Pub Date : 2024-01-02DOI: 10.1007/s12561-023-09411-8
Chenguang Zhang, Masayuki Nigo, Shivani Patel, Duo Yu, Edward Septimus, Hulin Wu
{"title":"Use of Real-World EMR Data to Rapidly Evaluate Treatment Effects of Existing Drugs for Emerging Infectious Diseases: Remdesivir for COVID-19 Treatment as an Example","authors":"Chenguang Zhang, Masayuki Nigo, Shivani Patel, Duo Yu, Edward Septimus, Hulin Wu","doi":"10.1007/s12561-023-09411-8","DOIUrl":"https://doi.org/10.1007/s12561-023-09411-8","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"112 45","pages":"1-30"},"PeriodicalIF":1.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-17DOI: 10.1007/s12561-023-09404-7
Joseph Boyle, Mary H. Ward, Stella Koutros, M. Karagas, M. Schwenn, Alison T. Johnson, Debra T. Silverman, David C. Wheeler
{"title":"Modeling Historic Arsenic Exposures and Spatial Risk for Bladder Cancer","authors":"Joseph Boyle, Mary H. Ward, Stella Koutros, M. Karagas, M. Schwenn, Alison T. Johnson, Debra T. Silverman, David C. Wheeler","doi":"10.1007/s12561-023-09404-7","DOIUrl":"https://doi.org/10.1007/s12561-023-09404-7","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"5 11","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138966433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-12DOI: 10.1007/s12561-023-09409-2
Alexander P. Keil, Katie M. O’Brien
{"title":"Considerations and Targeted Approaches to Identifying Bad Actors in Exposure Mixtures","authors":"Alexander P. Keil, Katie M. O’Brien","doi":"10.1007/s12561-023-09409-2","DOIUrl":"https://doi.org/10.1007/s12561-023-09409-2","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"6 13","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139006657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-02DOI: 10.1007/s12561-023-09402-9
Yao Li, Wei Xu
{"title":"Causal Mediation Tree Model for Feature Identification on High-Dimensional Mediators","authors":"Yao Li, Wei Xu","doi":"10.1007/s12561-023-09402-9","DOIUrl":"https://doi.org/10.1007/s12561-023-09402-9","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"79 8","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138606084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1007/s12561-023-09407-4
Trevor J. Thomson, X. Joan Hu, Bohdan Nosyk
{"title":"Evaluating Effects of Various Exposures on Mortality Risk of Opioid Use Disorders with Linked Administrative Databases","authors":"Trevor J. Thomson, X. Joan Hu, Bohdan Nosyk","doi":"10.1007/s12561-023-09407-4","DOIUrl":"https://doi.org/10.1007/s12561-023-09407-4","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":" 32","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-01DOI: 10.1007/s12561-023-09403-8
Kecheng Li, Tugba Akkaya Hocagil, Richard J. Cook, Louise M. Ryan, R. C. Carter, Khue-Dung Dang, J. Jacobson, S. Jacobson
{"title":"Use of Generalized Propensity Scores for Assessing Effects of Multiple Exposures","authors":"Kecheng Li, Tugba Akkaya Hocagil, Richard J. Cook, Louise M. Ryan, R. C. Carter, Khue-Dung Dang, J. Jacobson, S. Jacobson","doi":"10.1007/s12561-023-09403-8","DOIUrl":"https://doi.org/10.1007/s12561-023-09403-8","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":" 6","pages":""},"PeriodicalIF":1.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138617119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract We propose a functional linear model to predict a functional response using multiple functional and longitudinal predictors and to estimate the effect lags of predictors. The coefficient functions are written as the expansion of a basis system (e.g. functional principal components, splines), and the coefficients of the basis functions are estimated via optimizing a penalization criterion. Then effect lags are determined by simultaneously searching on a prior designed grid mesh based on minimization of a proposed prediction error criterion. Mathematical properties of the estimated regression functions and predicted responses are studied. The performance of the method is evaluated by extensive simulations and a real data analysis application on chronic obstructive pulmonary disease (COPD).
{"title":"On Estimation of the Effect Lag of Predictors and Prediction in a Functional Linear Model","authors":"Haiyan Liu, Georgios Aivaliotis, Vijay Kumar, Jeanine Houwing-Duistermaat","doi":"10.1007/s12561-023-09393-7","DOIUrl":"https://doi.org/10.1007/s12561-023-09393-7","url":null,"abstract":"Abstract We propose a functional linear model to predict a functional response using multiple functional and longitudinal predictors and to estimate the effect lags of predictors. The coefficient functions are written as the expansion of a basis system (e.g. functional principal components, splines), and the coefficients of the basis functions are estimated via optimizing a penalization criterion. Then effect lags are determined by simultaneously searching on a prior designed grid mesh based on minimization of a proposed prediction error criterion. Mathematical properties of the estimated regression functions and predicted responses are studied. The performance of the method is evaluated by extensive simulations and a real data analysis application on chronic obstructive pulmonary disease (COPD).","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135341192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-04DOI: 10.1007/s12561-023-09395-5
Jiyeon Song, Subharup Guha, Yi Li
{"title":"Bayesian Inference for High Dimensional Cox Models with Gaussian and Diffused-Gamma Priors: A Case Study of Mortality in COVID-19 Patients Admitted to the ICU","authors":"Jiyeon Song, Subharup Guha, Yi Li","doi":"10.1007/s12561-023-09395-5","DOIUrl":"https://doi.org/10.1007/s12561-023-09395-5","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"87 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135774370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-04DOI: 10.1007/s12561-023-09398-2
Phillip Shreeves, Jeffrey L. Andrews, Xinchen Deng, Ramie Ali-Adeeb, Andrew Jirasek
{"title":"Nonnegative Matrix Factorization with Group and Basis Restrictions","authors":"Phillip Shreeves, Jeffrey L. Andrews, Xinchen Deng, Ramie Ali-Adeeb, Andrew Jirasek","doi":"10.1007/s12561-023-09398-2","DOIUrl":"https://doi.org/10.1007/s12561-023-09398-2","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"16 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135726760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-03DOI: 10.1007/s12561-023-09401-w
Yingying Wei
{"title":"Introduction to Special Issue on Machine Learning Algorithms in Genomics and Genetics","authors":"Yingying Wei","doi":"10.1007/s12561-023-09401-w","DOIUrl":"https://doi.org/10.1007/s12561-023-09401-w","url":null,"abstract":"","PeriodicalId":45094,"journal":{"name":"Statistics in Biosciences","volume":"27 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135868576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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