Pub Date : 2023-08-26DOI: 10.3390/forensicsci3030034
A. Maier, Alessia Manzella, A. Bonicelli, E. Arnold, N. Márquez-Grant, Peter Zioupos
Assessing the timing of skeletal trauma significantly impacts the reconstruction of events surrounding death and deposition in forensic cases. However, there are no absolute time frames in which the characteristics of wet bone (peri-mortem) fractures transition to dry (post-mortem) fractures. The aim of this study was to attempt to identify a point within the post-mortem interval in which the characteristics of bone change from wet to dry bone properties. A total of 32 deer ribs were placed in a laboratory burial environment and a set of three were fractured with blunt force trauma every week during a ten-week period. All samples and the inflicted trauma effects were documented and analysed by macroscopic observation, scanning electron microscope (SEM) analysis, thermal analysis, biomechanical analysis, and attenuated total reflectance–Fourier transform infrared spectroscopy (ATR-FTIR). No significant difference was found in the macroscopic, microscopic, thermal, and biomechanical analyses of the trauma inflicted over the 10-week period. A significant difference was only found in the carbonate-to-phosphate ratio in analytical chemistry. The results suggest that interpreting wet bone characteristics in forensic anthropology as having been inflicted during the peri-mortem period (around the time of death) should also consider that these, in fact, could be inflicted well after death (post-mortem) as wet bone properties as this study has shown persist at least 10 weeks after death in a burial environment.
{"title":"Wet Bone Characteristics Persist in Buried Bone after 10 Weeks: Implications for Forensic Anthropology","authors":"A. Maier, Alessia Manzella, A. Bonicelli, E. Arnold, N. Márquez-Grant, Peter Zioupos","doi":"10.3390/forensicsci3030034","DOIUrl":"https://doi.org/10.3390/forensicsci3030034","url":null,"abstract":"Assessing the timing of skeletal trauma significantly impacts the reconstruction of events surrounding death and deposition in forensic cases. However, there are no absolute time frames in which the characteristics of wet bone (peri-mortem) fractures transition to dry (post-mortem) fractures. The aim of this study was to attempt to identify a point within the post-mortem interval in which the characteristics of bone change from wet to dry bone properties. A total of 32 deer ribs were placed in a laboratory burial environment and a set of three were fractured with blunt force trauma every week during a ten-week period. All samples and the inflicted trauma effects were documented and analysed by macroscopic observation, scanning electron microscope (SEM) analysis, thermal analysis, biomechanical analysis, and attenuated total reflectance–Fourier transform infrared spectroscopy (ATR-FTIR). No significant difference was found in the macroscopic, microscopic, thermal, and biomechanical analyses of the trauma inflicted over the 10-week period. A significant difference was only found in the carbonate-to-phosphate ratio in analytical chemistry. The results suggest that interpreting wet bone characteristics in forensic anthropology as having been inflicted during the peri-mortem period (around the time of death) should also consider that these, in fact, could be inflicted well after death (post-mortem) as wet bone properties as this study has shown persist at least 10 weeks after death in a burial environment.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"11 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86442417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.3390/forensicsci3030033
D. Garcovich, A. Zhou Wu, M. Adobes Martin
Background: Online attention is a relevant research feature that can be related to its societal impact. Online attention in the field of legal medicine was explored as well as the relation between citation count and the Altmetric Attention Score (AAS). Methods: A search was performed, through the free Dimensions app, during September 2020, on the journals related to legal medicine listed in the 2019 edition of the Journal Citation Reports (JCR). The 200 published items with the highest AAS were retrieved and screened for bibliometric data. Articles with related citations were gathered from Web of Science (WOS), Scopus, and Dimensions. Results: Seventy-five percent of the articles were published by five of the selected journals. Twitter and news outlets were the most prevalent Altmetric resources. Additionally, 73.5% of the articles were published between 2013 and 2020. The most frequent topics were the ones related to toxicology and pharmacology, followed by criminalistics and law and bioethics. A poor correlation was found between the citations in WOS, Dimensions, and Scopus and the AAS. Conclusions: The online attention on legal medicine-related topics can be considered high on social media. The high number of news outlets is a distinctive feature of the most discussed articles in legal medicine. In this field of medicine, citation-based metrics combined with Altmetric can allow a broader evaluation of research findings but it should be underlined that, when measuring very different aspects of a published item, the scores in classic citation databases and Altmetric do not have a direct relation.
背景:在线关注是一个相关的研究特征，可能与其社会影响有关。探讨了法律医学领域的在线关注度，以及被引次数与Altmetric attention Score (AAS)的关系。方法:于2020年9月通过免费的Dimensions应用程序对2019年版《期刊引用报告》(JCR)中列出的法律医学相关期刊进行检索。检索AAS最高的200篇已发表文献进行文献计量学数据筛选。相关引用的文章收集自Web of Science (WOS)、Scopus和Dimensions。结果:75%的文章被选定的5种期刊发表。Twitter和新闻媒体是最普遍的Altmetric资源。此外，73.5%的文章发表于2013年至2020年之间。最常见的主题是与毒理学和药理学有关的主题，其次是犯罪学和法律以及生物伦理学。WOS、Dimensions和Scopus的引文与AAS的相关性较差。结论:社交媒体对法律医学相关话题的在线关注度较高。大量的新闻媒体是法医学中讨论最多的文章的一个显著特征。在这一医学领域，基于引文的指标与Altmetric相结合可以对研究结果进行更广泛的评估，但应该强调的是，在测量已发表文献的不同方面时，经典引文数据库中的得分与Altmetric没有直接关系。
{"title":"The Online Attention to Research in Legal Medicine: An Altmetric Study on the Most Discussed Articles on the Web","authors":"D. Garcovich, A. Zhou Wu, M. Adobes Martin","doi":"10.3390/forensicsci3030033","DOIUrl":"https://doi.org/10.3390/forensicsci3030033","url":null,"abstract":"Background: Online attention is a relevant research feature that can be related to its societal impact. Online attention in the field of legal medicine was explored as well as the relation between citation count and the Altmetric Attention Score (AAS). Methods: A search was performed, through the free Dimensions app, during September 2020, on the journals related to legal medicine listed in the 2019 edition of the Journal Citation Reports (JCR). The 200 published items with the highest AAS were retrieved and screened for bibliometric data. Articles with related citations were gathered from Web of Science (WOS), Scopus, and Dimensions. Results: Seventy-five percent of the articles were published by five of the selected journals. Twitter and news outlets were the most prevalent Altmetric resources. Additionally, 73.5% of the articles were published between 2013 and 2020. The most frequent topics were the ones related to toxicology and pharmacology, followed by criminalistics and law and bioethics. A poor correlation was found between the citations in WOS, Dimensions, and Scopus and the AAS. Conclusions: The online attention on legal medicine-related topics can be considered high on social media. The high number of news outlets is a distinctive feature of the most discussed articles in legal medicine. In this field of medicine, citation-based metrics combined with Altmetric can allow a broader evaluation of research findings but it should be underlined that, when measuring very different aspects of a published item, the scores in classic citation databases and Altmetric do not have a direct relation.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"65 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79761495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-22DOI: 10.3390/forensicsci3030031
C. Vanhee, B. Jacobs, M. Mori, A. Kamugisha, Loïc Debehault, M. Canfyn, Bart Ceyssens, Hans Van Der Meersch, K. van Hoorde, E. Deconinck, M. Willocx
Illicit PDE-5 inhibitors are frequently encountered by regulatory agencies. Self-medicating with substandard and falsified (SF) PDE-5 inhibitors could be dangerous as they are likely taken without any medical supervision and might be of poor quality which could result in adverse reactions. In order to provide an overview of the quality deficiencies present in recently seized illicit PDE-5 samples that may pose health risks, we set out to identify the products’ different chemical and/or biological risks. Our results indicate that 38% of the samples harbored a chemical risk including the significant exceedance of the maximum recommended dosage, a large heterogeneity in API content between the different tablets in the same package or blister and the presence of only 40% of the claimed dosage. Moreover, our results also demonstrate that 16 of the 32 samples were not compliant with the internationally set microbiological quality standards. Startlingly, two samples were severely contaminated with potentially pathogenic bacteria, which could result in a gastrointestinal illness upon oral intake.
{"title":"Uncovering the Quality Deficiencies with Potentially Harmful Effects in Substandard and Falsified PDE-5 Inhibitors Seized by Belgian Controlling Agencies","authors":"C. Vanhee, B. Jacobs, M. Mori, A. Kamugisha, Loïc Debehault, M. Canfyn, Bart Ceyssens, Hans Van Der Meersch, K. van Hoorde, E. Deconinck, M. Willocx","doi":"10.3390/forensicsci3030031","DOIUrl":"https://doi.org/10.3390/forensicsci3030031","url":null,"abstract":"Illicit PDE-5 inhibitors are frequently encountered by regulatory agencies. Self-medicating with substandard and falsified (SF) PDE-5 inhibitors could be dangerous as they are likely taken without any medical supervision and might be of poor quality which could result in adverse reactions. In order to provide an overview of the quality deficiencies present in recently seized illicit PDE-5 samples that may pose health risks, we set out to identify the products’ different chemical and/or biological risks. Our results indicate that 38% of the samples harbored a chemical risk including the significant exceedance of the maximum recommended dosage, a large heterogeneity in API content between the different tablets in the same package or blister and the presence of only 40% of the claimed dosage. Moreover, our results also demonstrate that 16 of the 32 samples were not compliant with the internationally set microbiological quality standards. Startlingly, two samples were severely contaminated with potentially pathogenic bacteria, which could result in a gastrointestinal illness upon oral intake.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"210 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77519156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-22DOI: 10.3390/forensicsci3030032
Melissa Martineau, E. Spiridon, Mary Aiken
Cybercrime presents a significant threat to global society. With the number of cybercrimes increasing year after year and the financial losses escalating, law enforcement must advance its capacity to identify cybercriminals, collect probative evidence, and bring cybercriminals before the courts. Arguably to date, the approach to combatting cybercrime has been technologically centric (e.g., anti-virus, anti-spyware). Cybercrimes, however, are the result of human activities based on human motives. It is, therefore, important that any comprehensive law enforcement strategy for combatting cybercrime includes a deeper understanding of the hackers that sit behind the keyboards. The purpose of this systematic review was to examine the state of the literature relating to the application of a human-centric investigative tool (i.e., profiling) to cybercrime by conducting a qualitative meta-synthesis. Adhering to the PRISMA 2020 guidelines, this systematic review focuses specifically on cybercrime where a computer is the target (e.g., hacking, DDoS, distribution of malware). Using a comprehensive search strategy, this review used the following search terms: “cybercrime”, “computer crime”, “internet crime”, “cybercriminal”, “hacker”, “black hat”, “profiling”, “criminal profiling”, “psychological profiling”, “offender profiling”, “criminal investigative analysis”, “behavioral profiling”, “behavioral analysis”, “personality profiling”, “investigative psychology”, and “behavioral evidence analysis” in all combinations to identify the relevant literature in the ACM Digital Library, EBSCOhost databases, IEEE Xplore, ProQuest, Scopus, PsychInfo, and Google Scholar. After applying the inclusion/exclusion criteria, a total of 72 articles were included in the review. This article utilizes a systematic review of the current literature on cyber profiling as a foundation for the development of a comprehensive framework for applying profiling techniques to cybercrime—described as cyber behavioral analysis (CBA). Despite decades of research, our understanding of cybercriminals remains limited. A lack of dedicated researchers, the paucity of research regarding human behavior mediated by technology, and limited access to datasets have hindered progress. The aim of this article was to advance the knowledge base in cyber behavioral sciences, and in doing so, inform future empirical research relating to the traits and characteristics of cybercriminals along with the application of profiling techniques and methodologies to cybercrime.
{"title":"A Comprehensive Framework for Cyber Behavioral Analysis Based on a Systematic Review of Cyber Profiling Literature","authors":"Melissa Martineau, E. Spiridon, Mary Aiken","doi":"10.3390/forensicsci3030032","DOIUrl":"https://doi.org/10.3390/forensicsci3030032","url":null,"abstract":"Cybercrime presents a significant threat to global society. With the number of cybercrimes increasing year after year and the financial losses escalating, law enforcement must advance its capacity to identify cybercriminals, collect probative evidence, and bring cybercriminals before the courts. Arguably to date, the approach to combatting cybercrime has been technologically centric (e.g., anti-virus, anti-spyware). Cybercrimes, however, are the result of human activities based on human motives. It is, therefore, important that any comprehensive law enforcement strategy for combatting cybercrime includes a deeper understanding of the hackers that sit behind the keyboards. The purpose of this systematic review was to examine the state of the literature relating to the application of a human-centric investigative tool (i.e., profiling) to cybercrime by conducting a qualitative meta-synthesis. Adhering to the PRISMA 2020 guidelines, this systematic review focuses specifically on cybercrime where a computer is the target (e.g., hacking, DDoS, distribution of malware). Using a comprehensive search strategy, this review used the following search terms: “cybercrime”, “computer crime”, “internet crime”, “cybercriminal”, “hacker”, “black hat”, “profiling”, “criminal profiling”, “psychological profiling”, “offender profiling”, “criminal investigative analysis”, “behavioral profiling”, “behavioral analysis”, “personality profiling”, “investigative psychology”, and “behavioral evidence analysis” in all combinations to identify the relevant literature in the ACM Digital Library, EBSCOhost databases, IEEE Xplore, ProQuest, Scopus, PsychInfo, and Google Scholar. After applying the inclusion/exclusion criteria, a total of 72 articles were included in the review. This article utilizes a systematic review of the current literature on cyber profiling as a foundation for the development of a comprehensive framework for applying profiling techniques to cybercrime—described as cyber behavioral analysis (CBA). Despite decades of research, our understanding of cybercriminals remains limited. A lack of dedicated researchers, the paucity of research regarding human behavior mediated by technology, and limited access to datasets have hindered progress. The aim of this article was to advance the knowledge base in cyber behavioral sciences, and in doing so, inform future empirical research relating to the traits and characteristics of cybercriminals along with the application of profiling techniques and methodologies to cybercrime.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"28 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86994100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-19DOI: 10.3390/forensicsci3030030
Marshall S. Rich
This research article investigates the effectiveness of digital forensics analysis (DFA) techniques in identifying patterns and trends in malicious failed login attempts linked to public data breaches or compromised email addresses in Microsoft 365 (M365) environments. Pattern recognition techniques are employed to analyze security logs, revealing insights into negative behavior patterns. The findings contribute to the literature on digital forensics, opposing behavior patterns, and cloud-based cybersecurity. Practical implications include the development of targeted defense strategies and the prioritization of prevalent threats. Future research should expand the scope to other cloud services and platforms, capture evolving trends through more prolonged and extended analysis periods, and assess the effectiveness of specific mitigation strategies for identified tactics, techniques, and procedures (TTPs).
{"title":"Enhancing Microsoft 365 Security: Integrating Digital Forensics Analysis to Detect and Mitigate Adversarial Behavior Patterns","authors":"Marshall S. Rich","doi":"10.3390/forensicsci3030030","DOIUrl":"https://doi.org/10.3390/forensicsci3030030","url":null,"abstract":"This research article investigates the effectiveness of digital forensics analysis (DFA) techniques in identifying patterns and trends in malicious failed login attempts linked to public data breaches or compromised email addresses in Microsoft 365 (M365) environments. Pattern recognition techniques are employed to analyze security logs, revealing insights into negative behavior patterns. The findings contribute to the literature on digital forensics, opposing behavior patterns, and cloud-based cybersecurity. Practical implications include the development of targeted defense strategies and the prioritization of prevalent threats. Future research should expand the scope to other cloud services and platforms, capture evolving trends through more prolonged and extended analysis periods, and assess the effectiveness of specific mitigation strategies for identified tactics, techniques, and procedures (TTPs).","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"109 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84198569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-12DOI: 10.3390/forensicsci3030029
Haruto Matsuda, T. Kawashima, F. Sato
The eyelids, external nose, and lips play an important role in individual identification and facial recognition; however, they are excluded from tissue marker points, and are reconstructed based on generic methods for 3D facial reconstruction or facial approximation. Therefore, this study focused on nasal dimensions and evaluated whether Krogman’s widely used formula for estimating the dimensions of an external nose, regardless of sex, race, and body physique, can be applied to Japanese adults. A total of 146 postmortem CT images of Japanese adult cadavers (64 males and 82 females, aged 58–105 years old) were retrospectively analyzed. The total nasal projection (TNP) among Japanese adults was estimated using the formula, TNP = 1.9 × the anterior nasal spine projection (ANSP) + the mid-philtrum depth (MPD), which differed significantly from the coefficient (3.0) in the conventional formula, regardless of sex, race, and body physique, and therefore needed modification for Asians. Although there was no positive relationship between the total nasal width (TNW) and the maximum width of the anterior nasal aperture (ANAW), the TNW could be estimated by adding soft tissue that varies by sex and body physique to both sides of the nearly constant ANAW. Therefore, we determined a simple and practical formula to estimate nasal dimensions among Japanese adults for conventional 3D facial reconstruction and manual 3D facial sculpture.
{"title":"Simplified Formula for Estimating Nasal Dimensions for 3-Dimensional Facial Reconstruction among Japanese Adults","authors":"Haruto Matsuda, T. Kawashima, F. Sato","doi":"10.3390/forensicsci3030029","DOIUrl":"https://doi.org/10.3390/forensicsci3030029","url":null,"abstract":"The eyelids, external nose, and lips play an important role in individual identification and facial recognition; however, they are excluded from tissue marker points, and are reconstructed based on generic methods for 3D facial reconstruction or facial approximation. Therefore, this study focused on nasal dimensions and evaluated whether Krogman’s widely used formula for estimating the dimensions of an external nose, regardless of sex, race, and body physique, can be applied to Japanese adults. A total of 146 postmortem CT images of Japanese adult cadavers (64 males and 82 females, aged 58–105 years old) were retrospectively analyzed. The total nasal projection (TNP) among Japanese adults was estimated using the formula, TNP = 1.9 × the anterior nasal spine projection (ANSP) + the mid-philtrum depth (MPD), which differed significantly from the coefficient (3.0) in the conventional formula, regardless of sex, race, and body physique, and therefore needed modification for Asians. Although there was no positive relationship between the total nasal width (TNW) and the maximum width of the anterior nasal aperture (ANAW), the TNW could be estimated by adding soft tissue that varies by sex and body physique to both sides of the nearly constant ANAW. Therefore, we determined a simple and practical formula to estimate nasal dimensions among Japanese adults for conventional 3D facial reconstruction and manual 3D facial sculpture.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"18 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86547739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-10DOI: 10.3390/forensicsci3030028
I. Šoša
Many tools of clinical medicine, such as clinical chemistry and diagnostic imaging, are prioritized for clinical diagnosis over post mortem diagnosis. Indeed, it is reasonable that the assessment of a patient’s functional status should take priority over the post mortem, cross-sectional use of diagnostic tests and laboratory equipment. In addition, these tools are sometimes expensive, and their use does not always have a reasonable cost–benefit ratio. However, some post mortem observations, such as inflammation, pulmonary edema, or infiltration and cerebral swelling, cannot be explained without using immunohistochemical markers for post mortem diagnosis. Introducing blood-based biomarkers into post mortem care could significantly reduce the rates of inconclusive post mortems and discrepancies in autopsy findings and clinical diagnoses. This is particularly relevant in relation to vascular pathology, considering the significant burden that vascular diseases represent for overall mortality. Expanding traditional autopsies with blood-based (circulating) biomarkers to avoid invasive post mortem examination would have cultural, religious, and potentially economic advantages. All of the target molecules were discussed in the context of the processes they up-regulate or down-regulate, which turned out to be the final cause of death. Ultimately, it is evident that further studies are needed to provide concrete validation for using a combination of markers for each case to reach a post mortem diagnosis with or without clinical records.
{"title":"Improving Traditional Post Mortem Healthcare—The Cross-Sectional Use of Blood-Based Biomarkers","authors":"I. Šoša","doi":"10.3390/forensicsci3030028","DOIUrl":"https://doi.org/10.3390/forensicsci3030028","url":null,"abstract":"Many tools of clinical medicine, such as clinical chemistry and diagnostic imaging, are prioritized for clinical diagnosis over post mortem diagnosis. Indeed, it is reasonable that the assessment of a patient’s functional status should take priority over the post mortem, cross-sectional use of diagnostic tests and laboratory equipment. In addition, these tools are sometimes expensive, and their use does not always have a reasonable cost–benefit ratio. However, some post mortem observations, such as inflammation, pulmonary edema, or infiltration and cerebral swelling, cannot be explained without using immunohistochemical markers for post mortem diagnosis. Introducing blood-based biomarkers into post mortem care could significantly reduce the rates of inconclusive post mortems and discrepancies in autopsy findings and clinical diagnoses. This is particularly relevant in relation to vascular pathology, considering the significant burden that vascular diseases represent for overall mortality. Expanding traditional autopsies with blood-based (circulating) biomarkers to avoid invasive post mortem examination would have cultural, religious, and potentially economic advantages. All of the target molecules were discussed in the context of the processes they up-regulate or down-regulate, which turned out to be the final cause of death. Ultimately, it is evident that further studies are needed to provide concrete validation for using a combination of markers for each case to reach a post mortem diagnosis with or without clinical records.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"16 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85356533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Estimating an individual's age can be relevant in several areas primarily related to the clinical and forensic fields. In the latter, estimation of an individual's chronological age from biological material left by the perpetrator at a crime scene may provide helpful information for police investigation. Estimation of age is also beneficial in immigration cases, where age can affect the person's protection status under the law, or in disaster victim identification to narrow the list of potential missing persons. In the last decade, research has focused on establishing new approaches for age prediction in the forensic field. From the first forensic age estimations based on morphological inspections of macroscopic changes in bone and teeth, the focus has shifted to molecular methods for age estimation. These methods allow the use of samples from human biological material that does not contain morphological age features and can, in theory, be investigated in traces containing only small amounts of biological material. Molecular methods involving DNA analyses are the primary choice and estimation of DNA methylation levels at specific sites in the genome is the most promising tool. This review aims to provide an overview of the status of forensic age prediction using molecular methods, with particular focus in DNA methylation. The frequent challenges that impact forensic age prediction model development will be addressed, together with the importance of validation efforts within the forensic community.
估算一个人的年龄主要与临床和法医领域有关。在法医领域，从犯罪者在犯罪现场留下的生物材料中估算出个人的实际年龄可为警方调查提供有用信息。在移民案件中，年龄会影响个人的法律保护地位，因此年龄估算也很有帮助；在灾害受害者身份鉴定中，年龄估算也有助于缩小潜在失踪人员名单的范围。在过去的十年中，研究的重点是在法医领域建立新的年龄预测方法。从最初基于骨骼和牙齿宏观变化的形态学检查进行法医年龄估计，到现在的重点已转移到分子年龄估计方法上。这些方法可以使用不含形态学年龄特征的人体生物材料样本，理论上可以对仅含少量生物材料的痕迹进行调查。涉及 DNA 分析的分子方法是主要选择，而估算基因组特定位点的 DNA 甲基化水平是最有前途的工具。本综述旨在概述使用分子方法进行法医年龄预测的现状，尤其侧重于 DNA 甲基化。将讨论影响法医年龄预测模型开发的常见挑战，以及在法医界进行验证工作的重要性。
{"title":"Prediction of chronological age and its applications in forensic casework: methods, current practices, and future perspectives.","authors":"Mie Rath Refn, Marie-Louise Kampmann, Niels Morling, Jacob Tfelt-Hansen, Claus Børsting, Vania Pereira","doi":"10.1093/fsr/owad021","DOIUrl":"10.1093/fsr/owad021","url":null,"abstract":"<p><p>Estimating an individual's age can be relevant in several areas primarily related to the clinical and forensic fields. In the latter, estimation of an individual's chronological age from biological material left by the perpetrator at a crime scene may provide helpful information for police investigation. Estimation of age is also beneficial in immigration cases, where age can affect the person's protection status under the law, or in disaster victim identification to narrow the list of potential missing persons. In the last decade, research has focused on establishing new approaches for age prediction in the forensic field. From the first forensic age estimations based on morphological inspections of macroscopic changes in bone and teeth, the focus has shifted to molecular methods for age estimation. These methods allow the use of samples from human biological material that does not contain morphological age features and can, in theory, be investigated in traces containing only small amounts of biological material. Molecular methods involving DNA analyses are the primary choice and estimation of DNA methylation levels at specific sites in the genome is the most promising tool. This review aims to provide an overview of the status of forensic age prediction using molecular methods, with particular focus in DNA methylation. The frequent challenges that impact forensic age prediction model development will be addressed, together with the importance of validation efforts within the forensic community.</p>","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"8 2","pages":"85-97"},"PeriodicalIF":1.4,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10445583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10260842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-13DOI: 10.3390/forensicsci3020027
Joe Adserias-Garriga
Age-at-death is one of the most valuable pieces of information in a biological profile, and is an important step in identifying remains. Age-at-death estimation by dental means is performed by forensic odontologists and forensic anthropologists in their daily casework tasks. Both forensic odontologists and forensic anthropologists must be aware of all of the age indicators and of all of the methods that can offer the sufficient scientific robusticity that forensic cases require. Osteological and dental methods of age estimation rely on developmental changes in younger individuals and on degenerative changes in older individuals. Skeletal methods based on developmental changes are highly reliable, while methods based on degenerative or post-formation changes show higher variability. From all skeletal methods, those relying on tooth formation and development are the most accurate to assess an individual’s age. Dental methods of age estimation can be implemented in the skeletal analysis of juvenile and adult remains, representing an additional indicator of age. The aim of this review paper is to provide a practical reference for applying dental age estimation to human remains as a part of skeletal analysis.
{"title":"Age-at-Death Estimation by Dental Means as a Part of the Skeletal Analysis","authors":"Joe Adserias-Garriga","doi":"10.3390/forensicsci3020027","DOIUrl":"https://doi.org/10.3390/forensicsci3020027","url":null,"abstract":"Age-at-death is one of the most valuable pieces of information in a biological profile, and is an important step in identifying remains. Age-at-death estimation by dental means is performed by forensic odontologists and forensic anthropologists in their daily casework tasks. Both forensic odontologists and forensic anthropologists must be aware of all of the age indicators and of all of the methods that can offer the sufficient scientific robusticity that forensic cases require. Osteological and dental methods of age estimation rely on developmental changes in younger individuals and on degenerative changes in older individuals. Skeletal methods based on developmental changes are highly reliable, while methods based on degenerative or post-formation changes show higher variability. From all skeletal methods, those relying on tooth formation and development are the most accurate to assess an individual’s age. Dental methods of age estimation can be implemented in the skeletal analysis of juvenile and adult remains, representing an additional indicator of age. The aim of this review paper is to provide a practical reference for applying dental age estimation to human remains as a part of skeletal analysis.","PeriodicalId":45852,"journal":{"name":"Forensic Sciences Research","volume":"8 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2023-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88791114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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