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Recomendaciones nutricionales en la prevención y tratamiento de la dislipemia aterogénica. Grupo de Trabajo Dislipemia Aterogénica, Sociedad Española de Arteriosclerosis 预防和治疗动脉粥样硬化性血脂异常的营养建议。西班牙动脉硬化学会动脉粥样硬化性血脂异常工作组
IF 1.6 Q3 Medicine Pub Date : 2023-05-01 DOI: 10.1016/j.arteri.2022.09.002
Vicente Pascual , José Luis Díaz , Jesús Millán Nuñez-Cortés , Pablo Pérez-Martínez

The incorporation of a healthy diet, regular physical exercise and smoking cessation are the initial measures to reduce cardiovascular risk in patients with atherogenic dyslipidemia. In these patients, the nutritional quality of their diet should be improved, replacing foods with a greater atherogenic effect for others with a healthier effect. There is strong evidence that plant-based dietary patterns, low in saturated fatty acids, cholesterol and sodium, with a high content of fiber, potassium and unsaturated fatty acids, are beneficial and reduce the expression of cardiovascular risk factors. This document focuses on the role of nutrition in the prevention and treatment of atherogenic dyslipidemia, providing current evidence to serve as a tool for health professionals in its clinical management. To facilitate the reading of these recommendations, they are presented in a user-friendly table format, with a hierarchy of different levels of evidence.

健康饮食、定期体育锻炼和戒烟是降低动脉粥样硬化性血脂异常患者心血管风险的初步措施。在这些患者中,他们饮食的营养质量应该得到改善,用更健康的效果取代那些对动脉粥样硬化有更大影响的食物。有强有力的证据表明,植物性饮食模式,饱和脂肪酸、胆固醇和钠含量低,纤维、钾和不饱和脂肪酸含量高,有益于降低心血管风险因素的表达。本文件侧重于营养在预防和治疗动脉粥样硬化性血脂异常中的作用,为卫生专业人员的临床管理提供了最新的证据。为了便于阅读这些建议,这些建议以用户友好的表格格式呈现,并有不同级别的证据层次。
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引用次数: 0
Dietary modulation of advanced glycation end products metabolism on carotid intima-media thickness in type 2 diabetes patients: From the CORDIOPREV study 饮食调节2型糖尿病患者晚期糖基化终产物代谢对颈动脉内膜-中膜厚度的影响:来自CORDIOPREV研究
IF 1.6 Q3 Medicine Pub Date : 2023-05-01 DOI: 10.1016/j.arteri.2022.08.004
Elena M. Yubero-Serrano , Francisco M. Gutiérrez-Mariscal , Purificación Gómez-Luna , Juan F. Alcalá-Diaz , Pablo Pérez-Martinez , José López-Miranda

Background

Advanced glycation end products (AGEs) are pro-oxidant and cytotoxic compounds involved in the progression of chronic diseases as cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). The total body burden of AGEs also depend of those consume through the diet. Our aim was to analyze whether the reduction of AGE levels, after the consumption of two-healthy diets were associated with a greater decrease of intima-media thickness of both common carotid arteries (IMT-CC) in patients with T2DM and coronary heart disease (CHD).

Methods

540 CHD patients with T2DM, at baseline, from the CORDIOPREV study, were divided into two groups: (1) Responders, patients whose IMT-CC was reduced or not changed after dietary intervention and (2) Non-responders, patients whose IMT-CC was increased after dietary intervention. A total of 423 completed baseline and the 5-year follow-up carotid ultrasounds were analyzed in this study.

Results

Our data showed that Responders, despite had a higher baseline IMT-CC and serum methylglyoxal (MG) levels than Non-responders, showed a reduction of serum levels of this glycotoxin after dietary intervention. Conversely, in patients whose IMT-CC was increased after dietary intervention (Non-responders), serum MG levels were increased. Moreover, an increase of circulating level of AGEs (and in particular, MG), after dietary intervention, could be considered a risk factor for the progression of atherosclerosis in patients with T2DM and CHD.

Conclusion

These results support the importance of identifying underlying mechanisms in the context of secondary prevention of CVD that would provide therapeutic targets to reduce the high risk of cardiovascular events of these patients.

Clinical Trial registration-URL: https://clinicaltrials.gov/ct2/show/NCT00924937.

Unique Identifier: NCT00924937.

背景晚期糖基化终产物(AGEs)是一种促氧化和细胞毒性化合物,参与心血管疾病(CVD)和2型糖尿病(T2DM)等慢性疾病的进展。AGEs的总身体负担也取决于通过饮食摄入的AGEs。我们的目的是分析两种健康饮食后AGE水平的降低是否与T2DM和冠心病患者颈总动脉内膜-中膜厚度的更大降低有关,饮食干预后IMT-CC降低或未改变的患者和(2)饮食干预后无反应、IMT-CC增加的患者。本研究共分析了423例完成基线检查和5年随访的颈动脉超声。结果我们的数据显示,尽管应答者的基线IMT-CC和血清甲基乙二醛(MG)水平高于非应答者,但在饮食干预后,这种糖毒素的血清水平有所降低。相反,在饮食干预后IMT-CC增加的患者(无应答者)中,血清MG水平增加。此外,在饮食干预后,AGEs(尤其是MG)循环水平的增加,可被认为是T2DM和CHD患者动脉粥样硬化进展的危险因素。结论这些结果支持在心血管疾病二级预防的背景下确定潜在机制的重要性,这将为降低这些患者心血管事件的高风险提供治疗靶点。临床试验注册URL:https://clinicaltrials.gov/ct2/show/NCT00924937.Unique标识符:NCT00924937。
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引用次数: 1
Actualización y validación del riesgo cardiovascular de por vida en España: IBERLIFERISK2 西班牙终身心血管风险的更新和验证:IberLifeRisk2
IF 1.6 Q3 Medicine Pub Date : 2023-05-01 DOI: 10.1016/j.arteri.2022.09.003
Carlos Brotons , Irene Moral-Peláez , Johanna Vicuña , Cristina Ameixeiras , Carlos Fernández-Lavandera , Miguel Ángel Sánchez-Chaparro

Introduction

The function to estimate lifetime cardiovascular risk –IBERLIFERISK– in Spanish working population, obtained a satisfactory discrimination; however, there was a slight overestimation of the risk in men and an underestimation of the risk in women.

Objective

To recalibrate the current lifetime risk equation after extending the follow-up by 3 years.

Methods

Retrospective cohort study. 762.058 workers who underwent an occupational health examination between 2004 and 2007 were included. All episodes of temporary sickness and cardiovascular mortality up to December 2017 were evaluated. Regression models were combined to take into account the presence of competing risks in estimating cardiovascular risk in the derivation cohort. Calibration was performed by graphically representing the proportion of expected and observed events at 10 years of follow-up in the validation cohort, stratifying by risk deciles and calculating the Spiegelhalter Z statistic. Discrimination was evaluated graphically using the Receiver Operating Curve (ROC) and calculating Harrell's C index.

Results

The mean age was 35.48 years (SD 10.56). 71.14% were men. Harrell's C index was 0.78 (95% CI 0.76-0.79) in men and 0.73 (95% CI 0.69-0.77) in women. In general, there was a slight degree of underestimation in women and overestimation in men in the last decile of risk, although the Spiegelhalter Z statistic was not statistically significant in both sexes (p>0.05).

Conclusions

The updated model continues to discriminate satisfactorily, although the model's calibration has not substantially improved with the new update.

引言在西班牙工作人群中估计终身心血管风险的功能IBERLIFERISK获得了令人满意的判别;然而,男性的风险略有高估,女性的风险则有所低估。目的在延长随访3年后,重新校准当前的终生风险方程。方法回顾性队列研究。762.058名在2004年至2007年期间接受职业健康检查的工人也包括在内。对截至2017年12月的所有暂时性疾病发作和心血管死亡率进行了评估。将回归模型结合起来,以考虑衍生队列中估计心血管风险时存在的竞争风险。通过图形化表示验证队列中10年随访时预期和观察到的事件的比例,按风险十分位数进行分层,并计算Spiegelholter Z统计量来进行校准。使用受试者工作曲线(ROC)并计算Harrell的C指数以图形方式评估辨别度。结果平均年龄35.48岁(标准差10.56),男性71.14%。男性的Harrell C指数为0.78(95%CI 0.76-0.79),女性为0.73(95%CI 0.69-0.77)。总的来说,尽管Spiegelholter Z统计数据在两性中都没有统计学意义(p>0.05),但在最后十分之一的风险中,女性和男性都有轻微的低估和高估。
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引用次数: 2
Actualización y validación del riesgo cardiovascular 心血管风险的更新和验证
IF 1.6 Q3 Medicine Pub Date : 2023-05-01 DOI: 10.1016/j.arteri.2023.05.004
José Ignacio Cuende
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引用次数: 0
Association between physical activity and coronary artery calcification estimated by computed tomography: A systematic review 计算机断层扫描评估体力活动与冠状动脉钙化的关系:一项系统综述
IF 1.6 Q3 Medicine Pub Date : 2023-05-01 DOI: 10.1016/j.arteri.2022.10.001
Walter Masson, Leandro Barbagelata, Mariano Falconi, Diego Pérez de Arenaza

Background

The relationship between physical activity and coronary artery calcification (CAC) was evaluated in different studies during the last years, although the results were conflicting.

Objective

The main objective of the present systematic review was to assess the association between different levels of physical activity and CAC score estimated by computed tomography (CT).

Methods

This systematic review was performed according to PRISMA guidelines. A literature search was performed to detect studies that evaluated the association between physical activity and CAC score. The levels of physical activity evaluated were those reported by the original publications. The CAC score was estimated by CT and was reported in Agatston units.

Results

Twenty six studies including 89,405 subjects were considered eligible for this research. The studies developed in the general population showed different results regarding the association between physical activity and CAC score: no association (7 studies), a positive association (4 studies), an inverse relationship (6 studies), a U-shaped relationship (2 studies), or different results depending on the subgroup evaluated (2 studies). In the largest studies, a positive association was observed. When we analyzed the studies that evaluated athletes, four studies showed a positive association between exercise intensity and CAC.

Conclusion

This systematic review showed disparate results regarding the association between physical activity and CAC score. The largest studies and most studies developed in athletes suggest that intense physical activity could be associated with high CAC score, although this hypothesis should be confirmed in future research.

背景在过去几年中,不同的研究评估了体育活动与冠状动脉钙化(CAC)之间的关系,尽管结果相互矛盾。目的本系统综述的主要目的是评估不同水平的体力活动与计算机断层扫描(CT)估计的CAC评分之间的关系。方法根据PRISMA指南进行系统综述。进行文献检索,以检测评估体力活动与CAC评分之间相关性的研究。评估的体育活动水平是原始出版物所报告的水平。CAC评分由CT估计,并以Agaston单位报告。结果包括89405名受试者在内的26项研究被认为符合本研究的条件。在普通人群中进行的研究显示,关于体育活动与CAC评分之间的关联,结果不同:无关联(7项研究)、正关联(4项研究),反比关系(6项研究)和U型关系(2项研究)或根据评估的亚组得出不同结果(2项研究)。在规模最大的研究中,观察到了正相关。当我们分析评估运动员的研究时,有四项研究显示运动强度与CAC呈正相关。结论这项系统综述显示,关于体育活动与CAC评分之间的关联,结果各不相同。对运动员进行的最大规模的研究和大多数研究表明,剧烈的体育活动可能与高CAC分数有关,尽管这一假设应在未来的研究中得到证实。
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引用次数: 0
SmartLab 2.0 en prevención cardiovascular de dislipemia aterogénica SmartLab 2.0在心血管预防动脉粥样硬化性血脂异常中的应用
IF 1.6 Q3 Medicine Pub Date : 2023-05-01 DOI: 10.1016/j.arteri.2022.09.004
Raquel Galván Toribio , Teresa Arrobas Velilla , Cristóbal Morales Porillo , Miguel Ángel Rico , Mar Martínez Quesada , Antonio León Justel

Introduction

SmartLab 2.0 is an innovative concept of multidisciplinary collaboration between the clinical laboratory and the diabetes day unit that was born with the aim of identifying patients at high cardiovascular risk who require priority attention, such as patients with atherogenic dyslipidemia, in order to create a cardiovascular prevention strategy.

Objective

Implementation in the Laboratory Information System (LIS) of an automated biochemical algorithm for the identification of patients with atherogenic dyslipidemia in routine analyses and priority referral to the diabetes day unit.

Material and methods

The algorithm designed in the SIL was: HBA1c > 9.3 + TG > 150 mg/dl + HDLc < 40 mg/dl + LDL/ApoB < 1.3. A comment was inserted alerting the requesting physician of the diagnosis of atherogenic dyslipidemia and priority referral was made from the laboratory to the diabetes day unit in the necessary cases.

Results

In the 1-year period, a total of 899 patients with HBA1c > 7 and atherogenic dyslipidemia criteria were identified. Of these, 203 patients from primary care with HbA1c > 9.3 were referred to the diabetes day hospital.

Conclusions

Reinforcement of cardiovascular prevention is necessary at all levels. The clinical laboratory should play a fundamental role in the diagnosis of dyslipidemias. Early detection of patients at high cardiovascular risk is essential and collaboration between the different clinical units is fundamental to guarantee patient safety.

简介SmartLab 2.0是临床实验室和糖尿病日间单位之间多学科合作的创新概念,旨在识别需要优先关注的心血管高危患者,如动脉粥样硬化性血脂异常患者,以制定心血管预防策略。目的在实验室信息系统(LIS)中实现一种自动生化算法,用于在常规分析中识别动脉粥样硬化性血脂异常患者,并优先转诊至糖尿病日间病房。材料和方法SIL中设计的算法为:HBA1c>;9.3+TG>;150mg/dl+HDLc<;40mg/dl+LDL/ApoB<;1.3.插入了一条注释,提醒提出请求的医生诊断为动脉粥样硬化性血脂异常,在必要的情况下,从实验室优先转诊到糖尿病日间病房。结果1年内共有899例HBA1c>;7和动脉粥样硬化性血脂异常标准。其中203名来自初级保健的HbA1c>;9.3例转诊至糖尿病日间医院。结论加强各级心血管疾病的预防是必要的。临床实验室应在血脂异常的诊断中发挥基础性作用。早期发现心血管高危患者至关重要,不同临床单位之间的合作是保证患者安全的基础。
{"title":"SmartLab 2.0 en prevención cardiovascular de dislipemia aterogénica","authors":"Raquel Galván Toribio ,&nbsp;Teresa Arrobas Velilla ,&nbsp;Cristóbal Morales Porillo ,&nbsp;Miguel Ángel Rico ,&nbsp;Mar Martínez Quesada ,&nbsp;Antonio León Justel","doi":"10.1016/j.arteri.2022.09.004","DOIUrl":"https://doi.org/10.1016/j.arteri.2022.09.004","url":null,"abstract":"<div><h3>Introduction</h3><p>SmartLab 2.0 is an innovative concept of multidisciplinary collaboration between the clinical laboratory and the diabetes day unit that was born with the aim of identifying patients at high cardiovascular risk who require priority attention, such as patients with atherogenic dyslipidemia, in order to create a cardiovascular prevention strategy.</p></div><div><h3>Objective</h3><p>Implementation in the Laboratory Information System (LIS) of an automated biochemical algorithm for the identification of patients with atherogenic dyslipidemia in routine analyses and priority referral to the diabetes day unit.</p></div><div><h3>Material and methods</h3><p>The algorithm designed in the SIL was: HBA1c<!--> <!-->&gt;<!--> <!-->9.3 +<!--> <!-->TG<!--> <!-->&gt;<!--> <!-->150<!--> <!-->mg/dl +<!--> <!-->HDLc<!--> <!-->&lt;<!--> <!-->40<!--> <!-->mg/dl +<!--> <!-->LDL/ApoB<!--> <!-->&lt;<!--> <!-->1.3. A comment was inserted alerting the requesting physician of the diagnosis of atherogenic dyslipidemia and priority referral was made from the laboratory to the diabetes day unit in the necessary cases.</p></div><div><h3>Results</h3><p>In the 1-year period, a total of 899 patients with HBA1c<!--> <!-->&gt;<!--> <!-->7 and atherogenic dyslipidemia criteria were identified. Of these, 203 patients from primary care with HbA1c<!--> <!-->&gt;<!--> <!-->9.3 were referred to the diabetes day hospital.</p></div><div><h3>Conclusions</h3><p>Reinforcement of cardiovascular prevention is necessary at all levels. The clinical laboratory should play a fundamental role in the diagnosis of dyslipidemias. Early detection of patients at high cardiovascular risk is essential and collaboration between the different clinical units is fundamental to guarantee patient safety.</p></div>","PeriodicalId":45230,"journal":{"name":"Clinica e Investigacion en Arteriosclerosis","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49839973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Un paso adelante en el consenso sobre las características del perfil lipídico para la prevención cardiovascular 就预防心血管疾病的脂质特征达成共识的一步
IF 1.6 Q3 Medicine Pub Date : 2023-03-01 DOI: 10.1016/j.arteri.2023.03.001
Xavier Pintó , Juan Pedro-Botet
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引用次数: 0
Nutrición, riesgo de enfermedad cardiovascular y cambio climático 营养、心血管疾病风险和气候变化
IF 1.6 Q3 Medicine Pub Date : 2023-03-01 DOI: 10.1016/j.arteri.2022.06.001
Carlos A. González Svatetz
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引用次数: 0
Análisis geoestadístico desde el laboratorio clínico en prevención cardiovascular para atención primaria 初级保健心血管预防临床实验室的地质统计分析
IF 1.6 Q3 Medicine Pub Date : 2023-03-01 DOI: 10.1016/j.arteri.2022.08.003
Salomón Martín Pérez , Teresa Arrobas Velilla , Juan Fabiani de la Iglesia , Ignacio Vázquez Rico , Gema Varo Sánchez , Antonio León-Justel

Introduction and objectives

Cardiovascular diseases continue to lead the ranking of mortality in Spain. The implementation of geostatistical analysis techniques in the clinical laboratory are innovative tools that allow the design of new strategies in primary prevention of cardiovascular disease. The aim of this study was to study the prevalence and geolocation of severe dyslipidemia in the health areas under study in order to implement prevention strategies in primary care. A retrospective cohort study of low-density protein-bound cholesterol, triglyceride and lipoprotein (a) levels in the years 2019 and 2020 were carried out. In addition, a geostatistical analysis was performed including representation in choropleth maps and the detection of clustering clusters, using geographic information in zip code format included in the demographic data of each analytic.

Results

The analytical data included in the study were triglycerides (n = 365,384), low density protein-bound cholesterol (n = 289,594) and lipoprotein to lipoprotein (a) (n = 502). Areas with the highest and lowest percentage of cases were identified for the established cut-off points of LDL-C > 190 mg/dL and TG > 150 mg/dL. Two clustering clusters with statistical significance were detected for cLDL > 190 mg/dL and a total of 6 clusters for TG values > 150 mg/dL.

Conclusions

The detection of clusters, as well as the representation of choropleth maps, can be of great help in detecting geographic areas that require greater attention to intervene and improve cardiovascular risk.

引言和目的心血管疾病继续在西班牙的死亡率排名中名列前茅。地质统计学分析技术在临床实验室中的应用是一种创新工具,可以设计心血管疾病初级预防的新策略。本研究的目的是研究所研究健康地区严重血脂异常的患病率和地理位置,以便在初级保健中实施预防策略。对2019年和2020年低密度蛋白结合胆固醇、甘油三酯和脂蛋白(A)水平进行了回顾性队列研究。此外,还使用每个分析的人口统计数据中包含的邮政编码格式的地理信息进行了地质统计分析,包括在choropleth地图中的表示和聚类聚类检测。结果纳入研究的分析数据为甘油三酯(n=365384)、低密度蛋白结合胆固醇(n=289594)和脂蛋白-脂蛋白(a)(n=502)。具有最高和最低病例百分比的区域被确定为LDL-C>;190mg/dL和TG>;150 mg/dL。对于cLDL>;190mg/dL,并且对于TG值>;150 mg/dL。结论聚类的检测以及choropleth图的表示,可以在检测需要更多关注干预和改善心血管风险的地理区域方面提供很大帮助。
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引用次数: 0
Documento de consenso para la determinación e informe del perfil lipídico en laboratorios clínicos españoles 西班牙临床实验室脂质概况测定和报告共识文件
IF 1.6 Q3 Medicine Pub Date : 2023-03-01 DOI: 10.1016/j.arteri.2022.10.002
Teresa Arrobas Velilla , Carlos Guijarro , Raquel Campuzano Ruiz , Manuel Rodríguez Piñero , José Francisco Valderrama Marcos , Antonio Pérez Pérez , Manuel Antonio Botana López , Ana Morais López , José Antonio García Donaire , Juan Carlos Obaya , Luis Castilla Guerra , Vicente Pallares Carratalá , Isabel Egocheaga Cabello , Mercedes Salgueira Lazo , María Mar Castellanos Rodrigo , José María Mostaza Prieto , Juan José Gómez Doblas , Antonio Buño Soto , en representación del Grupo Multidisciplinar de Trabajo de Lípidos y Riesgo Vascular

Cardiovascular diseases (CVD) continue to be the main cause of death in our country. Adequate control of lipid metabolism disorders is a key challenge in cardiovascular prevention that is far from being achieved in real clinical practice. There is a great heterogeneity in the reports of lipid metabolism from Spanish clinical laboratories, which may contribute to its poor control. For this reason, a working group of the main scientific societies involved in the care of patients at vascular risk, has prepared this document with a consensus proposal on the determination of the basic lipid profile in cardiovascular prevention, recommendations for its realization and unification of criteria to incorporate the lipid control goals appropriate to the vascular risk of the patients in the laboratory reports.

心血管疾病(CVD)仍然是我国死亡的主要原因。充分控制脂质代谢紊乱是心血管预防的一个关键挑战,而这在实际临床实践中远未实现。西班牙临床实验室的脂质代谢报告存在很大的异质性,这可能是其控制不力的原因。出于这个原因,参与血管风险患者护理的主要科学学会的一个工作组编写了这份文件,并就确定心血管预防中的基本脂质状况提出了一致建议,在实验室报告中纳入适合患者血管风险的脂质控制目标的标准的实现和统一建议。
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引用次数: 3
期刊
Clinica e Investigacion en Arteriosclerosis
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