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Prevalence of latent autoimmune diabetes in adults and insulin resistance: a systematic review and meta-analysis. 成人潜在自身免疫性糖尿病的患病率与胰岛素抵抗:系统回顾与荟萃分析。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-28 DOI: 10.4081/ejtm.2024.12694
Malihe Mohammadi

Latent autoimmune diabetes in adults is a form of diabetes that progresses slowly and is controlled by diet and oral glucose-lowering medications before insulin is required. The aim of the present study was to evaluate the prevalence of latent autoimmune diabetes in adults. The present study was conducted based on PRISMA 2020-27-item checklist. To find the studies conducted in line with the purpose of the study, PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase databases and Google Scholar search engine were reviewed from 2013 to August 2023. Meta-analysis was performed using effect size with 95% confidence interval. Data analysis was done using STATA/MP. v17 software. The present study was carried out based on the PRISMA 2020 27-point checklist. To find out which studies were carried out in accordance with the purpose of the study, from 2013 to August, the databases PubMed, Web of Science, Scopus, Science Direct, Web of Knowledge, EBSCO, Wiley, ISI, Elsevier, Embase and the search engine Google Scholar reviewed 2023. Meta-analysis was performed using effect size with 95% confidence interval. Data analysis was carried out using STATA/MP. v17 software. The overall prevalence of Latent autoimmune diabetes of adults was found to be 7% (95%CI 0-20). Subgroup analysis of Latent autoimmune diabetes of adults in the context of geographic regions showed a higher prevalence in North America (15%) and South East Asia (5%). Since the identification of Latent autoimmune diabetes of adult patients with other forms of diabetes is misdiagnosed due to the combination of phenotypic features with T1D and T2D, studying its prevalence is of great importance.

成人潜伏性自身免疫性糖尿病是一种进展缓慢的糖尿病,在需要使用胰岛素之前,可通过饮食和口服降糖药物控制病情。本研究旨在评估成人潜伏性自身免疫性糖尿病的患病率。本研究根据 PRISMA 2020-27 条目清单进行。为了找到与本研究目的相符的研究,我们查阅了 2013 年至 2023 年 8 月期间的 PubMed、Web of Science、Scopus、Science Direct、Web of Knowledge、EBSCO、Wiley、ISI、Elsevier、Embase 数据库和 Google Scholar 搜索引擎。使用效应大小和 95% 置信区间进行元分析。数据分析使用 STATA/MP.本研究根据 PRISMA 2020 27 点清单进行。为找出符合研究目的的研究,从 2013 年 8 月起,PubMed、Web of Science、Scopus、Science Direct、Web of Knowledge、EBSCO、Wiley、ISI、Elsevier、Embase 和搜索引擎 Google Scholar 等数据库对 2023 项研究进行了审查。使用效应大小和 95% 的置信区间进行了 Meta 分析。数据分析使用 STATA/MP.发现成人潜伏性自身免疫性糖尿病的总体患病率为 7%(95%CI 0-20)。根据地理区域对成人潜伏性自身免疫性糖尿病进行的分组分析表明,北美(15%)和东南亚(5%)的发病率较高。由于合并有 T1D 和 T2D 的表型特征,成人潜伏自身免疫性糖尿病患者会被误诊为其他形式的糖尿病,因此研究其患病率非常重要。
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引用次数: 0
Invitations to join a new 2024 section of Ejtm and the 2025 Pdm3 from 25 to 29 March, Euganean Thermae, Padua, Italy. 邀请参加 3 月 25-29 日在意大利帕多瓦 Euganean Thermae 举行的新的 2024 年 Ejtm 会议和 2025 年 Pdm3 会议。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-28 DOI: 10.4081/ejtm.2024.12970
Ugo Carraro

This issue of the European Journal of Translational Myology (Ejtm) 34 (3) 2024 opens with a historic article by Roger Sabbadini, who recalls his years spent as a guest scientist at the Institute of General Pathology of the University of Padua, Italy and the many years spent valorising a fortuitous observation made in collaboration with the scientific group of Professor Giovanni Salviati, University of Padua, Italy. A further side effect of those years is the decision I recently made to add a new Section to the Ejtm Editorial board, namely: Myokines, Bioactive lipids, Adipokines, RNAkines (ncRNAs), Antonio Musarò, Roger Sabbadini, and Daniela Tavian, Editors. Readers are therefore warmly invited to contribute typescripts to this section. I am confident that young readers will be motivated to test preliminary in vitro and in vivo options for drug development, especially for the bioactive lipids. Furthermore, it is time to send your presentation proposals and registration/accommodation forms to participate in the International Meeting: Padua Days on Muscle and Mobility Medicine, which will be held at the Hotel Petrarca of the Euganean Thermae (Padua, Italy) from 25 to 29 March 2025 (2025Pdm3). The Preliminary Program is included, hoping that you will submit your abstract and the Registration forms by November 15, 2024.

本期《欧洲转化肌病学杂志》(Ejtm)第 34 (3) 2024 期以罗杰-萨巴迪尼(Roger Sabbadini)的一篇历史性文章开篇,他回顾了自己在意大利帕多瓦大学普通病理学研究所(Institute of General Pathology)担任客座科学家的岁月,以及与意大利帕多瓦大学乔瓦尼-萨尔维亚蒂(Giovanni Salviati)教授的科研小组合作进行偶然观察的多年经历。这些年的另一个副作用是,我最近决定在 Ejtm 编辑委员会中增设一个新栏目,即 "肌动蛋白、生物活性脂质":安东尼奥-穆萨罗(Antonio Musarò)、罗杰-萨巴迪尼(Roger Sabbadini)和丹妮拉-塔维安(Daniela Tavian)担任编辑。因此,我们热忱邀请读者为这一部分提供排版稿。我相信,年轻的读者们一定会积极测试药物开发的体外和体内初步方案,尤其是生物活性脂质。此外,现在是寄送您的演讲提案和参加国际会议的注册/住宿表格的时候了:帕多瓦肌肉与运动医学日 "国际会议将于 2025 年 3 月 25-29 日在意大利帕多瓦的 Euganean Thermae Petrarca 酒店举行(2025Pdm3)。初步日程已包含在内,希望您在 2024 年 11 月 15 日之前提交摘要和注册表。
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引用次数: 0
The biopuncture in dorsopathy. 背痛的生物针刺疗法。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-23 DOI: 10.4081/ejtm.2024.12777
Lev G Agasarov, Andrey A Maryanovskiy, Oxana Yu Kirgizova, Tatjana E Belousova, Marina V Bykova, Lilja R Voskanyan, Dmitriy V Fedorov, Andrey V Nefedov, Kirill V Terentev, Irina A Grishechkina

The article summarizes the results of our own scientific and practical research on biopuncture (or pharmacopuncture) - local stimulation of acupuncture points with small doses of drugs or other agents. The "object" of the work was dorsopathies at the lumbosacral level, the choice of which was explained by the widest coverage of the population, the protracted course and the severity of the consequences. In the course of the research, the addition and even potentiation of the reflex and drug links of the method under consideration was noted. In particular, favorable changes in the status of patients observed against the background of biopuncture by complex agents were accompanied by a significant improvement in the results of psychological and electrophysiological examination. In a series of studies on biopuncture with Alflutop, a significant superiority of this approach over the compared methods was manifested, in addition to clinical effects, in structurally-modifying changes in the intervertebral discs. Using the same drug, an original scheme of therapeutic action was proposed, combining the techniques of drug blockade and pharmacopuncture. Special attention should be paid to the fact that the effectiveness of biopuncture is enhanced due to the combined use of modern hardware techniques. In a series of separate studies, the efficacy of biopuncture with essential oils in dorsopathies was confirmed, largely explained by the cumulative effects.

文章总结了我们自己对生物针刺(或药物针刺)--用小剂量药物或其他制剂对穴位进行局部刺激--的科学和实践研究成果。这项工作的 "对象 "是腰骶部背痛,之所以选择这一病症,是因为其覆盖人群广、病程长、后果严重。在研究过程中,我们注意到所采用方法的反射和药物联系的增加甚至增强。特别是,在使用复合制剂进行生物穿刺的背景下,患者的状态发生了有利的变化,同时心理和电生理检查的结果也得到了显著改善。在一系列关于使用阿氟托普(Alflutop)进行生物穿刺的研究中,除临床效果外,这种方法在改变椎间盘结构方面也明显优于其他方法。通过使用同一种药物,结合药物阻滞和药物穿刺技术,提出了一种新颖的治疗方案。需要特别注意的是,由于结合使用了现代硬件技术,生物穿刺的有效性得到了提高。在一系列单独的研究中,使用精油进行生物针刺对背痛的疗效得到了证实,这在很大程度上归因于累积效应。
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引用次数: 0
Exploring the relationship between Total Athleticism score and CrossFit® Open Performance in amateur athletes: single measure involving body fat percentage, aerobic capacity, muscle power and local muscle endurance. 探索业余运动员总运动能力得分与 CrossFit® 公开赛成绩之间的关系:涉及体脂率、有氧能力、肌肉力量和局部肌肉耐力的单一测量。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-23 DOI: 10.4081/ejtm.2024.12309
Ramires Alsamir Tibana, Fábio Hech Dominski, Alexandro Andrade, Nuno Manuel Frade De Sousa, Fabricio Azevedo Voltarelli, Ivo Vieira de Sousa Neto

There has been an increasing interest among CrossFit® coaches and practitioners in identifying indicators of sport performance. This study aimed to examine the correlation between anthropometric measures, cardiorespiratory capacity, power, local muscle endurance, and total athleticism score, with performance in the CrossFit® Open 2021. Fourteen male volunteers (aged 30.3 ± 5.8 years) participated in the study and underwent a series of tests on separate weeks. These tests included assessments of body fat percentage (subcutaneous adipose thickness measured at seven sites), maximal oxygen consumption (2 km test in rowing ergometer), muscle power (one repetition maximum in power clean), and muscle endurance (Tibana test, which included the conclusion of four distinct rounds of work). These results were used to calculate the total score of athleticism, which was then compared to the participants performance during the CrossFit® Open 2021. The athletes presented an average of body fat (8.6 ± 2.0%), maximal oxygen consumption (53.3 ± 2.4 mL. (kg.min)-1), 2km row time (07:00 ± 00:21 mm:ss), 1-Repetition maximum in power clean (125.2 ± 21.2 kg) and Tibana test performance (281.0 ± 35.9 repetitions). Interestingly, the top five athletes with the highest scores also achieved the highest z-scores in the CrossFit® Open 2021. Conversely, the four athletes with the lowest TSA score had the lowest z-scores in the CrossFit® Open. Moreover, almost perfect correlation (r = 0.91; p<0.01) was found between the total athleticism score and z-scores in the CrossFit® Open 2021. The total score may be a single measure and holistic indication of athleticism level in CrossFit®. Furthermore, coaches can potentially apply this useful tool for monitoring athletic performance and designing training sessions that address specific areas of CrossFit® performance.

CrossFit® 教练和从业人员对确定运动成绩指标的兴趣与日俱增。本研究旨在探讨人体测量指标、心肺能力、力量、局部肌肉耐力和运动能力总分与 2021 年 CrossFit® 公开赛成绩之间的相关性。14 名男性志愿者(年龄为 30.3 ± 5.8 岁)参加了这项研究,并在不同的星期接受了一系列测试。这些测试包括身体脂肪百分比(在七个部位测量皮下脂肪厚度)、最大耗氧量(划船测力计 2 公里测试)、肌肉力量(力量清扫一次重复最大值)和肌肉耐力(蒂巴纳测试,包括完成四轮不同的工作)的评估。这些结果被用来计算运动能力总分,然后与参赛者在 2021 年 CrossFit® 公开赛中的表现进行比较。运动员的平均体脂率(8.6 ± 2.0%)、最大耗氧量(53.3 ± 2.4 mL.(kg.min)、2 公里划船时间(07:00 ± 00:21 mm:ss)、1 次重复最大力量清扫(125.2 ± 21.2 kg)和 Tibana 测试成绩(281.0 ± 35.9 次重复)。有趣的是,得分最高的前五名运动员在 CrossFit® 2021 年公开赛中也取得了最高的 Z 值。相反,TSA 得分最低的四名运动员在 CrossFit® 公开赛中的 z 值也最低。此外,几乎完美的相关性(r = 0.91; p
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引用次数: 0
Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study. 对透明质酸无反应的膝关节骨关节炎患者进行羧甲基壳聚糖关节内注射:一项试点研究。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-22 DOI: 10.4081/ejtm.2024.12413
Nicola Manocchio, Concetta Ljoka, Nicolò Piacentini, Roberto Sorge, Giulia Vita, Calogero Foti

Osteoarthritis (OA) is a disabling disease that causes pain and functional limitation. OA symptoms can be treated with intra-articular injections of anti-inflammatory, viscosupplementary, or viscoinductive products. Non-responders to these approaches have limited options, often surgical (e.g. knee replacement). This retrospective study aims to evaluate the efficacy of a single injection of Carboxymethyl-Chitosan for advanced (Kellgren-Lawrence ≥3) and symptomatic knee OA in non-responders to hyaluronic acid. We enrolled 10 patients (5 female, 5 male). Treatment efficacy was assessed through the Visual Analogue Scale (VAS, pain) and the Knee Injury and Osteoarthritis Outcome Score (KOOS, knee function). Data are acquired from rating scales were administered at the time of injection (T0), one month (T1), three months (T2), and six months (T3) after treatment as for clinical practice. Results showed a significant improvement in pain and function at T1, with a subsequent gradual resumption of symptoms. In conclusion, the treatment showed a better outcome in the short term (i.e. up to 1 month after treatment); however, raw values of VAS and KOOS did not return to baseline levels showing a maintenance of improvement albeit not statistically significant.

骨关节炎(OA)是一种致残性疾病,会导致疼痛和功能受限。治疗 OA 症状的方法有关节内注射消炎药、粘液补充剂或粘液诱导剂。对这些方法无反应者的选择有限,通常采用外科手术(如膝关节置换术)。这项回顾性研究旨在评估单次注射羧甲基壳聚糖对透明质酸无应答的晚期(Kellgren-Lawrence ≥3)和无症状膝关节 OA 的疗效。我们共招募了 10 名患者(5 名女性,5 名男性)。治疗效果通过视觉模拟量表(VAS,疼痛)和膝关节损伤与骨关节炎结果评分(KOOS,膝关节功能)进行评估。数据来自注射时(T0)、治疗后一个月(T1)、三个月(T2)和六个月(T3)的评分表,与临床实践一致。结果显示,T1 时疼痛和功能明显改善,随后症状逐渐恢复。总之,治疗在短期内(即治疗后 1 个月内)取得了较好的疗效;然而,VAS 和 KOOS 的原始值并未恢复到基线水平,这表明尽管没有统计学意义,但仍有改善。
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引用次数: 0
Vertebroplasty and kyphoplasty in the management of osteoporotic vertebral compression fractures in elderly individuals: evaluation of the health-related quality of life. 椎体成形术和椎体后凸成形术在治疗老年人骨质疏松性椎体压缩骨折中的应用:健康相关生活质量评估。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-08 DOI: 10.4081/ejtm.2024.12274
Stylianos Kapetanakis, Constantinos Chaniotakis, Periklis Zavridis, Periklis Kopsidas, Sotirios Apostolakis, Nikolaos Gkantsinikoudis

Aim of this study is to investigate the safety, efficacy and impact on Health-Related Quality of Life (HRQoL) of Vertebroplasty (VP) and Kyphoplasty (KP) in the management of Osteoporotic Vertebral Compression Fractures (OVCFs) in elderly individuals. VP and KP represent Minimally Invasive Vertebral Augmentation (MIVA) procedures that are increasingly implemented for surgical treatment of OVCFs in recent years. These interventions have been associated with minimal traumatization and intraoperative hemorrhage, considerable analgesic effect and rapid postoperative recovery. Seventy-seven (77) consecutive individuals with OVCFs were subjected to VP/KP and recruited in this prospectively designed non-randomized study. Clinical evaluation was performed preoperatively and postoperatively at particular chronic intervals at 1, 6 weeks and at 3, 6, 12 months and 2 years. Assessment was conducted via the standardized Visual Analogue Scale (VAS) and Short-Form 36 (SF-36) Medical Health Survey Questionnaire for pain and HRQoL, respectively. No perioperative complications were observed. All studied indices were demonstrated to present a statistically significant amelioration following overall analysis. Pain intensity measured by the VAS score was depicted to be significantly reduced during the first 3 months, but continuous improvement of all indices of SF-36 and VAS was demonstrated to reach a plateau at 6 months, featuring no further clinical improvement.VP and KP represent safe and efficient options for interventional treatment of OVCFs in elderly and oldest-old patients, improving self-reported symptoms of pain as well as overall HRQoL.

本研究旨在探讨椎体成形术(VP)和椎体后凸成形术(KP)在治疗老年人骨质疏松性椎体压缩性骨折(OVCFs)中的安全性、有效性以及对健康相关生活质量(HRQoL)的影响。椎体成形术(VP)和椎体成形术(KP)是微创椎体增强术(MIVA)的代表,近年来越来越多地用于 OVCF 的手术治疗。这些手术创伤小、术中出血少、镇痛效果显著、术后恢复快。在这项前瞻性设计的非随机研究中,有 77 名连续的 OVCF 患者接受了 VP/KP 治疗。术前和术后分别在 1 周、6 周、3 个月、6 个月、12 个月和 2 年的特定慢性间隔期进行了临床评估。通过标准化的视觉模拟量表(VAS)和短表 36(SF-36)医学健康调查问卷分别对疼痛和 HRQoL 进行评估。未发现围手术期并发症。经总体分析,所有研究指标均显示出统计学意义上的显著改善。VP和KP是老年患者和高龄患者进行OVCF介入治疗的安全有效的选择,可改善自述的疼痛症状以及整体的HRQoL。
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引用次数: 0
Making a difference. 有所作为。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-08-01 DOI: 10.4081/ejtm.2024.12811
Roger Sabbadini

This is a personal account of one academic scientist who founded two biotechnology companies. Both companies were initially incubated within the walls of the university under a creative student incubator program whereby biology students could pursue their graduate academic degrees while gaining valuable biotechnology experiences. After the companies transitioned out of the university environment, the professor and his students pursued diagnostic and therapeutic drug development resulting in the completion of several clinical trials. The value of international scientific collaborations with colleagues at the University of Padova (Italy) is also described.

这是一位学术科学家创办两家生物技术公司的亲身经历。这两家公司最初都是在大学内通过一项创意学生孵化器计划孵化出来的,生物学专业的学生可以通过这项计划在攻读研究生学位的同时获得宝贵的生物技术经验。公司脱离大学环境后,教授和他的学生们致力于诊断和治疗药物的开发,并完成了多项临床试验。此外,还介绍了与帕多瓦大学(意大利)同事开展国际科学合作的价值。
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引用次数: 0
Integrating psychological assessment in achalasia management: addressing mental health to enhance patient outcomes. 在贲门失弛缓症治疗中整合心理评估:解决心理健康问题,提高患者疗效。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-07-22 DOI: 10.4081/ejtm.2024.12727
Mohsen Khosravi, Ahoora Kavoosi, Rafat Rezapour-Nasrabad, Melody Omraninava, Alireza Nazari Anamagh, Seyed Teymur Seyedi Asl

Achalasia is a chronic esophageal disorder with a generally favorable prognosis; however, approximately 20% of patients experience persistent or recurrent symptoms despite therapeutic interventions. These ongoing symptoms can significantly diminish both disease-specific and overall quality of life. Although the physical manifestations of achalasia, such as regurgitation, dysphagia, chest pain, and weight loss, are well-documented and assessed using the Eckardt score, the psychological burden of the disease remains underexplored. Individuals with achalasia are at an increased risk of mental health issues, including depression, anxiety, and somatization, exacerbated by the emotional strain and social limitations imposed by the disease. Despite this, psychological impacts are often overlooked in clinical settings, leading to inadequate mental health support for these patients. This article underscores the necessity for prompt psychological assessments during the diagnosis of achalasia to better address these mental health challenges and improve overall patient care.

Achalasia 是一种慢性食道疾病,预后一般较好;然而,约有 20% 的患者在接受治疗干预后仍会出现持续或反复发作的症状。这些持续的症状会大大降低患者的生活质量和整体生活质量。尽管贲门失弛缓症的生理表现(如反胃、吞咽困难、胸痛和体重减轻)已被详细记录并使用 Eckardt 评分进行评估,但该疾病的心理负担仍未得到充分探讨。贲门失弛缓症患者出现心理健康问题(包括抑郁、焦虑和躯体化)的风险增加,而疾病带来的情感压力和社交限制又加剧了这种风险。尽管如此,在临床环境中心理影响往往被忽视,导致对这些患者的心理健康支持不足。本文强调了在诊断贲门失弛缓症时及时进行心理评估的必要性,以更好地应对这些心理健康挑战,改善对患者的整体护理。
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引用次数: 0
The effect of fascial manipulation therapy on lower limb spasticity and ankle clonus in stroke patients. 筋膜手法疗法对中风患者下肢痉挛和踝关节挛缩的影响。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-07-03 DOI: 10.4081/ejtm.2024.12172
Wenyan Li, Xin Liu, Yinghua Wen, Junying Wu, Federico Giordani, Carla Stecco

Lower limb spasticity and clonus are common sequelae after cerebral stroke. An important part of their etiopathogenesis has been related to the peripheral component of spasticity. Rheological properties of the tissues seem to be involved. Several studies highlighted anatomical and functional changes in the connective structures. The fasciae might be implicated in the pathological process. Thus, this study intends to investigate the effect of the Fascial Manipulation (FM) technique on triceps surae in stroke patients through a clinical randomized controlled trial, to provide a reference for clinical treatment of lower limb spasticity and ankle clonus. A total of 40 patients with post-stroke ankle clonus were selected and divided into a control group and an observation group by random number table method, with 20 cases in each group. Both groups received conventional rehabilitation therapy, while the FM group received Fascial Manipulation based on conventional rehabilitation therapy. Before the first treatment and after 3 weeks of treatment, the Comprehensive Spasticity Scale (CSS), the Passive Range Of Motion (PROM), the simplified Fugl-Meyer motor function score (FMA), and the Modified Ashworth Scale (MAS) were used to assess the degree of ankle clonus, ankle passive range of motion, and lower limb motor function of the two groups of patients. Before treatment, there was no statistically significant difference between the control group and the FM group in terms of CSS, PROM, FMA, and MAS of the affected lower limbs (P>0.05). After 3 weeks of treatment, the CSS and MAS of the affected lower limbs in the control group and FM group decreased, while PROM and FMA increased compared to pre-treatment evaluation, with statistically significant differences (P<0.05). Moreover, the FM group showed a statistically significant decrease in CSS and MAS, as well as an increase in PROM and FMA, compared to the control group (P<0.05). Conclusions: Fascial manipulation in addition to conventional therapy can effectively reduce spasticity and ankle clonus in stroke patients in a short time, and improve the passive range of motion of the ankle joint and the function of lower limbs.

下肢痉挛和阵挛是脑中风后常见的后遗症。其发病机制的一个重要部分与痉挛的外周成分有关。组织的流变特性似乎与此有关。一些研究强调了结缔结构的解剖和功能变化。筋膜可能与病理过程有关。因此,本研究拟通过临床随机对照试验,探讨筋膜手法(FM)对中风患者肱三头肌的影响,为下肢痉挛和踝关节挛缩的临床治疗提供参考。研究共选取 40 例脑卒中后踝关节痉挛患者,采用随机数字表法分为对照组和观察组,每组 20 例。两组均接受常规康复治疗,而调频组在常规康复治疗的基础上接受筋膜手法治疗。在首次治疗前和治疗 3 周后,采用痉挛综合量表(CSS)、被动活动范围(PROM)、简化 Fugl-Meyer 运动功能评分(FMA)和改良 Ashworth 量表(MAS)评估两组患者的踝关节挛缩程度、踝关节被动活动范围和下肢运动功能。治疗前,对照组和 FM 组患者患侧下肢的 CSS、PROM、FMA 和 MAS 均无统计学差异(P>0.05)。治疗 3 周后,与治疗前相比,对照组和 FM 组受累下肢的 CSS 和 MAS 有所下降,而 PROM 和 FMA 有所上升,差异有统计学意义(P
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引用次数: 0
The time course of irisin release after an acute exercise: relevant implications for health and future experimental designs. 急性运动后鸢尾素释放的时间过程:对健康和未来实验设计的相关影响。
IF 1.8 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-07-01 DOI: 10.4081/ejtm.2024.12693
Ester Tommasini, Sara Missaglia, Paola Vago, Christel Galvani, Claudio Pecci, Ermanno Rampinini, Andrea Bosio, Andrea Morelli, Andrea Bonanomi, Andrea Silvestrini, Alvaro Mordente, Daniela Tavian

This study aimed to analyze the acute impact of exercise on serum irisin levels in 22 young (YA, 24.6 ± 3.5 yrs) and in 12 middle-aged male adults (MA, 54.6 ± 5.7 yrs) 15 min and 24 h after an incremental cycling exercise test to exhaustion. ELISA assay was used for serum irisin detection. Circulating irisin increased significantly from baseline (9.0 ± 2.0 ng/ml) to 15 min post-exercise (10.2 ± 2.0 ng/ml, P < 0.001), but the greatest increment was detected after 24 h (13.5 ± 2.5 ng/ml, P < 0.001) reaching more than 50% of the basal release. Levels were significantly higher in YA (9.7 ± 1.7 to 11.1 ± 1.8 to 14.5 ± 2.2 ng/ml) than MA (7.6 ± 1.6 to 8.7 ± 1.5 to 11.8± 2.2 ng/ml) for all measured time-points (P < 0.05). Nevertheless, MA showed a comparable increase in serum irisin levels when compared to YA. These findings highlight the importance of acute physical exercise as a countermeasure against age-related deterioration of skeletal muscle mass and function in both YA and MA.

本研究旨在分析运动对 22 名年轻人(YA,24.6 ± 3.5 岁)和 12 名中年男性成年人(MA,54.6 ± 5.7 岁)血清鸢尾素水平的急性影响。采用 ELISA 法检测血清鸢尾素。从基线(9.0 ± 2.0 纳克/毫升)到运动后 15 分钟(10.2 ± 2.0 纳克/毫升,P < 0.001),循环中的鸢尾素明显增加,但 24 小时后检测到的增幅最大(13.5 ± 2.5 纳克/毫升,P < 0.001),达到基础释放量的 50%以上。在所有测量时间点,YA 的水平(9.7 ± 1.7 至 11.1 ± 1.8 至 14.5 ± 2.2 ng/ml)均明显高于 MA(7.6 ± 1.6 至 8.7 ± 1.5 至 11.8 ± 2.2 ng/ml)(P < 0.05)。然而,与 YA 相比,MA 的血清鸢尾素水平也有类似的增加。这些研究结果突显了急性体育锻炼的重要性,它是应对亚健康和马拉松运动员骨骼肌质量和功能衰退的重要措施。
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European Journal of Translational Myology
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