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Revista Espanola de Anestesiologia y Reanimacion最新文献

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Oxigenoterapia intraoperatoria de alto flujo para anestesia sin intubación en cirugía toracoscópica 胸腔镜手术无插管麻醉的术中高流量氧气疗法
IF 1.3 Q3 Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.redar.2022.05.011
R. Mato-Bua , D. Lopez-Lopez , A. Garcia-Perez , C. Bonome

Tubeless anaesthesia has become widespread in videothoracoscopic surgery, even in major procedures such as lobectomies. There are several advantages in avoiding general anaesthesia and one-lung mechanical ventilation, such as faster recovery and shorter hospital stays. However, hypoxaemia and hypercapnia are the most reported causes of conversion to general anaesthesia. High Flow Oxygen Therapy (HFOT) generates flow-dependent positive end-expiratory pressure, improves oxygenation and also carbon dioxide washout by flow-dependent dead space flushing. For this reason, intraoperative HFOT may reduce the rate of conversion to general anaesthesia. We report our experience with intraoperative HFOT in a 71-year-old female with lung adenocarcinoma undergoing VATS upper left lobectomy.

无管麻醉已广泛应用于视频胸腔镜手术,甚至是肺叶切除等大型手术。避免全身麻醉和单肺机械通气有很多好处,例如恢复更快、住院时间更短。然而,低氧血症和高碳酸血症是导致转为全身麻醉的最主要原因。高流量氧气疗法(HFOT)可产生流量依赖性呼气末正压,改善氧合,并通过流量依赖性死腔冲洗改善二氧化碳排出。因此,术中 HFOT 可以降低全身麻醉的转换率。我们报告了对一名 71 岁女性肺腺癌患者进行 VATS 左上肺叶切除术的术中 HFOT 经验。
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引用次数: 0
Estudio retrospectivo de pacientes intervenidos de implante valvular aórtico transcatéter (TAVI), entre los años 2012 y 2019, a los que se les realizó sedación con propofol/remifentanilo versus dexmedetomidina/remifentanilo 对2012年至2019年期间接受经导管主动脉瓣植入术(TAVI)的患者进行的回顾性研究,这些患者接受了异丙酚/瑞芬太尼与右美托咪定/瑞芬太尼的镇静治疗。
IF 1.3 Q3 Medicine Pub Date : 2024-02-01 DOI: 10.1016/j.redar.2023.03.007
B. Hernando Vela , P. Jarén Cubillo , C. Bueno Fernández , L. Gallego Ligorit , M.C. Ferrer García , J.A. Diarte

Background and objectives

Percutaneous implantation of an aortic valve prosthesis is a therapeutic alternative for patients with severe aortic stenosis. The procedure is traditionally performed under general anaesthesia; however, sedation is now gaining in popularity because it reduces the need for vasoactive drugs and shortens the patient's stay in the critical care unit and on the ward. The aim of this study is to evaluate the clinical efficacy, safety and potential benefits of sedation with dexmedetomidine in patients undergoing percutaneous implantation of an aortic valve prosthesis in terms of haemodynamic and respiratory complications.

Materials and methods

We performed a retrospective study of 222 patients that had undergone percutaneous implantation of an aortic valve prosthesis between 2012 and 2019 under sedation with either dexmedetomidine plus remifentanil (DEX-RMF) or propofol plus remifentanil (PROPO-RMF). We collected data on complications, mainly haemodynamic and respiratory, during and after the procedure.

Results

No significant differences were found between sedation with dexmedetomidine and propofol (in combination with remifentanil) in terms of haemodynamic stability and intraprocedural cerebral blood oxygen. In the DEX-RMF group, however, mean blood pressure, midazolam dose, and duration of anaesthesia were lower compared with the PROPO-RMF group, but the incidence of haemodynamic and respiratory complications did not differ significantly between groups.

Conclusions

Our results show that sedation, particularly with adjuvant dexmedetomidine, is a valid anaesthetic techniques in percutaneous aortic valve prosthesis implantation.

背景和目的经皮主动脉瓣假体植入术是重度主动脉瓣狭窄患者的一种治疗选择。该手术传统上在全身麻醉的情况下进行,但现在镇静剂越来越受欢迎,因为它减少了对血管活性药物的需求,缩短了患者在重症监护室和病房的逗留时间。本研究旨在评估使用右美托咪定镇静的临床疗效、安全性以及在主动脉瓣假体经皮植入术患者血液动力学和呼吸系统并发症方面的潜在益处。材料和方法我们对 2012 年至 2019 年期间接受经皮植入主动脉瓣假体手术的 222 例患者进行了回顾性研究,这些患者在使用右美托咪定加瑞芬太尼(DEX-RMF)或丙泊酚加瑞芬太尼(PROPO-RMF)镇静的情况下接受了手术。结果 在血流动力学稳定性和术中脑血氧方面,右美托咪定和丙泊酚(与瑞芬太尼联用)镇静剂之间没有发现明显差异。然而,DEX-RMF 组的平均血压、咪达唑仑剂量和麻醉持续时间均低于 PROPO-RMF 组,但血流动力学和呼吸系统并发症的发生率在各组之间没有显著差异。结论我们的结果表明,镇静,尤其是使用右美托咪定辅助镇静,是经皮主动脉瓣假体植入术中有效的麻醉技术。
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引用次数: 0
Análisis retrospectivo de la anestesia regional en la cirugía de cadera: Auditoría clínica 髋关节手术中区域麻醉的回顾性分析:临床审计
IF 1.3 Q3 Medicine Pub Date : 2024-01-30 DOI: 10.1016/j.redar.2023.07.004
P. Casas Reza, M. Gestal Vázquez, L. Sampayo Rodríguez, A. Vilar Castro, D. López-López, A. García Romar

Introduction

Total hip arthroplasty is one of the most frequent surgical interventions in the hospital setting. Nonetheless, the ideal method to manage post-operative pain is still unknown. Multimodal analgesia techniques based on regional anaesthesia are amongst the most promising solutions.

Objectives

The aim of this study was to evaluate postoperative pain after total hip arthroplasty according to whether peripheral nerve block was performed (femoral block, fascia iliaca block and pericapsular nerve group block). Intravenous morphine consumption during the patient's stay in the post-anaesthesia care unit was measured, as well as the number of opioid rescues at 24 and 48h post intervention. As secondary objectives, the prevalence of nerve injury, prolonged quadricipital block, and morphine consumption were established according to other variables of interest.

Materials and methods

In this observational retrospective study, data was collected from the electronic medical record of 656 traumatological surgery patients from April 2018 to August 2020, with the following inclusion criteria: over 18 years old, ASA I-III, primary total hip arthroplasty under general anaesthesia or subarachnoid anaesthesia (only with hyperbaric bupivacaine) and use of levobupivacaine for peripheral nerve block.

Results

A total of 362 patients were selected. The main surgical indication was coxarthrosis (61.3%), followed by hip fracture (22.6%). Peripheral nerve blocks were performed on 169 patients (66.3% femoral, 27.7% PENG, and 6.0% fascia iliaca). Mean postoperative opioid consumption in PACU was lower in patients in who received a PENG (2.2 mg) or a femoral (3.27 mg) block, compared to those who received neither (6.69 mg). There were no differences in opioid rescues at 24 and 48h after the procedure. Nerve injury incidence was low (.8%), and not associated with nerve blocks. The incidence of prolonged quadricipital paralysis was also low (1.3%), and was mainly associated with femoral nerve block (75% of cases).

Conclusions

This retrospective study supports the use of regional blocks as opioid- sparing techniques, highlighting their role in rapid functional recovery with no motor impairment.

导言全髋关节置换术是医院最常见的外科手术之一。然而,控制术后疼痛的理想方法仍是未知数。本研究的目的是根据是否进行了周围神经阻滞(股神经阻滞、髂筋膜阻滞和囊周神经组阻滞)来评估全髋关节置换术后的术后疼痛。研究还测量了患者在麻醉后护理病房的静脉注射吗啡消耗量,以及干预后 24 小时和 48 小时的阿片类药物抢救次数。作为次要目标,还根据其他相关变量确定了神经损伤、四肢阻滞时间延长和吗啡消耗量的发生率。材料和方法在这项观察性回顾研究中,从 2018 年 4 月至 2020 年 8 月期间 656 名创伤外科患者的电子病历中收集了数据,纳入标准如下:18 岁以上,ASA I-III 级,在全身麻醉或蛛网膜下腔麻醉(仅使用高压布比卡因)下进行初级全髋关节置换术,使用左旋布比卡因进行周围神经阻滞。主要手术适应症是髋关节病(61.3%),其次是髋部骨折(22.6%)。169名患者接受了周围神经阻滞(股神经占66.3%,PENG神经占27.7%,髂筋膜神经占6.0%)。接受PENG(2.2毫克)或股神经(3.27毫克)阻滞的患者术后在PACU的阿片类药物平均消耗量低于未接受阻滞的患者(6.69毫克)。术后24小时和48小时的阿片类药物抢救时间没有差异。神经损伤发生率较低(0.8%),与神经阻滞无关。结论这项回顾性研究支持使用区域阻滞作为阿片类药物稀释技术,强调了其在快速功能恢复和无运动障碍方面的作用。
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引用次数: 0
El tratamiento del dolor agudo pediátrico en España EN 2021: resultado de una encuesta nacional entre anestesiólogos pediátricos 2021 年西班牙儿科急性疼痛管理:儿科麻醉师全国调查结果
IF 1.3 Q3 Medicine Pub Date : 2024-01-30 DOI: 10.1016/j.redar.2023.09.003
F. Reinoso-Barbero , R. López-López , M.D. Cárceles Barón , M. Hervías-Sanz , J. García-Fernández , Grupo de Trabajo de Dolor Infantil de la Sección de Anestesia Pediátrica de la SEDAR

Objective

To improve knowledge about routine clinical practice in the management of paediatric acute pain in Spain.

Methods

A telematic survey was conducted via the Internet on a representative sample of healthcare professionals involved in the management of paediatric acute pain (specifically anaesthesiologists) in Spain. The survey included 28 questions about their usual clinical practice in the assessment and treatment of acute pain, and also training and organisational aspects in paediatric acute pain.

Results

The survey was completed during March 2021 by 150 specialists in anaesthesiology. The respondents widely experienced in the management of acute paediatric pain (mean years of experience: 14.3: SD: 7.8), essentially in acute postoperative pain (97% of cases). Although 80% routinely used validated paediatric acute pain assessment scales, only 2.6% used specific scales adapted for patients with cognitive impairment. Most of the respondents routinely used analgesic drugs such as paracetamol (99%) or metamizole (92%), but only 84% complemented these drugs with a loco-regional blocking technique or other non-steroidal anti-inflammatory drugs (62%). Furthermore, only 62.7% acknowledged having received specific training in paediatric acute pain, only 45% followed hospital institutional protocols, and a scant 28% did so through paediatric pain units.

Conclusions

The survey identified important points for improvement in the training and organisation of acute pain management in Spanish paediatric patients.

方法 通过互联网对西班牙参与儿科急性疼痛治疗的医护人员(特别是麻醉师)进行远程调查。调查包括 28 个问题,涉及他们在评估和治疗急性疼痛方面的日常临床实践,以及儿科急性疼痛的培训和组织方面。受访者在处理儿科急性疼痛方面经验丰富(平均年限:14.3 年:标度:7.8),主要集中在急性术后疼痛方面(97% 的病例)。虽然 80% 的受访者常规使用经过验证的儿科急性疼痛评估量表,但只有 2.6% 的受访者使用了针对认知障碍患者的特定量表。大多数受访者常规使用扑热息痛(99%)或甲氰咪唑(92%)等镇痛药物,但只有 84% 的受访者在使用这些药物的同时辅以局部区域阻断技术或其他非甾体抗炎药物(62%)。此外,只有 62.7% 的人承认接受过儿科急性疼痛方面的专门培训,只有 45% 的人遵循医院的机构协议,只有 28% 的人通过儿科疼痛科进行培训。
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引用次数: 0
Efectos intraoperatorios de una maniobra de reclutamiento alveolar en pacientes sometidos a cirugía laparoscópica de colon 在接受腹腔镜结肠手术的患者中实施肺泡扩张操作的术中效果
IF 1.3 Q3 Medicine Pub Date : 2024-01-24 DOI: 10.1016/j.redar.2023.06.002
R. Mato-Búa, A. Prado-Rodríguez, D. López-López, P. Rama-Maceiras, N. Molins-Gauna, F. Álvarez-Refojo

Introduction

Pulmonary atelectasis is common in patients undergoing laparoscopic abdominal surgery under general anaesthesia, which increases the risk of perioperative respiratory complications. Alveolar recruitment manoeuvres (ARM) are used to open up the lung parenchyma with atelectasis, although the duration of their benefit has not been clearly established. The aim of this study was to determine the effectiveness of an ARM in laparoscopic colon surgery, the duration of response over time, and its haemodynamic impact.

Methods

Twenty-five patients undergoing laparoscopic colon surgery were included. After anaesthetic induction and initiation of surgery with pneumoperitoneum, an ARM was performed, and then optimal PEEP determined. Respiratory mechanics and gas exchange variables, and haemodynamic parameters, were analysed before the manoeuvre and periodically over the following 90 minutes.

Results

Three patients were excluded for surgical reasons. The alveolar arterial oxygen gradient went from 94.3 (62.3-117.8) mmHg before to 60.7 (29.6-91.0) mmHg after the manoeuvre (P < .05). This difference was maintained during the 90 minutes of the study. Dynamic compliance of the respiratory system went from 31.3 ml/cmH2O (26.1-39.2) before the manoeuvre to 46.1 ml/cmH2O (37.5-53.5) after the manoeuvre (P < .05). This difference was maintained for 60 minutes. No significant changes were identified in any of the haemodynamic variables studied.

Conclusion

In patients undergoing laparoscopic colon surgery, performing an intraoperative ARM improves the mechanics of the respiratory system and oxygenation, without associated haemodynamic compromise. The benefit of these manoeuvres lasts for at least one hour.

导言在全身麻醉下接受腹腔镜腹部手术的患者中,肺不张很常见,这会增加围手术期呼吸系统并发症的风险。肺泡募集操作(ARM)可用于打开有肺偏流的肺实质,但其益处的持续时间尚未明确确定。本研究旨在确定腹腔镜结肠手术中 ARM 的有效性、反应持续时间及其对血流动力学的影响。麻醉诱导和腹腔积气手术开始后,进行 ARM,然后确定最佳 PEEP。结果有三名患者因手术原因被排除在外。肺泡动脉血氧梯度从操作前的 94.3 (62.3-117.8) mmHg 降至操作后的 60.7 (29.6-91.0) mmHg(P < .05)。这一差异在 90 分钟的研究过程中一直保持不变。呼吸系统的动态顺应性从操作前的 31.3 ml/cmH2O(26.1-39.2)上升到操作后的 46.1 ml/cmH2O(37.5-53.5)(P < .05)。这一差异保持了 60 分钟。结论在接受腹腔镜结肠手术的患者中,术中 ARM 可改善呼吸系统的力学和氧合,而不会对血液动力学造成影响。这些操作的益处可持续至少一小时。
{"title":"Efectos intraoperatorios de una maniobra de reclutamiento alveolar en pacientes sometidos a cirugía laparoscópica de colon","authors":"R. Mato-Búa,&nbsp;A. Prado-Rodríguez,&nbsp;D. López-López,&nbsp;P. Rama-Maceiras,&nbsp;N. Molins-Gauna,&nbsp;F. Álvarez-Refojo","doi":"10.1016/j.redar.2023.06.002","DOIUrl":"10.1016/j.redar.2023.06.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Pulmonary atelectasis is common in patients undergoing laparoscopic abdominal surgery under general anaesthesia, which increases the risk of perioperative respiratory complications. Alveolar recruitment manoeuvres (ARM) are used to open up the lung parenchyma with atelectasis, although the duration of their benefit has not been clearly established. The aim of this study was to determine the effectiveness of an ARM in laparoscopic colon surgery, the duration of response over time, and its haemodynamic impact.</p></div><div><h3>Methods</h3><p>Twenty-five patients undergoing laparoscopic colon surgery were included. After anaesthetic induction and initiation of surgery with pneumoperitoneum, an ARM was performed, and then optimal PEEP determined. Respiratory mechanics and gas exchange variables, and haemodynamic parameters, were analysed before the manoeuvre and periodically over the following 90 minutes.</p></div><div><h3>Results</h3><p>Three patients were excluded for surgical reasons. The alveolar arterial oxygen gradient went from 94.3 (62.3-117.8) mmHg before to 60.7 (29.6-91.0) mmHg after the manoeuvre (<em>P</em> &lt; .05). This difference was maintained during the 90 minutes of the study. Dynamic compliance of the respiratory system went from 31.3 ml/cmH<sub>2</sub>O (26.1-39.2) before the manoeuvre to 46.1 ml/cmH<sub>2</sub>O (37.5-53.5) after the manoeuvre (<em>P</em> &lt; .05). This difference was maintained for 60 minutes. No significant changes were identified in any of the haemodynamic variables studied.</p></div><div><h3>Conclusion</h3><p>In patients undergoing laparoscopic colon surgery, performing an intraoperative ARM improves the mechanics of the respiratory system and oxygenation, without associated haemodynamic compromise. The benefit of these manoeuvres lasts for at least one hour.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139638169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influencia de la linfopenia en la mortalidad a largo plazo en shock séptico, estudio observacional retrospectivo 淋巴细胞减少症对脓毒性休克长期死亡率的影响,一项回顾性观察研究。
IF 1.3 Q3 Medicine Pub Date : 2024-01-24 DOI: 10.1016/j.redar.2023.11.002
J. Rico-Feijoó , J.F. Bermejo-Martín , A. Pérez-González , S. Martín-Alfonso , C. Aldecoa

Background and objective

The diagnosis of infection, to diagnose septic shock, has been qualified by leukocyte counts and protein biomarkers. Septic shock mortality is persistently high (20%-50%), and rising in the long term. The definition of sepsis does not include leukocyte count, and lymphopenia has been associated with its mortality in the short term. Immunosuppression and increased mortality in the long term due to sepsis have not been demonstrated. The aim is to relate the occurrence of lymphopenia and its lack of recovery during septic shock with mortality at 2 years.

Patients and methods

Cohort of 332 elderly patients diagnosed with septic shock. Mortality at 28 days and 2 years was analysed according to leukocyte, neutrophil, and lymphocyte counts, and the ability to recover from lymphopenia (LRec).

Results

A total of 74.1% of patients showed lymphopenia, and 66.3% did not improve during ICU stay. Mortality was 31.0% and 50.3% at 28 days and 2 years, respectively. A leukocyte count < 12,000 /μL was a predictor of early mortality (OR: 2.96) and LRec of late mortality (OR: 3.98). Long-term mortality was associated with LRec (HR: 1.69).

Conclusions

In elderly patients with septic shock, the absence of leukocytosis and neutrophilia is associated with 28-day mortality, and LRec with 2-year mortality; this may represent two distinct phenotypes of behaviour after septic shock.

背景和目的感染的诊断,即脓毒性休克的诊断,一直由白细胞计数和蛋白质生物标志物来定性。脓毒性休克的死亡率一直居高不下(20%-50%),并且长期呈上升趋势。脓毒症的定义不包括白细胞计数,而淋巴细胞减少症在短期内与脓毒症的死亡率有关。免疫抑制和败血症导致的长期死亡率增加尚未得到证实。研究的目的是将脓毒性休克期间发生的淋巴细胞减少症及其缺乏恢复与 2 年后的死亡率联系起来。根据白细胞、中性粒细胞和淋巴细胞计数以及淋巴细胞减少症的恢复能力(LRec)分析了28天和2年后的死亡率。28天和2年后的死亡率分别为31.0%和50.3%。白细胞计数大于 12,000 /μL 可预测早期死亡率(OR:2.96),LRec 可预测晚期死亡率(OR:3.98)。结论在老年脓毒性休克患者中,没有白细胞增多和中性粒细胞增多与 28 天死亡率有关,而 LRec 与 2 年死亡率有关;这可能代表了脓毒性休克后两种不同的行为表型。
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引用次数: 0
Factores asociados a la limitación del soporte vital: estudio de casos de mortalidad post-UCI de un hospital terciario 与有限生命支持相关的因素:一家三级医院重症监护室术后死亡率的案例研究。
IF 1.3 Q3 Medicine Pub Date : 2024-01-23 DOI: 10.1016/j.redar.2023.05.013
U.A. López González , D. Bautista Rentero , M. Crespo Gómez , P. Cárcamo Ibarra , A.M. Míguez Santiyán

Antecedentes

La limitación del tratamiento de soporte vital (LTSV) es el acto médico de retirar o no iniciar medidas que se consideren fútiles en la situación concreta de un paciente. La LTSV en pacientes críticos sigue siendo un tema difícil de estudiar, debido a la multitud de factores que la condicionan.

Objetivo

Determinar los factores relacionados con la LTSV en la Unidad de Cuidados Intensivos (UCI) en casos de mortalidad hospitalaria post-UCI, así como los factores asociados a los días de supervivencia tras el alta de UCI.

Diseño

Estudio longitudinal retrospectivo.

Ámbito

UCI de un hospital terciario.

Pacientes

Personas fallecidas en sala de hospitalización tras tratamiento en UCI entre enero de 2014 y diciembre de 2019.

Intervenciones

No existen. Se trata de un estudio observacional.

Variables de interés

Edad, sexo, probabilidad de muerte, tipo de ingreso, LTSV en UCI, enfermedad oncológica, dependencia, ventilación mecánica invasiva (VMI) y hemodiálisis de urgencia (HDU), transfusión de hemoderivados (TDH), infección nosocomial (IN), estancias pre-UCI, intra-UCI y post-UCI.

Resultados

De 114 pacientes fallecidos fuera de la UCI, 49 tenían registrada LTSV en UCI (42,98%). La edad y la estancia previa al ingreso en UCI se asociaron positivamente a LTSV (OR 1,03 y 1,08, respectivamente) y la IN, negativamente (OR 0,19). Los pacientes sin LTSV presentaron una estancia post-UCI más alta, mientras que en los pacientes varones fue menor.

Conclusiones

Nuestros resultados apoyan que la LTSV instaurada dentro de UCI puede relacionarse con un menor número de complicaciones comúnmente asociadas a la prolongación innecesaria de la estancia, como la IN.

Background

Life-sustaining treatment limitation (LTSV) is the medical act of withdrawing or not initiating measures that are considered futile in a patient's specific situation. LTSV in critically ill patients remains a difficult topic to study, due to the multitude of factors that condition it.

Objective

To determine factors related to LTSV in ICU in cases of post-ICU in-hospital mortality, as well as factors associated with survival after discharge from ICU.

Design

Retrospective longitudinal study.

Ambit

Intensive care unit of a tertiary hospital.

Patients

People who died in the hospitalization ward after ICU treatment between January 2014 and December 2019.

Interventions

None. This is an observational study.

Variables of interest

Age, sex, probability of death, type of admission, LTSV in ICU, oncological disease, dependence, invasive mechanical ventilation, emergency hemodialysis, transfusion of blood products, noso

背景生命维持治疗限制(LSTL)是指根据患者的具体情况,撤消或不启动被认为是无效的措施的医疗行为。目的 确定重症监护病房(ICU)中 LSTL 的相关因素,以及 ICU 出院后存活天数的相关因素。设计回顾性纵向研究.地点一家三甲医院的重症监护室.患者2014年1月至2019年12月期间在重症监护室治疗后在病房死亡的患者.干预措施没有干预措施。相关变量年龄、性别、死亡概率、入院类型、ICU LSTL、肿瘤疾病、依赖性、有创机械通气(IMV)和紧急血液透析(EHD)、血制品输注(HDT)、院内感染(NI)、ICU前、ICU内和ICU后住院时间。结果在114名死于ICU外的患者中,49人在ICU内有LSTL记录(42.98%)。年龄和重症监护室前住院时间与 LSTL 呈正相关(OR 值分别为 1.03 和 1.08),与 NI 呈负相关(OR 值为 0.19)。结论我们的研究结果表明,在重症监护室内实施生命维持治疗限制(LTSV)可能会减少与不必要的住院时间延长(如 NI)相关的并发症。背景生命维持治疗限制(LTSV)是指根据患者的具体情况,撤消或不启动被认为是徒劳无益的措施的医疗行为。危重症患者的生命维持治疗限制仍是一个难以研究的课题,因为影响它的因素很多.Objective To determine factors related to LTSV in ICU in cases of postICU in-hospital mortality, as well as factors related to survival after discharge from ICU.DesignRetrospective longitudinal study.AmbitIntensive care unit of a tertiary hospital.PatientsPeople who died in the hospitalization ward after ICU treatment between January 2014 and December 2019.InterventionsNone.相关变量年龄、性别、死亡概率、入院类型、ICU中的LTSV、肿瘤疾病、依赖性、有创机械通气、紧急血液透析、输血产品、院内感染(NI)、ICU前、ICU内和ICU后的住院时间。结果在114名死于ICU外的患者中,49人在ICU中登记了LTSV(42.98%)。年龄和入住 ICU 前的住院时间与 LTSV 呈正相关(OR 分别为 1.03 和 1.08)。没有 LTSV 的患者在 ICU 后的住院时间较长,而男性患者的住院时间较短。
{"title":"Factores asociados a la limitación del soporte vital: estudio de casos de mortalidad post-UCI de un hospital terciario","authors":"U.A. López González ,&nbsp;D. Bautista Rentero ,&nbsp;M. Crespo Gómez ,&nbsp;P. Cárcamo Ibarra ,&nbsp;A.M. Míguez Santiyán","doi":"10.1016/j.redar.2023.05.013","DOIUrl":"10.1016/j.redar.2023.05.013","url":null,"abstract":"<div><h3>Antecedentes</h3><p>La limitación del tratamiento de soporte vital (LTSV) es el acto médico de retirar o no iniciar medidas que se consideren fútiles en la situación concreta de un paciente. La LTSV en pacientes críticos sigue siendo un tema difícil de estudiar, debido a la multitud de factores que la condicionan.</p></div><div><h3>Objetivo</h3><p>Determinar los factores relacionados con la LTSV en la Unidad de Cuidados Intensivos (UCI) en casos de mortalidad hospitalaria post-UCI, así como los factores asociados a los días de supervivencia tras el alta de UCI.</p></div><div><h3>Diseño</h3><p>Estudio longitudinal retrospectivo.</p></div><div><h3>Ámbito</h3><p>UCI de un hospital terciario.</p></div><div><h3>Pacientes</h3><p>Personas fallecidas en sala de hospitalización tras tratamiento en UCI entre enero de 2014 y diciembre de 2019.</p></div><div><h3>Intervenciones</h3><p>No existen. Se trata de un estudio observacional.</p></div><div><h3>Variables de interés</h3><p>Edad, sexo, probabilidad de muerte, tipo de ingreso, LTSV en UCI, enfermedad oncológica, dependencia, ventilación mecánica invasiva (VMI) y hemodiálisis de urgencia (HDU), transfusión de hemoderivados (TDH), infección nosocomial (IN), estancias pre-UCI, intra-UCI y post-UCI.</p></div><div><h3>Resultados</h3><p>De 114 pacientes fallecidos fuera de la UCI, 49 tenían registrada LTSV en UCI (42,98%). La edad y la estancia previa al ingreso en UCI se asociaron positivamente a LTSV (OR 1,03 y 1,08, respectivamente) y la IN, negativamente (OR 0,19). Los pacientes sin LTSV presentaron una estancia post-UCI más alta, mientras que en los pacientes varones fue menor.</p></div><div><h3>Conclusiones</h3><p>Nuestros resultados apoyan que la LTSV instaurada dentro de UCI puede relacionarse con un menor número de complicaciones comúnmente asociadas a la prolongación innecesaria de la estancia, como la IN.</p></div><div><h3>Background</h3><p>Life-sustaining treatment limitation (LTSV) is the medical act of withdrawing or not initiating measures that are considered futile in a patient's specific situation. LTSV in critically ill patients remains a difficult topic to study, due to the multitude of factors that condition it.</p></div><div><h3>Objective</h3><p>To determine factors related to LTSV in ICU in cases of post-ICU in-hospital mortality, as well as factors associated with survival after discharge from ICU.</p></div><div><h3>Design</h3><p>Retrospective longitudinal study.</p></div><div><h3>Ambit</h3><p>Intensive care unit of a tertiary hospital.</p></div><div><h3>Patients</h3><p>People who died in the hospitalization ward after ICU treatment between January 2014 and December 2019.</p></div><div><h3>Interventions</h3><p>None. This is an observational study.</p></div><div><h3>Variables of interest</h3><p>Age, sex, probability of death, type of admission, LTSV in ICU, oncological disease, dependence, invasive mechanical ventilation, emergency hemodialysis, transfusion of blood products, noso","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139636004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efecto del ácido tranexámico en sujetos con lesión cerebral traumática: metaanálisis 氨甲环酸对脑外伤患者的影响:一项荟萃分析
IF 1.3 Q3 Medicine Pub Date : 2024-01-20 DOI: 10.1016/j.redar.2023.04.005
R.M. Sarhan, M.S. Boshra, M.E.A. Abdelrahim, H. Osama

Background

We performed a meta-analysis to assess the effectiveness and safety of tranexamic acid in patients with traumatic brain injury (TBI).

Methods

We searched the literature for articles evaluating the effectiveness and safety of tranexamic acid (TXA) in TBI published between January 2012 and January 2021, and identified 8 studies with a total of 10860 patients: 5660 received TXA and 5200 served as controls. We used a dichotomous or continuous approach with a random or fixed-effect model to assess the efficacy and safety of TXA in TBI, and calculated the mean difference (MD) and odds ratio (OR) with the corresponding 95% confidence interval.

Results

In patients with TBI, early administration of TXA was associated with a greater relative benefit (MD - 2.45; 95% CI = - 4.78- - 0.12; p = 0.04) and less total haematoma expansion (MD - 2.52; 95% CI = - 4.85- - 0.19; p = 0.03) compared to controls.

There were no statistically significant differences in mortality (OR 0.94; 95% CI = 0.85-1.03; p = 0.18), presence of progressive haemorrhage (OR 0.75; 95% CI = 0.56-1.01; p = 0.06), need for neurosurgery (OR 1.15; 95% CI = 0.66-1.98; p = 0.63), high Disability Rating Scale score (OR 0.90; 95% CI = 0.56-1.45; p = 0.68), and incidence of ischaemic or thromboembolic complications (OR 1.34; 95% CI = 0.33-5.46; p = 0.68) between TBI patients treated with TXA and controls.

Conclusions

Early administration of TXA in TBI patients may have a greater relative benefit and may inhibit haematoma expansion. There were no significant differences in mortality, presence of progressive haemorrhage, need for neurosurgery, high Disability Rating Scale score, and incidence of ischaemic or thromboembolic complications between TBI patients treated with TXA and controls. Further studies are needed to validate these results.

背景我们进行了一项荟萃分析,以评估氨甲环酸在创伤性脑损伤(TBI)患者中的有效性和安全性。方法我们检索了2012年1月至2021年1月期间发表的评估氨甲环酸(TXA)在TBI中有效性和安全性的文献,并确定了8项研究,共计10860名患者:其中 5660 名患者接受了氨甲环酸治疗,5200 名患者作为对照组。我们采用随机或固定效应模型的二分法或连续法评估了TXA在TBI中的疗效和安全性,并计算了平均差(MD)和几率比(OR)以及相应的95%置信区间。结果在创伤性脑损伤患者中,与对照组相比,早期给予 TXA 有更大的相对益处(MD - 2.45; 95% CI = - 4.78- - 0.12; p = 0.04),且血肿扩大的程度更小(MD - 2.52; 95% CI = - 4.85- - 0.19; p = 0.03)。94;95% CI = 0.85-1.03;p = 0.18)、是否存在进行性出血(OR 0.75;95% CI = 0.56-1.01;p = 0.06)、是否需要神经外科手术(OR 1.15;95% CI = 0.66-1.98;p = 0.63)、高残疾评定量表评分(OR 0.90;95% CI = 0.56-1.45;p = 0.结论对创伤性脑损伤患者早期给予 TXA 可能具有更大的相对益处,并可抑制血肿扩大。接受 TXA 治疗的创伤性脑损伤患者与对照组患者在死亡率、进行性出血、神经外科手术需求、高度残疾评定量表评分以及缺血性或血栓栓塞并发症的发生率方面没有明显差异。需要进一步研究来验证这些结果。
{"title":"Efecto del ácido tranexámico en sujetos con lesión cerebral traumática: metaanálisis","authors":"R.M. Sarhan,&nbsp;M.S. Boshra,&nbsp;M.E.A. Abdelrahim,&nbsp;H. Osama","doi":"10.1016/j.redar.2023.04.005","DOIUrl":"10.1016/j.redar.2023.04.005","url":null,"abstract":"<div><h3>Background</h3><p>We performed a meta-analysis to assess the effectiveness and safety of tranexamic acid in patients with traumatic brain injury (TBI).</p></div><div><h3>Methods</h3><p>We searched the literature for articles evaluating the effectiveness and safety of tranexamic acid (TXA) in TBI published between January 2012 and January 2021, and identified 8 studies with a total of 10860 patients: 5660 received TXA and 5200 served as controls. We used a dichotomous or continuous approach with a random or fixed-effect model to assess the efficacy and safety of TXA in TBI, and calculated the mean difference (MD) and odds ratio (OR) with the corresponding 95% confidence interval.</p></div><div><h3>Results</h3><p>In patients with TBI, early administration of TXA was associated with a greater relative benefit (MD - 2.45; 95% CI = - 4.78- - 0.12; p = 0.04) and less total haematoma expansion (MD - 2.52; 95% CI = - 4.85- - 0.19; p = 0.03) compared to controls.</p><p>There were no statistically significant differences in mortality (OR 0.94; 95% CI = 0.85-1.03; p = 0.18), presence of progressive haemorrhage (OR 0.75; 95% CI = 0.56-1.01; p = 0.06), need for neurosurgery (OR 1.15; 95% CI = 0.66-1.98; p = 0.63), high Disability Rating Scale score (OR 0.90; 95% CI = 0.56-1.45; p = 0.68), and incidence of ischaemic or thromboembolic complications (OR 1.34; 95% CI = 0.33-5.46; p = 0.68) between TBI patients treated with TXA and controls.</p></div><div><h3>Conclusions</h3><p>Early administration of TXA in TBI patients may have a greater relative benefit and may inhibit haematoma expansion. There were no significant differences in mortality, presence of progressive haemorrhage, need for neurosurgery, high Disability Rating Scale score, and incidence of ischaemic or thromboembolic complications between TBI patients treated with TXA and controls. Further studies are needed to validate these results.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asociación entre diferentes pautas de corticoides empleadas en la infección grave por SARS-CoV-2 y la mortalidad a corto plazo: estudio de cohortes retrospectivo 严重 SARS-CoV-2 感染者使用的不同皮质类固醇治疗方案与短期死亡率之间的关系:一项回顾性队列研究。
IF 1.3 Q3 Medicine Pub Date : 2024-01-15 DOI: 10.1016/j.redar.2023.09.002
A. González-Castro, A. Fernandez, E. Cuenca-Fito, Y. Peñasco, J. Ceña, J.C. Rodríguez Borregán

Introduction

During the SARS-CoV-2 pandemic, several corticosteroid regimens have been used in the treatment of the disease, with disparate results according to drug and regimen used. For this reason, we wanted to analyze differences in early mortality derived from the use of different regimens of dexamethasone and methylprednisolone in SARS-CoV-2 infection in critically ill patients requiring admission to an ICU.

Method

Observational, analytical and retrospective study, in an intensive care unit of a third-level university hospital (March 2020 and June 2021). Adult patients (>18 years old) who were admitted consecutively for proven SARS-CoV-2 infection were included. The association with mortality in ICU at 28 days, different corticosteroid regimens used, was analyzed using a Cox proportional risk regression model.

Results

Data from a cohort of 539 patients were studied. Patient age (RR: 1.06; 95% CI: 1.02-1.10; P≤0.01) showed a significant association with 28-day mortality in the ICU. In the comparison of the different corticosteroid regimens analyzed, taking as a reference those patients who did not receive corticosteroid treatment, the dose of dexamethasone of 6 mg/day showed a clear trend towards statistical significance as a protector of mortality at 28 days in the ICU (RR: 0.40; 95% CI: 0.15-1.02; p=.05). The dose of dexamethasone of 6 mg/day and low doses of methylprednisolone show a similar association with survival at 28 days (OR: 1.19; 95% CI: 0.63-2.26).

Conclusions

The use of corticosteroids has been associated with better mortality outcomes in severe cases of SARS-CoV-2 infection. However, the therapeutic benefits of corticosteroids are not limited to dexamethasone alone.

导言在 SARS-CoV-2 大流行期间,有几种皮质类固醇治疗方案被用于治疗该疾病,不同的药物和治疗方案产生了不同的结果。因此,我们希望分析在需要入住重症监护病房的重症患者感染 SARS-CoV-2 时,使用地塞米松和甲基强的松龙的不同方案所导致的早期死亡率的差异。方法在一家三级甲等大学医院的重症监护病房进行观察、分析和回顾性研究(2020 年 3 月至 2021 年 6 月)。研究对象包括因证实感染 SARS-CoV-2 而连续入院的成年患者(18 岁)。采用 Cox 比例风险回归模型分析了不同皮质类固醇治疗方案与重症监护病房 28 天死亡率的关系。患者年龄(RR:1.06;95% CI:1.02-1.10;P≤0.01)与重症监护室 28 天死亡率有显著相关性。在对不同的皮质类固醇治疗方案进行分析比较时,以未接受皮质类固醇治疗的患者为参照,地塞米松剂量为 6 毫克/天显示出明显的统计学意义趋势,可降低重症监护室 28 天的死亡率(RR:0.40;95% CI:0.15-1.02;P=0.05)。地塞米松剂量为 6 毫克/天和小剂量甲基强的松龙与 28 天后的存活率有相似的关系(OR:1.19;95% CI:0.63-2.26)。然而,皮质类固醇的治疗效果并不仅限于地塞米松。
{"title":"Asociación entre diferentes pautas de corticoides empleadas en la infección grave por SARS-CoV-2 y la mortalidad a corto plazo: estudio de cohortes retrospectivo","authors":"A. González-Castro,&nbsp;A. Fernandez,&nbsp;E. Cuenca-Fito,&nbsp;Y. Peñasco,&nbsp;J. Ceña,&nbsp;J.C. Rodríguez Borregán","doi":"10.1016/j.redar.2023.09.002","DOIUrl":"10.1016/j.redar.2023.09.002","url":null,"abstract":"<div><h3>Introduction</h3><p>During the SARS-CoV-2 pandemic, several corticosteroid regimens have been used in the treatment of the disease, with disparate results according to drug and regimen used. For this reason, we wanted to analyze differences in early mortality derived from the use of different regimens of dexamethasone and methylprednisolone in SARS-CoV-2 infection in critically ill patients requiring admission to an ICU.</p></div><div><h3>Method</h3><p>Observational, analytical and retrospective study, in an intensive care unit of a third-level university hospital (March 2020 and June 2021). Adult patients (&gt;18 years old) who were admitted consecutively for proven SARS-CoV-2 infection were included. The association with mortality in ICU at 28 days, different corticosteroid regimens used, was analyzed using a Cox proportional risk regression model.</p></div><div><h3>Results</h3><p>Data from a cohort of 539 patients were studied. Patient age (RR: 1.06; 95% CI: 1.02-1.10; <em>P</em>≤0.01) showed a significant association with 28-day mortality in the ICU. In the comparison of the different corticosteroid regimens analyzed, taking as a reference those patients who did not receive corticosteroid treatment, the dose of dexamethasone of 6<!--> <!-->mg/day showed a clear trend towards statistical significance as a protector of mortality at 28 days in the ICU (RR: 0.40; 95% CI: 0.15-1.02; p=.05). The dose of dexamethasone of 6 mg/day and low doses of methylprednisolone show a similar association with survival at 28 days (OR: 1.19; 95% CI: 0.63-2.26).</p></div><div><h3>Conclusions</h3><p>The use of corticosteroids has been associated with better mortality outcomes in severe cases of SARS-CoV-2 infection. However, the therapeutic benefits of corticosteroids are not limited to dexamethasone alone.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dolor crónico tras la cirugía de mama: incidencia, factores de riesgo e impacto en la calidad de vida 乳房手术后的慢性疼痛:发生率、风险因素和对生活质量的影响
IF 1.3 Q3 Medicine Pub Date : 2024-01-13 DOI: 10.1016/j.redar.2023.04.006
S. Nogueira , D. Rodrigues , M. Barros , J. Menezes , L. Guimarães-Pereira

Introduction and objectives

Breast cancer is the most frequently diagnosed malignancy, and chronic pain after breast surgery (CPBS) is an increasingly recognized therapy-related problem. We evaluated CPBS incidence, characteristics, associated factors, and impact on patient quality of life (QoL).

Materials and methods

Six-month observational prospective study in patients undergoing breast surgery in a tertiary university hospital. Data were collected using several questionnaires: Pain Catastrophizing Scale, Brief Pain Inventory-Short Form, Douleur Neuropathique 4 Questionnaire, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and its Breast Cancer Module.

Results

A total of 112 patients completed the study. Approximately, one third (34.8%) developed CPBS, almost all with potentially neuropathic pain. CPBS interfered with patients’ daily life and reduced their QoL. Diabetes (p=.028), catastrophizing (p=.042), and acute postoperative pain severity (p<.001) were associated with CPBS.

Conclusions

This study broadens our understanding of CPBS and shows the impact of this syndrome. Healthcare workers need to be aware of CPBS and take steps to prevent and treat it, and provide patients with adequate information.

引言和目的乳腺癌是最常见的恶性肿瘤,而乳腺手术后慢性疼痛(CPBS)是一个日益受到重视的治疗相关问题。我们对 CPBS 的发生率、特征、相关因素以及对患者生活质量(QoL)的影响进行了评估。采用多种问卷收集数据:结果共有 112 名患者完成了研究。约有三分之一(34.8%)的患者出现了 CPBS,几乎所有患者都有潜在的神经病理性疼痛。CPBS 影响了患者的日常生活,降低了他们的生活质量。糖尿病(p=.028)、灾难化(p=.042)和急性术后疼痛严重程度(p< .001)与 CPBS 相关。医护人员需要了解 CPBS,采取措施预防和治疗 CPBS,并为患者提供足够的信息。
{"title":"Dolor crónico tras la cirugía de mama: incidencia, factores de riesgo e impacto en la calidad de vida","authors":"S. Nogueira ,&nbsp;D. Rodrigues ,&nbsp;M. Barros ,&nbsp;J. Menezes ,&nbsp;L. Guimarães-Pereira","doi":"10.1016/j.redar.2023.04.006","DOIUrl":"10.1016/j.redar.2023.04.006","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Breast cancer is the most frequently diagnosed malignancy, and chronic pain after breast surgery (CPBS) is an increasingly recognized therapy-related problem. We evaluated CPBS incidence, characteristics, associated factors, and impact on patient quality of life (QoL).</p></div><div><h3>Materials and methods</h3><p>Six-month observational prospective study in patients undergoing breast surgery in a tertiary university hospital. Data were collected using several questionnaires: Pain Catastrophizing Scale, Brief Pain Inventory-Short Form, Douleur Neuropathique 4 Questionnaire, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and its Breast Cancer Module.</p></div><div><h3>Results</h3><p>A total of 112 patients completed the study. Approximately, one third (34.8%) developed CPBS, almost all with potentially neuropathic pain. CPBS interfered with patients’ daily life and reduced their QoL. Diabetes <em>(p</em>=.028), catastrophizing <em>(p</em>=.042), and acute postoperative pain severity <em>(p</em>&lt;.001) were associated with CPBS.</p></div><div><h3>Conclusions</h3><p>This study broadens our understanding of CPBS and shows the impact of this syndrome. Healthcare workers need to be aware of CPBS and take steps to prevent and treat it, and provide patients with adequate information.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Revista Espanola de Anestesiologia y Reanimacion
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