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Current Colorectal Cancer Reports最新文献

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Conversion Therapy for Initially Borderline/Unresectable Metastases in Colon Cancer: What Is the Best Neoadjuvant Chemotherapy? 结肠癌初始临界/不可切除转移的转化治疗:什么是最好的新辅助化疗?
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-10-19 DOI: 10.1007/s11888-017-0393-2
S. Haraldsdottir, R. Goldberg
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引用次数: 1
Second-Line Therapy for Advanced Colorectal Cancer: EGFR vs. Continuation of VEGF Inhibition 晚期癌症的二线治疗：EGFR与持续抑制VEGF
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-09-18 DOI: 10.1007/s11888-017-0388-z
M. Serzan, B. Weinberg, M. Salem
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引用次数: 0
Immunotherapy in Colorectal Cancer: Where Are We Now? 结直肠癌的免疫治疗:我们现在在哪里?
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-08-29 DOI: 10.1007/s11888-017-0384-3
T. Baybutt, A. Aka, A. Snook
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引用次数: 4
Intraoperative Radiation Therapy for Locally Advanced or Locally Recurrent Rectal Cancer 局部晚期或局部复发直肠癌术中放射治疗
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-08-29 DOI: 10.1007/s11888-017-0387-0
M. Haddock, C. Hallemeier
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引用次数: 0
Molecular Profiling in Colon Cancer: Where Are We Now? 结肠癌的分子分析:我们现在在哪里?
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-08-26 DOI: 10.1007/s11888-017-0385-2
R. Fratamico, S. Cohen
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引用次数: 0
Colonoscopy and Flexible Sigmoidoscopy in Colorectal Cancer Screening and Surveillance 结肠镜和乙状结肠镜在结直肠癌筛查和监测中的应用
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-08-01 DOI: 10.1007/s11888-017-0377-2
Juliana Yang, J. Kwon
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引用次数: 0
Inflammation and Colorectal Cancer. 炎症与结直肠癌。
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-08-01 Epub Date: 2017-06-17 DOI: 10.1007/s11888-017-0373-6
Apple G Long, Emma T Lundsmith, Kathryn E Hamilton

Colorectal cancer (CRC) is the fourth most common cancer in both men and women in the United States, resulting in over 55,000 deaths annually. Environmental and genetic factors influence the development of CRC, and inflammation is a critical hallmark of cancer that may arise from a variety of factors.

Purpose of review: While patients with inflammatory bowel disease (IBD) have a higher risk of developing CRC, sporadic CRCs may engender or be potentiated by inflammation as well. In this review, we focus on recent advances in basic and translational research utilizing murine models to understand the contribution of inflammatory signaling pathways to CRC.

Recent findings: We discuss advances in the utility of three-dimensional enteroid/colonoid/tumoroid cultures to understand immune-epithelial interactions in CRC, as well as the potential for utilizing patient-derived tumoroids for personalized therapies.

Summary: This review underscores the importance of understanding the complex molecular mechanisms underlying inflammation in sporadic CRC and highlights up-and-coming or new avenues for CRC biomarkers or therapies.

结肠直肠癌（CRC）是美国男性和女性第四大常见癌症，每年导致 55,000 多人死亡。环境和遗传因素影响着 CRC 的发展，而炎症是癌症的一个重要标志，可能由多种因素引起：尽管炎症性肠病（IBD）患者罹患 CRC 的风险较高，但散发性 CRC 也可能因炎症而产生或加剧。在这篇综述中，我们将重点介绍基础研究和转化研究的最新进展，利用小鼠模型来了解炎症信号通路对 CRC 的影响：摘要：本综述强调了了解散发性 CRC 炎症的复杂分子机制的重要性，并重点介绍了 CRC 生物标记物或疗法的新途径。
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引用次数: 0
Adenomatous Polyposis Syndromes: Familial Adenomatous Polyposis and MutYH-Associated Polyposis 性腺瘤性息肉病综合征:家族性腺瘤性息肉病和mutyh相关性息肉病
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-06-30 DOI: 10.1007/s11888-017-0379-0
J. Ashburn, M. Kalady
{"title":"Adenomatous Polyposis Syndromes: Familial Adenomatous Polyposis and MutYH-Associated Polyposis","authors":"J. Ashburn, M. Kalady","doi":"10.1007/s11888-017-0379-0","DOIUrl":"https://doi.org/10.1007/s11888-017-0379-0","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-017-0379-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42997933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers that Predict Response to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer 预测局部晚期癌症新辅助化疗反应的生物标志物
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-06-27 DOI: 10.1007/s11888-017-0376-3
P. Oh, K. Du
{"title":"Biomarkers that Predict Response to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer","authors":"P. Oh, K. Du","doi":"10.1007/s11888-017-0376-3","DOIUrl":"https://doi.org/10.1007/s11888-017-0376-3","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-017-0376-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44649993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colorectal Cancer Surveillance: What Is the Optimal Frequency of Follow-up and Which Tools Best Predict Recurrence? 癌症结直肠癌监测：随访的最佳频率是多少？哪些工具最能预测复发？
Q3 Medicine
Current Colorectal Cancer Reports
Pub Date : 2017-06-23 DOI: 10.1007/s11888-017-0382-5
M. Gage, M. Hueman
{"title":"Colorectal Cancer Surveillance: What Is the Optimal Frequency of Follow-up and Which Tools Best Predict Recurrence?","authors":"M. Gage, M. Hueman","doi":"10.1007/s11888-017-0382-5","DOIUrl":"https://doi.org/10.1007/s11888-017-0382-5","url":null,"abstract":"","PeriodicalId":45986,"journal":{"name":"Current Colorectal Cancer Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s11888-017-0382-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43914303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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