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An Empirical Comparison of Rank-Based Surrogate Weights in Additive Multiattribute Decision Analysis 加性多属性决策分析中基于秩的代理权重的实证比较
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2022-06-17 DOI: 10.1287/deca.2022.0456
R. C. Burk, Richard M. Nehring
Many methods for creating surrogate swing weights based only on the rank order of the attributes are proposed to avoid the cost and effort of eliciting weights in multiattribute decision analysis. We explore empirically how well eight different methods perform based on a large sample of real-world elicited weights. We use the Euclidean distance from the elicited weights to judge the quality of the surrogate weights as well as three other metrics. The sum reciprocal method gives results, on average, statistically closest to the elicited weights for all metrics used. The equal ratio method using a fixed ratio of 0.716 performs just as well on three of the metrics. The rank sum method, the simplest and one of the oldest methods, performs generally next best. The rank order centroid method, which does well in simulation studies, performs relatively poorly in this evaluation using real-world data.
为了避免在多属性决策分析中产生权重的成本和工作量,提出了许多仅基于属性的等级顺序来创建代理摆动权值的方法。我们从经验上探讨了八种不同的方法基于现实世界的大样本得出的权重的表现。我们使用欧几里得距离从引出的权重来判断代理权重的质量以及其他三个指标。平均而言,和倒数法给出的结果在统计上最接近所使用的所有指标的所得权重。使用固定比率0.716的等比率方法在三个指标上的表现也一样好。秩和方法是最简单的方法之一,也是最古老的方法之一,它的性能通常是次优的。秩序质心方法在模拟研究中表现良好,但在使用实际数据进行评估时表现相对较差。
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引用次数: 1
Supporting Innovation in Early-Stage Pharmaceutical Development Decisions 支持早期药物开发决策的创新
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2022-04-07 DOI: 10.1287/deca.2022.0452
Florian Methling, Steffen A. Borden, Deepak Veeraraghavan, Insa Sommer, J. Siebert, Rudiger von Nitzsch, Mark Seidler
Pharmaceutical companies have frequent portfolio reviews to monitor development progress and prioritize development assets. The earliest assets are drug candidates whose efficacy is unknown and whose effects on the human body have yet to be fully investigated. These assets are characterized by a high degree of uncertainty in reaching the market and in being used in clinical practice. In addition, not all potential applications are foreseen and can often be very different. In the absence of satisfactory methods for making decisions on resource allocation among early development assets, decision makers focus almost exclusively on assessments of an asset’s probability of technical success. This study proposes a more holistic methodology to support early-stage pharmaceutical development decisions using value-focused thinking and multicriteria decision making. The methodology operates within the decision quality framework and provides a consistent evaluation of various early development assets across a diverse set of disease areas. This combination of concepts and methodologies has been implemented and proven valuable at Bayer Pharmaceuticals, which needed a new, more robust decision-making process for early development. Thus, this study discusses how to enable concrete trade-offs at the level of corporate objectives to align, communicate, and translate corporate strategy into portfolio strategy. In addition, this study presents learnings for decision analysts and decision makers in the pharmaceutical industry on how to develop a set of fundamental objectives, how to create scales to operationalize these objectives, and how to take steps to debias an organizational decision-making process.
制药公司经常进行投资组合审查,以监视开发进度并确定开发资产的优先级。最早的资产是药效未知的候选药物,其对人体的影响尚未得到充分研究。这些资产的特点是在进入市场和在临床实践中使用方面具有高度的不确定性。此外,并不是所有潜在的应用都可以预见,而且可能会有很大的不同。在缺乏对早期开发资产的资源分配做出决策的令人满意的方法的情况下,决策者几乎只关注于评估资产的技术成功概率。本研究提出了一种更全面的方法来支持早期药物开发决策,使用以价值为中心的思维和多标准决策。该方法在决策质量框架内运作,并对不同疾病领域的各种早期开发资产提供一致的评估。这种概念和方法的结合在拜耳制药公司得到了实施,并被证明是有价值的,该公司需要一个新的、更强大的决策过程来进行早期开发。因此,本研究讨论了如何在公司目标水平上实现具体的权衡,以协调、沟通并将公司战略转化为投资组合战略。此外,本研究还为制药行业的决策分析师和决策者提供了关于如何制定一套基本目标、如何创建实现这些目标的尺度以及如何采取措施消除组织决策过程中的偏见的学习。
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引用次数: 1
Balanced Opioid Prescribing via a Clinical Trade-Off: Pain Relief vs. Adverse Effects of Discomfort, Dependence, and Tolerance/Hypersensitivity 通过临床权衡平衡阿片类药物处方:疼痛缓解与不良反应,不适,依赖,耐受性/过敏
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2022-02-03 DOI: 10.1287/deca.2021.0447
Abdullah Gökçınar, M. Çakanyıldırım, Theodore John Price, Meredith C. B. Adams
In the backdrop of the opioid epidemic, opioid prescribing has distinct medical and social challenges. Overprescribing contributes to the ongoing opioid epidemic, whereas underprescribing yields inadequate pain relief. Moreover, opioids have serious adverse effects including tolerance and increased sensitivity to pain, paradoxically inducing more pain. Prescribing trade-offs are recognized but not modeled in the literature. We study the prescribing decisions for chronic, acute, and persistent pain types to minimize the cumulative pain that incorporates opioid adverse effects (discomfort and dependence) and the risk of tolerance or hypersensitivity (THS) developed with opioid use. After finding closed-form solutions for each pain type, we analytically investigate the sensitivity of acute pain prescriptions and examine policies on incorporation of THS, patient handover, and adaptive treatments. Our analyses show that the role of adverse effects in prescribing decisions is as critical as that of the pain level. Interestingly, we find that the optimal prescription duration is not necessarily increasing with the recovery time. We show that not incorporating THS or information curtailment at patient handovers leads to overprescribing that can be mitigated by adaptive treatments. Last, using real-life pain and opioid use data from two sources, we estimate THS parameters and discuss the proximity of our model to clinical practice. This paper has a pain management framework that leads to tractable models. These models can potentially support balanced opioid prescribing after their validation in a clinical setting. Then, they can be helpful to policy makers in assessment of prescription policies and of the controversy around over- and underprescribing.
在阿片类药物流行的背景下,阿片类药物处方具有明显的医疗和社会挑战。处方过量导致阿片类药物持续流行,而处方不足导致疼痛缓解不足。此外,阿片类药物具有严重的副作用,包括耐受性和对疼痛的敏感性增加,矛盾的是引起更多的疼痛。处方权衡是公认的,但没有在文献中建模。我们研究了慢性、急性和持续性疼痛类型的处方决定,以尽量减少阿片类药物不良反应(不适和依赖)的累积疼痛,以及阿片类药物使用引起的耐受或超敏反应(THS)的风险。在找到每种疼痛类型的封闭形式解决方案后,我们分析了急性疼痛处方的敏感性,并检查了结合三手疗法、患者移交和适应性治疗的政策。我们的分析表明,不良反应在处方决策中的作用与疼痛程度一样重要。有趣的是,我们发现最佳处方持续时间并不一定随着恢复时间的增加而增加。我们表明,在病人移交时不纳入三手烟或信息限制会导致处方过量,这可以通过适应性治疗来缓解。最后,利用来自两个来源的真实疼痛和阿片类药物使用数据,我们估计了三手烟参数,并讨论了我们的模型与临床实践的接近性。本文提供了一个疼痛管理框架,可以生成可处理的模型。这些模型在临床验证后可以潜在地支持平衡阿片类药物处方。然后,它们可以帮助政策制定者评估处方政策以及围绕处方过量和不足的争议。
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引用次数: 2
Stay Home or Not? Modeling Individuals’ Decisions During the COVID-19 Pandemic 呆在家里还是不呆?COVID-19大流行期间个人决策建模
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2021-09-07 DOI: 10.1287/deca.2021.0437
Qifeng Wan, Xuan-hua Xu, Kyle Hunt, J. Zhuang
During the COVID-19 pandemic, staying home proved to be an effective way to mitigate the spread of the virus. Stay-at-home orders and guidelines were issued by governments across the globe and were followed by a large portion of the population in the early stages of the outbreak when there was a lack of COVID-specific medical knowledge. The decision of whether to stay home came with many trade-offs, such as risking personal exposure to the virus when leaving home or facing financial and mental health burdens when remaining home. In this research, we study how individuals make strategic decisions to balance these conflicting outcomes. We present a model to study individuals’ decision making based on decision and prospect theory, and we conduct sensitivity analysis to study the fluctuations in optimal strategies when there are changes made to the model’s parameters. A Monte Carlo simulation is implemented to further study the performance of our model, and we compare our simulation results with real data that captures individuals’ stay-at-home decisions. Overall, this research models and analyzes the behaviors of individuals during the COVID-19 pandemic and can help support decision making regarding control measures and policy development when public health emergencies appear in the future.
在2019冠状病毒病大流行期间,待在家里被证明是缓解病毒传播的有效方法。全球各国政府发布了居家令和指导方针,在疫情爆发的早期阶段,由于缺乏针对covid - 19的医学知识,很大一部分人都遵循了这些命令和指导方针。是否留在家里的决定需要做出许多权衡,例如离开家时可能会有个人接触病毒的风险,或者留在家里时面临经济和精神健康负担。在这项研究中,我们研究个人如何做出战略决策来平衡这些冲突的结果。基于决策与前景理论,建立了个体决策模型,并对模型参数变化时最优策略的波动进行了敏感性分析。为了进一步研究模型的性能,我们实施了蒙特卡罗模拟,并将模拟结果与捕获个人在家决策的真实数据进行了比较。总体而言,本研究对COVID-19大流行期间的个人行为进行了建模和分析,可以为未来出现突发公共卫生事件时的控制措施和政策制定决策提供支持。
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引用次数: 5
From the Editor---Decisions over Time (Exploding Offers or Purchase Regret), in Game Settings (Embedded Nash Bargaining or Adversarial Games), and in Influence Diagrams 从编辑器——决策随着时间的推移(爆炸报价或购买后悔),在游戏设置(嵌入纳什讨价还价或对抗游戏),并在影响图
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2012-03-01 DOI: 10.1287/DECA.1110.0229
L. R. Keller
Our first two articles address decisions involving the passage of time. First, Steven A. Lippman and John W. Mamer explore the question of whether making “Exploding Offers” is beneficial to an employer seeking to hire or, in a more general framing of the question, to a purchaser of an asset. Next, in “Dynamic Purchase Decisions Under Regret: Price and Availability,” Enrico Diecidue, Nils Rudi, and Wenjie Tang examine situations in which a person can make a forward purchase in period 1 or a spot purchase in period 2. Our next two articles involve game theoretic models. In our third article, Steven A. Lippman and Kevin F. McCardle model joint decision making (motivated by dividing up a fortune) via “Embedded Nash Bargaining: Risk Aversion and Impatience.” The fourth article is “Robust Adversarial Risk Analysis: A Level-k Approach,” by Laura McLay, Casey Rothschild, and Seth Guikema. The final article is on “A Framework for Solving Hybrid Influence Diagrams Containing Deterministic Conditional Distributions,” by Yijing Li and Prakash P. Shenoy.
我们的前两篇文章讨论了涉及时间流逝的决策。首先,Steven a . Lippman和John W. Mamer探讨了这样一个问题,即“爆炸性报价”是否对寻求招聘的雇主有利,或者从更一般的角度来看,对资产的购买者有利。接下来,在“后悔下的动态购买决策:价格和可得性”一文中,Enrico Diecidue, Nils Rudi和Wenjie Tang研究了一个人可以在第一阶段进行远期购买或在第二阶段进行现货购买的情况。我们接下来的两篇文章涉及博弈论模型。在我们的第三篇文章中,Steven a . Lippman和Kevin F. McCardle通过“嵌入式纳什议价:风险厌恶和不耐烦”对共同决策(由分割财富驱动)进行了建模。第四篇文章是Laura McLay、Casey Rothschild和Seth Guikema撰写的“稳健的对抗性风险分析:Level-k方法”。最后一篇文章是关于“解决包含确定性条件分布的混合影响图的框架”,作者是Yijing Li和Prakash P. Shenoy。
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引用次数: 3
Call for Papers---Special Issue of Decision Analysis on Games and Decisions in Reliability and Risk: Deadline: April 25, 2011 论文征集——《可靠性与风险博弈与决策的决策分析》特刊:截止日期:2011年4月25日
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2011-03-01 DOI: 10.1287/DECA.1110.0200
L. R. Keller, R. Soyer, F. Ruggeri, Jason R. W. Merrick
The objective of the special issue is to introduce a new theme, the use of game theory and decision theory in reliability analysis and risk analysis. The special issue aims to bring together novel research from disciplines that have the potential to contribute to this theme, including (but not limited to) economics, engineering, finance, mathematics, medical sciences, military sciences, probability, and statistics. Papers must tackle a problem in risk or reliability using the tools of decision theory or game theory (or both). The issue will not only consider papers presented at the Second Symposium on Games and Decisions in Reliability and Risk, to be held at the Hotel Villa Carlotta, Belgirate (VB), Lake Maggiore, Italy, May 19–21, 2011 (http://www.mi.imati.cnr.it/conferences/gdrr11.html), but will also be open to the public for submission of papers relevant to the theme. The deadline for submission of papers is April 25, 2011. Papers limited to 12 double-spaced pages (including references and figures/tables) should be submitted at http://mc.manuscriptcentral.com/deca and should follow the Decision Analysis author submission guidelines given at http://www.informs.org/Pubs/DA/ Submission-Guidelines. All submissions will go through the standard review process of Decision Analysis. Submitting authors should indicate their desire to be considered for the special issue in the cover letter to Editor-in-Chief L. Robin Keller, completed during the submission process. Technical questions about submissions may be directed to Managing Editor Kelly M. Kophazi (kelly.kophazi@informs.org). For more information about the special issue, please contact:
这期特刊的目的是介绍一个新的主题,即博弈论和决策理论在可靠性分析和风险分析中的应用。本期特刊旨在汇集有可能对这一主题做出贡献的学科的新研究,包括(但不限于)经济学、工程学、金融学、数学、医学、军事科学、概率论和统计学。论文必须使用决策理论或博弈论(或两者兼而有之)的工具来解决风险或可靠性问题。该问题不仅将考虑在2011年5月19日至21日在意大利Maggiore湖的Belgirate Villa Carlotta酒店(VB)举行的关于可靠性和风险的游戏和决策的第二届研讨会(http://www.mi.imati.cnr.it/conferences/gdrr11.html)上发表的论文,而且还将向公众开放提交与主题相关的论文。论文提交截止日期为2011年4月25日。论文不超过12页,双倍行距(包括参考文献和图表/表格),应提交至http://mc.manuscriptcentral.com/deca,并应遵循http://www.informs.org/Pubs/DA/提交指南中给出的决策分析作者提交指南。所有提交的文件将通过决策分析的标准审查程序。投稿作者应在投稿过程中给主编L. Robin Keller的封面信中表明他们希望被特刊考虑的愿望。有关提交的技术问题可直接向总编辑Kelly M. Kophazi (kelly.kophazi@informs.org)询问。有关特刊的详情,请联络:
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引用次数: 7
Clinical Applications in the Decision Analysis Literature (Comment on Keefer et al. 2004) 决策分析文献中的临床应用(评论Keefer et al. 2004)
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2004-03-01 DOI: 10.1287/DECA.1.1.25.17849
S. Cantor
The author provides a comment to the companion literature review, focusing on clinical applications of decision analysis. The theory and application of clinical decision analysis has decreased in the management science and operations research literature, but has become a field in and of itself, with contributions to the medical and analytical communities. Decision scientists should be aware of methodological contributions in the health decision science literature.
作者对相关文献综述进行了评论,重点介绍了决策分析的临床应用。临床决策分析的理论和应用在管理科学和运筹学文献中有所减少,但它本身已经成为一个领域,对医学和分析界做出了贡献。决策科学家应该意识到卫生决策科学文献中方法论的贡献。
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引用次数: 8
Reversing the Perspective on the Applications of Decision Analysis (Comment on Keefer et al. 2004) 逆转决策分析应用的视角(评Keefer et al. 2004)
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2004-03-01 DOI: 10.1287/DECA.1.1.29.17846
R. Hämäläinen
This paper looks into the strengths, weaknesses, opportunities, and threats (SWOT) of the field of the applications based on DA techniques; focusing especially on MAVT. The need for best practices and bias-resistant analysis procedures is pointed out. In most application papers there are no reports on the verification or testing of the procedures used. The Internet provides great opportunities in the delivery of DA software and e-learning material. Public sites such as Decisionarium (www.decisionarium.hut.fi) provide encouragement and a low entry level to try value tree analysis in new applications. There are also great opportunities in reaching out the other MCDA communities such as AHP practitioners. Today the need and demand for decision support is perhaps growing most rapidly in environmental problems. A clear trend is also the integration of DA into GIS and other models. Many of the applications are now published in non-OR/MS subject area journals.
本文分析了基于数据分析技术的应用领域的优势、劣势、机会和威胁(SWOT);特别关注MAVT。指出了最佳实践和抗偏差分析程序的必要性。在大多数应用论文中,没有关于所使用程序的验证或测试的报告。Internet为数据处理软件和电子学习材料的交付提供了巨大的机会。像Decisionarium (www.decisionarium.hut.fi)这样的公共站点鼓励人们在新的应用程序中尝试价值树分析,并且门槛很低。在接触其他MCDA社区(如AHP从业者)方面也有很大的机会。今天,在环境问题上,对决策支持的需要和需求可能增长得最为迅速。一个明显的趋势是将数据集成到GIS和其他模型中。许多应用程序现在发表在非or /MS学科领域的期刊上。
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引用次数: 29
Response to Comments on Keefer et al. (2004) 对Keefer et al.(2004)评论的回应
IF 1.9 4区 管理学 Q3 MANAGEMENT Pub Date : 2004-03-01 DOI: 10.1287/DECA.1.1.36.17843
D. Keefer, C. Kirkwood, J. Corner
Our article "Perspective on Decision Analysis Applications, 1990--2001" provides a comprehensive listing of decision analysis applications published between 1990 and 2001 in the 16 journals that we surveyed and uses this together with results from a previous survey to identify, and provide perspective on, trends and developments in decision analysis applications. Cantor (2004) and HA¤mA¤lA¤inen (2004) provide useful comments and additional references that supplement the material in our article, and we agree with many of their comments. However, we do not agree with their view that our definition of "decision analysis" is too restrictive. We believe that, after 35 years, the core of decision analysis is now well established and that we have used the generally understood definition in selecting the applications included in our article.
我们的文章“决策分析应用展望,1990- 2001”提供了1990- 2001年间在我们调查的16种期刊上发表的决策分析应用的综合清单,并将其与之前调查的结果一起使用,以确定决策分析应用的趋势和发展,并提供观点。Cantor(2004)和HA·mA·lA·inen(2004)提供了有用的评论和额外的参考资料,以补充我们文章中的材料,我们同意他们的许多评论。然而,我们不同意他们的观点,即我们对“决策分析”的定义过于严格。我们认为,经过35年的发展,决策分析的核心现在已经很好地建立起来,并且我们在选择本文中包括的应用程序时使用了一般理解的定义。
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引用次数: 0
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Decision Analysis
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