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Treatment of a Neglected and Infected Knee Dislocation with a Traction Pin: A Case Report. 用牵引针治疗被忽视和感染的膝关节脱位:病例报告。
IF 1.2 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2023.73455.3402
Alireza Askari, Mahmoud Jabalameli, Hassan Kassir

Neglected knee dislocations are rare and challenging orthopedic injuries. We report using a traction pin to treat a neglected knee dislocation and a concurrent infection. Following the primary reduction with extensive soft-tissue release, a proximal tibial traction pin was used to obtain complete reduction via traction weight change.‎ No ligamentous repair was done for the patient. The patient's one-year follow-up showed an acceptable radiographic reduction supported by satisfactory clinical outcomes. In conclusion, the proximal tibial traction pin could be a good alternative for treating neglected knee dislocations. It makes future knee replacements more practical, a significant concern in such patients. Meanwhile, it is much more affordable than the other available techniques.

被忽视的膝关节脱位是一种罕见且具有挑战性的骨科损伤。我们报告了使用牵引针治疗被忽视的膝关节脱位和并发感染的病例。在进行了广泛的软组织松解的初级复位后,使用了胫骨近端牵引针,通过牵引重量的变化实现了完全复位。 患者没有进行韧带修复。患者一年后的随访结果显示,其影像学缩小程度可以接受,临床效果也令人满意。总之,胫骨近端牵引针是治疗被忽视的膝关节脱位的一个很好的选择。它使未来的膝关节置换手术更加切实可行,而这正是这类患者所关心的重要问题。同时,与其他现有技术相比,它的价格更低廉。
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引用次数: 0
Intramedullary Plating of Complex Proximal Humerus Fractures: A Case Series. 复杂肱骨近端骨折的髓内置换术:病例系列
IF 1.2 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.74258.3437
Stephen Mc Donald, Andrel Yoong, Piotr Skrzypiec, Alan Johnstone

Objectives: To assess fracture union rates using novel intramedullary plate technique. Post-operative humeral neck-shaft angles, patient range of motion and complication profile were secondary outcomes of interest.

Methods: Single surgeon, retrospective case series of surgical technique at major trauma centre in Scotland. A 2.0mm mini-fragment plate was secured to the humeral head to act as an intramedullary strut during fixation in complex proximal humerus fractures. Fracture union and neck-shaft angle were assessed radiologically, whilst range of motion and complication profiles were assessed clinically.

Results: Twelve patients were followed up for an average of 10 months post-operatively. All achieved bony union with a mean neck-shaft angle of 128°. Mean range of motion values were 100° forward elevation, 83° abduction, 60° internal rotation and 37° external rotation. Four patients required further surgical intervention- two for hardware prominence, one for adhesive capsulitis and one for subsequent rotator cuff failure. There were no cases of avascular necrosis or infection.

Conclusion: This novel technique addresses the established biomechanical propensity of proximal humerus fractures to fail in varus collapse and screw cut-out. This method provides an alternative to arthroplasty in the most severe proximal humerus fractures and is readily adopted via standard orthopaedic kit.

目的评估使用新型髓内钢板技术的骨折愈合率。术后肱骨颈轴角度、患者活动范围和并发症情况是次要关注结果:方法:苏格兰主要创伤中心的单个外科医生手术技术回顾性病例系列。在肱骨近端复杂骨折的固定过程中,将一块2.0毫米的微型钢板固定在肱骨头,作为髓内支柱。对骨折愈合和颈轴角进行放射学评估,对活动范围和并发症情况进行临床评估:对12名患者进行了平均10个月的术后随访。所有患者都实现了骨性结合,平均颈轴角为 128°。平均活动范围为前抬 100°、外展 83°、内旋 60°、外旋 37°。四名患者需要进一步手术治疗--两名患者因硬件突出而需要手术,一名患者因粘连性关节囊炎而需要手术,一名患者因后续肩袖功能衰竭而需要手术。没有出现血管坏死或感染病例:这项新技术解决了肱骨近端骨折在曲折塌陷和螺钉切出时失败的生物力学倾向。这种方法为最严重的肱骨近端骨折患者提供了关节置换术的替代方案,并可通过标准骨科工具包随时采用。
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引用次数: 0
Recent Advances in the Treatment of Spinal Cord Injury. 脊髓损伤治疗的最新进展。
IF 1.2 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2023.73944.3424
Davood Yari, Arezoo Saberi, Zahra Salmasi, Seyed Alireza Ghoreishi, Leila Etemad, Jebrail Movaffagh, Babak Ganjeifar

Spinal cord injury (SCI) is a complex, multifaceted, progressive, and yet incurable complication that can cause irreversible damage to the individual, family, and society. In recent years strategies for the management and rehabilitation of SCI besides axonal regeneration, remyelination, and neuronal plasticity of the injured spinal cord have significantly improved. Although most of the current research and therapeutic advances have been made in animal models, so far, no specific and complete treatment has been reported for SCI in humans. The failure to treat this complication has been due to the inherent neurological complexity and the structural, cellular, molecular, and biochemical characteristics of spinal cord injury. In this review, in addition to elucidating the causes of spinal cord injury from a molecular and pathophysiological perspective, the complexity and drawbacks of neural regeneration that lead to the failure in SCI treatment are described. Also, recent advances and cutting-edge strategies in most areas of SCI treatment are presented.

脊髓损伤(SCI)是一种复杂的、多方面的、渐进的、但无法治愈的并发症,可对个人、家庭和社会造成不可逆转的损害。近年来,除了损伤脊髓的轴突再生、再髓鞘化和神经元可塑性之外,SCI 的管理和康复策略也有了显著改善。虽然目前大多数研究和治疗进展都是在动物模型中取得的,但迄今为止,还没有关于人类 SCI 的具体和完整治疗方法的报道。这种并发症的治疗失败是由于其固有的神经系统复杂性以及脊髓损伤的结构、细胞、分子和生化特征造成的。在这篇综述中,除了从分子和病理生理学角度阐明脊髓损伤的原因外,还介绍了导致脊髓损伤治疗失败的神经再生的复杂性和弊端。此外,还介绍了大多数 SCI 治疗领域的最新进展和前沿策略。
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引用次数: 0
Intraosseous Regional Administration of Vancomycin Prophylaxis for Primary and Revision Total Knee Arthroplasty. 初次和翻修全膝关节置换术中的万古霉素预防性区域鼻内注射。
IF 1.3 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2023.71420.3337
E Carlos Rodriguez-Merchan, Carlos A Encinas-Ullan

The advantages of prophylaxis with intraosseous regional administration (IORA) of vancomycin for periprosthetic joint infection (PJI) in primary and revision total knee arthroplasty (TKA) include the ability to deliver antibiotics directly to the surgical bed and avert systemic delivery; the ability to precisely time and quickly administer vancomycin to achieve the highest concentrations at the beginning and throughout the surgical procedure; and the ability to avert several common and potentially serious adverse effects of intravenous vancomycin. Indications for IORA of vancomycin prophylaxis include the following clinical scenarios: revision TKA; obesity; diabetes; beta-lactam allergy; known colonization with methicillin-resistant Staphylococcus aureus (MRSA); individuals coming from institutions with a high MRSA incidence; previous ligamentous surgical procedure or osteotomy; current or recent smokers; in the primary TKA setting if the individual is considered high-risk as defined by the criteria above; and during reimplantation following 2-stage exchange for PJI.

在初次和翻修全膝关节置换术(TKA)中,采用万古霉素骨内区域给药(IORA)预防假体周围关节感染(PJI)的优势包括:可将抗生素直接输送到手术床,避免全身给药;可在手术开始时和整个手术过程中精确、快速地给药万古霉素,以达到最高浓度;可避免静脉注射万古霉素的几种常见和潜在的严重不良反应。万古霉素预防性 IORA 的适应症包括以下临床情况:翻修 TKA;肥胖;糖尿病;β-内酰胺过敏;已知耐甲氧西林金黄色葡萄球菌(MRSA)定植;来自 MRSA 高发机构的患者;既往接受过韧带手术或截骨术;目前或近期吸烟者;在初级 TKA 设置中,如果患者根据上述标准被认为是高风险患者;以及在 PJI 两阶段置换术后的再植期间。
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引用次数: 0
Antegrade vs Retrograde Intra-Medullary Nailing in Femoral Shaft Fractures: A Systematic Review and Meta-Analysis. 股骨柄骨折髓内钉顺行钉与逆行钉的对比:系统回顾与元分析》。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.78871.3623
Mohammad Daher, Jean Tarchichi, Ziad Zalaquett, Jack C Casey, Joe Ghanimeh, Jad Mansour

Objectives: Femoral shaft fractures are one of the most prevalent fractures found in clinical practice. Numerous operative and non-operative options are readily available for the treatment of such fractures with intra-medullary nailing being the gold standard. To date, no consensus has been reached favoring one approach over the other. Thus, this meta-analysis aims to compare the outcomes between an antegrade and retrograde intra-medullary nailing for the treatment of femoral shaft fractures.

Methods: PubMed, Cochrane, Google Scholar (page 1-20), and Embase were searched till January 2024. The clinical outcomes evaluated were the incidence of adverse events, reoperations, hip and knee pain, and surgery-related parameters.

Results: Higher rates of hip pain, and heterotopic ossification (p=0.0003, and p=0.0002 respectively) was observed with antegrade nailing. However, a higher rate of knee pain (p=0.02) was appreciated in retrograde nailing. There was no statistically significant difference in the remaining analyzed outcomes such as operative time, reoperation rate or other complications.

Conclusion: Despite a higher rate of heterotopic ossification using the antegrade nailing technique, both the antegrade and retrograde nailing techniques yield overall similar outcomes. Therefore, the decision to choose one or the other should be based on patient-related factors, and the surgeon's experience and preference.

目的:股骨干骨折是临床上最常见的骨折之一。目前治疗此类骨折的手术和非手术方法很多,其中髓内钉是金标准。迄今为止,还没有达成一种方法优于另一种方法的共识。因此,本荟萃分析旨在比较前向髓内钉和后向髓内钉治疗股骨干骨折的效果:方法:检索了PubMed、Cochrane、Google Scholar(第1-20页)和Embase,检索期至2024年1月。评估的临床结果包括不良事件发生率、再次手术、髋关节和膝关节疼痛以及手术相关参数:结果:观察到前行钉的髋关节疼痛和异位骨化发生率较高(分别为P=0.0003和P=0.0002)。然而,逆行钉的膝关节疼痛发生率更高(P=0.02)。其余分析结果如手术时间、再次手术率或其他并发症均无统计学差异:结论:尽管逆行钉技术的异位骨化率较高,但逆行钉技术和顺行钉技术的总体疗效相似。因此,应根据患者相关因素、外科医生的经验和偏好来决定选择其中一种。
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引用次数: 0
History of Sports Medicine and Successful Career in Orthopedic Sports Medicine. 运动医学史和成功的矫形运动医学职业生涯。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.79208.3656
James R Andrews, Mohammadreza Abbasian
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引用次数: 0
Brand Videos among Orthopedic Surgery Residency Programs. 矫形外科住院医师培训项目中的品牌视频。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.76143.3522
Quincy T Cheesman, Johnlevi S Lazaro, Hope S Thalody, Danielle Y Ponzio, Zachary D Post, Alvin C Ong

Objectives: The use of brand videos has provided residency programs with another platform to showcase themselves and attract potential applicants. Despite the rise in brand videos following the COVID-19 pandemic, not all orthopedic surgery residency programs have developed one. This study aimed to determine the prevalence of brand videos on orthopedic surgery residency program websites and evaluate their contents.

Methods: This was a cross-sectional analysis of all orthopedic surgery residencies participating in the National Resident Matching Program (NRMP) in November 2022. The presence of a brand video was reviewed on each program's website and data was collected from the contents of existing videos.

Results: Forty-seven percent (90/192) of programs had a brand video with an average length of 6 minutes and 13 seconds. The top two program qualities highlighted were a family friendly atmosphere with camaraderie (83%; 75/90) and early hands-on surgical experience (72%; 65/90). Despite brand videos being tailored to an audience of prospective residents, only 9% (8/90) of programs noted qualities they look for in prospective residents. Furthermore, only 19% (17/90) of programs displayed a closing slide containing contact information or links to social media accounts.

Conclusion: Only 47% of orthopedic surgery residency programs have established a brand video. The absence of a brand video may be due to programs not perceiving them as important, shortage of resources, or unfamiliarity with video marketing. Based on our findings, we propose recommendations to assist programs in their development of a brand video.

目标:品牌视频的使用为住院医师培训项目提供了另一个展示自己和吸引潜在申请者的平台。尽管在 COVID-19 大流行后品牌视频兴起,但并非所有骨科住院医师培训项目都制作了品牌视频。本研究旨在确定骨科住院医师培训项目网站上品牌视频的普遍程度,并对其内容进行评估:这是对2022年11月参与国家住院医师配对计划(NRMP)的所有骨科住院医师进行的横断面分析。对每个项目网站上是否有品牌视频进行审查,并从现有视频内容中收集数据:结果:47%(90/192)的项目拥有品牌视频,平均时长为 6 分 13 秒。最突出的两个项目特质是家庭友好的友爱氛围(83%;75/90)和早期的手术实践经验(72%;65/90)。尽管品牌视频是为未来住院医师受众量身定制的,但只有 9%(8/90)的项目提到了他们在未来住院医师身上寻找的特质。此外,只有19%(17/90)的项目在结尾幻灯片中显示了联系方式或社交媒体账户链接:结论:只有47%的骨科住院医师培训项目建立了品牌视频。没有品牌视频的原因可能是项目认为视频不重要、资源短缺或不熟悉视频营销。根据我们的研究结果,我们提出了一些建议,以帮助项目开发品牌视频。
{"title":"Brand Videos among Orthopedic Surgery Residency Programs.","authors":"Quincy T Cheesman, Johnlevi S Lazaro, Hope S Thalody, Danielle Y Ponzio, Zachary D Post, Alvin C Ong","doi":"10.22038/ABJS.2024.76143.3522","DOIUrl":"10.22038/ABJS.2024.76143.3522","url":null,"abstract":"<p><strong>Objectives: </strong>The use of brand videos has provided residency programs with another platform to showcase themselves and attract potential applicants. Despite the rise in brand videos following the COVID-19 pandemic, not all orthopedic surgery residency programs have developed one. This study aimed to determine the prevalence of brand videos on orthopedic surgery residency program websites and evaluate their contents.</p><p><strong>Methods: </strong>This was a cross-sectional analysis of all orthopedic surgery residencies participating in the National Resident Matching Program (NRMP) in November 2022. The presence of a brand video was reviewed on each program's website and data was collected from the contents of existing videos.</p><p><strong>Results: </strong>Forty-seven percent (90/192) of programs had a brand video with an average length of 6 minutes and 13 seconds. The top two program qualities highlighted were a family friendly atmosphere with camaraderie (83%; 75/90) and early hands-on surgical experience (72%; 65/90). Despite brand videos being tailored to an audience of prospective residents, only 9% (8/90) of programs noted qualities they look for in prospective residents. Furthermore, only 19% (17/90) of programs displayed a closing slide containing contact information or links to social media accounts.</p><p><strong>Conclusion: </strong>Only 47% of orthopedic surgery residency programs have established a brand video. The absence of a brand video may be due to programs not perceiving them as important, shortage of resources, or unfamiliarity with video marketing. Based on our findings, we propose recommendations to assist programs in their development of a brand video.</p>","PeriodicalId":46704,"journal":{"name":"Archives of Bone and Joint Surgery-ABJS","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calculation of the Forearm and Hand Three-Dimensional Anthropometry Based on Two-Dimensional Image Feature Extraction: An Approach for Cock-up Splint Design. 基于二维图像特征提取的前臂和手部三维人体测量计算:一种夹板设计方法。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.73439.3435
Mahla Daliri, Mahla Rajabi, Sedigheh Rastaghi, Mehdi Ataei, Mona Meybodi, Nafiseh Jirofti, Mohadeseh Mohadesi, Afsaneh Jahani, Ali Moradi

Objectives: An alternative to both the time-consuming traditional and the expensive three-dimensional (3D) methods for splint design is to use two-dimensional (2D) images. The present study utilized image processing to achieve an automatic and practical method of anthropometry measurement to design and build a personalized and remote cock-up splint. This method is applicable for patients unable to personally attend clinic appointments.

Methods: The defined landmarks of the cock-up splint of 100 adult participants were measured manually. Each individual had a 2D image taken of their upper limb using a customized imaging device. The 2D image portions that corresponded to the manual measurements were then identified, and their sizes were retrieved in pixels using MATLAB software. To find equations between manual 3D measurements and 2D image processing ones, multiple linear regression analysis was performed on landmark variables.

Results: We were able to determine equations to estimate manual dimensions based on 2D image data. In the men's group, we could predict the third finger length, forearm circumference at three levels, and the largest forearm circumference. In the women's group, in addition to variables predicted for men, hand circumference at the distal palmar crease and first web levels, as well as arm circumference, could be predicted using the identified equations.

Conclusion: Based on the findings, 2D image processing could be an appropriate method for designing personalized cock-up splints.

目的:使用二维(2D)图像进行夹板设计是既耗时又昂贵的传统三维(3D)方法的替代方法。本研究利用图像处理技术实现了一种自动、实用的人体测量方法,从而设计并制作出个性化的远程自锁夹板。这种方法适用于无法亲自到诊所就诊的患者:方法:对 100 名成年参与者的翘臀夹板定义地标进行人工测量。每个人都使用定制的成像设备拍摄了上肢的二维图像。然后确定与手动测量结果相对应的二维图像部分,并使用 MATLAB 软件以像素为单位检索其大小。为了找到手动三维测量和二维图像处理之间的等式,我们对地标变量进行了多元线性回归分析:结果:我们能够根据二维图像数据确定估算人工尺寸的方程。在男性组中,我们可以预测第三指长度、三级前臂周长和最大前臂周长。在女性组中,除了可以预测男性的变量外,还可以使用确定的方程预测手掌远端皱褶和第一蹼水平的手围以及臂围:根据研究结果,二维图像处理可以作为设计个性化翘臀夹板的一种适当方法。
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引用次数: 0
Ultrasound Applications in Pediatric Orthopedics. 超声波在小儿骨科中的应用。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.59904.2950
Themistoklis Tzatzairis, Konstantinos Skarentzos, Christos Grammatikos, Charalampos Karamalis, Konstantinos Korakianitis, Romanos Kourempeles, Georgios Drosos

Imaging techniques have significantly impacted physicians' capability for diagnosis and differential diagnosis for decades. The aim of this review is to update our knowledge regarding the use of US in orthopedic pediatric patients for diagnostic purposes or procedural/therapeutic purposes. This review demonstrates the application of US in trauma (long bone fractures, radial neck fractures, etc.), developmental anomalies such as developmental dysplasia of the hip and congenital dislocation of the patella, soft tissue pathologies (ganglion cyst, popliteal cyst, hemangioma, lipoma, etc.), tumors, apophysitis, joint effusion, and femoral acetabular impingement. US aid in musculoskeletal procedures has also been reported; US-guided procedures such as aspiration, injection, biopsy, foreign body removal, and peripheral nerve block reduce complications, thus making the procedures safer for the patient. Sonography is a fast, low-cost, mobile, non-invasive, and radiation-free diagnostic tool. Even though US requires a skilled operator and has a long learning curve, in experienced hands is the "orthopedic surgeon's stethoscope".

几十年来,成像技术对医生的诊断和鉴别诊断能力产生了重大影响。本综述旨在更新我们对儿科骨科患者使用 US 进行诊断或手术/治疗的认识。本综述展示了 US 在创伤(长骨骨折、桡骨颈骨折等)、发育异常(如髋关节发育不良和先天性髌骨脱位)、软组织病变(神经节囊肿、腘窝囊肿、血管瘤、脂肪瘤等)、肿瘤、骨骺炎、关节积液和股骨髋臼撞击等方面的应用。也有报道称,超声波在肌肉骨骼手术中起辅助作用;在超声波引导下进行抽吸、注射、活检、异物取出和周围神经阻滞等手术可减少并发症,从而使手术对患者更加安全。超声造影是一种快速、低成本、可移动、无创伤、无辐射的诊断工具。尽管超声造影需要熟练的操作人员和较长的学习曲线,但在经验丰富的医生手中,超声造影就是 "骨科医生的听诊器"。
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引用次数: 0
Prospect of Mesenchymal Stem Cells in Enhancing Nerve Regeneration in Brachial Plexus Injury in Animals: A Systematic Review. 间充质干细胞在动物臂丛神经损伤中促进神经再生的前景:系统综述
IF 1.3 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.68053.3224
Wahyu Widodo, Indah Suci Widyahening, Irfan Kurnia Pratama, Mohamad Walid Kuncoro

Objectives: Brachial plexus injuries (BPI), although rare, often results in significant morbidity. Stem cell was thought to be one of BPI treatment modalities because of their nerve-forming regeneration potential. Although there is a possibility for the use of mesenchymal stem cells as one of BPI treatment, it is still limited on animal studies. Therefore, this systematic review aimed to analyze the role of mesenchymal stem cells in nerve regeneration in animal models of brachial plexus injury.

Method: This study is a systematic review with PROSPERO registration number CRD4202128321. Literature searching was conducted using keywords experimental, animal, brachial plexus injury, mesenchymal stem cell implantation, clinical outcomes, electrophysiological outcomes, and histologic outcomes. Searches were performed in the PubMed, Scopus, and ScienceDirect databases. The risk of bias was assessed using SYRCLE's risk of bias tool for animal studies. The data obtained were described and in-depth analysis was performed.

Result: Four studies were included in this study involving 183 animals from different species those are rats and rabbits. There was an increase in muscle weight and shortened initial onset time of muscle contraction in the group treated with stem cells. Electrophysiological results showed that mesenchymal stem cells exhibited higher (Compound muscle action potential) CMAP amplitude and shorter CMAP latency than control but not better than autograft. Histological outcomes showed an increase in axon density, axon number, and the formation of connections between nerve cells and target muscles.

Conclusion: Mesenchymal stem cell implantation to animals with brachial plexus injury showed its ability to regenerate nerve cells as evidenced by clinical, electrophysiological, and histopathological results. However, this systematic study involved experimental animals from various species so that the results cannot be uniformed, and conclusion should be drawn cautiously.

目的:臂丛神经损伤(BPI)虽然罕见,但往往会导致严重的发病率。由于干细胞具有神经再生潜力,因此被认为是治疗臂丛神经损伤的方法之一。虽然间充质干细胞有可能被用作治疗 BPI 的方法之一,但目前仍仅限于动物实验。因此,本系统综述旨在分析间充质干细胞在臂丛神经损伤动物模型中的神经再生作用:本研究为系统综述,PROSPERO 注册号为 CRD4202128321。使用关键词实验、动物、臂丛神经损伤、间充质干细胞植入、临床结果、电生理学结果和组织学结果进行文献检索。检索在PubMed、Scopus和ScienceDirect数据库中进行。使用SYRCLE的动物研究偏倚风险工具对偏倚风险进行了评估。对获得的数据进行了描述和深入分析:本研究共纳入四项研究,涉及 183 只不同物种的动物,包括大鼠和兔子。干细胞治疗组的肌肉重量增加,肌肉收缩的初始开始时间缩短。电生理学结果显示,间充质干细胞比对照组表现出更高的(复合肌肉动作电位)CMAP振幅和更短的CMAP潜伏期,但不优于自体移植。组织学结果显示,轴突密度、轴突数量以及神经细胞与靶肌肉之间连接的形成均有所增加:结论:从临床、电生理学和组织病理学结果来看,间充质干细胞植入臂丛神经损伤动物体内显示了其再生神经细胞的能力。然而,这项系统性研究涉及不同物种的实验动物,因此结果不能统一,应谨慎得出结论。
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引用次数: 0
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Archives of Bone and Joint Surgery-ABJS
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