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Current Colorectal Cancer Reports最新文献

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Systemic Therapy in BRAF V600E-Mutant Metastatic Colorectal Cancer: Recent Advances and Future Strategies BRAF V600E突变转移性癌症的系统治疗:最新进展和未来策略
Q3 Medicine Pub Date : 2019-03-06 DOI: 10.1007/s11888-019-00429-z
V. Morris
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引用次数: 6
Deciphering the Colorectal Cancer Gut Microbiota: Association vs. Causality 解读结直肠癌肠道菌群:关联与因果关系
Q3 Medicine Pub Date : 2019-02-20 DOI: 10.1007/s11888-019-00431-5
Kristina M. Bridges, K. Greiner, S. Umar
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引用次数: 6
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Cytoreductive Surgery (CRS) for Colorectal Cancer: Potential for Individualized Care, Review of Current Treatment Trends, Recent Advancements, and a Look into the Future 结肠直肠癌的高温腹腔化疗(HIPEC)和细胞减少手术(CRS):个体化治疗的潜力,当前治疗趋势的回顾,最近的进展,以及对未来的展望
Q3 Medicine Pub Date : 2019-02-15 DOI: 10.1007/s11888-019-00427-1
C. Follette, Sean C. Liebscher, T. Mouw, M. Al-kasspooles
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引用次数: 1
Current Surgical Strategies in the Management of Rectal Cancer 当前癌症直肠手术治疗策略
Q3 Medicine Pub Date : 2019-02-13 DOI: 10.1007/s11888-019-00428-0
J. Azevedo, B. Vailati, G. Julião, L. Fernández, R. Perez
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引用次数: 2
Techniques for Colorectal Anastomotic Construction Following Proctectomy and Variables Influencing Anastomotic Leak 直肠切除术后结肠吻合口构建技术及影响吻合口渗漏的因素
Q3 Medicine Pub Date : 2019-02-01 DOI: 10.1007/s11888-019-00425-3
Seth I. Felder, Janet T. Lee
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引用次数: 1
Current Status of Maintenance Systemic Therapies in Metastatic Colorectal Cancer: 2018 Update 转移性结直肠癌维持系统治疗的现状:2018年更新
Q3 Medicine Pub Date : 2019-02-01 DOI: 10.1007/s11888-019-00426-2
J. Mann, A. Stein
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引用次数: 1
A Surgeon's Guide to Treating Older Patients with Colorectal Cancer. 外科医生治疗老年结直肠癌患者指南
Q3 Medicine Pub Date : 2019-02-01 Epub Date: 2019-02-07 DOI: 10.1007/s11888-019-00424-4
Sooyeon Kim, Simon C Lee, Celette S Skinner, Cynthia J Brown, Courtney J Balentine

Purpose of review: Review strategies to improve outcomes of colorectal cancer treatment in older patients.

Recent findings: Older colorectal patients face many barriers to recovery during their initial inpatient stay following surgery and after leaving the hospital. In addition to the risk of inpatient morbidity and mortality, older patients are more likely to require post-acute care services, to face nutritional deficits, and to experience complications of chemoradiation.

Summary: In order to improve outcomes for older patients with colorectal cancer, it is important for surgeons to recognize their unique needs and to develop plans to address them. The involvement of a multidisciplinary team with geriatric experience can guide planning for surgery, the immediate postoperative recovery, and long-term survivorship.

综述目的:回顾改善老年患者结直肠癌治疗效果的策略:老年结直肠癌患者在术后最初住院期间和出院后的康复过程中面临着许多障碍。除了住院病人的发病率和死亡率风险外,老年患者还更有可能需要后期护理服务、面临营养障碍以及出现化疗放疗并发症。摘要:为了改善老年结直肠癌患者的治疗效果,外科医生必须认识到他们的独特需求,并制定相应的计划来满足这些需求。具有老年病学经验的多学科团队的参与可以指导手术规划、术后即刻恢复和长期生存。
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引用次数: 0
Microbiome and Colorectal Cancer. 微生物组与结直肠癌。
Q3 Medicine Pub Date : 2018-12-01 Epub Date: 2018-10-11 DOI: 10.1007/s11888-018-0416-7
Ishfaq Ahmed, Shahid Umar

Purpose of review: The trillions of microbes collectively referred to as the human microbiota, inhabit the human body and establish a beneficial relationship with the host. It is clear however that dysbiosis impacting microbial diversity in the gut, may lead to development of inflammatory and malignant gastrointestinal diseases including colorectal cancer (CRC). We provide a literature review of the recent influx of information related to the alterations in gut microbiota composition that influences CRC incidence and progression.

Recent findings: A growing body of evidence implicates altered gut microbiota in the development of CRC. Profiles of CRC associated microbiota have been shown to differ from those in healthy subjects and bacterial phylotypes vary depending on the primary tumor location. The compositional variation in the microbial profile is not restricted to cancerous tissue however and is different between cancers of the proximal and distal colons, respectively. More recently, studies have shed light on the "driver-passenger" model for CRC wherein, driver bacteria cause inflammation, increased cell proliferation and production of genotoxic substances to contribute towards mutational acquisition associated with adenoma-carcinoma sequence. These changes facilitate gradual replacement of driver bacteria by passengers that either promote or suppress tumor progression. Significant advances have also been made in associating individual bacterial species to consensus molecular subtypes (CMS) of CRC and this remarkable development is expected to galvanize scientific community into advancing therapeutic strategies for CRC.

Summary: Increasing evidence suggests a link between the intestinal microbiota and CRC development although the mechanisms through which the bacterial constituents of the microbiome contribute towards CRC are complex and yet to be fully fathomed. Thus, more exhaustive and mechanistic studies are needed to identify key interactions amongst diet, microbial community and metabolites that help facilitate the adenoma-carcinoma sequence evolution in CRC. It is expected that development of therapeutics based on microbial association with CMS will likely facilitate the translation of molecular subtypes into the clinic for CRCs and potentially other malignancies.

综述目的:数以万亿计的微生物统称为人体微生物群,它们栖息在人体中,并与宿主建立了有益的关系。然而,很明显,影响肠道微生物多样性的生态失调可能导致包括结直肠癌(CRC)在内的炎症性和恶性胃肠道疾病的发展。我们对近期大量与肠道菌群组成改变影响结直肠癌发病率和进展相关的信息进行了文献综述。最近发现:越来越多的证据表明,肠道微生物群的改变与结直肠癌的发展有关。结直肠癌相关微生物群的概况已被证明与健康受试者不同,细菌的种型根据原发肿瘤的位置而变化。然而,微生物谱的组成变化并不局限于癌组织,并且分别在近端和远端结肠癌症之间是不同的。最近,研究揭示了CRC的“驾驶员-乘客”模型,其中驾驶员细菌引起炎症,增加细胞增殖和产生基因毒性物质,从而导致与腺瘤-癌序列相关的突变获得。这些变化促进了驱动细菌逐渐被促进或抑制肿瘤进展的乘客所取代。在将单个细菌种类与结直肠癌的共识分子亚型(CMS)联系起来方面也取得了重大进展,这一显著的发展有望激励科学界推进结直肠癌的治疗策略。摘要:越来越多的证据表明,肠道微生物群与结直肠癌发展之间存在联系,尽管微生物群中的细菌成分对结直肠癌的作用机制很复杂,尚未完全了解。因此,需要更详尽和机制的研究来确定饮食、微生物群落和代谢物之间的关键相互作用,这些相互作用有助于促进结直肠癌中腺瘤-癌序列的进化。预计基于微生物与CMS关联的治疗方法的发展可能会促进分子亚型转化为临床治疗crc和潜在的其他恶性肿瘤。
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引用次数: 7
What Is the Future of Circulating Tumor Cells in Colorectal Cancer? 癌症大肠癌循环肿瘤细胞的未来是什么?
Q3 Medicine Pub Date : 2018-11-26 DOI: 10.1007/s11888-018-0418-5
Yun Deng, Hui Zhang, Zhen Zhang
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引用次数: 0
Colorectal Cancer and Metabolism 癌症与大肠癌代谢
Q3 Medicine Pub Date : 2018-11-16 DOI: 10.1007/s11888-018-0420-y
Rachel E. Brown, Sarah P. Short, Christopher S. Williams
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引用次数: 75
期刊
Current Colorectal Cancer Reports
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