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Relationships between environmental variables and free-living nematode communities in seasonally flooded wetlands. 季节性淹水湿地环境变量与自由生活线虫群落的关系
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.07
T. Tran, Y. Nguyen, L. T. Pham, Bijeesh KV, S. Hoang, Q. Ngô
The Lo Go-Xa Mat is a national park in the southeastern region of Vietnam, which has a particularly high biodiversity and it includes different wetlands which are unique diverse in species composition. It can be categorized into two types: temporarily-seasonally and permanently flooded wetlands. Ta Not grassy marsh is representative of the seasonally flooded wetland. Whilst the diversity and ecology of plants and mammals are well documented, little or no information of the benthic ecology in the seasonally flooded wetland exist. This study aims to provide a new database of the nematode’s structure in the seasonally flooded wetland and its relation with environmental variables as well as detection of the ecological quality, considering nematodes as bioindicators. This work is the first investigation on nematodes communities in associate with some environmental variables in the Ta Not grassy marsh. The results showed that free-living nematodes in the Ta Not seasonally flooded grassy marsh are characterized by the high density (ranged from 235.01 to 898.43 inds.10cm-2) but rather low diversity. More specifically, the genus richness (S) ranged from 8.20 to 8.60. The observed Margalef’s species richness (d) was ranging from 1.07 to 1.53 and the Shannon-Wiener index (H') was measured from 2.36 to 2.52. In addition, the Pielou's evenness (J′) ranged from 0.55 to 0.68 and the Hill indices indicated average values ranging between 5.46- 5.84 for N1, between 4.32-4.60 for N2, and between 2.64-2.86 for Ninf. Specifically, our results indicated that deep level, pH, and NH4+ showed a significant correlation with the nematode density and bio-indices. The sediment of the Ta Not grassy marsh was assessed as in good conditions in all stations based on the Maturity Index of nematodes.
Lo Go-Xa Mat是越南东南部地区的一个国家公园,拥有特别高的生物多样性,它包括不同的湿地,物种组成独特多样。它可以分为两种类型:临时季节性和永久淹没湿地。塔诺草沼泽是季节性淹水湿地的代表。虽然植物和哺乳动物的多样性和生态有充分的记录,但关于季节性洪水湿地的底栖生物生态的资料很少或根本没有。本研究旨在以线虫为生物指标,建立季节性淹水湿地线虫结构及其与环境变量的关系以及生态质量检测的新数据库。本研究首次对塔诺草地湿地线虫群落与环境变量的关系进行了研究。结果表明:塔中季节淹水草地湿地线虫密度较高(235.01 ~ 898.43 ind.10 cm-2),多样性较低;属丰富度(S)在8.20 ~ 8.60之间。Margalef的物种丰富度(d)为1.07 ~ 1.53,Shannon-Wiener指数(H)为2.36 ~ 2.52。Pielou均匀度(J′)为0.55 ~ 0.68,Hill指数平均值N1为5.46 ~ 5.84,N2为4.32 ~ 4.60,Ninf为2.64 ~ 2.86。结果表明,深度、pH和NH4+与线虫密度和生物指数呈显著相关。利用线虫的成熟指数,各监测站的沉积物状况均为良好。
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引用次数: 0
Use of natural coagulants for industrial wastewater treatment. 使用天然混凝剂处理工业废水。
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.10
S. Gautam, G. Saini
Industrial effluents are a menace to the environment and the fact that their characteristics vary from industry-to-industry only adds to the complex challenge they offer to the engineers and scientists. Resource-efficient and environment-friendly solutions to this hazard are a call of the hour. Coagulation, by synthetic chemicals, has been used as a cost-effective and efficient method for managing the effluents generated by a large number of industries. However, the synthetic chemicals themselves are a cause of concern due to their non-native nature, non-degradability, and health conditions associated with their left-over residues. Natural coagulants offer a cost-effective, environment-friendly, and sustainable alternative to the application of synthetic chemicals. Such natural coagulants, despite their demonstrated effectiveness in treating the industrial wastewaters, have their own limitations and are yet to be investigated for large-scale applications. The current work presents a state-of-the-art review of the natural coagulants' application in treating industrial wastewaters and their relative advantages and disadvantages as compared to the chemical coagulants. Future research areas have also been identified that may ultimately lead to the large-scale commercial application of natural coagulants and will result in an environment-friendly and sustainable solution to the problems created by industrial effluents and synthetic chemical coagulants.
工业废水对环境是一种威胁,它们的特性因工业而异,这一事实只会给工程师和科学家带来更复杂的挑战。解决这一危害的资源节约型和环境友好型方案是当务之急。通过合成化学品进行混凝,已被用作管理大量工业产生的废水的成本效益高和效率高的方法。然而,合成化学品本身是一个令人担忧的问题,因为它们的非天然性质,不可降解性,以及与它们残留的残留物相关的健康状况。天然混凝剂为合成化学品的应用提供了一种经济、环保和可持续的替代方案。尽管这种天然混凝剂在处理工业废水方面已被证明有效,但也有其自身的局限性,尚未对大规模应用进行研究。本文综述了天然混凝剂在工业废水处理中的应用,以及与化学混凝剂相比天然混凝剂的优缺点。还确定了未来的研究领域,这些领域可能最终导致天然混凝剂的大规模商业应用,并将为工业废水和合成化学混凝剂造成的问题提供环境友好和可持续的解决方案。
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引用次数: 40
Solid waste management beliefs and practices in rural households towards sustainable development and pro-environmental citizenship 农村家庭对可持续发展和环保公民的固体废物管理信念和做法
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.02
M. Limon, J. Vallente, N.C.T. Corales
This study examined the waste management beliefs and practices of selected households in a Philippine rural municipality.  The sample used for this study involved rural families comprising of 332 households, which was drawn from the population using multistage cluster unequal allocation sampling technique. Descriptive statistics was used to analyze data gathered. Findings show that households encountered many problems when it comes to practicing traditional and modern ways of solid waste management. Moreover, it was revealed that participants were ill-informed about the various aspects of waste management, and that there was little reuse and recycling of waste materials among the households. In terms of the participants’ solid waste management beliefs, their ratings yielded a X score of 1.08, which means that they generally have positive beliefs towards managing household wastes. When it comes to their practices, participants obtained a X score of 2.59, suggesting that the selected households apply, to certain degrees, various acceptable waste disposal measures. Nevertheless, they also demonstrated beliefs and practices that were not environment friendly. From these findings, this study proposed a plan of solid waste management activities for households, which was collaboratively assessed by local government authorities. The proposed plan was unanimously accepted by the evaluators, who approved of the intervention’s wide-scale implementation in the province. A number of significant implications were offered in this study, such as conducting community workshops and campaigns for the effective management of solid wastes.
本研究考察了菲律宾农村市选定家庭的废物管理信念和做法。本研究采用多阶段聚类不均匀分配抽样技术,抽取农村家庭332户。描述性统计用于分析收集到的数据。调查结果表明,家庭在实践传统和现代固体废物管理方法时遇到了许多问题。此外,调查显示,参与者对废物管理的各个方面了解不足,家庭中很少再使用和回收废物。在参与者的固体废物管理信念方面,他们的评级产生了1.08的X分,这意味着他们普遍对管理生活垃圾持积极态度。在实践方面,受访者获得2.59分的X分,表明所选住户在一定程度上采用了各种可接受的废物处置措施。然而,他们也表现出不利于环境的信仰和做法。根据这些发现,本研究提出了一项家庭固体废物管理活动计划,并由地方政府当局共同评估。提出的计划得到了评估人员的一致接受,他们批准在该省大规模实施干预措施。这项研究提出了一些重要的影响,例如为有效管理固体废物举办社区讲习班和运动。
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引用次数: 11
Species distribution modelling of invasive alien species; Pterois miles for current distribution and future suitable habitats 外来入侵物种分布模型研究为目前的分布和未来的适宜栖息地
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.01
C. Turan
The present study aims to predict the potential geographic distribution and future expansion of invasive alien lionfish (Pterois miles) with ecological niche modelling along the Mediterranean Sea. The primary data consisted of occurrence points of P. miles in the Mediterranean and marine climatic data layers were collected from global databases. All the used models run 100% success predictions, and true skill statistics and area under the receiver operating characteristic curve values ranged from 0.42 and 0.71 to 0.86 and 0.95 for current distribution modelling; and 0.0 and 0.0 to 0.83 and 0.94 for the future distribution modelling, respectively. The mean sea surface temperature and maximum bathymetry played an important role in the prediction of the model and explained relatively higher biological importance to the extension and adaptation of P. miles with extreme environmental factors. The predicted suitable habitats of P. miles under the current climate dominantly occurred in the east parts of coastal areas of the Mediterranean. The predicted future suitable habitats of P. miles revealed that P. miles increase its range of distribution dominantly to the central and west part of the Mediterranean in a spatial extent, indicating high suitability of these areas for its future distribution.
本研究旨在通过地中海沿岸的生态位模型预测入侵外来狮子鱼(Pterois miles)的潜在地理分布和未来扩张。主要数据包括地中海P.miles的发生点,海洋气候数据层是从全球数据库中收集的。所有使用的模型都运行100%的成功预测,对于电流分布建模,真实技能统计数据和受试者工作特性曲线下面积值的范围从0.42和0.71到0.86和0.95;未来分布建模分别为0.0和0.0至0.83和0.94。平均海面温度和最大水深在模型的预测中发挥了重要作用,并解释了P.miles在极端环境因素下的扩展和适应具有相对较高的生物学重要性。在当前气候条件下,预测的P.miles的适宜栖息地主要分布在地中海东部沿海地区。对P.miles未来适宜栖息地的预测表明,P.miles在空间上的分布范围主要增加到地中海中部和西部,表明这些地区对其未来的分布具有高度的适宜性。
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引用次数: 5
The effect of mulch on properties of erosion sensitive soil using a wind tunnel 利用风洞研究覆盖物对侵蚀敏感土壤特性的影响
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.09
P. Gholamiderami, P. Lahooti, H. Darbam
The aim of this study was to produce mulch by combining natural mineral and organic substances in order to reach soil stabilization and improve soil physical and mechanical properties in Koopal area. The effects of organic mulch (at 3 levels of O1: combination of 1% sugarcane bagasse biochar+0.5% gum Arabic+0.5% gelatin; O2: combination of 3% sugarcane bagasse biochar+1% gum Arabic+1% gelatin; and O3: combination of 5% sugarcane bagasse biochar+1.5% gum Arabic+ 1.5% gelatin) and MNF organomineral mulch (at 3 levels of MNF1: 1%; MNF2: 3%; and MNF3: 5%) on soil were investigated. The soil samples were incubated for 2 and 4 months and finally placed in a wind tunnel. Some physical and chemical properties of soil were obtained as pH=7.42, O.M%=0.223, and soil texture of silty loam. The obtained results showed that compared to control, application of the mulches increased soil organic carbon percentage (1.1%), mean weight diameter (2.47 mm), geometric mean diameter (1.27 mm), penetration resistance (370), shear strength (27.38) and tensile strength (0.8) significantly and decreased soil loss (0.10 g/m2/s), fracture index, soil texture index (62.16), and crust index (1.18) significantly (P<0.01) in both incubation periods. Effects of the mulches on soil organic carbon were reduced after 4 months. In mulch treatments, soil loss rate, mean weight diameter, geometric mean diameter and tensile strength were increased significantly. In general, the organic mulch could stabilize the soil and improve the physical and mechanical properties of the soil.
本研究的目的是通过将天然矿物和有机物质相结合来生产覆盖物,以达到土壤稳定和改善库帕尔地区土壤物理力学性能的目的。研究了有机覆盖物(O1:1%甘蔗渣生物炭+0.5%阿拉伯树胶+0.5%明胶的组合;O2:3%甘蔗渣生物碳+1%阿拉伯树胶+1%明胶的组合和O3:5%甘蔗渣生物木炭+1.5%阿拉伯树脂+1.5%明胶的组合)和MNF有机矿物覆盖物(MNF1:1%、MNF2:3%和MNF3:5%)对土壤的影响。将土壤样品培育2个月和4个月,最后放置在风洞中。土壤的一些物理和化学性质为:pH=7.42,O.M%=0.223,土壤质地为粉砂质壤土。结果表明,与对照相比,施用地膜显著提高了土壤有机碳百分比(1.1%)、平均重量直径(2.47mm)、几何平均直径(1.27mm)、渗透阻力(370)、抗剪强度(27.38)和抗拉强度(0.8),并降低了土壤损失(0.10g/m2/s)、断裂指数、土壤质地指数(62.16),结皮指数(1.18)在两个潜伏期均有显著性差异(P<0.01)。4个月后,覆盖层对土壤有机碳的影响减小。覆盖处理显著提高了土壤流失率、平均重量直径、几何平均直径和抗拉强度。一般来说,有机覆盖物可以稳定土壤,改善土壤的物理力学性能。
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引用次数: 7
Impact of floating platforms on the limnological aspects of hydropower plant reservoirs 浮式平台对水电站水库水文方面的影响
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.03
L. S. Vanzela, D. C. Pereira, L.D.S.C. Lima, K. Khan, C. F. Mansano
Floating platforms at the hydropower plant reservoirs are attractive sites for aquaculture, fishing and other recreational activities. However, the unregulated construction of these platforms may negatively affect the fauna, flora and water quality of reservoirs. Thus, this study aimed to evaluate the impact of floating platforms on the limnological aspects of Nova Ponte hydropower plant reservoirs at the Center-West of Minas Gerais State of Brazil. The obtained data were analyzed using the correlation and regression analysis. Dissolved oxygen, biochemical oxygen demand, chemical oxygen demand, total coliforms and thermotolerant bacteria were plotted against the density of floating platforms. The density of platforms significantly (p-value > 0.05) impacted the analyzed limnological aspects of reservoirs. Based on the present results, 4 floating platforms/km2 (1 platform per 25 hectares) of surface water should be the maximum density in order to avoid the deterioration of water quality of reservoirs. With 4 platforms/km2, the expected values in fishing period were estimated to be 5.4 mg/L for biochemical oxygen demand, 375 most probable number per 100 mL of sample for thermotolerant bacteria and 6.1 mg/L for chemical oxygen demand. In fishing-ban period, the expected values were estimated to be 4.1 mg/L for dissolved oxygen, 3.4 mg/L for biochemical oxygen demand, 379 most probable number per 100 mL of sample for thermotolerant bacteria and 4.2 mg/L for chemical oxygen demand. This finding provides important base-line information which could help policy makers to take effective measurements for the appropriate management of surface water resources.
水电站水库的浮动平台是水产养殖、捕鱼和其他娱乐活动的有吸引力的场所。然而,这些平台的建设不受监管,可能会对水库的动植物群和水质产生负面影响。因此,本研究旨在评估浮动平台对巴西米纳斯吉拉斯州中西部Nova Ponte水电站水库湖沼学方面的影响。使用相关和回归分析对所获得的数据进行分析。溶解氧、生化需氧量、化学需氧量、总大肠菌群和耐热细菌与浮式平台密度的关系。平台的密度显著影响了所分析的储层的湖沼学方面(p值>0.05)。根据目前的结果,4个浮式平台/km2(每25公顷1个平台)的地表水应为最大密度,以避免水库水质恶化。在4个平台/km2的情况下,捕捞期的预期值估计为5.4 mg/L的生化需氧量,375个最可能的数量/100 mL样品的耐热细菌和6.1 mg/L的化学需氧量。在禁渔期,溶解氧的预期值估计为4.1 mg/L,生化需氧量的预期值为3.4 mg/L,耐热细菌的最可能数为每100 mL样本379,化学需氧量的预计值为4.2 mg/L。这一发现提供了重要的基线信息,有助于决策者采取有效措施,对地表水资源进行适当管理。
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引用次数: 0
Effective energy consumption parameters in residential buildings using building information modeling. 基于建筑信息模型的住宅建筑有效能耗参数研究。
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.04
N. Amani, ABDULAMIR REZASOROUSH
Building information modeling can help in predicting the energy efficiency in future based on dynamic patterns obtained by visualization of data. The aim of this study was to investigate the effective parameters of energy consumption using BIM technology which can evaluate the buildings energy performance. First, three forms of general states in the building were modeled to evaluate the proposed designs in Autodesk Revit Software. Then, the main building form for energy modeling and analysis was selected. Autodesk Revit 2020 software was also used to obtain the results of climate data analysis and building energy consumption index. Finally, the most optimal mode was selected by examining different energy consumption modes. The results showed that the use of building information modeling technology in adjusting the parameters affecting energy consumption can save energy cost up to 58.23% in block D. Energy cost savings for block C and the western lobby were obtained as 51.03% and 43.05%, respectively. Based on energy use intensity, energy cost savings for blocks C, D, and the western lobby were estimated as 16.67%, 16.30%, and 11%, respectively. The results of parametric studies on alternative schemes of energy use intensity optimization showed that 16.30% savings could be achieved by the base building model in a 30-year time horizon. Therefore, it was concluded that optimization of energy consumption would reduce the environmental pollutants emission and contribute to preservation and sustainability of the environment.
建筑信息建模有助于根据数据可视化获得的动态模式预测未来的能源效率。本研究的目的是利用BIM技术研究建筑能耗的有效参数,以评估建筑的能源性能。首先,对建筑中三种形式的一般状态进行建模,以评估Autodesk Revit软件中提出的设计。然后,选择了用于能量建模和分析的主要建筑形式。Autodesk Revit 2020软件还用于获得气候数据分析结果和建筑能耗指数。最后,通过考察不同的能源消耗模式,选择了最优模式。结果表明,利用建筑信息建模技术调整影响能耗的参数,D座可节约能源成本高达58.23%。C座和西大堂的能源成本分别节约51.03%和43.05%。根据能源使用强度,C、D和西部大堂的能源成本节约估计分别为16.67%、16.30%和11%。对能源使用强度优化备选方案的参数研究结果表明,在30年的时间范围内,基础建筑模型可以实现16.30%的节约。因此,得出的结论是,优化能源消耗将减少环境污染物的排放,有助于环境的保护和可持续性。
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引用次数: 7
Impact of forced migration on the sustainable development of rural territories 强迫移民对农村地区可持续发展的影响
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-10-01 DOI: 10.22034/GJESM.2020.04.05
V. Shcherbak, Iryna Anatoliivna Brizgan, V. Chevhanova, L. Svistun, O. Hryhoryeva
This study provides a comprehensive scientific analysis of contemporary problems resulted from the forced migration of the Ukrainian population and its impact on the sustainable development of 47 host communities of Poltava region. By means of cluster analysis 4 clusters of 26 rural territories were identified. They differ in the size of local budgets and the involvement level of forcedly displaced population into the local economy. Factor analysis showed that the involvement level of forcedly displaced population in the region's economy is determined by 2 groups according to 10 indicators. 8 indicators of the first factor determine 2/3 of the dispersion of refugees' impact on rural economy. The first factor reduces the gross regional product by 61.75%. The indicators of the second factor shows a positive impact and determines 15% of the dispersion. The use of game theory to identify conflicts of interest between refugees and host communities was justified. The reasonability to use the taxonomy method to construct a map of positioning rural areas according to the size of local budgets and the degree of integration of refugees is justified. The use of the created map identified the “growth points” in particular clusters. As a result of the implementation of the proposed conflict resolution mechanism between refugees and host communities, the budget of the rural areas of the first cluster increased by 18%, the second cluster by 14.5%, the third cluster by 13%, the fourth by 8%, refugee participation by 30%.
这项研究对乌克兰人口被迫移徙所造成的当代问题及其对波尔塔瓦地区47个东道社区可持续发展的影响进行了全面的科学分析。通过聚类分析,确定了26个农村地区的4个聚类。它们在地方预算的规模和被迫流离失所人口参与地方经济的程度上有所不同。因子分析表明,被迫流离失所人口对区域经济的参与程度由两个群体根据10个指标决定。第一个因素的8个指标决定了2/3的离散难民对农村经济的影响。第一个因素使地区生产总值减少了61.75%。第二个因素的指标显示出积极的影响,并决定了15%的分散。利用博弈论来确定难民和收容社区之间的利益冲突是合理的。根据地方预算规模和难民融入程度,采用分类学方法构建农村地区定位地图的合理性是合理的。使用创建的地图确定了特定集群中的“增长点”。由于实施了拟议的难民与收容社区之间的冲突解决机制,第一集群农村地区的预算增加了18%,第二集群增加了14.5%,第三集群增加了13%,第四集群增加了8%,难民参与增加了30%。
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引用次数: 3
Prioritization of the effective factors in reducing energy consumption in a residential building using computer simulation 利用计算机模拟确定降低住宅能耗的有效因素的优先级
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-09-06 DOI: 10.22034/GJESM.2021.02.02
N. Amani, F. Fakheri, K. Safarzadeh
BACKGROUND AND OBJECTIVES: According to the latest energy balance sheets, the average energy consumption in the residential sector of Iran is about 41% of the total energy consumption in the country. Increasing the energy efficiency of buildings can decrease the annual energy consumption in the residential sector and, thereby, the energy costs of families. The objectives of this study were to evaluate and prioritize the effective factors in reducing the energy consumption in residential buildings in the north of Iran using the climatic conditions analysis. METHODS: In the first step, the amount of energy consumption in the cooling and heating section was estimated in the base conditions, and in the next step, the amount of energy consumption was calculated. The obtained results were compared with each other with the help of optimization strategies for energy consumption using the Design Builder software. Finally, a set of effective factors were determined to be involved in decreasing the energy consumption. FINDING: The results showed that application of the LED lamps instead of the conventional fluorescent lamps could decrease the energy consumption by 980.4 kWh. Moreover, changing the materials of the walls and ceiling, using the polyurethane foam insulation with the thickness of 20 mm, and using the double-glazed UPVC windows reduced the energy consumption by 770 kWh. Energy reduction of about 101.5 kWh was also obtained after external movable awning and internal blind. CONCLUSION: The most commonly used materials were analyzed by the Design Builder software. The analysis was done by integrating building architecture engineering (the best form of orientation and facade) based on the reasonable costs of consuming common materials in the area. The obtained results can be used for both evaluating the energy efficiency in residential buildings and producing a comfortable living environment in a moderate and humid climate.
背景和目标:根据最新的能源资产负债表,伊朗住宅部门的平均能源消耗约占该国总能源消耗的41%。提高建筑物的能源效率可以减少住宅部门的年度能源消耗,从而减少家庭的能源成本。本研究的目的是利用气候条件分析来评估和优先考虑降低伊朗北部住宅建筑能耗的有效因素。方法:首先对基础工况下的冷热段能耗进行估算,然后进行能耗计算。利用Design Builder软件对得到的结果进行了比较,并制定了能耗优化策略。最后,确定了降低能耗所涉及的一系列有效因素。研究发现:采用LED灯替代传统荧光灯可降低能耗980.4 kWh。此外,改变墙体和吊顶的材料,使用厚度为20毫米的聚氨酯泡沫保温材料,使用双层UPVC窗户,减少了770千瓦时的能耗。采用外活动遮阳篷加内百叶窗后,节能约101.5 kWh。结论:采用Design Builder软件对最常用的材料进行分析。分析是通过综合建筑工程(朝向和立面的最佳形式)来完成的,这是基于该地区消耗普通材料的合理成本。所得结果既可用于评价住宅建筑的能源效率,也可用于在温和湿润的气候条件下创造舒适的生活环境。
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引用次数: 2
Environmental friendly carrier material for nifedipine as hypertension drug 硝苯地平作为高血压药物的环保载体材料
IF 3.4 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2020-09-01 DOI: 10.22034/GJESM.2020.04.08
E. Budianto, S. Astuti
Nifedipine is a hypertension drug must be consumed three times a day due to its low oral bioavailability. One way of developing a controlled drug delivery system is making nifedipine microcapsules by using environmentally friendly polymers of polylactic acid and polycaprolactone via the evaporation method using oil-in-water solvents. Polylactic acid and polycaprolactone can be said to be environmentally friendly polymers, because they can be degraded naturally in nature both in the biotic, and abiotic environment, or microorganism. In this study, polylactic acid, Polycaprolactone, and nifedipine were dissolved in dichloromethane solvent; then, an emulsifier was added for the emulsification stage. After passing through the dispersion stage for the process of compaction of the microcapsules by solvent evaporation, the microcapsules were filtered. Microcapsules were characterized using particle size analysis, X-ray diffractometry, and scanning electron microscopy, respectively. The drug release percentage was determined by dissolving microcapsules for 55 hours using a buffer at the potential of hydrogen 1.2 and pH 7.4 as dissolution media. In this study, all variations in the composition of polyblend resulted in a percent efficiency of encapsulation ranging from 78.82%-89.84%, and percent release ranging from 6.80%-39.07%. The composition of 100% polylactic acid produces the highest percent encapsulation efficiency of 89.84% but produces the lowest percentage of drug release at 6.80%. The best composition obtained was polylactic acid: polycaprolactone 1:9 (weight per weight), with a percent release of 39.07% and percent encapsulation of 78.82%. Microcapsule solids produced are approximately 96%. Particle Size of microcapsule ranges at 0.5 μM.
硝苯地平是一种高血压药物,由于其口服生物利用度低,必须每天服用三次。开发可控药物递送系统的一种方法是通过使用水包油溶剂的蒸发法,使用环境友好的聚乳酸和聚己内酯聚合物制备硝苯地平微胶囊。聚乳酸和聚己内酯可以说是环境友好的聚合物,因为它们可以在生物、非生物环境或微生物中自然降解。在本研究中,将聚乳酸、聚己内酯和硝苯地平溶解在二氯甲烷溶剂中;然后,添加乳化剂用于乳化阶段。在通过用于通过溶剂蒸发压实微胶囊的过程的分散阶段之后,过滤微胶囊。分别使用粒度分析、X射线衍射仪和扫描电子显微镜对微胶囊进行了表征。药物释放百分比是通过使用电势为氢1.2和pH 7.4的缓冲液作为溶解介质将微胶囊溶解55小时来测定的。在本研究中,共混物组成的所有变化导致包封率在78.82%-89.84%之间,100%聚乳酸的包封率最高,为89.84%,但药物释放率最低,为6.80%。得到的最佳组合物是聚乳酸:聚己内酯1:9(重量/重量),释放率为39.07%,包封率为78.82%。产生的微胶囊固体约为96%。微胶囊的粒径范围为0.5μM。
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引用次数: 0
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GLOBAL JOURNAL OF ENVIRONMENTAL SCIENCE AND MANAGEMENT-GJESM
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