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Establishing forensic DNA databases in Africa. 在非洲建立法医 DNA 数据库。
IF 1.4 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-04-02 eCollection Date: 2024-06-01 DOI: 10.1093/fsr/owae024
Johannes Hendrik Smith, Juanida Suzette Horne
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引用次数: 0
Acknowledgment to reviewers-November 2022 to December 2023. 致谢审稿人--2022 年 11 月至 2023 年 12 月。
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-02-22 eCollection Date: 2023-12-01 DOI: 10.1093/fsr/owae007
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引用次数: 0
Expression of Concern: Sequencing of Human Identification Markers in an Uyghur Population Using the MiSeq FGx™ Forensic Genomics System. 表达关切:使用 MiSeq FGx™ 法医基因组学系统对维吾尔族人群的人类识别标记进行测序。
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-02-05 eCollection Date: 2024-03-01 DOI: 10.1093/fsr/owae010
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引用次数: 0
Expression of Concern: Mitochondrial Genome Sequencing with Short Overlapping Amplicons on Miseq FGx System. 表达关注:在 Miseq FGx 系统上使用短重叠扩增子进行线粒体基因组测序。
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-02-05 eCollection Date: 2024-03-01 DOI: 10.1093/fsr/owae012
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引用次数: 0
Forensic DNA database and criminal investigation in the Sahel region: a need to update the national security policy? 萨赫勒地区的法医 DNA 数据库和刑事调查:是否需要更新国家安全政策?
IF 1.4 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2024-01-09 eCollection Date: 2024-06-01 DOI: 10.1093/fsr/owad056
Moutanou M J Zeye, Serge Y Ouedraogo, Missa Millogo, Florencia W Djigma, Abdou A Zoure, Moctar Zeba, Rachide Palenfo, Noe Dakio, Silvere D Zaongo, Xiang Wu, Jacques Simpore

Ongoing terrorist attacks in the Sahel region call for strengthening the security system by using human DNA identification technology. In this context, public opinion must be considered when establishing solid standards and universal safeguards for one of the most invasive forms of surveillance and profiling. For this purpose, we gathered internet users' opinions in Burkina Faso (a country located in the Sahel region) on the use of DNA technology to support criminal investigations. The results revealed that 91.7% (431) of the 470 participants believed that this technology is currently necessary for the Burkina Faso's criminal justice system. However, the respondents expressed concerns about the custody and management of a national forensic DNA database. In this particular security setting, the public opinion of this study may provide leaders and political policymakers with clues for considering genetic fingerprints and implementing an national forensic DNA database to support criminal investigations in Burkina Faso whilst also considering the ethical implications.

萨赫勒地区正在发生的恐怖袭击要求利用人类 DNA 识别技术加强安全系统。在这种情况下,在为最具侵入性的监视和特征分析形式之一制定坚实标准和普遍保障措施时,必须考虑公众意见。为此,我们收集了布基纳法索(萨赫勒地区的一个国家)网民对使用 DNA 技术辅助刑事调查的意见。结果显示,470 名参与者中有 91.7%(431 人)认为布基纳法索的刑事司法系统目前需要这项技术。然而,受访者对国家法医 DNA 数据库的保管和管理表示担忧。在这种特殊的安全环境下,本研究的公众意见可能会为领导人和政治决策者提供线索,帮助他们考虑基因指纹和实施国家法医 DNA 数据库,以支持布基纳法索的刑事调查,同时也考虑到伦理方面的影响。
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引用次数: 0
Homicide among Indigenous females in North Carolina: a comparison of publicly generated data and violent death reporting system. 北卡罗来纳州土著女性中的凶杀案:公开生成的数据与暴力死亡报告系统的比较。
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2023-12-30 eCollection Date: 2024-03-01 DOI: 10.1093/fsr/owad057
Muhammad Hudhud, Scott Proescholdbell, Tammy Norwood, Crystal Cavalier-Keck, Ronny A Bell

Like other minoritized populations, American Indian/Alaska Native (AI/AN) females experience disparate morbidity and mortality outcomes to that of the general US population. This study identified discrepancies in reporting of AI/AN female decedents between the North Carolina Violent Death Reporting System (NC-VDRS) and an online, user-generated database. Female AI/AN decedent data of all ages were collected from the NC-VDRS and compared against that of the publicly available North Carolina Missing and Murdered Indigenous Women (MMIW NC) database for the study period, 2004-2019. Twenty-four of the 72 cases matched between data systems (33.3%). Substantive differences between the NC-VDRS and the MMIW NC database were found. Future efforts should be directed towards supporting Indigenous communities with the comprehensive data the NC-VDRS can provide. This paper highlights statewide public health systems like the NC-VDRS supporting community efforts to understand, advocate for, and disseminate information on MMIW.

与其他少数群体一样,美国印第安人/阿拉斯加原住民(AI/AN)女性的发病率和死亡率与美国普通人群存在差异。本研究发现,北卡罗来纳州暴力死亡报告系统(NC-VDRS)和用户生成的在线数据库在报告美国印第安人/阿拉斯加原住民女性死者方面存在差异。研究人员从北卡罗来纳州暴力死亡报告系统(NC-VDRS)中收集了所有年龄段的亚裔美国人/印第安人女性死者数据,并与研究期间(2004-2019 年)公开的北卡罗来纳州失踪和遇害土著妇女(MMIW NC)数据库中的数据进行了比较。在 72 个案例中,有 24 个案例在数据系统之间匹配(33.3%)。发现 NC-VDRS 与 MMIW NC 数据库之间存在实质性差异。未来的努力方向应该是利用 NC-VDRS 可以提供的全面数据为土著社区提供支持。本文重点介绍了全州公共卫生系统(如 NC-VDRS)如何支持社区了解、宣传和传播有关 MMIW 的信息。
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引用次数: 0
Dissimulation in forensic psychiatric evaluations, a case-control study of the Millon Clinical Multiaxial Inventory-III. 法医精神病学评估中的拟态,对 Millon Clinical Multiaxial Inventory-III 的病例对照研究。
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2023-12-29 eCollection Date: 2024-03-01 DOI: 10.1093/fsr/owad054
Roberta Risola, Gabriele Mandarelli, Ignazio Grattagliano, Anna Cassano, Antonia Valerio, Cristiano Barbieri, Roberto Catanesi

The possible tendency of subjects to decrease, hide, or omit symptomatic aspects of their mental functioning is one of the main problems in forensic psychological and psychiatric evaluations. We aimed at verifying the possible existence of significant differences in the Millon Clinical Multiaxial Inventory-III (MCMI-III) scales scores between a sample of dissimulators (n = 40) and their non-dissimulator counterpart matched by age, sex, and diagnosis. Cases and comparisons were retrieved from the archive of a single university forensic psychiatric centre between 2013 and 2022. Results showed statistically significant higher scores in the sample of dissimulators in the Desirability, Histrionic, Narcissistic, and Compulsive MCMI-III scales than in the comparison sample. Point biserial correlation test disclosed a strong positive correlation between the Desirability, Histrionic, Narcissistic, and Compulsive scales of the MCMI-III and being in the dissimulator group of subjects while a negative correlation emerged for all the other scales except drug dependence.

Key points: The forensic setting can affect a subject's behaviour.Dissimulation is a mechanism of minimization or concealment of a psycho-pathological condition.The MCMI-III can be a useful tool for a forensic psychiatrist or forensic psychologist in assessing dissimulation.

受试者可能会减少、隐藏或遗漏其心理功能的症状方面,这是法医心理和精神评估中的主要问题之一。我们的目的是验证在年龄、性别和诊断相匹配的异体样本(n = 40)和非异体样本之间,米隆临床多轴量表-III(MCMI-III)量表评分是否存在显著差异。2013年至2022年期间,从一所大学法医精神病学中心的档案中检索了病例和对比数据。结果显示,在统计意义上,异化者样本在欲望型、嗜好型、自恋型和强迫型 MCMI-III 量表中的得分明显高于对比样本。点双项相关测试显示,MCMI-III 中的渴望型、嗜好型、自恋型和强迫型量表与被试中的异化者组之间存在很强的正相关,而除药物依赖外,其他所有量表之间均存在负相关:法医环境会影响受试者的行为。"拟态 "是一种最小化或隐藏心理病理状态的机制。
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引用次数: 0
Bullet ricochet mark plan-view morphology in concrete: an experimental assessment of five bullet types and two distances using machine learning. 混凝土中的子弹跳痕平面形态:利用机器学习对五种子弹类型和两种距离进行实验评估。
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2023-12-29 eCollection Date: 2024-03-01 DOI: 10.1093/fsr/owad051
Metin I Eren, Jay Romans, Robert S Walker, Briggs Buchanan, Alastair Key

Bullet ricochets are common occurrences during shooting incidents and can provide a wealth of information useful for shooting incident reconstruction. However, there have only been a small number of studies that have systematically investigated bullet ricochet impact site morphology. Here, this study reports on an experiment that examined the plan-view morphology of 297 ricochet impact sites in concrete that were produced by five different bullet types shot from two distances. This study used a random forest machine learning algorithm to classify bullet types with morphological dimensions of the ricochet mark (impact) with length and perimeter-to-area ratio emerging as the top predictor variables. The 0.22 LR leaves the most distinctive impact mark on the concrete, and overall, the classification accuracy using leave-one-out cross-validation is 62%, considerably higher than a random classification accuracy of 20%. Adding in distance to the model as a predictor increases the classification accuracy to 66%. These initial results are promising, in that they suggest that an unknown bullet type can potentially be determined, or at least probabilistically assessed, from the morphology of the ricochet impact site alone. However, the substantial amount of overlap this study documented among distinct bullet types' ricochet mark morphologies under highly controlled conditions and with machine learning suggests that the human identification of ricochet marks in real-world shooting incident reconstructions may be on occasion, or perhaps regularly, in error.

Key points: Bullet ricochet impact sites can help with shooting incident reconstruction.A random forest machine learning algorithm classified bullet type from ricochet morphology.Results suggest that unknown bullets can potentially be determined from ricochet impact site morphology.Human identification of bullet types from ricochet sites may be erroneous.

子弹跳弹是枪击事件中的常见现象,可为重建枪击事件提供大量有用信息。然而,目前只有少数研究对子弹跳弹弹着点形态进行了系统研究。在此,本研究报告了一项实验,该实验检测了从两个距离射击的五种不同类型子弹在混凝土中产生的 297 个跳弹弹着点的平面形态。本研究使用随机森林机器学习算法,根据跳弹痕迹(撞击)的形态维度对子弹类型进行分类,其中长度和周长与面积之比成为最主要的预测变量。0.22 LR 在混凝土上留下了最明显的冲击痕迹,总体而言,采用留空交叉验证的分类准确率为 62%,大大高于 20% 的随机分类准确率。将距离作为预测因子加入模型后,分类准确率提高到 66%。这些初步结果很有希望,因为它们表明,仅从跳弹撞击点的形态就有可能确定或至少有可能评估未知的子弹类型。然而,本研究在高度受控的条件下,通过机器学习记录了不同类型子弹跳弹痕迹形态之间的大量重叠,这表明在真实世界的枪击事件重建中,人类对跳弹痕迹的识别可能偶尔会出现错误,甚至经常出现错误:通过随机森林机器学习算法从跳弹痕迹形态对子弹类型进行分类。结果表明,未知子弹有可能从跳弹痕迹形态中确定。
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引用次数: 0
Improving the strategy to identify historical military remains: a literature review and Y-STR meta-analysis. 改进识别历史军事遗骸的策略:文献综述和 Y-STR 元分析。
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2023-12-25 eCollection Date: 2024-03-01 DOI: 10.1093/fsr/owad050
Melinda R Mitchell, Janet Chaseling, Lee Jones, Toni White, Andrew Bernie, Larisa M Haupt, Lyn R Griffiths, Kirsty M Wright

The identification of historical military remains by Unrecovered War Casualties-Army (UWC-A) currently relies on Y-chromosome Short Tandem Repeat (Y-STR) testing when maternal relatives are not available, or when a mitochondrial DNA match does not provide sufficient certainty of identification. However, common Y-STR profiles (using Yfiler™) between sets of remains or families often prevent identification. To resolve these cases, an investigation of additional Y-DNA markers is needed for their potential inclusion into the DNA identification strategy. The number of genetic transmissions between missing soldiers and their living relatives needs to be considered to avoid false exclusions between paternal relatives. Analysis of 236 World War I/II (WWI/II) era pairs of relatives identified up to seven genetic transmissions between WWII soldiers and their living relatives, and nine for WWI. Previous Y-STR meta-analyses were published approximately 10 years ago when rapidly mutating markers were relatively new. This paper reports a contemporary literature review and meta-analysis of 35 studies (which includes 23 studies not previously used in meta-analysis) and 23 commonly used Y-STR's mutation rates to inform the inclusion of additional loci to UWC-A's DNA identification strategy. Meta-analysis found mutation data for a given Y-STR locus could be pooled between studies and that the mutation rates were significantly different between some loci (at P < 0.05). Based on this meta-analysis, we have identified two additional markers from PowerPlex® Y23 for potential inclusion in UWC-A's identification strategy. Further avenues for potential experimental exploration are discussed.

Key points: From 236 UWC-A pairs of relatives, we observed up to nine genetic transmissions between WWI soldiers and their living relatives, and seven for WWII.MedCalc® software for meta-analysis utilizing the Freeman-Tukey transformation was run, which analysed 35 published studies and 23 commonly used loci. Previous Y-STR mutation rate meta-analyses are now 10 years old; this paper includes 23 studies that were not included in previous meta-analyses.Through meta-analysis, we identify two markers from PowerPlex® Y23 for potential inclusion in UWC-A's historical remains identification strategy (alongside Yfiler™). We discuss potential next steps for experimental exploration of additional Y-DNA markers.

目前,在没有母系亲属,或线粒体 DNA 匹配不能提供足够的鉴定确定性时,未发现的战争伤亡人员-军队(UWC-A)对历史军事遗骸的鉴定依赖于 Y 染色体短串联重复(Y-STR)测试。然而,各组遗骸或家族之间共同的 Y-STR 图谱(使用 Yfiler™)往往会阻碍身份鉴定。为了解决这些问题,需要对其他 Y-DNA 标记进行调查,以便将其纳入 DNA 鉴定策略。需要考虑失踪士兵与其在世亲属之间基因传递的数量,以避免父系亲属之间的错误排除。对 236 对一战/二战(WWI/II)时期的亲属进行分析后发现,二战士兵与其在世亲属之间的基因传递多达 7 次,而一战士兵与其在世亲属之间的基因传递为 9 次。之前的 Y-STR 元分析发表于大约 10 年前,当时快速变异的标记相对较新。本文报告了对 35 项研究(其中包括 23 项以前未用于荟萃分析的研究)和 23 项常用 Y-STR 变异率的当代文献回顾和荟萃分析,为将更多位点纳入 UWC-A 的 DNA 鉴定策略提供依据。荟萃分析发现,特定Y-STR位点的突变数据可以在不同研究之间进行汇总,而且某些位点之间的突变率存在显著差异(P关键点):从236对UWC-A亲属中,我们观察到一战士兵与其在世亲属之间有多达9次基因变异,二战士兵与其在世亲属之间有7次基因变异。运行MedCalc®软件,利用Freeman-Tukey转换进行荟萃分析,分析了35项已发表的研究和23个常用位点。通过荟萃分析,我们从 PowerPlex® Y23 中确定了两个可能纳入 UWC-A 历史遗骸识别战略(与 Yfiler™ 并列)的标记。我们还讨论了下一步对其他 Y-DNA 标记进行实验探索的可能性。
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引用次数: 0
Comprehensive explorations of population characteristics and genetic background of the Chinese Mongolian group from Northwest China via a self-developed multiplex InDel panel 通过自主研发的多重 InDel 染色体组全面探索中国西北蒙古族的人群特征和遗传背景
IF 1.3 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2023-12-21 DOI: 10.1093/fsr/owad047
Xuebing Chen, Hui Xu, Wei Cui, Ming Zhao, Bofeng Zhu
This study aimed to investigate the genetic polymorphisms and population characteristics of the Mongolian group from northwest China (NCM) through the self-developed panel of 43 autosomal insertion/deletion (A-InDel) polymorphism genetic markers. Herein, 288 unrelated healthy individuals from the NCM group were employed to obtain the genetic data of 43 A-InDels through PCR amplification and InDel genotyping. In addition, multiplex forensic genetic analyses were performed between the NCM group and 27 reference populations. There were no deviations from Hardy–Weinberg equilibrium (HWE) in the NCM group. The observed heterozygosity (Ho) value ranged from 0.3128 to 0.5592, and the combined power of discrimination (CPD) and the cumulative probability of exclusion (CPE) values were 0.9999999999999999999877 and 0.999814, respectively, in the NCM group. Forensic parameters indicate that this panel is polymorphic and informative in the NCM group and can be used as an effective complementary tool for forensic personal identification. Furthermore, the results of pairwise genetic distance, principal component analysis, multidimensional scaling analysis, phylogenetic tree construction, and admixture analysis between the NCM group and 27 reference populations reveal that there is a close genetic relationship between the NCM group and East Asian populations, especially the Chinese Hui group (CHH) group from the northwest China, consistent with the geographical location. These findings contribute to the ongoing genetic exploration and insights into the genetic architecture of the NCM group.
本研究旨在通过自主开发的 43 个常染色体插入/缺失(A-InDel)多态性遗传标记,研究中国西北蒙古族(NCM)的遗传多态性和人群特征。本研究采用 NCM 群体中 288 个无血缘关系的健康个体,通过 PCR 扩增和 InDel 基因分型获得 43 个 A-InDel 的遗传数据。此外,还对 NCM 群体和 27 个参考人群进行了多重法医遗传分析。NCM 组没有偏离哈代-温伯格平衡(HWE)。观察到的杂合度(Ho)值在 0.3128 至 0.5592 之间,NCM 组的综合区分度(CPD)和累积排除概率(CPE)值分别为 0.9999999999999999999877 和 0.999814。法证参数表明,该面板在 NCM 组中具有多态性和信息量,可作为法证个人身份鉴定的有效补充工具。此外,NCM 群体与 27 个参照人群之间的配对遗传距离、主成分分析、多维尺度分析、系统发生树构建和掺杂分析结果显示,NCM 群体与东亚人群,尤其是来自中国西北部的中国回族群体(CHH)之间存在密切的遗传关系,这与地理位置相符。这些发现有助于对 NCM 群体遗传结构的不断探索和深入了解。
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引用次数: 0
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Forensic Sciences Research
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