Pub Date : 2019-02-20DOI: 10.1007/s11888-019-00431-5
Kristina M. Bridges, K. Greiner, S. Umar
{"title":"Deciphering the Colorectal Cancer Gut Microbiota: Association vs. Causality","authors":"Kristina M. Bridges, K. Greiner, S. Umar","doi":"10.1007/s11888-019-00431-5","DOIUrl":"https://doi.org/10.1007/s11888-019-00431-5","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-019-00431-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45982974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-15DOI: 10.1007/s11888-019-00427-1
C. Follette, Sean C. Liebscher, T. Mouw, M. Al-kasspooles
{"title":"Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Cytoreductive Surgery (CRS) for Colorectal Cancer: Potential for Individualized Care, Review of Current Treatment Trends, Recent Advancements, and a Look into the Future","authors":"C. Follette, Sean C. Liebscher, T. Mouw, M. Al-kasspooles","doi":"10.1007/s11888-019-00427-1","DOIUrl":"https://doi.org/10.1007/s11888-019-00427-1","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-019-00427-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47457210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-13DOI: 10.1007/s11888-019-00428-0
J. Azevedo, B. Vailati, G. Julião, L. Fernández, R. Perez
{"title":"Current Surgical Strategies in the Management of Rectal Cancer","authors":"J. Azevedo, B. Vailati, G. Julião, L. Fernández, R. Perez","doi":"10.1007/s11888-019-00428-0","DOIUrl":"https://doi.org/10.1007/s11888-019-00428-0","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-019-00428-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45370132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.1007/s11888-019-00425-3
Seth I. Felder, Janet T. Lee
{"title":"Techniques for Colorectal Anastomotic Construction Following Proctectomy and Variables Influencing Anastomotic Leak","authors":"Seth I. Felder, Janet T. Lee","doi":"10.1007/s11888-019-00425-3","DOIUrl":"https://doi.org/10.1007/s11888-019-00425-3","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-019-00425-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41364107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01DOI: 10.1007/s11888-019-00426-2
J. Mann, A. Stein
{"title":"Current Status of Maintenance Systemic Therapies in Metastatic Colorectal Cancer: 2018 Update","authors":"J. Mann, A. Stein","doi":"10.1007/s11888-019-00426-2","DOIUrl":"https://doi.org/10.1007/s11888-019-00426-2","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-019-00426-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43954707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-02-01Epub Date: 2019-02-07DOI: 10.1007/s11888-019-00424-4
Sooyeon Kim, Simon C Lee, Celette S Skinner, Cynthia J Brown, Courtney J Balentine
Purpose of review: Review strategies to improve outcomes of colorectal cancer treatment in older patients.
Recent findings: Older colorectal patients face many barriers to recovery during their initial inpatient stay following surgery and after leaving the hospital. In addition to the risk of inpatient morbidity and mortality, older patients are more likely to require post-acute care services, to face nutritional deficits, and to experience complications of chemoradiation.
Summary: In order to improve outcomes for older patients with colorectal cancer, it is important for surgeons to recognize their unique needs and to develop plans to address them. The involvement of a multidisciplinary team with geriatric experience can guide planning for surgery, the immediate postoperative recovery, and long-term survivorship.
{"title":"A Surgeon's Guide to Treating Older Patients with Colorectal Cancer.","authors":"Sooyeon Kim, Simon C Lee, Celette S Skinner, Cynthia J Brown, Courtney J Balentine","doi":"10.1007/s11888-019-00424-4","DOIUrl":"10.1007/s11888-019-00424-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>Review strategies to improve outcomes of colorectal cancer treatment in older patients.</p><p><strong>Recent findings: </strong>Older colorectal patients face many barriers to recovery during their initial inpatient stay following surgery and after leaving the hospital. In addition to the risk of inpatient morbidity and mortality, older patients are more likely to require post-acute care services, to face nutritional deficits, and to experience complications of chemoradiation.</p><p><strong>Summary: </strong>In order to improve outcomes for older patients with colorectal cancer, it is important for surgeons to recognize their unique needs and to develop plans to address them. The involvement of a multidisciplinary team with geriatric experience can guide planning for surgery, the immediate postoperative recovery, and long-term survivorship.</p>","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45296491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-12-01Epub Date: 2018-10-11DOI: 10.1007/s11888-018-0416-7
Ishfaq Ahmed, Shahid Umar
Purpose of review: The trillions of microbes collectively referred to as the human microbiota, inhabit the human body and establish a beneficial relationship with the host. It is clear however that dysbiosis impacting microbial diversity in the gut, may lead to development of inflammatory and malignant gastrointestinal diseases including colorectal cancer (CRC). We provide a literature review of the recent influx of information related to the alterations in gut microbiota composition that influences CRC incidence and progression.
Recent findings: A growing body of evidence implicates altered gut microbiota in the development of CRC. Profiles of CRC associated microbiota have been shown to differ from those in healthy subjects and bacterial phylotypes vary depending on the primary tumor location. The compositional variation in the microbial profile is not restricted to cancerous tissue however and is different between cancers of the proximal and distal colons, respectively. More recently, studies have shed light on the "driver-passenger" model for CRC wherein, driver bacteria cause inflammation, increased cell proliferation and production of genotoxic substances to contribute towards mutational acquisition associated with adenoma-carcinoma sequence. These changes facilitate gradual replacement of driver bacteria by passengers that either promote or suppress tumor progression. Significant advances have also been made in associating individual bacterial species to consensus molecular subtypes (CMS) of CRC and this remarkable development is expected to galvanize scientific community into advancing therapeutic strategies for CRC.
Summary: Increasing evidence suggests a link between the intestinal microbiota and CRC development although the mechanisms through which the bacterial constituents of the microbiome contribute towards CRC are complex and yet to be fully fathomed. Thus, more exhaustive and mechanistic studies are needed to identify key interactions amongst diet, microbial community and metabolites that help facilitate the adenoma-carcinoma sequence evolution in CRC. It is expected that development of therapeutics based on microbial association with CMS will likely facilitate the translation of molecular subtypes into the clinic for CRCs and potentially other malignancies.
{"title":"Microbiome and Colorectal Cancer.","authors":"Ishfaq Ahmed, Shahid Umar","doi":"10.1007/s11888-018-0416-7","DOIUrl":"https://doi.org/10.1007/s11888-018-0416-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>The trillions of microbes collectively referred to as the human microbiota, inhabit the human body and establish a beneficial relationship with the host. It is clear however that dysbiosis impacting microbial diversity in the gut, may lead to development of inflammatory and malignant gastrointestinal diseases including colorectal cancer (CRC). We provide a literature review of the recent influx of information related to the alterations in gut microbiota composition that influences CRC incidence and progression.</p><p><strong>Recent findings: </strong>A growing body of evidence implicates altered gut microbiota in the development of CRC. Profiles of CRC associated microbiota have been shown to differ from those in healthy subjects and bacterial phylotypes vary depending on the primary tumor location. The compositional variation in the microbial profile is not restricted to cancerous tissue however and is different between cancers of the proximal and distal colons, respectively. More recently, studies have shed light on the \"driver-passenger\" model for CRC wherein, driver bacteria cause inflammation, increased cell proliferation and production of genotoxic substances to contribute towards mutational acquisition associated with adenoma-carcinoma sequence. These changes facilitate gradual replacement of driver bacteria by passengers that either promote or suppress tumor progression. Significant advances have also been made in associating individual bacterial species to consensus molecular subtypes (CMS) of CRC and this remarkable development is expected to galvanize scientific community into advancing therapeutic strategies for CRC.</p><p><strong>Summary: </strong>Increasing evidence suggests a link between the intestinal microbiota and CRC development although the mechanisms through which the bacterial constituents of the microbiome contribute towards CRC are complex and yet to be fully fathomed. Thus, more exhaustive and mechanistic studies are needed to identify key interactions amongst diet, microbial community and metabolites that help facilitate the adenoma-carcinoma sequence evolution in CRC. It is expected that development of therapeutics based on microbial association with CMS will likely facilitate the translation of molecular subtypes into the clinic for CRCs and potentially other malignancies.</p>","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0416-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38828961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-26DOI: 10.1007/s11888-018-0418-5
Yun Deng, Hui Zhang, Zhen Zhang
{"title":"What Is the Future of Circulating Tumor Cells in Colorectal Cancer?","authors":"Yun Deng, Hui Zhang, Zhen Zhang","doi":"10.1007/s11888-018-0418-5","DOIUrl":"https://doi.org/10.1007/s11888-018-0418-5","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0418-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49081616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-11-16DOI: 10.1007/s11888-018-0420-y
Rachel E. Brown, Sarah P. Short, Christopher S. Williams
{"title":"Colorectal Cancer and Metabolism","authors":"Rachel E. Brown, Sarah P. Short, Christopher S. Williams","doi":"10.1007/s11888-018-0420-y","DOIUrl":"https://doi.org/10.1007/s11888-018-0420-y","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-018-0420-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49279955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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