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Erratum regarding missing Declaration of Competing Interest statements in previously published articles 关于先前发表的文章中缺少竞争利益声明的勘误表
IF 3.2 Pub Date : 2020-10-01 DOI: 10.1016/j.wse.2020.10.002
P. K. Surendran
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引用次数: 0
Detection of human papillomaviruses in paired healthy skin and actinic keratosis by next generation sequencing 用下一代测序检测健康皮肤和光化性角化病配对的人乳头瘤病毒
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2020.100196
Luisa Galati , Rosario Nicola Brancaccio , Alexis Robitaille , Cyrille Cuenin , Fabiola Luzi , Gianna Fiorucci , Maria Vincenza Chiantore , Nadia Marascio , Giovanni Matera , Maria Carla Liberto , Maria Gabriella Donà , Paola Di Bonito , Tarik Gheit , Massimo Tommasino

Actinic keratosis (AK) arises on photo-damaged skin and is considered to be the precursor lesion of cutaneous squamous cell carcinoma (cSCC). Many findings support the involvement of β human papillomaviruses (HPVs) in cSCC, while very little is known on γ HPV types. The objective of this study was to characterize the spectrum of PV types in healthy skin (HS) and AK samples of the same immunocompetent individuals using next generation sequencing (NGS). Viral DNA of 244 AK and 242 HS specimens were amplified by PCR using two different sets of primers (FAP59/64 and FAPM1). Purified amplicons were pooled and sequenced using NGS. The study resulted in the identification of a large number of known β and γ PV types. In addition, 27 putative novel β and 16 γ and 4 unclassified PVs were isolated. HPV types of species γ-1 (e.g. HPV4) appeared to be strongly enriched in AK versus HS. The NGS analysis revealed that a large spectrum of known and novel PVs is present in HS and AK. The evidence that species γ-1 HPV types appears to be enriched in AK in comparison to HS warrants further studies to evaluate their role in development of skin (pre)cancerous lesions.

光化性角化病(AK)发生于光损伤皮肤,被认为是皮肤鳞状细胞癌(cSCC)的前兆病变。许多研究结果支持β人乳头瘤病毒(HPV)参与cSCC,而对γ HPV类型知之甚少。本研究的目的是利用下一代测序技术(NGS)表征相同免疫功能个体健康皮肤(HS)和AK样品中的PV型谱。采用FAP59/64和FAPM1两组引物,扩增了244份AK和242份HS标本的病毒DNA。纯化的扩增子汇集并使用NGS测序。该研究鉴定了大量已知的β和γ PV类型。此外,还分离到了27个推测的新型β和16个γ以及4个未分类的pv。HPV类型γ-1(如HPV4)似乎在AK和HS中强烈富集。NGS分析显示,在HS和AK中存在大量已知的和新的pv。与HS相比,γ-1型HPV似乎在AK中富集的证据值得进一步研究,以评估其在皮肤(癌前)病变发展中的作用。
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引用次数: 15
Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia 由基于云的电子数据系统辅助的家庭HPV自我抽样:从埃塞俄比亚农村试点社区宫颈癌筛查运动中吸取的经验教训
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2020.100198
Felix Jede , Theresa Brandt , Molla Gedefaw , Solomon Berhe Wubneh , Tamrat Abebe , Brhanu Teka , Kassahun Alemu , Binyam Tilahun , Temesgen Azemeraw , Abebaw Gebeyehu , Dietmar Schmidt , Aleksandra Pesic , Andreas M. Kaufmann , Bewketu Abebe , Zelalem Ayichew , Michael Byczkowski , Timoté Vaucher , Heike Sartor , Gashaw Andargie , Till Bärnighausen , Hermann Bussmann

Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system is in place.

A cervical cancer screening campaign was conducted in a rural community in Ethiopia. All women aged 25–65 years were offered genital self-sampling using the Evalyn Brush®. Samples were HPV-DNA-tested at a central laboratory. Key indicators were captured on tablet computers and linked by a cloud-based information system. HPV-positive women were examined at the local clinic using portable colposcopy, p16/Ki-67 dual stain cytology and biopsy examination. CIN2+ women were referred for LEEP to the referral hospital.

Of 749 enumerated age-eligible women 634 (85%, (95% CI 82–88)) consented to screening, 429 samples were adequate for HPV testing, giving a total testing coverage of 57% (95% CI 53–62). The hrHPV prevalence was 14% (95% CI 5–22), 72% (95% CI 60–84) attended the clinic for a triage examination. Home-based HPV-DNA self-sampling and clinic-based triage assisted by cloud-based information technology is feasible in rural Ethiopia. Key components of such strategy are broad community awareness, high competency of community workers, and establishment of an adequate self-sampling and HPV-DNA testing platform.

对HPV阳性妇女进行初步HPV检测和分诊是一种有效的宫颈癌筛查策略。如果有一个健全的跟踪系统,这种多次访问筛查算法也有望用于资源贫乏社区的社区筛查。在埃塞俄比亚的一个农村社区开展了宫颈癌筛查运动。所有25-65岁的女性都使用Evalyn刷子进行生殖器自采样。在一个中心实验室对样本进行了hpv dna检测。关键指标被记录在平板电脑上,并通过基于云的信息系统进行链接。hpv阳性妇女在当地诊所进行便携式阴道镜检查、p16/Ki-67双染色细胞学检查和活检检查。CIN2+的妇女因LEEP被转介到转诊医院。在749名经点算的符合年龄的妇女中,634名(85%,95% CI 82-88)同意接受筛查,429份样本足以进行HPV检测,总检测覆盖率为57% (95% CI 53-62)。hrHPV患病率为14% (95% CI 5-22), 72% (95% CI 60-84)到诊所接受分诊检查。在埃塞俄比亚农村,基于家庭的HPV-DNA自采样和基于云的信息技术辅助的基于诊所的分诊是可行的。这一战略的关键组成部分是广泛的社区意识、社区工作人员的高能力以及建立适当的自我采样和HPV-DNA检测平台。
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引用次数: 13
IPVS Policy Statement addressing the burden of HPV disease for Indigenous peoples 解决土著人民HPV疾病负担的IPVS政策声明
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2019.100191
Beverley Lawton , Margaret Heffernan , George Wurtak , Marc Steben , Pema Lhaki , Fiona Cram , Magaly Blas , Merilyn Hibma , Anna Adcock , Kendall Stevenson , Lisa Whop , Julia Brotherton , Suzanne M. Garland
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引用次数: 7
Corrigendum to “Efficacy of strategies to increase participation in cervical cancer screening: GPs offering self-sampling kits for HPV testing versus recommendations to have a pap smear taken - A randomised controlled trial” [Papillomavirus Res. 9 (2020) 100194] “提高宫颈癌筛查参与策略的有效性:全科医生提供HPV检测自采样试剂盒与建议进行子宫颈抹片检查-一项随机对照试验”的勘误表[乳头瘤病毒杂志,9 (2020)100194]
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2020.100201
E. Peeters , K. Cornet , H. Cammu , V. Verhoeven , D. Devroey , M. Arbyn
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引用次数: 2
Methylation analysis in urine fractions for optimal CIN3 and cervical cancer detection 尿组分甲基化分析对CIN3和宫颈癌的最佳检测
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2020.100193
Rianne van den Helder , Nienke E. van Trommel , Annina P. van Splunter , Birgit I. Lissenberg-Witte , Maaike C.G. Bleeker , Renske D.M. Steenbergen

Introduction

Urine sampling is an interesting solution for CIN3 and cervical cancer detection. Urine can be separated in different fractions: full void urine, urine sediment and urine supernatant. We aimed to determine which urine fraction is most competent for CIN3 and cervical cancer detection by methylation analysis.

Methods

Urine samples (27 controls, 30 CIN3 and 17 cervical cancer) were processed into 3 fractions and tested for 5 methylation markers (ASCL1, GHSR, LHX8, SST, ZIC1). We determined Spearman correlation coefficients between fractions, compared methylation levels and calculated AUCs for CIN3 and cancer detection.

Results

In general strong correlations (r > 0.60) were found between urine fractions. Methylation levels increased significantly with severity of underlying disease in all urine fractions. CIN3 and controls differed significantly for 2 markers in full void urine, 4 markers in urine sediment and 1 marker in urine supernatant, with AUCs of 0.55–0.79. Comparison of cancer to controls was highly significant for all markers in all fractions, yielding AUCs of 0.87–0.99.

Conclusion

Methylation analysis performs excellent in all urine fractions for cervical cancer detection. Our results indicate the potential of CIN3 detection by urinary methylation analysis, and demonstrate that urine sediment performs best to detect CIN3.

尿液取样是CIN3和宫颈癌检测的一种有趣的解决方案。尿液可分为不同的馏分:全空尿、尿沉渣和尿上清。我们的目的是通过甲基化分析确定哪个尿液部分最能用于CIN3和宫颈癌检测。方法将27例对照组、30例CIN3、17例宫颈癌患者的尿样分成3组,检测5种甲基化标志物(ASCL1、GHSR、LHX8、SST、ZIC1)。我们确定了分数之间的Spearman相关系数,比较了甲基化水平,并计算了CIN3和癌症检测的auc。结果一般强相关性(r >0.60)。所有尿液中甲基化水平随潜在疾病的严重程度显著增加。全空尿中2个标志物、尿沉渣中4个标志物和尿上清中1个标志物与对照组差异显著,auc为0.55 ~ 0.79。癌症与对照组的比较在所有部分的所有标记上都是高度显著的,得到0.87-0.99的auc。结论甲基化分析在宫颈癌检测中具有良好的效果。我们的研究结果表明了通过尿甲基化分析检测CIN3的潜力,并表明尿沉积物是检测CIN3的最佳方法。
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引用次数: 14
IPVS policy statement. Equity in cervical cancer prevention: for all and not just for some IPVS策略声明。预防子宫颈癌的公平性:人人平等,而非部分人平等
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2019.100192
Julia Brotherton , Cristyn Davies
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引用次数: 4
Efficacy of strategies to increase participation in cervical cancer screening: GPs offering self-sampling kits for HPV testing versus recommendations to have a pap smear taken - A randomised controlled trial 提高宫颈癌筛查参与策略的有效性:全科医生提供HPV检测自采样试剂盒与建议进行巴氏涂片检查-一项随机对照试验
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2020.100194
E. Peeters , K. Cornet , D. Devroey , M. Arbyn
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引用次数: 9
IPVS statement on “Temporary HPV vaccine shortage: Implications globally to achieve equity” IPVS关于“人乳头瘤病毒疫苗暂时短缺:对实现全球公平的影响”的声明
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2020.100195
Suzanne M. Garland, Margaret A. Stanley, Anna R. Giuliano, Anna-Barbara Moscicki, Andreas Kaufmann, Neerja Bhatla, Yin Ling Woo
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引用次数: 18
Oral HPV prevalence assessment by Linear Array vs. SPF10 PCR-DEIA-LiPA25 system in the HPV Infection in Men (HIM) study 线性阵列与SPF10 PCR-DEIA-LiPA25系统在男性HPV感染(HIM)研究中的应用
IF 3.2 Pub Date : 2020-06-01 DOI: 10.1016/j.pvr.2020.100199
Deepti Bettampadi , Bradley A. Sirak , William J. Fulp , Martha Abrahamsen , Luisa L. Villa , Eduardo Lazcano-Ponce , Jorge Salmeron , Kimberly A. Isaacs-Soriano , Maria L. Baggio , Manuel Quiterio Trenado , Anna R. Giuliano

Introduction

Oral human papillomavirus (HPV) attributable oropharyngeal cancers are on the rise in many countries. Oral HPV infections among healthy individuals are commonly detected using oral gargle samples. However, the optimal method for HPV genotyping oral gargle specimens in research studies has not been previously evaluated.

Materials and methods

Oral gargle samples from 1455 HPV Infection in Men (HIM) study participants were HPV genotyped using two different methods: Linear Array and the SPF10 PCR-DEIA-LiPA25. The sensitivity of the two tests for detecting individual HPV types and grouped HPV types, high-risk HPV, low-risk HPV, grouped 4-HPV-vaccine types, and grouped 9-HPV-vaccine-types, and the degree of concordance between the two tests was assessed. We also examined whether socio-demographic-behavioral factors were associated with concordance between the two assays.

Results

The sensitivity of SPF10 PCR-DEIA-LiPA25 was higher than Linear Array, with the exception of HPV 70, for the detection of oral HPV. The prevalence ratio of SPF10 PCR-DEIA-LiPA25 to Linear Array varied between 1.0 and 9.0 for individual HPV genotypes, excluding HPV 70, and between 3.8 and 4.4 for grouped 4-valent and 9-valent HPV vaccine types, respectively. There was no association between socio-demographic-behavioral factors and discordance in results between the two tests for oral HPV 16 detection.

Discussion

SPF10 PCR-DEIA-LiPA25 was more sensitive than Linear Array for detecting HPV in oral gargle samples. Given the growing importance of detecting oral HPV infection for research studies of oral HPV natural history and vaccine effectiveness evaluation, we recommend using methods with higher sensitivity such as SPF10 PCR-DEIA-LiPA25 for detecting HPV in oral gargle samples.

在许多国家,由口腔人乳头瘤病毒(HPV)引起的口咽癌呈上升趋势。健康人的口腔HPV感染通常是通过使用口腔含漱液样本来检测的。然而,研究中口腔含漱液样本HPV基因分型的最佳方法尚未得到评估。材料与方法对1455例男性HPV感染(HIM)研究对象的口腔含漱液样本进行HPV基因分型,采用两种不同的方法:线性阵列法和SPF10 PCR-DEIA-LiPA25。评估两种检测方法对HPV个体型和HPV分组型、高危型、低危型、4-HPV疫苗分组型和9-HPV疫苗分组型的敏感性,以及两种检测方法之间的一致性。我们还研究了社会人口行为因素是否与两种分析之间的一致性有关。结果除HPV 70外,SPF10 PCR-DEIA-LiPA25检测口腔HPV的灵敏度均高于线性阵列。在不同HPV基因型(不包括HPV 70)中,SPF10 PCR-DEIA-LiPA25对线性阵列的检出率在1.0 ~ 9.0之间,在4价和9价HPV疫苗组中,检出率分别在3.8 ~ 4.4之间。社会人口行为因素与两种口腔HPV 16检测结果的不一致之间没有关联。讨论spf10 PCR-DEIA-LiPA25检测口腔含漱液中HPV的灵敏度高于线性阵列。鉴于口腔HPV感染检测在口腔HPV自然史研究和疫苗有效性评估中的重要性日益增加,我们建议使用SPF10 PCR-DEIA-LiPA25等灵敏度更高的方法检测口腔含漱液样本中的HPV。
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引用次数: 4
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Papillomavirus Research
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