European Journal of Translational Myology最新文献

Hand-grip strength was evaluated in 757 recreational downhill skiers and compared to 1021 community-dwellers. Findings are reported for age and sex categories consistent with community-dwelling norms. Effect size (Cohen's d) was calculated to estimate the clinical relevance of strength differences between populations. Most male and half of the female age categories of downhill skiers demonstrated higher grip strength of the dominant hand (moderate to large effect size) compared to the reference population. Hand-grip strength in skiers declined with age at a similar rate as in the reference population. Relative grip strength (per kg body mass) was significantly and positively correlated with physical activity (hours/week), and with the number of ski days per year, and negatively with body mass. Thus, hand-grip strength may be related to the type, volume and intensity of exercise regularly performed. These results can help to assess whether the individual hand-grip strength is above or below average with regard to the normal population and the skier population as well and will support advice for training and/or rehabilitation.

Explosive strength is fundamental in the performance of athletes. The objective is to identify the criteria used for the prescription of Explosive Strength Training (EST) and to verify the changes it produces in futsal players. A systematic review of studies analyzing the criteria used for the prescription of explosive strength training was conducted in PubMed/MEDLINE and Scielo, considering the period between 2017 and 2023. The search strategy used the terms: players, Futsal, Futsal training, strength, physical exercise, explosive strength, intervention, experimental study. Data extraction included: year of publication, country, sample, protocol performed (content and activity developed, duration, intensity, frequency, total weeks). A total of six studies were identified. Fifty percent of the studies were developed in Brazil, the others in Italy, Spain and Portugal. Five studies applied a training of 2 sessions per week and one indicated 2-3 sessions. Three studies describe the training sessions (study 1: 15-30 minutes, study 2: 20-25 minutes, study 3: 1 hour). Five studies used 1RM and one study used subjective perception of exertion (PSE). The contents of the interventions were varied, from squats with weights, accelerations and decelerations, leg press, leg extension, plyometrics. The training criteria for explosive strength were: intensity controlled by a 1RM, frequency of 2 to 3 sessions per week, duration of 15 to 30 minutes per session and the training contents were varied. These results suggest positive changes in CMJ, increasing explosive strength from ∼2.0 to 4.6 cm (5.8 to 13.7%). These findings highlight the need to develop a more standardized protocol to optimize the benefits of explosive strength training in this athletic population.

Realizar un análisis bibliométrico integral de la productividad científica relacionada con programas de intervención que buscan mejorar la función cognitiva en adultos mayores, según revista, país y tema de intervención en la base de datos pubmed. Se realizó un estudio bibliométrico durante el periodo 2018 al 2023. La búsqueda bibliográfica se realizó en la base de datos PubMed. Los términos de búsqueda fueron: cognitivecayden, cognitivecayden, exercise program, intervention program, physical exercise,older adult, elderly. Cada artículo identificó: año de publicación, idioma de publicación, país de publicación, nombre de la revista y tema del estudio. Se utilizaron los lineamientos establecidos por PRISMA. Se incluyeron 51 publicaciones científicas, analizadas en 34 revistas. China lidera con 14 estudios (27,5%), seguido de Estados Unidos con 5 artículos (9,8%). Corea y Singapur están en tercer lugar con 4 estudios cada uno (7,8%), seguido de Japón con 3 estudios (5,9%). En cuanto al idioma de publicación, el 96,1% (n=49) fueron publicados en inglés. Solo el 3,9% (n=2) fueron publicados en español. La revista con mayor frecuencia de publicaciones fue Nutrients, con 6 artículos publicados, lo que representa el 11,8% del total y destaca como líder en este campo. Le siguió BMC Geriatrics con 3 artículos publicados, lo que representa el 5,9% del total. Destaca el aumento de las investigaciones sobre intervenciones para el deterioro cognitivo en OA, concentradas principalmente en los años 2020 y 2023. China lidera la producción de estudios seguida de Estados Unidos, Corea y Singapur. Los programas de intervención más estudiados incluyen el ejercicio y el deporte, seguido de la nutrición y el entrenamiento computarizado. Destaca la revista "Nutrients" con mayor número de artículos, seguida de "BMC Geriatrics".

This study aimed to investigate changes in protein signaling associated with muscle regeneration in aged rats with obesity and diabetes following high-intensity interval training (HIIT) and SP supplementation. Forty male Wistar rats weighting 280-325 g were used in this study. Obesity was induced by eight weeks of a high-fat diet, and diabetes was induced by intraperitoneal injection of 40 mg/kg streptozocin. Rats were randomly divided into control (CON), sham, SP, HIIT, and HIIT+SP groups. HIIT was performed five times per week during the 8-week period. SP dose was 50 mg/kg. Real-time PCR was used to evaluate the expression of myogenin, MyoD1, and Pax7. The decreases in body mass in the HIIT, HIIT+SP and SP groups were significantly higher than those in the sham and CON groups (p=0.0001). The soleus muscle mass increased significantly only in the HIIT and HIIT+SP groups (p<0.01). HIIT+SP improved fasting blood glucose and insulin levels more than HIIT alone and SP (p<0.05), while HIIT increased the expression levels of myogenic factors more than other groups (p=0.0001). In conclusion HIIT alone had a significant impact on myogenic factors, whereas Spirulina had an effect only when combined with HIIT.

Introduction: Adipocyte levels including leptin and FABS-4 levels, adiponectin, obesity, and vitamin D can be related to the occurrence and exacerbation of MS disease.

Objective: This research aimed at determining the relationship between VDR gene changes and clinical and inflammatory factors in patients with relapsing-remitting multiple sclerosis (RRMS).

Method: This case/control study was conducted based on the ethical principles of Helsinki. RRMS disease was confirmed based on history, clinical signs, radiological signs, and neurologist's diagnosis. The research population consisted of healthy people and patients with RRMS referring to Hazrat Rasool Akram Hospital between 2021 and 2023 who met the criteria for entering the research.

Results: FokI polymorphism is associated with a substantial increase in risk, with an odds ratio of 7.28, for those with the FF genotype who have RRMS compared to healthy individuals (OR=7.28: 95% CI; 1.86, 28.41). The presence of FokI polymorphism significantly raises the likelihood of developing RRMS in persons with the FF genotype compared to healthy individuals, with an odds ratio of 28.7. RRMS patients with genotypes did not exhibit a significant increase in risk compared to controls for FokI, ApaI, TaqI, and BsmI polymorphisms.

Conclusion: None of the studied polymorphisms revealed a significant risk in obese patients with different genotypes compared to the obese people. Further research, including more cases, is needed to avoid results that could be inflated by small samples or low frequencies of minor alleles.

We collected biosignals from 63 participants and extracted the features corresponding to each level of exerted muscle force. Data were classified into typical and atypical patterns. Data analysis was performed using the Linear Latent Curve Model (LCM) and the Conditional Linear LCM. The typical patterns demonstrated a high degree of fit. Factors, such as ankle circumference and muscle mass, influenced the model intercept. A larger ankle circumference indicated attenuation of signal transmission from the tendon to the skin surface, leading to lower biosignal values.  These results indicate that biosignals from the tendons near the ankle can be captured using piezoelectric film sensors. There are studies that define biosignals originating from tendons as mechanotendography. It has been demonstrated that the relationship between biosignals originating from tendons and the exerted muscle force can be explained linearly. Insights from this study may facilitate individualized approaches in the fields of motion control and rehabilitation. Physiological studies to elucidate the mechanisms underlying biosignal generation are necessary.

I was interested to read the article by Quadrelli et al. on a study on the prevention of sarcopenia using daily "Home Gym Bed" training for 30 minutes per day over 10 years in a 70-year-old man who was examined using 3D CT imaging.1 It was found that muscle mass did not change over the 10 years despite ageing.1 It was concluded that whole-body exercise in bed can help preserve muscle mass and density in older people,1 and that advanced imaging techniques can quantify the effectiveness of non-pharmacological interventions against sarcopenia.1 The study is excellent, but some points should be discussed.[...].

We appreciate the thorough and insightful comments provided by Josef Finsterer regarding our study on the prevention of sarcopenia using the "Gym Bed" exercise regimen. We welcome the opportunity to address the points raised and to elaborate on the implications and limitations of our research.[...].

We appreciate the insightful comments provided by Josef Finsterer regarding our article on the first evidence on the effects of the Home Full-Body in-Bed Gym protocol as a potential intervention to mitigate age-related muscle loss based on the preliminary positive results of a Padua prospective observational study.1 We acknowledge the importance of the points raised and would like to address them in this response. At the University of Padua, we conducted a study aimed at evaluating the impact of a home-based Full-Body in-Bed Gym protocol on various outcomes in elderly individuals, which was published in 2023.1 The rational of our proposal is based on the fact that functional muscle decay of aging is inevitable, but that the general population is highly hypoactive, let's say "lazy". The increase in daily muscular activity even through "Home In-Bed Gym" recovers at least in part the potential abilities progressively lost. Therefore, it is easy to rejuvenate the "lazy" population, that is, the vast majority of elderlies.[...].

Osteoporosis, a common bone disorder, increases fracture and spinal surgery complications risk. This study evaluates the potential of the Magnetic Resonance Imaging (MRI)-based Vertebral Bone Quality (VBQ) score as an alternative for assessing bone density in lumbosacral fusion surgery patients. In a prospective cohort study from April 2021 to November 2022, 134 patients with lumbar degenerative diseases underwent lumbar Dual-Energy X-ray Absorptiometry (DXA) and lumbosacral non-contrast T1-weighted MRI. VBQ scores were calculated and analyzed using IBM SPSS Statistics and MedCalc software. Osteopenia/Osteoporosis patients exhibited significantly higher VBQ scores than normal bone mineral density patients (3.37 ± 0.51 vs. 2.99 ± 0.44, P<0.001). VBQ correlated significantly with lumbar DXA T scores (r value= -0.415, p<0.001). Receiver Operating Characteristic (ROC) analysis showed VBQ AUC values of 0.730 (CI 95% 0.647-0.803, P<0.001) and 0.839 (CI 95% 0.765-0.897, P<0.001) for Osteopenia/Osteoporosis and osteoporosis diagnosis, respectively. The study suggests MRI-derived VBQ scores may benefit pre-lumbosacral fusion surgery bone density assessment, potentially improving patient care and aiding osteoporosis detection in spinal surgery candidates.