Early detection and accurate diagnosis of neurocognitive disorders (NCDs) are essential for enabling timely interventions to slow disease progression, preserve cognitive function, and enhance quality of life. This study introduces an EEG-based classification framework utilizing four AI-driven deep learning models—ResNet50-V2, EfficientNetB0, NasNetMobile, and MobileNetV2—to classify four neurocognitive groups: healthy controls (HC), mild cognitive impairment (MCI), Alzheimer’s disease (AD), and epilepsy (Ep) under eyes-closed (EC) conditions. To reduce complexity and improve accuracy, Fisher’s score was used to select 16 significant EEG channels from frontal, parietal, occipital, temporal, and central regions. Phase-amplitude coupling (PAC) images were generated from EC EEG signals to capture cross-frequency interactions, specifically how delta (0.5–4Hz) and theta (4–8Hz) phase modulate alpha (8–12Hz) and beta (12–35Hz) amplitudes—revealing functional brain connectivity. HC exhibited strong delta-alpha and reduced theta-beta coupling, while MCI and AD showed weakened delta-alpha and increased theta-beta interactions, reflecting cognitive decline. In contrast, Ep displayed elevated delta-alpha and reduced delta-beta coupling, linked to neural hyperexcitability. Among all models, MobileNetV2 achieved the best performance with 98.25% accuracy and 98.40% F score, attributed to its lightweight design and effective image feature extraction. This study’s novelty lies in its PAC image-based approach for NCD classification using MobileNetV2, providing valuable insights into non-linear hemispheric dynamics related to cognitive decline.
扫码关注我们
求助内容:
应助结果提醒方式:
