Journal of Experimental Therapeutics and Oncology最新文献

Objective: Oral focal mucinosis an oral counterpart of cutaneous focal mucinosis, is a rare disease of unknown etiology. Its pathogenesis may be due to the overproduction of hyaluronic acid by a fibroblast, at the expense of collagen production, resulting in focal myxoid degeneration of the connective tissue, primarily affecting the mucosa overlying the bone. Oral focal mucinosis occurs predonderantly in adults during the fourth and fifth decade of life, although it has been reported sparingly in children and adolescents. It has no distinctive clinical features, as the diagnosis is solely based on the histopathological features and treatment involves complete surgical excision. Recurrence is unreported. This case report put forward the clinical and histological presentation and consequent management of Oral focal mucinosis in an adolescent female patient.

Objective: To control the rate of growth of the cancer cell is the objective of this paper. In cancer, the rate of the growth of the cancer cell is indefinite. This paper proposes a method to transform into definite rate of growth of the cancer cell from indefinite. This indefiniteness lies with the set of unknown elements. This paper finds these unknown elements by matrix method.

Objective: Statement of the Problem: Benign appearing dentigerous cyst (DC), also the most common developmental odontogenic cyst, shows various complications due to its pluripotent cell lining. The spectrum of diseases produced by conversion of its pluripotent cell varies from unicystic ameloblastoma, intraosseous epidermoid and central mucoepidermoid carcinoma. So, the need of the hour is to be acquainted with the etiopathogenesis of DC at molecular level and an attempt should be made to minimize its rate of tumor conversion.

Purpose: To analyze the potential complications, their demographic profile, disease characteristics which can arise from the dentigerous cyst, and to be geared up for such situations in future.

Materials and method: Retrospective analysis was conducted and data was collected from the requisition forms during the time frame 2011- 2016 in the Department at Government Dental College, Haryana. Histopathologically diagnosed cases of dentigerous cyst were reviewed by three different observers and recorded, out of which DCs that showed potential complications were reviewed in detail.

Results: Six cases of DC out of 26 showed transformation into central mucoepidermoid carcinoma, adenomatoid odontogenic tumor (two) and ameloblastoma (three) respectively.

Conclusion: The present research highlights the probable complications of DC encountered in our institute and conscientious vigilance should be exercised while histopathological examination of biopsied specimens. This study further unravels the enigma behind the emergence of neoplasms arising from DC.

Background: Oral squamous cell carcinoma is a major contributor to disability and death caused by malignant tumors. Variations in social, cultural, and geographic factors affect the tumor behavior and response to treatment. In this study, we undertake a seven years institutional review and analysis of Oral squamous cell carcinoma cases in Bareilly.

Materials and methods: A total of 1938 histologically diagnosed cases during the period of seven years i.e. from 2010 to 2016 were extracted from the archives of Department of Oral & Maxillofacial Pathology, Institute of Dental Sciences, Bareilly and evaluated to know the prevalence of Oral squamous cell carcinoma. The details like age, sex, habits and anatomical site were also recorded from the archived patient's case sheets.

Results: Out of the total 1938 cases, 318 were found to be Oral squamous cell carcinoma of which 232 were males and 86 were females. Incidence was highest in 40-49 year age group. The most common site was buccal mucosa (190 cases), followed by tongue (68 cases). Most lesions were well differentiated Oral squamous cell carcinoma (230 cases). Patients with poorly differentiated lesions had a comparatively lower mean age than their counterparts with other histological varieties.

Conclusion: The pattern of Oral squamous cell carcinoma differs from that of previous studies in relation to incidence and age correlation with the grade of carcinoma. The majority of the lesions were well differentiated. There is a need for intensive oral health awareness to encourage early presentation to cancer center as early detection will further enhance prognosis.

Objective: The vaccine of the cancer can be prepared. This paper presents a direction for preparing the vaccine of cancer by algebraic and geometric study of the cancer cell.

Objective: Ameloblastoma is a true neoplasm of enamel organ type tissue which does not undergo differentiation to the point of enamel formation. It is a benign, locally invasive tumour of the oral cavity, most commonly affecting the maxilla and the mandible. Histologically there are several variants of ameloblastoma, the basal cell type being the least reported one. In this paper, we are presenting a case of basal cell ameloblastoma of the mandible with a brief review of literature.

Introduction: Oral submucous fibrosis (OSMF), an insidious disease, has not been widely studied with respect to levels of serum beta-carotene (b-carotene). Hence present study aimed to estimate level of serum beta carotene in patients with OSMF.

Material and methods: 40 subjects (study subjects) with different grades of OSMF and 40 apparently healthy subjects without OSMF (control subjects with age and sex matched as that of study subjects) were screened for serum b-carotene levels employing Sobel and Snow's method. Subjects in both the groups had areca nut or gutkha chewing habit.

Results: Study subjects with OSMF showed lower levels of serum b-carotene as compared to control group subjects without OSMF. When the levels were compared between different disease stages, least levels of serum b-carotene were seen in Grade III OSMF subjects, as compared with Grade I and II subjects. Females showed higher levels of serum b-carotene than males in both the groups. Smokers showed depleted levels as compared to non-smokers in both groups.

Conclusion: b-carotene plays an important role in the pathogenesis of OSMF, and its level decreases with disease progression.

Aim: The aim of this study is to evaluate whether omission of parametrial removal in low risk patients with early stage cervical cancer is safe, taking into account the favorable prognostic characteristics that are usually used in recent studies debating a more conservative treatment in such patients.

Methods: A comprehensive search conducted in PubMed and MEDLINE databases.

Results: In low risk patients with favorable prognostic factors such as tumor size ≤2 cm, depth of stromal invasion ≤10 mm and no LVSI, there are 5% of patients having positive pelvic lymph nodes. Although parametrial involvement is associated with positive pelvic lymph node metastasis, there are studies which report patients with negative pelvic lymph node involvement with parametrial metastases. This indicates that although negative pelvic lymph nodes in low risk patients is a favorable criterion among of those previously reported for conservative treatment, does not eliminate the possibility of parametrial involvement.

Conclusions: Although specific favorable prognostic characteristics may indicate less radical treatment for low risk patients with early stage cervical cancer, more research is needed to estimate the risk of parametrial involvement in low risk patients without pelvic node involvement.

Objective: Uterine sarcomas are very rare malignancies, and when a hysterectomy is performed for benign causes, a risk of about 1/500 is mentioned for possible uterine sarcomas. Endometrial stromal neoplasms are a rare subgroup of uterine sarcomas that account for less than 10% of all uterine sarcomas. Mixed endometrial stromal and smooth muscle tumors, also known as stromomyomas, are defined as having at least 30% each of endometrial stromal and smooth muscle components. As a result, stromomyoma is an extremely rare malignant mixed mesenchymal tumor of the uterus. Both clinically and histologically, the differential diagnosis is challenging. Stromomyoma should be kept in mind in the differential diagnosis of large uterine masses, even if these masses are seen in an asymptomatic woman of reproductive age. In this study, we aimed to present this bizarre tumor of the uterus detected in a premenopausal woman.

Objective: Ephrin type-B receptor 4 (EphB4) plays an important role in human carcinogenesis. This study investigated the effects of EphB4 expression in drug-resistance of acute myeloid leukemia cells to Adriamycin using myeloid leukemia cell lines with different degrees of differentiation, including an Adriamycin-resistant HL60 cell line as a model. The data showed that the EphB4 protein was differentially expressed in these myeloid leukemia cell lines, which expression was associated with sensitivity of myeloid leukemia cells to Adriamycin treatment in vitro. Furthermore, EphB4 protein stimulated by EphrinB2-Fc sensitized HL60/ADM cells to Adriamycin in a dose-dependent manner. Specifically, pre-incubation of HL60/ADM with 4 µg/ml EphrinB2-Fc protein for 30 min significantly sensitized tumor cell to Adriamycin treatment by reduction of tumor cell viability and induction of apoptosis (p<0.001), while there was no significant change in other groups (p>0.05). These data provided a proof-of-principle for further development of the EphB4-based strategy for treatment of drug-resistant leukemia.