Latent autoimmune diabetes in adults is a form of diabetes that progresses slowly and is controlled by diet and oral glucose-lowering medications before insulin is required. The aim of the present study was to evaluate the prevalence of latent autoimmune diabetes in adults. The present study was conducted based on PRISMA 2020-27-item checklist. To find the studies conducted in line with the purpose of the study, PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase databases and Google Scholar search engine were reviewed from 2013 to August 2023. Meta-analysis was performed using effect size with 95% confidence interval. Data analysis was done using STATA/MP. v17 software. The present study was carried out based on the PRISMA 2020 27-point checklist. To find out which studies were carried out in accordance with the purpose of the study, from 2013 to August, the databases PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase and the search engine Google Scholar reviewed 2023. Meta-analysis was performed using effect size with 95% confidence interval. Data analysis was carried out using STATA/MP. v17 software. The overall prevalence of Latent autoimmune diabetes of adults was found to be 7% (95%CI 0-20). Subgroup analysis of Latent autoimmune diabetes of adults in the context of geographic regions showed a higher prevalence in North America (15%) and South East Asia (5%). Since the identification of Latent autoimmune diabetes of adult patients with other forms of diabetes is misdiagnosed due to the combination of phenotypic features with T1D and T2D, studying its prevalence is of great importance.
成人潜伏性自身免疫性糖尿病是一种进展缓慢的糖尿病,在需要使用胰岛素之前,可通过饮食和口服降糖药物控制病情。本研究旨在评估成人潜伏性自身免疫性糖尿病的患病率。本研究根据 PRISMA 2020-27 条目清单进行。为了找到与本研究目的相符的研究,我们查阅了 2013 年至 2023 年 8 月期间的 PubMed、Web of Science、Scopus、Science Direct、Web of Knowledge、EBSCO、Wiley、ISI、Elsevier、Embase 数据库和 Google Scholar 搜索引擎。使用效应大小和 95% 置信区间进行元分析。数据分析使用 STATA/MP.本研究根据 PRISMA 2020 27 点清单进行。为找出符合研究目的的研究,从 2013 年 8 月起,PubMed、Web of Science、Scopus、Science Direct、Web of Knowledge、EBSCO、Wiley、ISI、Elsevier、Embase 和搜索引擎 Google Scholar 等数据库对 2023 项研究进行了审查。使用效应大小和 95% 的置信区间进行了 Meta 分析。数据分析使用 STATA/MP.发现成人潜伏性自身免疫性糖尿病的总体患病率为 7%(95%CI 0-20)。根据地理区域对成人潜伏性自身免疫性糖尿病进行的分组分析表明,北美(15%)和东南亚(5%)的发病率较高。由于合并有 T1D 和 T2D 的表型特征,成人潜伏自身免疫性糖尿病患者会被误诊为其他形式的糖尿病,因此研究其患病率非常重要。
{"title":"Prevalence of latent autoimmune diabetes in adults and insulin resistance: a systematic review and meta-analysis.","authors":"Malihe Mohammadi","doi":"10.4081/ejtm.2024.12694","DOIUrl":"10.4081/ejtm.2024.12694","url":null,"abstract":"<p><p>Latent autoimmune diabetes in adults is a form of diabetes that progresses slowly and is controlled by diet and oral glucose-lowering medications before insulin is required. The aim of the present study was to evaluate the prevalence of latent autoimmune diabetes in adults. The present study was conducted based on PRISMA 2020-27-item checklist. To find the studies conducted in line with the purpose of the study, PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase databases and Google Scholar search engine were reviewed from 2013 to August 2023. Meta-analysis was performed using effect size with 95% confidence interval. Data analysis was done using STATA/MP. v17 software. The present study was carried out based on the PRISMA 2020 27-point checklist. To find out which studies were carried out in accordance with the purpose of the study, from 2013 to August, the databases PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase and the search engine Google Scholar reviewed 2023. Meta-analysis was performed using effect size with 95% confidence interval. Data analysis was carried out using STATA/MP. v17 software. The overall prevalence of Latent autoimmune diabetes of adults was found to be 7% (95%CI 0-20). Subgroup analysis of Latent autoimmune diabetes of adults in the context of geographic regions showed a higher prevalence in North America (15%) and South East Asia (5%). Since the identification of Latent autoimmune diabetes of adult patients with other forms of diabetes is misdiagnosed due to the combination of phenotypic features with T1D and T2D, studying its prevalence is of great importance.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This issue of the European Journal of Translational Myology (Ejtm) 34 (3) 2024 opens with a historic article by Roger Sabbadini, who recalls his years spent as a guest scientist at the Institute of General Pathology of the University of Padua, Italy and the many years spent valorising a fortuitous observation made in collaboration with the scientific group of Professor Giovanni Salviati, University of Padua, Italy. A further side effect of those years is the decision I recently made to add a new Section to the Ejtm Editorial board, namely: Myokines, Bioactive lipids, Adipokines, RNAkines (ncRNAs), Antonio Musarò, Roger Sabbadini, and Daniela Tavian, Editors. Readers are therefore warmly invited to contribute typescripts to this section. I am confident that young readers will be motivated to test preliminary in vitro and in vivo options for drug development, especially for the bioactive lipids. Furthermore, it is time to send your presentation proposals and registration/accommodation forms to participate in the International Meeting: Padua Days on Muscle and Mobility Medicine, which will be held at the Hotel Petrarca of the Euganean Thermae (Padua, Italy) from 25 to 29 March 2025 (2025Pdm3). The Preliminary Program is included, hoping that you will submit your abstract and the Registration forms by November 15, 2024.
{"title":"Invitations to join a new 2024 section of Ejtm and the 2025 Pdm3 from 25 to 29 March, Euganean Thermae, Padua, Italy.","authors":"Ugo Carraro","doi":"10.4081/ejtm.2024.12970","DOIUrl":"10.4081/ejtm.2024.12970","url":null,"abstract":"<p><p>This issue of the European Journal of Translational Myology (Ejtm) 34 (3) 2024 opens with a historic article by Roger Sabbadini, who recalls his years spent as a guest scientist at the Institute of General Pathology of the University of Padua, Italy and the many years spent valorising a fortuitous observation made in collaboration with the scientific group of Professor Giovanni Salviati, University of Padua, Italy. A further side effect of those years is the decision I recently made to add a new Section to the Ejtm Editorial board, namely: Myokines, Bioactive lipids, Adipokines, RNAkines (ncRNAs), Antonio Musarò, Roger Sabbadini, and Daniela Tavian, Editors. Readers are therefore warmly invited to contribute typescripts to this section. I am confident that young readers will be motivated to test preliminary in vitro and in vivo options for drug development, especially for the bioactive lipids. Furthermore, it is time to send your presentation proposals and registration/accommodation forms to participate in the International Meeting: Padua Days on Muscle and Mobility Medicine, which will be held at the Hotel Petrarca of the Euganean Thermae (Padua, Italy) from 25 to 29 March 2025 (2025Pdm3). The Preliminary Program is included, hoping that you will submit your abstract and the Registration forms by November 15, 2024.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lev G Agasarov, Andrey A Maryanovskiy, Oxana Yu Kirgizova, Tatjana E Belousova, Marina V Bykova, Lilja R Voskanyan, Dmitriy V Fedorov, Andrey V Nefedov, Kirill V Terentev, Irina A Grishechkina
The article summarizes the results of our own scientific and practical research on biopuncture (or pharmacopuncture) - local stimulation of acupuncture points with small doses of drugs or other agents. The "object" of the work was dorsopathies at the lumbosacral level, the choice of which was explained by the widest coverage of the population, the protracted course and the severity of the consequences. In the course of the research, the addition and even potentiation of the reflex and drug links of the method under consideration was noted. In particular, favorable changes in the status of patients observed against the background of biopuncture by complex agents were accompanied by a significant improvement in the results of psychological and electrophysiological examination. In a series of studies on biopuncture with Alflutop, a significant superiority of this approach over the compared methods was manifested, in addition to clinical effects, in structurally-modifying changes in the intervertebral discs. Using the same drug, an original scheme of therapeutic action was proposed, combining the techniques of drug blockade and pharmacopuncture. Special attention should be paid to the fact that the effectiveness of biopuncture is enhanced due to the combined use of modern hardware techniques. In a series of separate studies, the efficacy of biopuncture with essential oils in dorsopathies was confirmed, largely explained by the cumulative effects.
{"title":"The biopuncture in dorsopathy.","authors":"Lev G Agasarov, Andrey A Maryanovskiy, Oxana Yu Kirgizova, Tatjana E Belousova, Marina V Bykova, Lilja R Voskanyan, Dmitriy V Fedorov, Andrey V Nefedov, Kirill V Terentev, Irina A Grishechkina","doi":"10.4081/ejtm.2024.12777","DOIUrl":"10.4081/ejtm.2024.12777","url":null,"abstract":"<p><p>The article summarizes the results of our own scientific and practical research on biopuncture (or pharmacopuncture) - local stimulation of acupuncture points with small doses of drugs or other agents. The \"object\" of the work was dorsopathies at the lumbosacral level, the choice of which was explained by the widest coverage of the population, the protracted course and the severity of the consequences. In the course of the research, the addition and even potentiation of the reflex and drug links of the method under consideration was noted. In particular, favorable changes in the status of patients observed against the background of biopuncture by complex agents were accompanied by a significant improvement in the results of psychological and electrophysiological examination. In a series of studies on biopuncture with Alflutop, a significant superiority of this approach over the compared methods was manifested, in addition to clinical effects, in structurally-modifying changes in the intervertebral discs. Using the same drug, an original scheme of therapeutic action was proposed, combining the techniques of drug blockade and pharmacopuncture. Special attention should be paid to the fact that the effectiveness of biopuncture is enhanced due to the combined use of modern hardware techniques. In a series of separate studies, the efficacy of biopuncture with essential oils in dorsopathies was confirmed, largely explained by the cumulative effects.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade De Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto
There has been an increasing interest among CrossFit® coaches and practitioners in identifying indicators of sport performance. This study aimed to examine the correlation between anthropometric measures, cardiorespiratory capacity, power, local muscle endurance, and total athleticism score, with performance in the CrossFit® Open 2021. Fourteen male volunteers (aged 30.3 ± 5.8 years) participated in the study and underwent a series of tests on separate weeks. These tests included assessments of body fat percentage (subcutaneous adipose thickness measured at seven sites), maximal oxygen consumption (2 km test in rowing ergometer), muscle power (one repetition maximum in power clean), and muscle endurance (Tibana test, which included the conclusion of four distinct rounds of work). These results were used to calculate the total score of athleticism, which was then compared to the participants performance during the CrossFit® Open 2021. The athletes presented an average of body fat (8.6 ± 2.0%), maximal oxygen consumption (53.3 ± 2.4 mL. (kg.min)-1), 2km row time (07:00 ± 00:21 mm:ss), 1-Repetition maximum in power clean (125.2 ± 21.2 kg) and Tibana test performance (281.0 ± 35.9 repetitions). Interestingly, the top five athletes with the highest scores also achieved the highest z-scores in the CrossFit® Open 2021. Conversely, the four athletes with the lowest TSA score had the lowest z-scores in the CrossFit® Open. Moreover, almost perfect correlation (r = 0.91; p<0.01) was found between the total athleticism score and z-scores in the CrossFit® Open 2021. The total score may be a single measure and holistic indication of athleticism level in CrossFit®. Furthermore, coaches can potentially apply this useful tool for monitoring athletic performance and designing training sessions that address specific areas of CrossFit® performance.
{"title":"Exploring the relationship between Total Athleticism score and CrossFit® Open Performance in amateur athletes: single measure involving body fat percentage, aerobic capacity, muscle power and local muscle endurance.","authors":"Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade De Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto","doi":"10.4081/ejtm.2024.12309","DOIUrl":"10.4081/ejtm.2024.12309","url":null,"abstract":"<p><p>There has been an increasing interest among CrossFit® coaches and practitioners in identifying indicators of sport performance. This study aimed to examine the correlation between anthropometric measures, cardiorespiratory capacity, power, local muscle endurance, and total athleticism score, with performance in the CrossFit® Open 2021. Fourteen male volunteers (aged 30.3 ± 5.8 years) participated in the study and underwent a series of tests on separate weeks. These tests included assessments of body fat percentage (subcutaneous adipose thickness measured at seven sites), maximal oxygen consumption (2 km test in rowing ergometer), muscle power (one repetition maximum in power clean), and muscle endurance (Tibana test, which included the conclusion of four distinct rounds of work). These results were used to calculate the total score of athleticism, which was then compared to the participants performance during the CrossFit® Open 2021. The athletes presented an average of body fat (8.6 ± 2.0%), maximal oxygen consumption (53.3 ± 2.4 mL. (kg.min)-1), 2km row time (07:00 ± 00:21 mm:ss), 1-Repetition maximum in power clean (125.2 ± 21.2 kg) and Tibana test performance (281.0 ± 35.9 repetitions). Interestingly, the top five athletes with the highest scores also achieved the highest z-scores in the CrossFit® Open 2021. Conversely, the four athletes with the lowest TSA score had the lowest z-scores in the CrossFit® Open. Moreover, almost perfect correlation (r = 0.91; p<0.01) was found between the total athleticism score and z-scores in the CrossFit® Open 2021. The total score may be a single measure and holistic indication of athleticism level in CrossFit®. Furthermore, coaches can potentially apply this useful tool for monitoring athletic performance and designing training sessions that address specific areas of CrossFit® performance.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osteoarthritis (OA) is a disabling disease that causes pain and functional limitation. OA symptoms can be treated with intra-articular injections of anti-inflammatory, viscosupplementary, or viscoinductive products. Non-responders to these approaches have limited options, often surgical (e.g. knee replacement). This retrospective study aims to evaluate the efficacy of a single injection of Carboxymethyl-Chitosan for advanced (Kellgren-Lawrence ≥3) and symptomatic knee OA in non-responders to hyaluronic acid. We enrolled 10 patients (5 female, 5 male). Treatment efficacy was assessed through the Visual Analogue Scale (VAS, pain) and the Knee Injury and Osteoarthritis Outcome Score (KOOS, knee function). Data are acquired from rating scales were administered at the time of injection (T0), one month (T1), three months (T2), and six months (T3) after treatment as for clinical practice. Results showed a significant improvement in pain and function at T1, with a subsequent gradual resumption of symptoms. In conclusion, the treatment showed a better outcome in the short term (i.e. up to 1 month after treatment); however, raw values of VAS and KOOS did not return to baseline levels showing a maintenance of improvement albeit not statistically significant.
骨关节炎(OA)是一种致残性疾病,会导致疼痛和功能受限。治疗 OA 症状的方法有关节内注射消炎药、粘液补充剂或粘液诱导剂。对这些方法无反应者的选择有限,通常采用外科手术(如膝关节置换术)。这项回顾性研究旨在评估单次注射羧甲基壳聚糖对透明质酸无应答的晚期(Kellgren-Lawrence ≥3)和无症状膝关节 OA 的疗效。我们共招募了 10 名患者(5 名女性,5 名男性)。治疗效果通过视觉模拟量表(VAS,疼痛)和膝关节损伤与骨关节炎结果评分(KOOS,膝关节功能)进行评估。数据来自注射时(T0)、治疗后一个月(T1)、三个月(T2)和六个月(T3)的评分表,与临床实践一致。结果显示,T1 时疼痛和功能明显改善,随后症状逐渐恢复。总之,治疗在短期内(即治疗后 1 个月内)取得了较好的疗效;然而,VAS 和 KOOS 的原始值并未恢复到基线水平,这表明尽管没有统计学意义,但仍有改善。
{"title":"Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study.","authors":"Nicola Manocchio, Concetta Ljoka, Nicolò Piacentini, Roberto Sorge, Giulia Vita, Calogero Foti","doi":"10.4081/ejtm.2024.12413","DOIUrl":"10.4081/ejtm.2024.12413","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a disabling disease that causes pain and functional limitation. OA symptoms can be treated with intra-articular injections of anti-inflammatory, viscosupplementary, or viscoinductive products. Non-responders to these approaches have limited options, often surgical (e.g. knee replacement). This retrospective study aims to evaluate the efficacy of a single injection of Carboxymethyl-Chitosan for advanced (Kellgren-Lawrence ≥3) and symptomatic knee OA in non-responders to hyaluronic acid. We enrolled 10 patients (5 female, 5 male). Treatment efficacy was assessed through the Visual Analogue Scale (VAS, pain) and the Knee Injury and Osteoarthritis Outcome Score (KOOS, knee function). Data are acquired from rating scales were administered at the time of injection (T0), one month (T1), three months (T2), and six months (T3) after treatment as for clinical practice. Results showed a significant improvement in pain and function at T1, with a subsequent gradual resumption of symptoms. In conclusion, the treatment showed a better outcome in the short term (i.e. up to 1 month after treatment); however, raw values of VAS and KOOS did not return to baseline levels showing a maintenance of improvement albeit not statistically significant.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142113292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim of this study is to investigate the safety, efficacy and impact on Health-Related Quality of Life (HRQoL) of Vertebroplasty (VP) and Kyphoplasty (KP) in the management of Osteoporotic Vertebral Compression Fractures (OVCFs) in elderly individuals. VP and KP represent Minimally Invasive Vertebral Augmentation (MIVA) procedures that are increasingly implemented for surgical treatment of OVCFs in recent years. These interventions have been associated with minimal traumatization and intraoperative hemorrhage, considerable analgesic effect and rapid postoperative recovery. Seventy-seven (77) consecutive individuals with OVCFs were subjected to VP/KP and recruited in this prospectively designed non-randomized study. Clinical evaluation was performed preoperatively and postoperatively at particular chronic intervals at 1, 6 weeks and at 3, 6, 12 months and 2 years. Assessment was conducted via the standardized Visual Analogue Scale (VAS) and Short-Form 36 (SF-36) Medical Health Survey Questionnaire for pain and HRQoL, respectively. No perioperative complications were observed. All studied indices were demonstrated to present a statistically significant amelioration following overall analysis. Pain intensity measured by the VAS score was depicted to be significantly reduced during the first 3 months, but continuous improvement of all indices of SF-36 and VAS was demonstrated to reach a plateau at 6 months, featuring no further clinical improvement.VP and KP represent safe and efficient options for interventional treatment of OVCFs in elderly and oldest-old patients, improving self-reported symptoms of pain as well as overall HRQoL.
{"title":"Vertebroplasty and kyphoplasty in the management of osteoporotic vertebral compression fractures in elderly individuals: evaluation of the health-related quality of life.","authors":"Stylianos Kapetanakis, Constantinos Chaniotakis, Periklis Zavridis, Periklis Kopsidas, Sotirios Apostolakis, Nikolaos Gkantsinikoudis","doi":"10.4081/ejtm.2024.12274","DOIUrl":"10.4081/ejtm.2024.12274","url":null,"abstract":"<p><p>Aim of this study is to investigate the safety, efficacy and impact on Health-Related Quality of Life (HRQoL) of Vertebroplasty (VP) and Kyphoplasty (KP) in the management of Osteoporotic Vertebral Compression Fractures (OVCFs) in elderly individuals. VP and KP represent Minimally Invasive Vertebral Augmentation (MIVA) procedures that are increasingly implemented for surgical treatment of OVCFs in recent years. These interventions have been associated with minimal traumatization and intraoperative hemorrhage, considerable analgesic effect and rapid postoperative recovery. Seventy-seven (77) consecutive individuals with OVCFs were subjected to VP/KP and recruited in this prospectively designed non-randomized study. Clinical evaluation was performed preoperatively and postoperatively at particular chronic intervals at 1, 6 weeks and at 3, 6, 12 months and 2 years. Assessment was conducted via the standardized Visual Analogue Scale (VAS) and Short-Form 36 (SF-36) Medical Health Survey Questionnaire for pain and HRQoL, respectively. No perioperative complications were observed. All studied indices were demonstrated to present a statistically significant amelioration following overall analysis. Pain intensity measured by the VAS score was depicted to be significantly reduced during the first 3 months, but continuous improvement of all indices of SF-36 and VAS was demonstrated to reach a plateau at 6 months, featuring no further clinical improvement.VP and KP represent safe and efficient options for interventional treatment of OVCFs in elderly and oldest-old patients, improving self-reported symptoms of pain as well as overall HRQoL.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This is a personal account of one academic scientist who founded two biotechnology companies. Both companies were initially incubated within the walls of the university under a creative student incubator program whereby biology students could pursue their graduate academic degrees while gaining valuable biotechnology experiences. After the companies transitioned out of the university environment, the professor and his students pursued diagnostic and therapeutic drug development resulting in the completion of several clinical trials. The value of international scientific collaborations with colleagues at the University of Padova (Italy) is also described.
{"title":"Making a difference.","authors":"Roger Sabbadini","doi":"10.4081/ejtm.2024.12811","DOIUrl":"10.4081/ejtm.2024.12811","url":null,"abstract":"<p><p>This is a personal account of one academic scientist who founded two biotechnology companies. Both companies were initially incubated within the walls of the university under a creative student incubator program whereby biology students could pursue their graduate academic degrees while gaining valuable biotechnology experiences. After the companies transitioned out of the university environment, the professor and his students pursued diagnostic and therapeutic drug development resulting in the completion of several clinical trials. The value of international scientific collaborations with colleagues at the University of Padova (Italy) is also described.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141894587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohsen Khosravi, Ahoora Kavoosi, Rafat Rezapour-Nasrabad, Melody Omraninava, Alireza Nazari Anamagh, Seyed Teymur Seyedi Asl
Achalasia is a chronic esophageal disorder with a generally favorable prognosis; however, approximately 20% of patients experience persistent or recurrent symptoms despite therapeutic interventions. These ongoing symptoms can significantly diminish both disease-specific and overall quality of life. Although the physical manifestations of achalasia, such as regurgitation, dysphagia, chest pain, and weight loss, are well-documented and assessed using the Eckardt score, the psychological burden of the disease remains underexplored. Individuals with achalasia are at an increased risk of mental health issues, including depression, anxiety, and somatization, exacerbated by the emotional strain and social limitations imposed by the disease. Despite this, psychological impacts are often overlooked in clinical settings, leading to inadequate mental health support for these patients. This article underscores the necessity for prompt psychological assessments during the diagnosis of achalasia to better address these mental health challenges and improve overall patient care.
{"title":"Integrating psychological assessment in achalasia management: addressing mental health to enhance patient outcomes.","authors":"Mohsen Khosravi, Ahoora Kavoosi, Rafat Rezapour-Nasrabad, Melody Omraninava, Alireza Nazari Anamagh, Seyed Teymur Seyedi Asl","doi":"10.4081/ejtm.2024.12727","DOIUrl":"10.4081/ejtm.2024.12727","url":null,"abstract":"<p><p>Achalasia is a chronic esophageal disorder with a generally favorable prognosis; however, approximately 20% of patients experience persistent or recurrent symptoms despite therapeutic interventions. These ongoing symptoms can significantly diminish both disease-specific and overall quality of life. Although the physical manifestations of achalasia, such as regurgitation, dysphagia, chest pain, and weight loss, are well-documented and assessed using the Eckardt score, the psychological burden of the disease remains underexplored. Individuals with achalasia are at an increased risk of mental health issues, including depression, anxiety, and somatization, exacerbated by the emotional strain and social limitations imposed by the disease. Despite this, psychological impacts are often overlooked in clinical settings, leading to inadequate mental health support for these patients. This article underscores the necessity for prompt psychological assessments during the diagnosis of achalasia to better address these mental health challenges and improve overall patient care.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lower limb spasticity and clonus are common sequelae after cerebral stroke. An important part of their etiopathogenesis has been related to the peripheral component of spasticity. Rheological properties of the tissues seem to be involved. Several studies highlighted anatomical and functional changes in the connective structures. The fasciae might be implicated in the pathological process. Thus, this study intends to investigate the effect of the Fascial Manipulation (FM) technique on triceps surae in stroke patients through a clinical randomized controlled trial, to provide a reference for clinical treatment of lower limb spasticity and ankle clonus. A total of 40 patients with post-stroke ankle clonus were selected and divided into a control group and an observation group by random number table method, with 20 cases in each group. Both groups received conventional rehabilitation therapy, while the FM group received Fascial Manipulation based on conventional rehabilitation therapy. Before the first treatment and after 3 weeks of treatment, the Comprehensive Spasticity Scale (CSS), the Passive Range Of Motion (PROM), the simplified Fugl-Meyer motor function score (FMA), and the Modified Ashworth Scale (MAS) were used to assess the degree of ankle clonus, ankle passive range of motion, and lower limb motor function of the two groups of patients. Before treatment, there was no statistically significant difference between the control group and the FM group in terms of CSS, PROM, FMA, and MAS of the affected lower limbs (P>0.05). After 3 weeks of treatment, the CSS and MAS of the affected lower limbs in the control group and FM group decreased, while PROM and FMA increased compared to pre-treatment evaluation, with statistically significant differences (P<0.05). Moreover, the FM group showed a statistically significant decrease in CSS and MAS, as well as an increase in PROM and FMA, compared to the control group (P<0.05). Conclusions: Fascial manipulation in addition to conventional therapy can effectively reduce spasticity and ankle clonus in stroke patients in a short time, and improve the passive range of motion of the ankle joint and the function of lower limbs.
下肢痉挛和阵挛是脑中风后常见的后遗症。其发病机制的一个重要部分与痉挛的外周成分有关。组织的流变特性似乎与此有关。一些研究强调了结缔结构的解剖和功能变化。筋膜可能与病理过程有关。因此,本研究拟通过临床随机对照试验,探讨筋膜手法(FM)对中风患者肱三头肌的影响,为下肢痉挛和踝关节挛缩的临床治疗提供参考。研究共选取 40 例脑卒中后踝关节痉挛患者,采用随机数字表法分为对照组和观察组,每组 20 例。两组均接受常规康复治疗,而调频组在常规康复治疗的基础上接受筋膜手法治疗。在首次治疗前和治疗 3 周后,采用痉挛综合量表(CSS)、被动活动范围(PROM)、简化 Fugl-Meyer 运动功能评分(FMA)和改良 Ashworth 量表(MAS)评估两组患者的踝关节挛缩程度、踝关节被动活动范围和下肢运动功能。治疗前,对照组和 FM 组患者患侧下肢的 CSS、PROM、FMA 和 MAS 均无统计学差异(P>0.05)。治疗 3 周后,与治疗前相比,对照组和 FM 组受累下肢的 CSS 和 MAS 有所下降,而 PROM 和 FMA 有所上升,差异有统计学意义(P
{"title":"The effect of fascial manipulation therapy on lower limb spasticity and ankle clonus in stroke patients.","authors":"Wenyan Li, Xin Liu, Yinghua Wen, Junying Wu, Federico Giordani, Carla Stecco","doi":"10.4081/ejtm.2024.12172","DOIUrl":"10.4081/ejtm.2024.12172","url":null,"abstract":"<p><p>Lower limb spasticity and clonus are common sequelae after cerebral stroke. An important part of their etiopathogenesis has been related to the peripheral component of spasticity. Rheological properties of the tissues seem to be involved. Several studies highlighted anatomical and functional changes in the connective structures. The fasciae might be implicated in the pathological process. Thus, this study intends to investigate the effect of the Fascial Manipulation (FM) technique on triceps surae in stroke patients through a clinical randomized controlled trial, to provide a reference for clinical treatment of lower limb spasticity and ankle clonus. A total of 40 patients with post-stroke ankle clonus were selected and divided into a control group and an observation group by random number table method, with 20 cases in each group. Both groups received conventional rehabilitation therapy, while the FM group received Fascial Manipulation based on conventional rehabilitation therapy. Before the first treatment and after 3 weeks of treatment, the Comprehensive Spasticity Scale (CSS), the Passive Range Of Motion (PROM), the simplified Fugl-Meyer motor function score (FMA), and the Modified Ashworth Scale (MAS) were used to assess the degree of ankle clonus, ankle passive range of motion, and lower limb motor function of the two groups of patients. Before treatment, there was no statistically significant difference between the control group and the FM group in terms of CSS, PROM, FMA, and MAS of the affected lower limbs (P>0.05). After 3 weeks of treatment, the CSS and MAS of the affected lower limbs in the control group and FM group decreased, while PROM and FMA increased compared to pre-treatment evaluation, with statistically significant differences (P<0.05). Moreover, the FM group showed a statistically significant decrease in CSS and MAS, as well as an increase in PROM and FMA, compared to the control group (P<0.05). Conclusions: Fascial manipulation in addition to conventional therapy can effectively reduce spasticity and ankle clonus in stroke patients in a short time, and improve the passive range of motion of the ankle joint and the function of lower limbs.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141493931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ester Tommasini, Sara Missaglia, Paola Vago, Christel Galvani, Claudio Pecci, Ermanno Rampinini, Andrea Bosio, Andrea Morelli, Andrea Bonanomi, Andrea Silvestrini, Alvaro Mordente, Daniela Tavian
This study aimed to analyze the acute impact of exercise on serum irisin levels in 22 young (YA, 24.6 ± 3.5 yrs) and in 12 middle-aged male adults (MA, 54.6 ± 5.7 yrs) 15 min and 24 h after an incremental cycling exercise test to exhaustion. ELISA assay was used for serum irisin detection. Circulating irisin increased significantly from baseline (9.0 ± 2.0 ng/ml) to 15 min post-exercise (10.2 ± 2.0 ng/ml, P < 0.001), but the greatest increment was detected after 24 h (13.5 ± 2.5 ng/ml, P < 0.001) reaching more than 50% of the basal release. Levels were significantly higher in YA (9.7 ± 1.7 to 11.1 ± 1.8 to 14.5 ± 2.2 ng/ml) than MA (7.6 ± 1.6 to 8.7 ± 1.5 to 11.8± 2.2 ng/ml) for all measured time-points (P < 0.05). Nevertheless, MA showed a comparable increase in serum irisin levels when compared to YA. These findings highlight the importance of acute physical exercise as a countermeasure against age-related deterioration of skeletal muscle mass and function in both YA and MA.
{"title":"The time course of irisin release after an acute exercise: relevant implications for health and future experimental designs.","authors":"Ester Tommasini, Sara Missaglia, Paola Vago, Christel Galvani, Claudio Pecci, Ermanno Rampinini, Andrea Bosio, Andrea Morelli, Andrea Bonanomi, Andrea Silvestrini, Alvaro Mordente, Daniela Tavian","doi":"10.4081/ejtm.2024.12693","DOIUrl":"10.4081/ejtm.2024.12693","url":null,"abstract":"<p><p>This study aimed to analyze the acute impact of exercise on serum irisin levels in 22 young (YA, 24.6 ± 3.5 yrs) and in 12 middle-aged male adults (MA, 54.6 ± 5.7 yrs) 15 min and 24 h after an incremental cycling exercise test to exhaustion. ELISA assay was used for serum irisin detection. Circulating irisin increased significantly from baseline (9.0 ± 2.0 ng/ml) to 15 min post-exercise (10.2 ± 2.0 ng/ml, P < 0.001), but the greatest increment was detected after 24 h (13.5 ± 2.5 ng/ml, P < 0.001) reaching more than 50% of the basal release. Levels were significantly higher in YA (9.7 ± 1.7 to 11.1 ± 1.8 to 14.5 ± 2.2 ng/ml) than MA (7.6 ± 1.6 to 8.7 ± 1.5 to 11.8± 2.2 ng/ml) for all measured time-points (P < 0.05). Nevertheless, MA showed a comparable increase in serum irisin levels when compared to YA. These findings highlight the importance of acute physical exercise as a countermeasure against age-related deterioration of skeletal muscle mass and function in both YA and MA.</p>","PeriodicalId":46459,"journal":{"name":"European Journal of Translational Myology","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11264220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141471505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}