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Painful Unicompartmental Knee Arthroplasty: Etiology, Diagnosis and Management. 疼痛的单关节膝关节置换术:病因、诊断和处理。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.61787.3030
Justin M Walsh, Robert A Burnett, Joseph Serino, Tad L Gerlinger

Unicompartmental knee arthroplasty (UKA) is an increasingly common procedure. Patients with persistent or new postoperative pain can present a challenge for surgeons to accurately diagnose and treat. The purpose of this study is to provide a comprehensive review of the presentation, diagnosis, and management of the various pathologies contributing to pain after UKA. The most common causes of a painful UKA include aseptic component loosening and progression of osteoarthritis. Both of these conditions may be treated with either revision UKA or conversion to total knee arthroplasty. While technically challenging, these procedures are often associated with favorable outcomes. Other causes of pain after UKA include infection, atraumatic tibial component subsidence, periprosthetic fracture and malalignment. Careful clinical, radiographic, and laboratory evaluation is therefore critical to accurately identify the source of pain and guide appropriate management.

单间室膝关节置换术(UKA)是一种越来越常见的手术。术后持续或新出现疼痛的患者给外科医生的准确诊断和治疗带来了挑战。本研究旨在全面回顾导致 UKA 术后疼痛的各种病理表现、诊断和治疗。导致UKA疼痛的最常见原因包括无菌性组件松动和骨关节炎进展。这两种情况都可以通过翻修UKA或转为全膝关节置换术来治疗。虽然这些手术在技术上具有挑战性,但通常都能取得良好的疗效。UKA术后疼痛的其他原因包括感染、外伤性胫骨组件下沉、假体周围骨折和错位。因此,仔细的临床、影像学和实验室评估对于准确识别疼痛来源和指导适当的治疗至关重要。
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引用次数: 0
Preoperative Three-Dimensional Planning of Screw Length is not Reliable in Osteotomies of the Humerus and Forearm. 在肱骨和前臂截骨术中,术前三维规划螺钉长度并不可靠。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.72837.3611
Martine Van Den Boogaard, Lisette C Langenberg, Bertram The, Christiaan J A Van Bergen, Denise Eygendaal

Objectives: Pediatric upper extremity fractures are seen frequently and sometimes lead to malunion. Three-dimensional (3D) surgery planning is an innovative addition to surgical treatment for the correction of post-traumatic arm deformities. The detailed planning in three dimensions allows for optimization of correction and provides planning of the exact osteotomies which include the advised material for correction and fixation. However, no literature is available on the precision of this computerized sizing of implants and screws. This study aimed to investigate the differences between 3D planned and surgically implanted screws in patients with a corrective osteotomy of the arm.

Methods: Planned and implanted screw lengths were evaluated in patients who underwent a 3D planned corrective osteotomy of the humerus or forearm using patient-specific 3D printed drill- and sawblade guides. Postoperative information on implanted hardware was compared to the original planned screw lengths mentioned in the 3D planned surgery reports.

Results: Of the 159 included screws in 17 patients, 45% differed >1 mm from the planned length (P<0.001). Aberrant screws in the radius and ulna were often longer, while those in the humerus were often shorter. Most aberrant screws were seen in the proximity of the elbow joint.

Conclusion: This study showed that 3D-planned screws in corrective osteotomies of the humerus and forearm differ significantly from screw lengths used during surgery. This illustrates that surgeons should be cautious when performing osteotomies with 3D techniques and predefined screw sizes.

目的:小儿上肢骨折是常见病,有时会导致骨折愈合不良。三维(3D)手术规划是矫正创伤后手臂畸形手术治疗的创新补充。通过三维详细规划,可以优化矫形,并提供精确的截骨规划,包括建议的矫形和固定材料。然而,目前还没有关于这种计算机化植入物和螺钉尺寸精确度的文献。本研究旨在调查手臂矫正截骨术患者的三维规划螺钉和手术植入螺钉之间的差异:方法:使用患者专用的三维打印钻头和锯片导向器,对肱骨或前臂接受三维计划矫正截骨术的患者的计划螺钉长度和植入螺钉长度进行评估。将植入硬件的术后信息与三维计划手术报告中提到的原始计划螺钉长度进行了比较:结果:在17名患者的159颗螺钉中,45%的螺钉长度与计划长度相差1毫米以上(PC结论:3D计划螺钉的长度与计划长度相差1毫米以上:这项研究表明,肱骨和前臂矫正截骨术中的三维计划螺钉与手术中使用的螺钉长度存在显著差异。这说明外科医生在使用三维技术和预定螺钉尺寸进行截骨手术时应谨慎。
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引用次数: 0
An Efficiency Model for Decreasing Operative Room Turnover Time for Total Joint Arthroplasties. 减少全关节关节置换术手术室周转时间的效率模型。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.77381.3575
Kathryn Hedden, Samantha Harrer, Jong Hyun Choi, Pietro M Gentile, Alisina Shahi, Matthew L Brown

Objectives: Despite an increased demand for total joint arthroplasty (TJA), rising health-care costs and bundling of payments by payers have shifted the focus to improving operating room (OR) efficiency. This study aimed to assess the efficacy of an efficiency model that optimized instrument trays on decreasing OR turnover time (TOT) and the benefits made possible by this improved efficiency.

Methods: All primary TJA procedures performed by a single fellowship-trained surgeon from January 2022 to August 2023 were reviewed. The surgeon partnered with Zimmer Biomet to condense the total knee and total hip arthroplasty instrument trays from seven to three trays each. Patient in OR time and patient out of OR times were collected and used to calculate TOT. Mean TOTs pre-efficiency model implementation (January - October 2022) and post-efficiency model implementation (March - August 2023) were compared. Annual cost savings were calculated based on an average cost per one minute of OR time of $47.99 and an average cost for the Sterile Processing Department (SPD) to process a single TJA tray of $79.41.

Results: Following implementation of the efficiency model, the average OR TOT significantly decreased by 19 minutes (P < 0.0001), a greater than 44% reduction in TOT. At this surgeon's current case volume, conservatively estimated at 280 primary TJA cases per year, annual savings in OR and SPD processing costs were $169,597 and $88,939, respectively. Moreover, this led to increased case volume per operative day.

Conclusion: A small-scale intervention such as optimizing instrument trays for TJA is a valuable and sustainable solution to improve efficiency in the OR by decreasing OR TOT, thereby generating considerable cost-savings and opportunity to increase surgical volume.

目标:尽管对全关节成形术(TJA)的需求不断增加,但医疗成本的上升和支付方的捆绑支付已将重点转移到提高手术室(OR)的效率上。本研究旨在评估优化器械托盘的效率模式在减少手术室周转时间(TOT)方面的效果,以及效率提高带来的益处:研究回顾了一位接受过研究培训的外科医生在 2022 年 1 月至 2023 年 8 月期间实施的所有主要 TJA 手术。该外科医生与 Zimmer Biomet 合作,将全膝关节和全髋关节置换术的器械托盘从七个减少到三个。收集了患者进入手术室的时间和患者离开手术室的时间,并用于计算 TOT。对实施高效模式前(2022 年 1 月至 10 月)和实施高效模式后(2023 年 3 月至 8 月)的平均 TOT 进行了比较。根据手术室每分钟的平均成本为 47.99 美元,以及消毒处理部门(SPD)处理一个 TJA 盘的平均成本为 79.41 美元,计算出了每年可节省的成本:实施增效模式后,手术室平均 TOT 显著减少了 19 分钟(P < 0.0001),TOT 减少了 44%。根据该外科医生目前的病例量(保守估计为每年 280 例初级 TJA),手术室和 SPD 处理成本每年分别可节省 169,597 美元和 88,939 美元。此外,这还提高了每个手术日的病例量:结论:优化 TJA 器械托盘等小规模干预措施是一种有价值且可持续的解决方案,可通过减少手术室 TOT 来提高手术室效率,从而节省大量成本并增加手术量。
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引用次数: 0
Comparison of the Effects of Cognitive Dual-Task and Single-Task Balance Exercises on Static Balance among People with Anterior Cruciate Ligament Reconstruction: A Randomized Controlled Trial. 认知性双重任务和单一任务平衡练习对前十字韧带重建患者静态平衡的影响比较:随机对照试验
IF 1.3 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.77458.3579
Masumeh Hallaj Mazidluie, Jalal Ahadi, Fatemeh Oraei Eslami, Tabassom Ghanavati, Amin Moradi

Objectives: The anterior cruciate ligament (ACL) reconstruction surgery improves mechanical stability; however, functional stability remains impaired. Balance exercises can help improve functional stability. The effect of cognitive dual-task balance exercises has not been studied in people with ACL reconstruction surgery; therefore, this study aimed to compare the effect of cognitive dual-task and single-task balance exercises on the static balance indices in these individuals.

Methods: This study was a randomized clinical trial. After a period of conventional physiotherapy and applying inclusion criteria, 28 patients with ACL reconstruction surgery were randomly divided into two groups of cognitive dual-task and single-task balance exercises. Each group received the relevant exercises for four weeks, three times a week, with each session lasting 20 min. Center of pressure variables, including mean displacement in anterior-posterior and medial-lateral directions, total path length, mean velocity of displacement, root mean square of displacement and velocity, and the elliptical area, were measured using the FDM pressure platform before and after the interventions as the primary outcomes. Knee Injury and Osteoarthritis Outcome Score (KOOS) scale was completed by the participants before and after the interventions.

Results: The measured static balance variables and KOOS subscales had significant differences before and after intervention in both groups (P<0.05); however, no statistically significant difference was observed in these variables between the two groups. There was no significant correlation between KOOS subscales and measured static balance variables.

Conclusion: Both cognitive dual-task and single-task balance exercises improved the indicators related to static balance and the level of functional disability of the knee. However, cognitive dual-task balance exercises had no superiority over single-task balance exercises in ACL-reconstructed individuals.

目的:前十字韧带(ACL)重建手术改善了机械稳定性,但功能稳定性仍然受损。平衡练习有助于提高功能稳定性。认知性双任务平衡练习对前交叉韧带重建手术患者的影响尚未进行过研究;因此,本研究旨在比较认知性双任务平衡练习和单任务平衡练习对这些患者静态平衡指数的影响:本研究是一项随机临床试验。28名前交叉韧带重建手术患者在经过一段时间的常规物理治疗并符合纳入标准后,被随机分为认知双任务和单任务平衡训练两组。每组接受相关练习四周,每周三次,每次 20 分钟。在干预前后,使用 FDM 压力平台测量压力中心变量,包括前后方向和内外侧方向的平均位移、总路径长度、位移平均速度、位移和速度的均方根以及椭圆面积,作为主要结果。干预前后,参与者填写膝关节损伤和骨关节炎结果评分表(KOOS):结果:两组受试者的静态平衡变量和 KOOS 分量表在干预前后均有显著差异(结论:认知双任务和单一任务均有显著差异:认知双任务平衡练习和单任务平衡练习都能改善静态平衡相关指标和膝关节功能障碍程度。然而,在前交叉韧带重建者中,认知双任务平衡练习并不优于单任务平衡练习。
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引用次数: 0
Response to Letter to the Editor: "How to avoid Common Complications in Hamstrings Harvest for Anterior Cruciate Ligament Reconstruction. A Practical Guide." 回应致编辑的信:"如何避免用于前十字韧带重建的腘绳肌切除术中的常见并发症。实用指南"。
IF 1.3 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.78488.3613
Filippo Familiari, Michelangelo Palco, Raffaella Russo, Robert F LaPrade, Roberto Simonetta
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引用次数: 0
Biomolecules-Loading of 3D-Printed Alginate-Based Scaffolds for Cartilage Tissue Engineering Applications: A Review on Current Status and Future Prospective. 用于软骨组织工程应用的三维打印藻酸盐基支架的生物大分子加载:现状与未来展望综述。
IF 1.3 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2023.73275.3396
Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Mohammad H Ebrahimzadeh, Marzieh Mohammadi, Davood Yari, Ali Moradi

Osteoarthritis (OA) can arise from various factor including trauma, overuse, as well as degeneration resulting from age or disease. The specific treatment options will vary based on the severity of the condition, and the affected joints. Some common treatments for OA include lifestyle modifications, medications, physical therapy, surgery and tissue engineering (TE). For cartilage tissue engineering (CTE), three-dimension (3D) scaffolds are made of biocompatible natural polymers, which allow for the regeneration of new cartilage tissue. An ideal scaffold should possess biological and mechanical properties that closely resemble those of the cartilage tissue, and lead to improved functional of knee. These scaffolds are specifically engineered to serve as replacements for damaged and provide support to the knee joint. 3D-bioprinted scaffolds are made of biocompatible materials natural polymers, which allow for the regeneration of new cartilage. The utilization of 3D bioprinting method has emerged as a novel approach for fabricating scaffolds with optimal properties for CTE applications. This method enables the creation of scaffolds that closely mimic the native cartilage in terms of mechanical characteristics and biological functionality. Alginate, that has the capability to fabricate a cartilage replacement customized for each individual patient. This polymer exhibits hydrophilicity, biocompatibility, and biodegradability, along with shear-thinning properties. These unique properties enable Alginate to be utilized as a bio-ink for 3D bioprinting method. Furthermore, chondrogenesis is the complex process through which cartilage is formed via a series of cellular and molecular signaling. Signaling pathway is as a fundamental mechanism in cartilage formation, enhanced by the incorporation of biomolecules and growth factors that induce the differentiation of stem cells. Accordingly, ongoing review is focusing to promote of 3D bioprinting scaffolds through the utilization of advanced biomolecules-loading of Alginate-based that has the capability to fabricate a cartilage replacement tailored specifically to each patient's unique needs and anatomical requirements.

骨关节炎(OA)可由多种因素引起,包括创伤、过度使用以及年龄或疾病导致的退化。具体的治疗方案会根据病情的严重程度和受影响的关节而有所不同。一些常见的 OA 治疗方法包括调整生活方式、药物、物理治疗、手术和组织工程(TE)。就软骨组织工程(CTE)而言,三维(3D)支架由生物相容性天然聚合物制成,可使新软骨组织再生。理想的支架应具有与软骨组织非常相似的生物和机械特性,并能改善膝关节的功能。这些支架经过专门设计,可替代受损的膝关节,并为膝关节提供支撑。三维生物打印支架由生物相容性材料天然聚合物制成,可促进新软骨的再生。利用三维生物打印方法制造具有最佳性能的 CTE 应用支架已成为一种新方法。这种方法能制造出在机械特性和生物功能方面近似于原生软骨的支架。藻酸盐,能够为每位患者定制软骨替代物。这种聚合物具有亲水性、生物相容性、生物可降解性以及剪切稀化特性。这些独特的特性使得海藻酸盐可以用作三维生物打印方法的生物墨水。此外,软骨生成是通过一系列细胞和分子信号形成软骨的复杂过程。信号通路是软骨形成的基本机制,通过加入诱导干细胞分化的生物大分子和生长因子而得到加强。因此,目前的研究重点是通过利用先进的生物大分子--以海藻酸盐为基础的负载--促进三维生物打印支架的发展,这种支架能够根据每位患者的独特需求和解剖学要求制造出专门的软骨替代物。
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引用次数: 0
Which Pre-Operative, Modifiable Risk Factors are Most Predictive of Complications in orthopedic Upper Extremity Surgery? 哪些术前可调整风险因素最能预测上肢矫形手术的并发症?
IF 1.3 Q2 Medicine Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2023.64324.3098
Kamil M Amer, Dominick V Congiusta, Akhil Dondapati, Robert L Dalcortivo, Michael M Vosbikian, Irfan H Ahmed

Objectives: Identification of modifiable comorbid conditions in the preoperative period is important in optimizing outcomes. We evaluate the association between such risk factors and postoperative outcomes after upper extremity surgery using a national database.

Methods: The National Surgical Quality Improvement Program (NSQIP) 2006-2016 database was used to identify patients undergoing an upper extremity principle surgical procedure using CPT codes. Modifiable risk factors were defined as smoking status, use of alcohol, obesity, recent loss of >10% body weight, malnutrition, and anemia. Outcomes included discharge destination, major complications, bleeding complications, unplanned re-operation, sepsis, and prolonged length of stay. Chi square and multivariable logistic regressions were used to identify significant predictors of outcomes. Significance was defined as P<0.01.

Results: After applying exclusion criteria, 53,780 patients were included in the final analysis. Preoperative malnutrition was significantly associated with non-routine discharge (OR=4.75), major complications (OR=7.27), bleeding complications (OR=7.43), unplanned re-operation (OR=2.44), sepsis (OR=10.22), and prolonged length of stay (OR=5.27). Anemia was associated with non-routine discharge (OR=2.67), bleeding complications (OR=13.27), and prolonged length of stay (OR=3.26). In patients who had a weight loss of greater than 10%, there was an increase of non-routine discharge (OR=2.77), major complications (OR=2.93), and sepsis (OR=3.7). Smoking, alcohol use, and obesity were not associated with these complications.

Conclusion: Behavioral risk factors (smoking, alcohol use, and obesity) were not associated with increased complication rates. Malnutrition, weight loss, and anemia were associated with an increase in postoperative complication rates in patients undergoing upper limb orthopaedic procedures and should be addressed prior to surgery, suggesting nutrition labs should be part of the initial blood work.

目的:在术前确定可改变的合并症对优化预后非常重要。我们利用国家数据库评估了此类风险因素与上肢手术术后预后之间的关联:方法:我们使用国家外科质量改进计划(NSQIP)2006-2016 年数据库,通过 CPT 编码识别接受上肢原则性外科手术的患者。可改变的风险因素定义为吸烟状况、饮酒、肥胖、近期体重下降>10%、营养不良和贫血。结果包括出院去向、主要并发症、出血并发症、计划外再次手术、败血症和住院时间延长。采用卡方检验和多变量逻辑回归来确定结果的重要预测因素。显著性定义为 PR 结果:在应用排除标准后,53,780 名患者被纳入最终分析。术前营养不良与非例行出院(OR=4.75)、主要并发症(OR=7.27)、出血并发症(OR=7.43)、计划外再次手术(OR=2.44)、败血症(OR=10.22)和住院时间延长(OR=5.27)显著相关。贫血与非例行出院(OR=2.67)、出血并发症(OR=13.27)和住院时间延长(OR=3.26)有关。体重下降超过 10%的患者,非正常出院(OR=2.77)、主要并发症(OR=2.93)和败血症(OR=3.7)的发生率增加。吸烟、饮酒和肥胖与这些并发症无关:行为风险因素(吸烟、饮酒和肥胖)与并发症发生率增加无关。营养不良、体重减轻和贫血与上肢矫形手术患者术后并发症发生率的增加有关,应在手术前解决,建议将营养化验作为初始血液检查的一部分。
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引用次数: 0
Tendinopathy of the Distal Biceps Tendon is a Common Incidental Finding on Magnetic Resonance Imaging of the Elbow. 肱二头肌远端肌腱的腱鞘炎是肘部磁共振成像的常见意外发现。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.79788.3646
Céline K Tuik, Rachel E Cross, Yannick Albert J Hoftiezer, Floris V Raasveld, Michel P J Van Den Bekerom, Neal C Chen

Objectives: The prevalence of tendinopathic changes of the distal biceps tendon (DBT) is not clear, in both the general population and patients with symptoms that may be related to distal biceps tendinopathy. The purpose of this study is to retrospectively determine the prevalence of distal biceps tendinopathy in symptomatic and asymptomatic patients undergoing an MRI of the elbow. A secondary aim is to assess the association between age and the prevalence of incidental distal biceps tendinopathy.

Methods: We assessed 1,180 MRI-reports describing the elbow region and calculated prevalence of incidental and symptomatic DBT tendinopathies. Symptomatic DBT tendinopathy was defined as patients that had complaints of anterior elbow pain. With a multivariate logistic regression analysis we tested whether age, sex, and race were independently associated with DBT tendinopathy.

Results: 276 of 1,180 (23%) of the distal biceps tendons showed signal changes on the MRI. Only 114 (10%) showed DBT tendinopathy, of which60 (5% of all tendons, 53% of tendons with tendinopathy) were incidental. The prevalence peaked between 40-49.9 years (37%) and 50-59.9 years (30%). There was no significant association between increasing age and incidental DBT tendinopathy (P= 0.935). However, there was a significant association between increasing age and tendinopathy, whether the tendinopathy was incidental or symptomatic (P< 0.001).

Conclusion: Signal changes in the DBT are common on MRI scans, however 53% of detected tendinopathies are incidental. There is no association between increasing age and prevalence of incidental DBT tendinopathy, though there is a significant association between increasing age and DBT tendinopathy.

目的:肱二头肌远端肌腱(DBT)腱鞘病变在普通人群和症状可能与肱二头肌远端肌腱病变有关的患者中的患病率尚不明确。本研究旨在回顾性地确定接受肘部核磁共振成像检查的有症状和无症状患者中肱二头肌远端肌腱病变的患病率。另一个目的是评估年龄与偶发性肱二头肌远端肌腱病发病率之间的关系:我们评估了 1,180 份描述肘部区域的 MRI 报告,并计算了偶发和症状性 DBT 肌腱病的患病率。有症状的DBT肌腱病被定义为主诉肘关节前部疼痛的患者。通过多变量逻辑回归分析,我们检验了年龄、性别和种族是否与 DBT 肌腱病独立相关。只有 114 条(10%)显示 DBT 肌腱病变,其中 60 条(占所有肌腱的 5%,占有肌腱病变肌腱的 53%)是偶发的。发病率在 40-49.9 岁(37%)和 50-59.9 岁(30%)之间达到高峰。年龄增长与偶发性 DBT 肌腱病之间无明显关联(P= 0.935)。然而,无论肌腱病变是偶发的还是有症状的,年龄的增加与肌腱病变之间都有明显的关联(P< 0.001):结论:DBT的信号变化在核磁共振扫描中很常见,但53%的腱鞘病变是偶然发现的。年龄的增长与偶发性DBT肌腱病的发病率之间没有关联,但年龄的增长与DBT肌腱病之间存在显著关联。
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引用次数: 0
Management of Infected Segmental Bone Defects with Antibiotic-Cement-Coated Nails in the First Stage of the Masquelet Technique. Implantation and Removal of the Cement Spacer around the Nail: A Technical Note. 在 Masquelet 技术的第一阶段使用抗生素水泥涂层钉治疗感染性节段性骨缺损。钉子周围水泥垫片的植入和移除:技术说明。
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.72941.3383
Germán Garabano, Gonzalo M Viollaz, Cesar Angel Pesciallo

Infected segmental bone defects (ISBD) of the femur and tibia pose a significant challenge. Traditionally, bone fixation in the first stage of the Masquelet technique involves external fixation, but intramedullary nail fixation has recently gained popularity. Despite this, little attention has been focused on the elaboration, implantation, and removal of the spacer around the nail. In this technical note, we present gentamicin cement-coated rigid nails as definitive fixation in the first stage. We also detail the technique for placing and removing the one-piece dyed antibiotic spacer around the nail. We highlight its potential benefits in one of the critical steps of this versatile technique.

股骨和胫骨感染性节段性骨缺损(ISBD)是一项重大挑战。传统上,Masquelet 技术第一阶段的骨固定包括外固定,但髓内钉固定近来越来越受欢迎。尽管如此,人们却很少关注髓内钉周围间隔物的制作、植入和移除。在本技术说明中,我们介绍了庆大霉素骨水泥涂层硬质钉作为第一阶段的最终固定。我们还详细介绍了在钉子周围植入和取出一体式染色抗生素垫片的技术。我们强调了这一多功能技术的关键步骤之一的潜在优势。
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引用次数: 0
Challenges in Managing Vancomycin Flushing Syndrome Following Vancomycin-Loaded Bone Cement for Periprosthetic Joint Infection: A Case Report. 处理万古霉素骨水泥治疗假体周围关节感染后万古霉素潮红综合征的挑战:病例报告
IF 1.2 Q3 ORTHOPEDICS Pub Date : 2024-01-01 DOI: 10.22038/ABJS.2024.79046.3626
Mehdi Motififard, Mehdi Teimouri, Hossein Akbari Aghdam, Hadi Ravanbod, Mohammad Shahsavan

Periprosthetic joint infection (PJI) is a critical complication following arthroplasties, often treated with a two-stage revision using antibiotic-loaded bone cement spacers. Although these spacers can effectively manage infections, they occasionally cause severe adverse reactions. We reported the case of a 68-year-old female who developed vancomycin flushing syndrome (VFS), previously known as the red man syndrome, following the insertion of a vancomycin-loaded bone cement spacer during the first-stage revision surgery for PJI after undergoing total knee arthroplasty. Six hours postoperatively, she developed pruritus, diffuse rash, tachycardia, and hypotension. VFS was diagnosed based on clinical presentation after excluding other potential causes. She was treated with intravenous epinephrine, antihistamines, steroids, and fluid resuscitation without requiring spacer removal. The patient recovered uneventfully, underwent second-stage reimplantation after 6 weeks, and remained asymptomatic at 2-year follow-up. This highlights the importance of anticipating and managing this potentially severe reaction through a multidisciplinary approach, considering the risks and benefits of retaining versus removing antibiotic-loaded bone-cement spacers.

假体周围关节感染(PJI)是关节置换术后的一个重要并发症,通常使用抗生素骨水泥垫片进行两阶段翻修治疗。虽然这些垫片能有效控制感染,但偶尔也会引起严重的不良反应。我们报告了一例 68 岁女性的病例,她在接受全膝关节置换术后的第一阶段翻修手术治疗 PJI 时,插入了万古霉素骨水泥垫片,随后出现了万古霉素潮红综合征(VFS),以前称为 "红人综合征"。术后六小时,她出现了瘙痒、弥漫性皮疹、心动过速和低血压。在排除了其他可能的病因后,根据临床表现确诊为 VFS。她接受了静脉注射肾上腺素、抗组胺药、类固醇和液体复苏治疗,无需移除隔膜。患者恢复顺利,6 周后接受了第二阶段再植术,随访 2 年仍无症状。这凸显了通过多学科方法预测和处理这种潜在严重反应的重要性,同时考虑了保留与移除装有抗生素的骨水泥垫片的风险和益处。
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Archives of Bone and Joint Surgery-ABJS
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