Pub Date : 2024-02-01DOI: 10.1016/j.redar.2022.05.011
R. Mato-Bua , D. Lopez-Lopez , A. Garcia-Perez , C. Bonome
Tubeless anaesthesia has become widespread in videothoracoscopic surgery, even in major procedures such as lobectomies. There are several advantages in avoiding general anaesthesia and one-lung mechanical ventilation, such as faster recovery and shorter hospital stays. However, hypoxaemia and hypercapnia are the most reported causes of conversion to general anaesthesia. High Flow Oxygen Therapy (HFOT) generates flow-dependent positive end-expiratory pressure, improves oxygenation and also carbon dioxide washout by flow-dependent dead space flushing. For this reason, intraoperative HFOT may reduce the rate of conversion to general anaesthesia. We report our experience with intraoperative HFOT in a 71-year-old female with lung adenocarcinoma undergoing VATS upper left lobectomy.
{"title":"Oxigenoterapia intraoperatoria de alto flujo para anestesia sin intubación en cirugía toracoscópica","authors":"R. Mato-Bua , D. Lopez-Lopez , A. Garcia-Perez , C. Bonome","doi":"10.1016/j.redar.2022.05.011","DOIUrl":"10.1016/j.redar.2022.05.011","url":null,"abstract":"<div><p>Tubeless anaesthesia has become widespread in videothoracoscopic surgery, even in major procedures such as lobectomies. There are several advantages in avoiding general anaesthesia and one-lung mechanical ventilation, such as faster recovery and shorter hospital stays. However, hypoxaemia and hypercapnia are the most reported causes of conversion to general anaesthesia. High Flow Oxygen Therapy (HFOT) generates flow-dependent positive end-expiratory pressure, improves oxygenation and also carbon dioxide washout by flow-dependent dead space flushing. For this reason, intraoperative HFOT may reduce the rate of conversion to general anaesthesia. We report our experience with intraoperative HFOT in a 71-year-old female with lung adenocarcinoma undergoing VATS upper left lobectomy.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135606265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-01DOI: 10.1016/j.redar.2023.03.007
B. Hernando Vela , P. Jarén Cubillo , C. Bueno Fernández , L. Gallego Ligorit , M.C. Ferrer García , J.A. Diarte
Background and objectives
Percutaneous implantation of an aortic valve prosthesis is a therapeutic alternative for patients with severe aortic stenosis. The procedure is traditionally performed under general anaesthesia; however, sedation is now gaining in popularity because it reduces the need for vasoactive drugs and shortens the patient's stay in the critical care unit and on the ward. The aim of this study is to evaluate the clinical efficacy, safety and potential benefits of sedation with dexmedetomidine in patients undergoing percutaneous implantation of an aortic valve prosthesis in terms of haemodynamic and respiratory complications.
Materials and methods
We performed a retrospective study of 222 patients that had undergone percutaneous implantation of an aortic valve prosthesis between 2012 and 2019 under sedation with either dexmedetomidine plus remifentanil (DEX-RMF) or propofol plus remifentanil (PROPO-RMF). We collected data on complications, mainly haemodynamic and respiratory, during and after the procedure.
Results
No significant differences were found between sedation with dexmedetomidine and propofol (in combination with remifentanil) in terms of haemodynamic stability and intraprocedural cerebral blood oxygen. In the DEX-RMF group, however, mean blood pressure, midazolam dose, and duration of anaesthesia were lower compared with the PROPO-RMF group, but the incidence of haemodynamic and respiratory complications did not differ significantly between groups.
Conclusions
Our results show that sedation, particularly with adjuvant dexmedetomidine, is a valid anaesthetic techniques in percutaneous aortic valve prosthesis implantation.
{"title":"Estudio retrospectivo de pacientes intervenidos de implante valvular aórtico transcatéter (TAVI), entre los años 2012 y 2019, a los que se les realizó sedación con propofol/remifentanilo versus dexmedetomidina/remifentanilo","authors":"B. Hernando Vela , P. Jarén Cubillo , C. Bueno Fernández , L. Gallego Ligorit , M.C. Ferrer García , J.A. Diarte","doi":"10.1016/j.redar.2023.03.007","DOIUrl":"10.1016/j.redar.2023.03.007","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Percutaneous implantation of an aortic valve prosthesis is a therapeutic alternative for patients with severe aortic stenosis. The procedure is traditionally performed under general anaesthesia; however, sedation is now gaining in popularity because it reduces the need for vasoactive drugs and shortens the patient's stay in the critical care unit and on the ward. The aim of this study is to evaluate the clinical efficacy, safety and potential benefits of sedation with dexmedetomidine in patients undergoing percutaneous implantation of an aortic valve prosthesis in terms of haemodynamic and respiratory complications.</p></div><div><h3>Materials and methods</h3><p>We performed a retrospective study of 222 patients that had undergone percutaneous implantation of an aortic valve prosthesis between 2012 and 2019 under sedation with either dexmedetomidine plus remifentanil (DEX-RMF) or propofol plus remifentanil (PROPO-RMF). We collected data on complications, mainly haemodynamic and respiratory, during and after the procedure.</p></div><div><h3>Results</h3><p>No significant differences were found between sedation with dexmedetomidine and propofol (in combination with remifentanil) in terms of haemodynamic stability and intraprocedural cerebral blood oxygen. In the DEX-RMF group, however, mean blood pressure, midazolam dose, and duration of anaesthesia were lower compared with the PROPO-RMF group, but the incidence of haemodynamic and respiratory complications did not differ significantly between groups.</p></div><div><h3>Conclusions</h3><p>Our results show that sedation, particularly with adjuvant dexmedetomidine, is a valid anaesthetic techniques in percutaneous aortic valve prosthesis implantation.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138627106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-30DOI: 10.1016/j.redar.2023.07.004
P. Casas Reza, M. Gestal Vázquez, L. Sampayo Rodríguez, A. Vilar Castro, D. López-López, A. García Romar
Introduction
Total hip arthroplasty is one of the most frequent surgical interventions in the hospital setting. Nonetheless, the ideal method to manage post-operative pain is still unknown. Multimodal analgesia techniques based on regional anaesthesia are amongst the most promising solutions.
Objectives
The aim of this study was to evaluate postoperative pain after total hip arthroplasty according to whether peripheral nerve block was performed (femoral block, fascia iliaca block and pericapsular nerve group block). Intravenous morphine consumption during the patient's stay in the post-anaesthesia care unit was measured, as well as the number of opioid rescues at 24 and 48h post intervention. As secondary objectives, the prevalence of nerve injury, prolonged quadricipital block, and morphine consumption were established according to other variables of interest.
Materials and methods
In this observational retrospective study, data was collected from the electronic medical record of 656 traumatological surgery patients from April 2018 to August 2020, with the following inclusion criteria: over 18 years old, ASA I-III, primary total hip arthroplasty under general anaesthesia or subarachnoid anaesthesia (only with hyperbaric bupivacaine) and use of levobupivacaine for peripheral nerve block.
Results
A total of 362 patients were selected. The main surgical indication was coxarthrosis (61.3%), followed by hip fracture (22.6%). Peripheral nerve blocks were performed on 169 patients (66.3% femoral, 27.7% PENG, and 6.0% fascia iliaca). Mean postoperative opioid consumption in PACU was lower in patients in who received a PENG (2.2 mg) or a femoral (3.27 mg) block, compared to those who received neither (6.69 mg). There were no differences in opioid rescues at 24 and 48h after the procedure. Nerve injury incidence was low (.8%), and not associated with nerve blocks. The incidence of prolonged quadricipital paralysis was also low (1.3%), and was mainly associated with femoral nerve block (75% of cases).
Conclusions
This retrospective study supports the use of regional blocks as opioid- sparing techniques, highlighting their role in rapid functional recovery with no motor impairment.
{"title":"Análisis retrospectivo de la anestesia regional en la cirugía de cadera: Auditoría clínica","authors":"P. Casas Reza, M. Gestal Vázquez, L. Sampayo Rodríguez, A. Vilar Castro, D. López-López, A. García Romar","doi":"10.1016/j.redar.2023.07.004","DOIUrl":"https://doi.org/10.1016/j.redar.2023.07.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Total hip arthroplasty is one of the most frequent surgical interventions in the hospital setting. Nonetheless, the ideal method to manage post-operative pain is still unknown. Multimodal analgesia techniques based on regional anaesthesia are amongst the most promising solutions.</p></div><div><h3>Objectives</h3><p>The aim of this study was to evaluate postoperative pain after total hip arthroplasty according to whether peripheral nerve block was performed (femoral block, fascia iliaca block and pericapsular nerve group block). Intravenous morphine consumption during the patient's stay in the post-anaesthesia care unit was measured, as well as the number of opioid rescues at 24 and 48h post intervention. As secondary objectives, the prevalence of nerve injury, prolonged quadricipital block, and morphine consumption were established according to other variables of interest.</p></div><div><h3>Materials and methods</h3><p>In this observational retrospective study, data was collected from the electronic medical record of 656 traumatological surgery patients from April 2018 to August 2020, with the following inclusion criteria: over 18 years old, ASA I-III, primary total hip arthroplasty under general anaesthesia or subarachnoid anaesthesia (only with hyperbaric bupivacaine) and use of levobupivacaine for peripheral nerve block.</p></div><div><h3>Results</h3><p>A total of 362 patients were selected. The main surgical indication was coxarthrosis (61.3%), followed by hip fracture (22.6%). Peripheral nerve blocks were performed on 169 patients (66.3% femoral, 27.7% PENG, and 6.0% fascia iliaca). Mean postoperative opioid consumption in PACU was lower in patients in who received a PENG (2.2 mg) or a femoral (3.27 mg) block, compared to those who received neither (6.69 mg). There were no differences in opioid rescues at 24 and 48h after the procedure. Nerve injury incidence was low (.8%), and not associated with nerve blocks. The incidence of prolonged quadricipital paralysis was also low (1.3%), and was mainly associated with femoral nerve block (75% of cases).</p></div><div><h3>Conclusions</h3><p>This retrospective study supports the use of regional blocks as opioid- sparing techniques, highlighting their role in rapid functional recovery with no motor impairment.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139985677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-30DOI: 10.1016/j.redar.2023.09.003
F. Reinoso-Barbero , R. López-López , M.D. Cárceles Barón , M. Hervías-Sanz , J. García-Fernández , Grupo de Trabajo de Dolor Infantil de la Sección de Anestesia Pediátrica de la SEDAR
Objective
To improve knowledge about routine clinical practice in the management of paediatric acute pain in Spain.
Methods
A telematic survey was conducted via the Internet on a representative sample of healthcare professionals involved in the management of paediatric acute pain (specifically anaesthesiologists) in Spain. The survey included 28 questions about their usual clinical practice in the assessment and treatment of acute pain, and also training and organisational aspects in paediatric acute pain.
Results
The survey was completed during March 2021 by 150 specialists in anaesthesiology. The respondents widely experienced in the management of acute paediatric pain (mean years of experience: 14.3: SD: 7.8), essentially in acute postoperative pain (97% of cases). Although 80% routinely used validated paediatric acute pain assessment scales, only 2.6% used specific scales adapted for patients with cognitive impairment. Most of the respondents routinely used analgesic drugs such as paracetamol (99%) or metamizole (92%), but only 84% complemented these drugs with a loco-regional blocking technique or other non-steroidal anti-inflammatory drugs (62%). Furthermore, only 62.7% acknowledged having received specific training in paediatric acute pain, only 45% followed hospital institutional protocols, and a scant 28% did so through paediatric pain units.
Conclusions
The survey identified important points for improvement in the training and organisation of acute pain management in Spanish paediatric patients.
{"title":"El tratamiento del dolor agudo pediátrico en España EN 2021: resultado de una encuesta nacional entre anestesiólogos pediátricos","authors":"F. Reinoso-Barbero , R. López-López , M.D. Cárceles Barón , M. Hervías-Sanz , J. García-Fernández , Grupo de Trabajo de Dolor Infantil de la Sección de Anestesia Pediátrica de la SEDAR","doi":"10.1016/j.redar.2023.09.003","DOIUrl":"https://doi.org/10.1016/j.redar.2023.09.003","url":null,"abstract":"<div><h3>Objective</h3><p>To improve knowledge about routine clinical practice in the management of paediatric acute pain in Spain.</p></div><div><h3>Methods</h3><p>A telematic survey was conducted via the Internet on a representative sample of healthcare professionals involved in the management of paediatric acute pain (specifically anaesthesiologists) in Spain. The survey included 28 questions about their usual clinical practice in the assessment and treatment of acute pain, and also training and organisational aspects in paediatric acute pain.</p></div><div><h3>Results</h3><p>The survey was completed during March 2021 by 150 specialists in anaesthesiology. The respondents widely experienced in the management of acute paediatric pain (mean years of experience: 14.3: SD: 7.8), essentially in acute postoperative pain (97% of cases). Although 80% routinely used validated paediatric acute pain assessment scales, only 2.6% used specific scales adapted for patients with cognitive impairment. Most of the respondents routinely used analgesic drugs such as paracetamol (99%) or metamizole (92%), but only 84% complemented these drugs with a loco-regional blocking technique or other non-steroidal anti-inflammatory drugs (62%). Furthermore, only 62.7% acknowledged having received specific training in paediatric acute pain, only 45% followed hospital institutional protocols, and a scant 28% did so through paediatric pain units.</p></div><div><h3>Conclusions</h3><p>The survey identified important points for improvement in the training and organisation of acute pain management in Spanish paediatric patients.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-24DOI: 10.1016/j.redar.2023.06.002
R. Mato-Búa, A. Prado-Rodríguez, D. López-López, P. Rama-Maceiras, N. Molins-Gauna, F. Álvarez-Refojo
Introduction
Pulmonary atelectasis is common in patients undergoing laparoscopic abdominal surgery under general anaesthesia, which increases the risk of perioperative respiratory complications. Alveolar recruitment manoeuvres (ARM) are used to open up the lung parenchyma with atelectasis, although the duration of their benefit has not been clearly established. The aim of this study was to determine the effectiveness of an ARM in laparoscopic colon surgery, the duration of response over time, and its haemodynamic impact.
Methods
Twenty-five patients undergoing laparoscopic colon surgery were included. After anaesthetic induction and initiation of surgery with pneumoperitoneum, an ARM was performed, and then optimal PEEP determined. Respiratory mechanics and gas exchange variables, and haemodynamic parameters, were analysed before the manoeuvre and periodically over the following 90 minutes.
Results
Three patients were excluded for surgical reasons. The alveolar arterial oxygen gradient went from 94.3 (62.3-117.8) mmHg before to 60.7 (29.6-91.0) mmHg after the manoeuvre (P < .05). This difference was maintained during the 90 minutes of the study. Dynamic compliance of the respiratory system went from 31.3 ml/cmH2O (26.1-39.2) before the manoeuvre to 46.1 ml/cmH2O (37.5-53.5) after the manoeuvre (P < .05). This difference was maintained for 60 minutes. No significant changes were identified in any of the haemodynamic variables studied.
Conclusion
In patients undergoing laparoscopic colon surgery, performing an intraoperative ARM improves the mechanics of the respiratory system and oxygenation, without associated haemodynamic compromise. The benefit of these manoeuvres lasts for at least one hour.
{"title":"Efectos intraoperatorios de una maniobra de reclutamiento alveolar en pacientes sometidos a cirugía laparoscópica de colon","authors":"R. Mato-Búa, A. Prado-Rodríguez, D. López-López, P. Rama-Maceiras, N. Molins-Gauna, F. Álvarez-Refojo","doi":"10.1016/j.redar.2023.06.002","DOIUrl":"10.1016/j.redar.2023.06.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Pulmonary atelectasis is common in patients undergoing laparoscopic abdominal surgery under general anaesthesia, which increases the risk of perioperative respiratory complications. Alveolar recruitment manoeuvres (ARM) are used to open up the lung parenchyma with atelectasis, although the duration of their benefit has not been clearly established. The aim of this study was to determine the effectiveness of an ARM in laparoscopic colon surgery, the duration of response over time, and its haemodynamic impact.</p></div><div><h3>Methods</h3><p>Twenty-five patients undergoing laparoscopic colon surgery were included. After anaesthetic induction and initiation of surgery with pneumoperitoneum, an ARM was performed, and then optimal PEEP determined. Respiratory mechanics and gas exchange variables, and haemodynamic parameters, were analysed before the manoeuvre and periodically over the following 90 minutes.</p></div><div><h3>Results</h3><p>Three patients were excluded for surgical reasons. The alveolar arterial oxygen gradient went from 94.3 (62.3-117.8) mmHg before to 60.7 (29.6-91.0) mmHg after the manoeuvre (<em>P</em> < .05). This difference was maintained during the 90 minutes of the study. Dynamic compliance of the respiratory system went from 31.3 ml/cmH<sub>2</sub>O (26.1-39.2) before the manoeuvre to 46.1 ml/cmH<sub>2</sub>O (37.5-53.5) after the manoeuvre (<em>P</em> < .05). This difference was maintained for 60 minutes. No significant changes were identified in any of the haemodynamic variables studied.</p></div><div><h3>Conclusion</h3><p>In patients undergoing laparoscopic colon surgery, performing an intraoperative ARM improves the mechanics of the respiratory system and oxygenation, without associated haemodynamic compromise. The benefit of these manoeuvres lasts for at least one hour.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139638169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-24DOI: 10.1016/j.redar.2023.11.002
J. Rico-Feijoó , J.F. Bermejo-Martín , A. Pérez-González , S. Martín-Alfonso , C. Aldecoa
Background and objective
The diagnosis of infection, to diagnose septic shock, has been qualified by leukocyte counts and protein biomarkers. Septic shock mortality is persistently high (20%-50%), and rising in the long term. The definition of sepsis does not include leukocyte count, and lymphopenia has been associated with its mortality in the short term. Immunosuppression and increased mortality in the long term due to sepsis have not been demonstrated. The aim is to relate the occurrence of lymphopenia and its lack of recovery during septic shock with mortality at 2 years.
Patients and methods
Cohort of 332 elderly patients diagnosed with septic shock. Mortality at 28 days and 2 years was analysed according to leukocyte, neutrophil, and lymphocyte counts, and the ability to recover from lymphopenia (LRec).
Results
A total of 74.1% of patients showed lymphopenia, and 66.3% did not improve during ICU stay. Mortality was 31.0% and 50.3% at 28 days and 2 years, respectively. A leukocyte count < 12,000 /μL was a predictor of early mortality (OR: 2.96) and LRec of late mortality (OR: 3.98). Long-term mortality was associated with LRec (HR: 1.69).
Conclusions
In elderly patients with septic shock, the absence of leukocytosis and neutrophilia is associated with 28-day mortality, and LRec with 2-year mortality; this may represent two distinct phenotypes of behaviour after septic shock.
{"title":"Influencia de la linfopenia en la mortalidad a largo plazo en shock séptico, estudio observacional retrospectivo","authors":"J. Rico-Feijoó , J.F. Bermejo-Martín , A. Pérez-González , S. Martín-Alfonso , C. Aldecoa","doi":"10.1016/j.redar.2023.11.002","DOIUrl":"10.1016/j.redar.2023.11.002","url":null,"abstract":"<div><h3>Background and objective</h3><p>The diagnosis of infection, to diagnose septic shock, has been qualified by leukocyte counts and protein biomarkers. Septic shock mortality is persistently high (20%-50%), and rising in the long term. The definition of sepsis does not include leukocyte count, and lymphopenia has been associated with its mortality in the short term. Immunosuppression and increased mortality in the long term due to sepsis have not been demonstrated. The aim is to relate the occurrence of lymphopenia and its lack of recovery during septic shock with mortality at 2<!--> <!-->years.</p></div><div><h3>Patients and methods</h3><p>Cohort of 332 elderly patients diagnosed with septic shock. Mortality at 28<!--> <!-->days and 2<!--> <!-->years was analysed according to leukocyte, neutrophil, and lymphocyte counts, and the ability to recover from lymphopenia (LRec).</p></div><div><h3>Results</h3><p>A total of 74.1% of patients showed lymphopenia, and 66.3% did not improve during ICU stay. Mortality was 31.0% and 50.3% at 28<!--> <!-->days and 2<!--> <!-->years, respectively. A leukocyte count < 12,000 /μL was a predictor of early mortality (OR: 2.96) and LRec of late mortality (OR: 3.98). Long-term mortality was associated with LRec (HR: 1.69).</p></div><div><h3>Conclusions</h3><p>In elderly patients with septic shock, the absence of leukocytosis and neutrophilia is associated with 28-day mortality, and LRec with 2-year mortality; this may represent two distinct phenotypes of behaviour after septic shock.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-23DOI: 10.1016/j.redar.2023.05.013
U.A. López González , D. Bautista Rentero , M. Crespo Gómez , P. Cárcamo Ibarra , A.M. Míguez Santiyán
Antecedentes
La limitación del tratamiento de soporte vital (LTSV) es el acto médico de retirar o no iniciar medidas que se consideren fútiles en la situación concreta de un paciente. La LTSV en pacientes críticos sigue siendo un tema difícil de estudiar, debido a la multitud de factores que la condicionan.
Objetivo
Determinar los factores relacionados con la LTSV en la Unidad de Cuidados Intensivos (UCI) en casos de mortalidad hospitalaria post-UCI, así como los factores asociados a los días de supervivencia tras el alta de UCI.
Diseño
Estudio longitudinal retrospectivo.
Ámbito
UCI de un hospital terciario.
Pacientes
Personas fallecidas en sala de hospitalización tras tratamiento en UCI entre enero de 2014 y diciembre de 2019.
Intervenciones
No existen. Se trata de un estudio observacional.
Variables de interés
Edad, sexo, probabilidad de muerte, tipo de ingreso, LTSV en UCI, enfermedad oncológica, dependencia, ventilación mecánica invasiva (VMI) y hemodiálisis de urgencia (HDU), transfusión de hemoderivados (TDH), infección nosocomial (IN), estancias pre-UCI, intra-UCI y post-UCI.
Resultados
De 114 pacientes fallecidos fuera de la UCI, 49 tenían registrada LTSV en UCI (42,98%). La edad y la estancia previa al ingreso en UCI se asociaron positivamente a LTSV (OR 1,03 y 1,08, respectivamente) y la IN, negativamente (OR 0,19). Los pacientes sin LTSV presentaron una estancia post-UCI más alta, mientras que en los pacientes varones fue menor.
Conclusiones
Nuestros resultados apoyan que la LTSV instaurada dentro de UCI puede relacionarse con un menor número de complicaciones comúnmente asociadas a la prolongación innecesaria de la estancia, como la IN.
Background
Life-sustaining treatment limitation (LTSV) is the medical act of withdrawing or not initiating measures that are considered futile in a patient's specific situation. LTSV in critically ill patients remains a difficult topic to study, due to the multitude of factors that condition it.
Objective
To determine factors related to LTSV in ICU in cases of post-ICU in-hospital mortality, as well as factors associated with survival after discharge from ICU.
Design
Retrospective longitudinal study.
Ambit
Intensive care unit of a tertiary hospital.
Patients
People who died in the hospitalization ward after ICU treatment between January 2014 and December 2019.
Interventions
None. This is an observational study.
Variables of interest
Age, sex, probability of death, type of admission, LTSV in ICU, oncological disease, dependence, invasive mechanical ventilation, emergency hemodialysis, transfusion of blood products, noso
背景生命维持治疗限制(LSTL)是指根据患者的具体情况,撤消或不启动被认为是无效的措施的医疗行为。目的 确定重症监护病房(ICU)中 LSTL 的相关因素,以及 ICU 出院后存活天数的相关因素。设计回顾性纵向研究.地点一家三甲医院的重症监护室.患者2014年1月至2019年12月期间在重症监护室治疗后在病房死亡的患者.干预措施没有干预措施。相关变量年龄、性别、死亡概率、入院类型、ICU LSTL、肿瘤疾病、依赖性、有创机械通气(IMV)和紧急血液透析(EHD)、血制品输注(HDT)、院内感染(NI)、ICU前、ICU内和ICU后住院时间。结果在114名死于ICU外的患者中,49人在ICU内有LSTL记录(42.98%)。年龄和重症监护室前住院时间与 LSTL 呈正相关(OR 值分别为 1.03 和 1.08),与 NI 呈负相关(OR 值为 0.19)。结论我们的研究结果表明,在重症监护室内实施生命维持治疗限制(LTSV)可能会减少与不必要的住院时间延长(如 NI)相关的并发症。背景生命维持治疗限制(LTSV)是指根据患者的具体情况,撤消或不启动被认为是徒劳无益的措施的医疗行为。危重症患者的生命维持治疗限制仍是一个难以研究的课题,因为影响它的因素很多.Objective To determine factors related to LTSV in ICU in cases of postICU in-hospital mortality, as well as factors related to survival after discharge from ICU.DesignRetrospective longitudinal study.AmbitIntensive care unit of a tertiary hospital.PatientsPeople who died in the hospitalization ward after ICU treatment between January 2014 and December 2019.InterventionsNone.相关变量年龄、性别、死亡概率、入院类型、ICU中的LTSV、肿瘤疾病、依赖性、有创机械通气、紧急血液透析、输血产品、院内感染(NI)、ICU前、ICU内和ICU后的住院时间。结果在114名死于ICU外的患者中,49人在ICU中登记了LTSV(42.98%)。年龄和入住 ICU 前的住院时间与 LTSV 呈正相关(OR 分别为 1.03 和 1.08)。没有 LTSV 的患者在 ICU 后的住院时间较长,而男性患者的住院时间较短。
{"title":"Factores asociados a la limitación del soporte vital: estudio de casos de mortalidad post-UCI de un hospital terciario","authors":"U.A. López González , D. Bautista Rentero , M. Crespo Gómez , P. Cárcamo Ibarra , A.M. Míguez Santiyán","doi":"10.1016/j.redar.2023.05.013","DOIUrl":"10.1016/j.redar.2023.05.013","url":null,"abstract":"<div><h3>Antecedentes</h3><p>La limitación del tratamiento de soporte vital (LTSV) es el acto médico de retirar o no iniciar medidas que se consideren fútiles en la situación concreta de un paciente. La LTSV en pacientes críticos sigue siendo un tema difícil de estudiar, debido a la multitud de factores que la condicionan.</p></div><div><h3>Objetivo</h3><p>Determinar los factores relacionados con la LTSV en la Unidad de Cuidados Intensivos (UCI) en casos de mortalidad hospitalaria post-UCI, así como los factores asociados a los días de supervivencia tras el alta de UCI.</p></div><div><h3>Diseño</h3><p>Estudio longitudinal retrospectivo.</p></div><div><h3>Ámbito</h3><p>UCI de un hospital terciario.</p></div><div><h3>Pacientes</h3><p>Personas fallecidas en sala de hospitalización tras tratamiento en UCI entre enero de 2014 y diciembre de 2019.</p></div><div><h3>Intervenciones</h3><p>No existen. Se trata de un estudio observacional.</p></div><div><h3>Variables de interés</h3><p>Edad, sexo, probabilidad de muerte, tipo de ingreso, LTSV en UCI, enfermedad oncológica, dependencia, ventilación mecánica invasiva (VMI) y hemodiálisis de urgencia (HDU), transfusión de hemoderivados (TDH), infección nosocomial (IN), estancias pre-UCI, intra-UCI y post-UCI.</p></div><div><h3>Resultados</h3><p>De 114 pacientes fallecidos fuera de la UCI, 49 tenían registrada LTSV en UCI (42,98%). La edad y la estancia previa al ingreso en UCI se asociaron positivamente a LTSV (OR 1,03 y 1,08, respectivamente) y la IN, negativamente (OR 0,19). Los pacientes sin LTSV presentaron una estancia post-UCI más alta, mientras que en los pacientes varones fue menor.</p></div><div><h3>Conclusiones</h3><p>Nuestros resultados apoyan que la LTSV instaurada dentro de UCI puede relacionarse con un menor número de complicaciones comúnmente asociadas a la prolongación innecesaria de la estancia, como la IN.</p></div><div><h3>Background</h3><p>Life-sustaining treatment limitation (LTSV) is the medical act of withdrawing or not initiating measures that are considered futile in a patient's specific situation. LTSV in critically ill patients remains a difficult topic to study, due to the multitude of factors that condition it.</p></div><div><h3>Objective</h3><p>To determine factors related to LTSV in ICU in cases of post-ICU in-hospital mortality, as well as factors associated with survival after discharge from ICU.</p></div><div><h3>Design</h3><p>Retrospective longitudinal study.</p></div><div><h3>Ambit</h3><p>Intensive care unit of a tertiary hospital.</p></div><div><h3>Patients</h3><p>People who died in the hospitalization ward after ICU treatment between January 2014 and December 2019.</p></div><div><h3>Interventions</h3><p>None. This is an observational study.</p></div><div><h3>Variables of interest</h3><p>Age, sex, probability of death, type of admission, LTSV in ICU, oncological disease, dependence, invasive mechanical ventilation, emergency hemodialysis, transfusion of blood products, noso","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139636004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-20DOI: 10.1016/j.redar.2023.04.005
R.M. Sarhan, M.S. Boshra, M.E.A. Abdelrahim, H. Osama
Background
We performed a meta-analysis to assess the effectiveness and safety of tranexamic acid in patients with traumatic brain injury (TBI).
Methods
We searched the literature for articles evaluating the effectiveness and safety of tranexamic acid (TXA) in TBI published between January 2012 and January 2021, and identified 8 studies with a total of 10860 patients: 5660 received TXA and 5200 served as controls. We used a dichotomous or continuous approach with a random or fixed-effect model to assess the efficacy and safety of TXA in TBI, and calculated the mean difference (MD) and odds ratio (OR) with the corresponding 95% confidence interval.
Results
In patients with TBI, early administration of TXA was associated with a greater relative benefit (MD - 2.45; 95% CI = - 4.78- - 0.12; p = 0.04) and less total haematoma expansion (MD - 2.52; 95% CI = - 4.85- - 0.19; p = 0.03) compared to controls.
There were no statistically significant differences in mortality (OR 0.94; 95% CI = 0.85-1.03; p = 0.18), presence of progressive haemorrhage (OR 0.75; 95% CI = 0.56-1.01; p = 0.06), need for neurosurgery (OR 1.15; 95% CI = 0.66-1.98; p = 0.63), high Disability Rating Scale score (OR 0.90; 95% CI = 0.56-1.45; p = 0.68), and incidence of ischaemic or thromboembolic complications (OR 1.34; 95% CI = 0.33-5.46; p = 0.68) between TBI patients treated with TXA and controls.
Conclusions
Early administration of TXA in TBI patients may have a greater relative benefit and may inhibit haematoma expansion. There were no significant differences in mortality, presence of progressive haemorrhage, need for neurosurgery, high Disability Rating Scale score, and incidence of ischaemic or thromboembolic complications between TBI patients treated with TXA and controls. Further studies are needed to validate these results.
背景我们进行了一项荟萃分析,以评估氨甲环酸在创伤性脑损伤(TBI)患者中的有效性和安全性。方法我们检索了2012年1月至2021年1月期间发表的评估氨甲环酸(TXA)在TBI中有效性和安全性的文献,并确定了8项研究,共计10860名患者:其中 5660 名患者接受了氨甲环酸治疗,5200 名患者作为对照组。我们采用随机或固定效应模型的二分法或连续法评估了TXA在TBI中的疗效和安全性,并计算了平均差(MD)和几率比(OR)以及相应的95%置信区间。结果在创伤性脑损伤患者中,与对照组相比,早期给予 TXA 有更大的相对益处(MD - 2.45; 95% CI = - 4.78- - 0.12; p = 0.04),且血肿扩大的程度更小(MD - 2.52; 95% CI = - 4.85- - 0.19; p = 0.03)。94;95% CI = 0.85-1.03;p = 0.18)、是否存在进行性出血(OR 0.75;95% CI = 0.56-1.01;p = 0.06)、是否需要神经外科手术(OR 1.15;95% CI = 0.66-1.98;p = 0.63)、高残疾评定量表评分(OR 0.90;95% CI = 0.56-1.45;p = 0.结论对创伤性脑损伤患者早期给予 TXA 可能具有更大的相对益处,并可抑制血肿扩大。接受 TXA 治疗的创伤性脑损伤患者与对照组患者在死亡率、进行性出血、神经外科手术需求、高度残疾评定量表评分以及缺血性或血栓栓塞并发症的发生率方面没有明显差异。需要进一步研究来验证这些结果。
{"title":"Efecto del ácido tranexámico en sujetos con lesión cerebral traumática: metaanálisis","authors":"R.M. Sarhan, M.S. Boshra, M.E.A. Abdelrahim, H. Osama","doi":"10.1016/j.redar.2023.04.005","DOIUrl":"10.1016/j.redar.2023.04.005","url":null,"abstract":"<div><h3>Background</h3><p>We performed a meta-analysis to assess the effectiveness and safety of tranexamic acid in patients with traumatic brain injury (TBI).</p></div><div><h3>Methods</h3><p>We searched the literature for articles evaluating the effectiveness and safety of tranexamic acid (TXA) in TBI published between January 2012 and January 2021, and identified 8 studies with a total of 10860 patients: 5660 received TXA and 5200 served as controls. We used a dichotomous or continuous approach with a random or fixed-effect model to assess the efficacy and safety of TXA in TBI, and calculated the mean difference (MD) and odds ratio (OR) with the corresponding 95% confidence interval.</p></div><div><h3>Results</h3><p>In patients with TBI, early administration of TXA was associated with a greater relative benefit (MD - 2.45; 95% CI = - 4.78- - 0.12; p = 0.04) and less total haematoma expansion (MD - 2.52; 95% CI = - 4.85- - 0.19; p = 0.03) compared to controls.</p><p>There were no statistically significant differences in mortality (OR 0.94; 95% CI = 0.85-1.03; p = 0.18), presence of progressive haemorrhage (OR 0.75; 95% CI = 0.56-1.01; p = 0.06), need for neurosurgery (OR 1.15; 95% CI = 0.66-1.98; p = 0.63), high Disability Rating Scale score (OR 0.90; 95% CI = 0.56-1.45; p = 0.68), and incidence of ischaemic or thromboembolic complications (OR 1.34; 95% CI = 0.33-5.46; p = 0.68) between TBI patients treated with TXA and controls.</p></div><div><h3>Conclusions</h3><p>Early administration of TXA in TBI patients may have a greater relative benefit and may inhibit haematoma expansion. There were no significant differences in mortality, presence of progressive haemorrhage, need for neurosurgery, high Disability Rating Scale score, and incidence of ischaemic or thromboembolic complications between TBI patients treated with TXA and controls. Further studies are needed to validate these results.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-15DOI: 10.1016/j.redar.2023.09.002
A. González-Castro, A. Fernandez, E. Cuenca-Fito, Y. Peñasco, J. Ceña, J.C. Rodríguez Borregán
Introduction
During the SARS-CoV-2 pandemic, several corticosteroid regimens have been used in the treatment of the disease, with disparate results according to drug and regimen used. For this reason, we wanted to analyze differences in early mortality derived from the use of different regimens of dexamethasone and methylprednisolone in SARS-CoV-2 infection in critically ill patients requiring admission to an ICU.
Method
Observational, analytical and retrospective study, in an intensive care unit of a third-level university hospital (March 2020 and June 2021). Adult patients (>18 years old) who were admitted consecutively for proven SARS-CoV-2 infection were included. The association with mortality in ICU at 28 days, different corticosteroid regimens used, was analyzed using a Cox proportional risk regression model.
Results
Data from a cohort of 539 patients were studied. Patient age (RR: 1.06; 95% CI: 1.02-1.10; P≤0.01) showed a significant association with 28-day mortality in the ICU. In the comparison of the different corticosteroid regimens analyzed, taking as a reference those patients who did not receive corticosteroid treatment, the dose of dexamethasone of 6 mg/day showed a clear trend towards statistical significance as a protector of mortality at 28 days in the ICU (RR: 0.40; 95% CI: 0.15-1.02; p=.05). The dose of dexamethasone of 6 mg/day and low doses of methylprednisolone show a similar association with survival at 28 days (OR: 1.19; 95% CI: 0.63-2.26).
Conclusions
The use of corticosteroids has been associated with better mortality outcomes in severe cases of SARS-CoV-2 infection. However, the therapeutic benefits of corticosteroids are not limited to dexamethasone alone.
{"title":"Asociación entre diferentes pautas de corticoides empleadas en la infección grave por SARS-CoV-2 y la mortalidad a corto plazo: estudio de cohortes retrospectivo","authors":"A. González-Castro, A. Fernandez, E. Cuenca-Fito, Y. Peñasco, J. Ceña, J.C. Rodríguez Borregán","doi":"10.1016/j.redar.2023.09.002","DOIUrl":"10.1016/j.redar.2023.09.002","url":null,"abstract":"<div><h3>Introduction</h3><p>During the SARS-CoV-2 pandemic, several corticosteroid regimens have been used in the treatment of the disease, with disparate results according to drug and regimen used. For this reason, we wanted to analyze differences in early mortality derived from the use of different regimens of dexamethasone and methylprednisolone in SARS-CoV-2 infection in critically ill patients requiring admission to an ICU.</p></div><div><h3>Method</h3><p>Observational, analytical and retrospective study, in an intensive care unit of a third-level university hospital (March 2020 and June 2021). Adult patients (>18 years old) who were admitted consecutively for proven SARS-CoV-2 infection were included. The association with mortality in ICU at 28 days, different corticosteroid regimens used, was analyzed using a Cox proportional risk regression model.</p></div><div><h3>Results</h3><p>Data from a cohort of 539 patients were studied. Patient age (RR: 1.06; 95% CI: 1.02-1.10; <em>P</em>≤0.01) showed a significant association with 28-day mortality in the ICU. In the comparison of the different corticosteroid regimens analyzed, taking as a reference those patients who did not receive corticosteroid treatment, the dose of dexamethasone of 6<!--> <!-->mg/day showed a clear trend towards statistical significance as a protector of mortality at 28 days in the ICU (RR: 0.40; 95% CI: 0.15-1.02; p=.05). The dose of dexamethasone of 6 mg/day and low doses of methylprednisolone show a similar association with survival at 28 days (OR: 1.19; 95% CI: 0.63-2.26).</p></div><div><h3>Conclusions</h3><p>The use of corticosteroids has been associated with better mortality outcomes in severe cases of SARS-CoV-2 infection. However, the therapeutic benefits of corticosteroids are not limited to dexamethasone alone.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-13DOI: 10.1016/j.redar.2023.04.006
S. Nogueira , D. Rodrigues , M. Barros , J. Menezes , L. Guimarães-Pereira
Introduction and objectives
Breast cancer is the most frequently diagnosed malignancy, and chronic pain after breast surgery (CPBS) is an increasingly recognized therapy-related problem. We evaluated CPBS incidence, characteristics, associated factors, and impact on patient quality of life (QoL).
Materials and methods
Six-month observational prospective study in patients undergoing breast surgery in a tertiary university hospital. Data were collected using several questionnaires: Pain Catastrophizing Scale, Brief Pain Inventory-Short Form, Douleur Neuropathique 4 Questionnaire, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and its Breast Cancer Module.
Results
A total of 112 patients completed the study. Approximately, one third (34.8%) developed CPBS, almost all with potentially neuropathic pain. CPBS interfered with patients’ daily life and reduced their QoL. Diabetes (p=.028), catastrophizing (p=.042), and acute postoperative pain severity (p<.001) were associated with CPBS.
Conclusions
This study broadens our understanding of CPBS and shows the impact of this syndrome. Healthcare workers need to be aware of CPBS and take steps to prevent and treat it, and provide patients with adequate information.
{"title":"Dolor crónico tras la cirugía de mama: incidencia, factores de riesgo e impacto en la calidad de vida","authors":"S. Nogueira , D. Rodrigues , M. Barros , J. Menezes , L. Guimarães-Pereira","doi":"10.1016/j.redar.2023.04.006","DOIUrl":"10.1016/j.redar.2023.04.006","url":null,"abstract":"<div><h3>Introduction and objectives</h3><p>Breast cancer is the most frequently diagnosed malignancy, and chronic pain after breast surgery (CPBS) is an increasingly recognized therapy-related problem. We evaluated CPBS incidence, characteristics, associated factors, and impact on patient quality of life (QoL).</p></div><div><h3>Materials and methods</h3><p>Six-month observational prospective study in patients undergoing breast surgery in a tertiary university hospital. Data were collected using several questionnaires: Pain Catastrophizing Scale, Brief Pain Inventory-Short Form, Douleur Neuropathique 4 Questionnaire, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and its Breast Cancer Module.</p></div><div><h3>Results</h3><p>A total of 112 patients completed the study. Approximately, one third (34.8%) developed CPBS, almost all with potentially neuropathic pain. CPBS interfered with patients’ daily life and reduced their QoL. Diabetes <em>(p</em>=.028), catastrophizing <em>(p</em>=.042), and acute postoperative pain severity <em>(p</em><.001) were associated with CPBS.</p></div><div><h3>Conclusions</h3><p>This study broadens our understanding of CPBS and shows the impact of this syndrome. Healthcare workers need to be aware of CPBS and take steps to prevent and treat it, and provide patients with adequate information.</p></div>","PeriodicalId":46479,"journal":{"name":"Revista Espanola de Anestesiologia y Reanimacion","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}