomaterials used in Bioinks for 3D Bioprinting","authors":"Sheba Goklany","doi":"10.1142/S1793984421300053","DOIUrl":"https://doi.org/10.1142/S1793984421300053","url":null,"abstract":"Biofabrication for tissue engineering and regenerative medicine is a rapidly evolving field that incorporates bioprinting or bioassembly for the development of biologically functional products with structural organization using cells, bioactive molecules, and biomaterials. Bioprinting is a biofabrication technology that utilizes biomaterials, living cells, and supporting materials, called bioink, to generate three-dimensional tissue constructs. Bioprinting offers several advantages over traditional scaffolding and microengineering methods such as precise architecture control, high reproducibility, and versatility. The ideal bioink should possess appropriate structural, mechanical, gelation, rheological, chemical, biological, degradation, and biomimetic properties for the desired application of the final product. Several natural and synthetic bioinks have been developed and this review has focused on conductive nanomaterials that have been used in combination with hydrogel materials for bioink synthesis.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46538224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-05DOI: 10.1142/S1793984421400043
Wenying Yao, Jin-Xia Yang, Xin Wang, Min Shen
Aim: To develop a nursing early warning system in children’s hospital during the outbreak of the novel coronavirus pneumonia, and to accomplish the construction and application of this system, so as to provide decision-support of the prevention and control for COVID-19 in children’s medical institutions. Method: Children’s hospital nursing early warning system was divided into three modules: hospital nursing early warning platform includes internal and external early warning platform, nursing staff early warning program includes protection, human resources early warning plan and patient early warning program includes outpatient, emergency and ward early warning plan. The data of epidemic training, assessment, prevention and control screening from January to June 2020 were collected from the nursing early warning system to evaluate the application effect of the system. Results: A total of 18 procedures and specifications were formulated, nine hospital-level trainings and about 1000 department-level trainings were organized, two hospital-level assessments (pass rate 95.6% and 98.2%), and 78 nurses were reserved, and 10 popular science articles, five popular science videos were published during the application of the nursing early warning system. A total of 583,435 children and 139,308 caregivers were screened in outpatient, emergency and wards during pre-checks, 2385 suspected cases of novel coronavirus pneumonia were confirmed (0.41%) after the screening and 1 case (0.0002%) was finally confirmed. Conclusion: The nursing early warning system of children’s hospital can prevent and control the novel coronavirus pneumonia epidemic from each module, ensure early warning and triage of suspected infected patients, reduce the risk of cross-infection in hospital and improve the safety of the children’s hospital medical environment.
{"title":"Application of Early Warning Nursing System During COVID-19 Epidemic in Children’s Hospital","authors":"Wenying Yao, Jin-Xia Yang, Xin Wang, Min Shen","doi":"10.1142/S1793984421400043","DOIUrl":"https://doi.org/10.1142/S1793984421400043","url":null,"abstract":"Aim: To develop a nursing early warning system in children’s hospital during the outbreak of the novel coronavirus pneumonia, and to accomplish the construction and application of this system, so as to provide decision-support of the prevention and control for COVID-19 in children’s medical institutions. Method: Children’s hospital nursing early warning system was divided into three modules: hospital nursing early warning platform includes internal and external early warning platform, nursing staff early warning program includes protection, human resources early warning plan and patient early warning program includes outpatient, emergency and ward early warning plan. The data of epidemic training, assessment, prevention and control screening from January to June 2020 were collected from the nursing early warning system to evaluate the application effect of the system. Results: A total of 18 procedures and specifications were formulated, nine hospital-level trainings and about 1000 department-level trainings were organized, two hospital-level assessments (pass rate 95.6% and 98.2%), and 78 nurses were reserved, and 10 popular science articles, five popular science videos were published during the application of the nursing early warning system. A total of 583,435 children and 139,308 caregivers were screened in outpatient, emergency and wards during pre-checks, 2385 suspected cases of novel coronavirus pneumonia were confirmed (0.41%) after the screening and 1 case (0.0002%) was finally confirmed. Conclusion: The nursing early warning system of children’s hospital can prevent and control the novel coronavirus pneumonia epidemic from each module, ensure early warning and triage of suspected infected patients, reduce the risk of cross-infection in hospital and improve the safety of the children’s hospital medical environment.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48638413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01Epub Date: 2021-06-09DOI: 10.1142/s179398442130003x
Chen-Hua Ma, Jeffrey Yang, Jenna L Mueller, Huang-Chiao Huang
Photodynamic therapy (PDT) is a two-step procedure that involves the administration of special drugs, commonly called photosensitizers, followed by the application of certain wavelengths of light. The light activates these photosensitizers to produce reactive molecular species that induce cell death in tissues. There are numerous factors to consider when selecting the appropriate photosensitizer administration route, such as which part of the body is being targeted, the pharmacokinetics of photosensitizers, and the formulation of photosensitizers. While intravenous, topical, and oral administration of photosensitizers are widely used in preclinical and clinical applications of PDT, other administration routes, such as intraperitoneal, intra-arterial, and intratumoral injections, are gaining traction for their potential in treating advanced diseases and reducing off-target toxicities. With recent advances in targeted nanotechnology, biomaterials, and light delivery systems, the exciting possibilities of targeted photosensitizer delivery can be fully realized for preclinical and clinical applications. Further, in light of the growing burden of cancer mortality in low and middle-income countries and development of low-cost light sources and photosensitizers, PDT could be used to treat cancer patients in low-income settings. This short article introduces aspects of interfaces of intratumoral photosensitizer injections and nano-biomaterials for PDT applications in both high-income and low-income settings but does not present a comprehensive review due to space limitations.
{"title":"Intratumoral Photosensitizer Delivery and Photodynamic Therapy.","authors":"Chen-Hua Ma, Jeffrey Yang, Jenna L Mueller, Huang-Chiao Huang","doi":"10.1142/s179398442130003x","DOIUrl":"https://doi.org/10.1142/s179398442130003x","url":null,"abstract":"<p><p>Photodynamic therapy (PDT) is a two-step procedure that involves the administration of special drugs, commonly called photosensitizers, followed by the application of certain wavelengths of light. The light activates these photosensitizers to produce reactive molecular species that induce cell death in tissues. There are numerous factors to consider when selecting the appropriate photosensitizer administration route, such as which part of the body is being targeted, the pharmacokinetics of photosensitizers, and the formulation of photosensitizers. While intravenous, topical, and oral administration of photosensitizers are widely used in preclinical and clinical applications of PDT, other administration routes, such as intraperitoneal, intra-arterial, and intratumoral injections, are gaining traction for their potential in treating advanced diseases and reducing off-target toxicities. With recent advances in targeted nanotechnology, biomaterials, and light delivery systems, the exciting possibilities of targeted photosensitizer delivery can be fully realized for preclinical and clinical applications. Further, in light of the growing burden of cancer mortality in low and middle-income countries and development of low-cost light sources and photosensitizers, PDT could be used to treat cancer patients in low-income settings. This short article introduces aspects of interfaces of intratumoral photosensitizer injections and nano-biomaterials for PDT applications in both high-income and low-income settings but does not present a comprehensive review due to space limitations.</p>","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":"11 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8412167/pdf/nihms-1724482.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39385977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guangqing Duan, Kaixuan Lv, Juncheng Lyu, N. Tian, Lichun Zhang, Qi Liu, Mengjie Wang, Shiyu Sun, Jielun Yu, G. Guo, Wei Tan, Nana Yang
Background: The influence of coronary atherosclerosis and related treatment drugs on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) development requires in-depth study. The study investigated the effect of coronary artery calcification (CAC) and drugs for CAC on the development of AECOPD. Methods: This retrospective clinical study recruited subjects with AECOPD from May 2017 to May 2019. All subjects performed spirometry and coronary computed tomography (CT), and were divided into three groups according to whether coronary CT revealed CAC and whether they had received oral aspirin and statins: AECOPD group, AECOPD[Formula: see text]CAC nonmedication and AECOPD[Formula: see text]CAC medication. The t-test and nonparametric test were used for analyzing the lung function, arterial blood gas, routine blood and lipid between groups. Results: Compared with the AECOPD group, Lym% were significantly higher ([Formula: see text]) in both the AECOPD[Formula: see text]CAC nonmedication and the AECOPD[Formula: see text]CAC medication. The AECOPD[Formula: see text]CAC medication group also had significantly higher PaO2 ([Formula: see text]). WBC, Neu, and Neu% in the AECOPD[Formula: see text]CAC medication group were significantly lower ([Formula: see text]) compared to the AECOPD group. Conclusions: Aspirin and statins for the treatment of cardiovascular diseases may be linked to improving lung function, normalizing blood gas levels, and reducing inflammation in patients with AECOPD and CAC. Further, randomized controlled trials are needed to explore this topic.
{"title":"Effect of Aspirin and Statins on Pulmonary Function and Inflammation in Patients with AECOPD","authors":"Guangqing Duan, Kaixuan Lv, Juncheng Lyu, N. Tian, Lichun Zhang, Qi Liu, Mengjie Wang, Shiyu Sun, Jielun Yu, G. Guo, Wei Tan, Nana Yang","doi":"10.21203/rs.2.23404/v1","DOIUrl":"https://doi.org/10.21203/rs.2.23404/v1","url":null,"abstract":"Background: The influence of coronary atherosclerosis and related treatment drugs on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) development requires in-depth study. The study investigated the effect of coronary artery calcification (CAC) and drugs for CAC on the development of AECOPD. Methods: This retrospective clinical study recruited subjects with AECOPD from May 2017 to May 2019. All subjects performed spirometry and coronary computed tomography (CT), and were divided into three groups according to whether coronary CT revealed CAC and whether they had received oral aspirin and statins: AECOPD group, AECOPD[Formula: see text]CAC nonmedication and AECOPD[Formula: see text]CAC medication. The t-test and nonparametric test were used for analyzing the lung function, arterial blood gas, routine blood and lipid between groups. Results: Compared with the AECOPD group, Lym% were significantly higher ([Formula: see text]) in both the AECOPD[Formula: see text]CAC nonmedication and the AECOPD[Formula: see text]CAC medication. The AECOPD[Formula: see text]CAC medication group also had significantly higher PaO2 ([Formula: see text]). WBC, Neu, and Neu% in the AECOPD[Formula: see text]CAC medication group were significantly lower ([Formula: see text]) compared to the AECOPD group. Conclusions: Aspirin and statins for the treatment of cardiovascular diseases may be linked to improving lung function, normalizing blood gas levels, and reducing inflammation in patients with AECOPD and CAC. Further, randomized controlled trials are needed to explore this topic.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2020-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44477917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-19DOI: 10.1142/S1793984419410046
X. Xiong, F. Savira, Kevin W. Huang, Zuoren Yu, B. Wang
Stem cell therapy has been tested for cardiac disease therapy for decades. Initially, researchers only considered stem cells’ differentiative ability to repair damaged cardiac tissue. However, studies have now uncovered novel mechanisms contributing to stem cell healing properties to repair injured cardiac tissue, including via paracrine signaling and exosome secretions, leading to amelioration of cardiac remodeling and enhancement of proliferation, regeneration and survival of stem cell-derived cardiac cells. Understanding these underlying mechanisms could help researchers utilize stem cells as a therapeutic strategy for cardiac disease effectively and address the current limitations, mainly surrounding its survival and differentiative ability in the cardiac milieu. This review will discuss the known potential mechanisms underlying the role of stem cells in contributing to and for the treatment of heart diseases.
{"title":"Potential Mechanisms Underlying Therapeutic Benefits of Stem Cell for Heart Failure","authors":"X. Xiong, F. Savira, Kevin W. Huang, Zuoren Yu, B. Wang","doi":"10.1142/S1793984419410046","DOIUrl":"https://doi.org/10.1142/S1793984419410046","url":null,"abstract":"Stem cell therapy has been tested for cardiac disease therapy for decades. Initially, researchers only considered stem cells’ differentiative ability to repair damaged cardiac tissue. However, studies have now uncovered novel mechanisms contributing to stem cell healing properties to repair injured cardiac tissue, including via paracrine signaling and exosome secretions, leading to amelioration of cardiac remodeling and enhancement of proliferation, regeneration and survival of stem cell-derived cardiac cells. Understanding these underlying mechanisms could help researchers utilize stem cells as a therapeutic strategy for cardiac disease effectively and address the current limitations, mainly surrounding its survival and differentiative ability in the cardiac milieu. This review will discuss the known potential mechanisms underlying the role of stem cells in contributing to and for the treatment of heart diseases.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793984419410046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41434593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-19DOI: 10.1142/S1793984419410022
Yan-bin Fu, Zhiying He, Chao Zhang
Stem cell therapy is being developed as a promising novel strategy for the treatment of heart-associated diseases. Several types of cells such as skeletal myoblasts, bone marrow (BM) mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), adipose stem cells (ADSCs), cardiac progenitor cells (CPCs), induced pluripotent stem cells (iPSCs) have been tested in pre-clinical and clinical cardiac repairing models. Fibroblasts, as terminally differentiated cells, could also be trans-differentiated into cardiomyocytes in vitro. In this review, we will summarize the recent advances of cell types, potential applications and challenges of stem cell therapy in the treatment of heart failure.
{"title":"Advances of Stem Cell Therapy to Treat Heart Failure","authors":"Yan-bin Fu, Zhiying He, Chao Zhang","doi":"10.1142/S1793984419410022","DOIUrl":"https://doi.org/10.1142/S1793984419410022","url":null,"abstract":"Stem cell therapy is being developed as a promising novel strategy for the treatment of heart-associated diseases. Several types of cells such as skeletal myoblasts, bone marrow (BM) mesenchymal stem cells (MSCs), endothelial progenitor cells (EPCs), adipose stem cells (ADSCs), cardiac progenitor cells (CPCs), induced pluripotent stem cells (iPSCs) have been tested in pre-clinical and clinical cardiac repairing models. Fibroblasts, as terminally differentiated cells, could also be trans-differentiated into cardiomyocytes in vitro. In this review, we will summarize the recent advances of cell types, potential applications and challenges of stem cell therapy in the treatment of heart failure.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":" ","pages":""},"PeriodicalIF":0.8,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793984419410022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43109046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-19DOI: 10.1142/S1793984419410010
Tianxiao Mei, Wenjun Le, H. Cao, Zhan Wang, Wenjie Tang, Zhongmin Liu, Donglu Shi
Heart failure (HF) remains the major cause of morbidity and mortality in the world with an alarming rapid rise in heart diseases. Myocardial infarction (MI), depriving of blood flow to the heart muscle, causes myocardial necrosis and apoptosis resulting in decrease of myocardial quantity and ventricular remodeling, which is the main cause of HF. As mature cardiomyocytes (CMs) are incapable of differentiation and proliferation, cardiomyocytes damage is not likely to be reversed. Recent research has advanced to the point where damaged CMs or myocardium can be repaired by exogenous cells or artificial tissue. This review provides the most up-to-date information on the current status of cell therapy and tissue three-dimensional (3D) bioprinting for the treatment of HF. Requirements on 3D printing of biomaterials will be provided including biophysical properties, biocompatibility and biodegradable absorption in vivo that are key factors on the survival and proliferation of transplanted cells in the MI area. Also discussed are the current challenges in cell-based HF therapies and future perspectives in clinical applications.
{"title":"Cell Therapy and 3D Regenerative Tissue to Remodel Heart Failure","authors":"Tianxiao Mei, Wenjun Le, H. Cao, Zhan Wang, Wenjie Tang, Zhongmin Liu, Donglu Shi","doi":"10.1142/S1793984419410010","DOIUrl":"https://doi.org/10.1142/S1793984419410010","url":null,"abstract":"Heart failure (HF) remains the major cause of morbidity and mortality in the world with an alarming rapid rise in heart diseases. Myocardial infarction (MI), depriving of blood flow to the heart muscle, causes myocardial necrosis and apoptosis resulting in decrease of myocardial quantity and ventricular remodeling, which is the main cause of HF. As mature cardiomyocytes (CMs) are incapable of differentiation and proliferation, cardiomyocytes damage is not likely to be reversed. Recent research has advanced to the point where damaged CMs or myocardium can be repaired by exogenous cells or artificial tissue. This review provides the most up-to-date information on the current status of cell therapy and tissue three-dimensional (3D) bioprinting for the treatment of HF. Requirements on 3D printing of biomaterials will be provided including biophysical properties, biocompatibility and biodegradable absorption in vivo that are key factors on the survival and proliferation of transplanted cells in the MI area. Also discussed are the current challenges in cell-based HF therapies and future perspectives in clinical applications.","PeriodicalId":44929,"journal":{"name":"Nano Life","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1142/S1793984419410010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64072681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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