Numerous healthcare procedures can be viewed as medical sector decisions. In the modern era, computers have become indispensable in the realm of medical decision-making. However, the common view of computers in the medical field typically extends only to applications that support doctors in diagnosing diseases. To more tightly intertwine computers with the biomedical sciences, professionals are now more frequently utilising knowledge-driven deep learning systems (KDLS) and their foundational technologies, especially in the domain of neuroimaging (NI).
Data for medical purposes can be sourced from a variety of imaging techniques, including but not limited to Computed Tomography (CT), Magnetic Resonance Imaging (MRI), Ultrasound, Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), Magnetic Particle Imaging (MPI), Electroencephalography (EEG), Magnetoencephalography (MEG), Optical Microscopy and Tomography, Photoacoustic Tomography, Electron Tomography, and Atomic Force Microscopy.
Historically, these imaging techniques have been analysed using traditional statistical methods, such as hypothesis testing or Bayesian inference, which often presuppose certain conditions that are not always met. An emerging solution is the implementation of machine learning (ML) within the context of KDLS, allowing for the empirical mapping of complex, multi-dimensional relationships within data sets.
The objective of this special issue is to showcase the latest advancements in the methodology of KDLS for evaluating functional connectivity, neurological disorders, and clinical neuroscience, such as conditions like Alzheimer's, Parkinson's, cerebrovascular accidents, brain tumours, epilepsy, multiple sclerosis, ALS, Autism Spectrum Disorder, and more. Additionally, the special issue seeks to elucidate the mechanisms behind the predictive capabilities of ML methods within KDLS for brain-related diseases and disorders.
We received an abundance of submissions, totalling more than 40, from over 10 countries. After a meticulous and rigorous peer review process, which employed a double-blind methodology, we ultimately selected eight outstanding papers for publication. This process ensured the highest standards of quality and impartiality in the selection.
In the article ‘A deep learning fusion model for accurate classification of brain tumours in Magnetic Resonance images’, Zebari et al. created a robust deep learning (DL) fusion model for accurate brain tumour classification. To enhance performance, they employed data augmentation to expand the training dataset. The model leveraged VGG16, ResNet50, and convolutional deep belief networks to extract features from MRI images using a softmax classifier. By fusing features from two DL models, the fusion model notably boosted classification precision. Tested with a publicly available dataset, it achieved a remarkable 98.98% accuracy rate, outperforming existing me