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A decade of liver transplantation in Mongolia: Economic insights and cost analysis. 蒙古肝移植十年:经济学见解和成本分析。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-19 DOI: 10.1186/s13561-024-00528-0
Amarjargal Tsengel, Sergelen Orgoi, Otgonbayar Damdinbazar, Bat-Ireedui Badarch, Urnultsaikhan Ganbold, Batsaikhan Batsuuri, Yerkyebulan Mukhtar, Batsaikhan Bat-Erdene, Liu Lei, Tserenbat Bazarsad, Undarmaa Zandanbazar, Gantugs Yundendorj

Background: Mongolia introduced liver transplantation 10 years ago, becoming the 46th country globally to successfully perform this procedure. However, the cost of liver transplantation treatment remains expensive in Mongolia, a lower-middle-income country. Thus, the need to calculate the cost of liver transplants, a highly-valued treatment, forms the basis for this study.

Methods: This study employed a retrospective research design with secondary data. The primary dataset comprised 143 cases of liver transplantation performed at the First Central Hospital of Mongolia between 2011 and 2021.

Results: The average cost of a liver transplant in Mongolia is $39,589 ± 10,308, with 79.6% being direct costs and 20.4% indirect costs. Of the direct costs, 71% were attributed to drugs, medical equipment, and supplies, while 8.6% accounted for salaries. In terms of the Model of End-Stage Liver Disease (MELD) scores, treatment costs were $39,205 ± 10,786 for patients with MELD ≤ 14 points, $40,296 ± 1,517 for patients with MELD 15-20 points, $39,352 ± 8,718 for patients with MELD 21-27 points, and $39,812 ± 9,954 for patients with MELD ≤ 28 points, with no statistically significant difference (P = 0.953). However, when calculated according to the Child-Turcotte-Pugh (CTP) score classification, treatment cost for CTP-A patients was $35,970 ± 6,879, for CTP-B patients $41,951 ± 12,195, and for CTP-C patients $37,396 ± 6,701, which was statistically significant (Р=0.015).

Conclusion: The average cost of liver transplantation treatment in Mongolia was $39,589. Despite medical facilities' capacity to treat up to 50 patients annually, the waiting list exceeds 300 individuals, highlighting significant unmet healthcare needs.

背景:蒙古在 10 年前引入了肝脏移植手术,成为全球第 46 个成功实施该手术的国家。然而,在蒙古这个中低收入国家,肝移植治疗的费用依然昂贵。因此,有必要计算肝移植这一价值极高的治疗费用,这也是本研究的基础:本研究采用了回顾性研究设计和二手数据。主要数据集包括 2011 年至 2021 年期间在蒙古第一中心医院进行的 143 例肝移植手术:蒙古肝移植手术的平均费用为(39,589 美元± 10,308 美元),其中 79.6% 为直接费用,20.4% 为间接费用。在直接成本中,药品、医疗设备和用品占 71%,工资占 8.6%。根据终末期肝病模型(MELD)评分,MELD ≤ 14 分的患者治疗费用为 39,205 美元(10,786 分),MELD 15-20 分的患者为 40,296 美元(1,517 分),MELD 21-27 分的患者为 39,352 美元(8,718 分),MELD ≤ 28 分的患者为 39,812 美元(9,954 分),差异无统计学意义(P = 0.953)。然而,根据Child-Turcotte-Pugh(CTP)评分分类计算,CTP-A患者的治疗费用为35,970美元±6,879分,CTP-B患者为41,951美元±12,195分,CTP-C患者为37,396美元±6,701分,差异有统计学意义(Р=0.015):结论:蒙古肝移植治疗的平均费用为39,589美元。结论:蒙古肝移植治疗的平均费用为39,589美元。尽管医疗机构每年最多可为50名患者提供治疗,但候诊名单上的患者却超过了300人,这凸显了医疗保健需求严重得不到满足。
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引用次数: 0
Has China's hierarchical medical system improved doctor-patient relationships? 中国的分级诊疗制度是否改善了医患关系?
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-18 DOI: 10.1186/s13561-024-00520-8
Yang Gao, Yang Yang, Shoupeng Wang, Wenqian Zhang, Jiao Lu

Background and objective: Developing harmonious doctor-patient relationships is a powerful way to promote the construction of a new pattern of medical reform in developing countries. We aim to analyze the effects of China's hierarchical medical system on doctor-patient relationships, thus contributing to China's medical and health system reform.

Methods: With panel data on prefectural-level cities in China from 2012 to 2019, we used a time-varying difference-in-differences model to evaluate the effect of hierarchical medical treatment policy.

Results: Hierarchical medical treatment policies can significantly improve doctor-patient relationships, and this conclusion is supported by various robustness tests. And improving doctor-patient relationships can be indirectly realized by the optimization of resource allocation and saving of medical costs. In addition, the marginal effect of the pilot policy on doctor-patient relationships decreased with age within the city population. In focal cities and cities with high levels of fiscal spending on health care, the effect of the pilot policy on doctor-patient relationships was stronger.

Conclusion: While reinforcing the literature on the doctor-patient relationship, this study also provides a reference for further exploration of the pilot policy of hierarchical medical treatment and the development of new medical and health system reform in developing countries.

背景和目的:发展和谐医患关系是推动发展中国家构建医疗改革新格局的有力途径。我们旨在分析中国分级诊疗制度对医患关系的影响,从而为中国医疗卫生体制改革做出贡献:利用 2012 年至 2019 年中国地级市的面板数据,采用时变差分模型评估分级诊疗政策的效果:分级诊疗政策可以显著改善医患关系,这一结论得到了各种稳健性检验的支持。而医患关系的改善可以通过优化资源配置和节约医疗成本来间接实现。此外,试点政策对医患关系的边际效应随城市人口年龄的增长而递减。在重点城市和医疗卫生财政支出水平较高的城市,试点政策对医患关系的影响更大:本研究在丰富医患关系相关文献的同时,也为发展中国家进一步探索分级诊疗试点政策和开展新的医疗卫生体制改革提供了参考。
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引用次数: 0
Insured-non-insured disparity of catastrophic health expenditure in Northwest Ethiopia: a multivariate decomposition analysis. 埃塞俄比亚西北部投保与未投保的灾难性医疗支出差异:多变量分解分析。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-17 DOI: 10.1186/s13561-024-00533-3
Yawkal Tsega, Gebeyehu Tsega, Asnakew Molla Mekonen, Tesfaye Birhane, Elsabeth Addisu, Abebe Getie, Fekade Demeke Bayou, Mulugeta Desalegn Kasaye, Natnael Kebede, Amare Muche
<p><strong>Background: </strong>Financial risk protection is one indicator of universal health coverage (UHC). All people should be protected from financial risks such as catastrophic health expenditures (CHE) to ensure equitable health services. Ethiopia has launched community-based health insurance (CBHI) since 2011 to protect people from financial risk. However, out-of-pocket health expenditure is a financial barriers to achieve UHC. The insured-non-insured disparity of CHE has not been well studied in Ethiopia in general and in Debre Tabor town in particular. Therefore, this study aimed to assess the disparity of CHE between insured and non-insured households and its contributing factors in Debre Tabor town.</p><p><strong>Methods: </strong>This study used the primary household survey data collected from May to June 2022 in Debre Tabor town. Data were collected from 825 household heads and analyzed using STATA version 17.0 statistical software. Logit-based multivariate decomposition analysis was conducted to determine insured-non-insured disparity of CHE. Statistical significance for all analysis was declared at a p < 0.05.</p><p><strong>Results: </strong>The incidence of CHE was 17.94% and 5.58% among non-insured and insured households, respectively. About 53% and 153.20% of the insured-non-insured disparities in the magnitude of CHE were due to the difference in characteristics (endowments) and the effect of characteristics (coefficients), respectively. Age of the household head between 46 and 60 years and above 60 years, divorced and widowed marital status of household head, and chronic health conditions were the explanatory variables widening the gap in the incidence of CHE. However, do not seeking traditional medicine, family size above 4, and age of household head between 31 and 45 years were the variables contribute in reducing the gap (i.e. due to endowments) in the incidence of CHE between insured and non-insured households. Moreover, the variables that contributed to the gap in the incidence of CHE due to covariate effects were age (31-45) and marital status of household head, wealth status, family size, ownership of the household, and seeking traditional medicines.</p><p><strong>Conclusion: </strong>This study revealed there is a significant disparity in the incidence of CHE between insured and non-insured households. Age, marital status and occupation of the household head, family size of household, presence of a chronically ill household member and seeking traditional medicine were significantly contributing factors for the disparity of CHE between insured and non-insured households due to endowments. The variables that contributed to the disparity in the incidence of CHE due to covariate effects were age and marital status of household head, wealth status, family size, ownership of the household, and seeking traditional medicines. Therefore, the policy makers need to emphasize in increasing the insurance coverage among households
背景:财务风险保护是全民医保(UHC)的一项指标。所有人都应受到保护,免受灾难性医疗支出(CHE)等财务风险的影响,以确保公平的医疗服务。埃塞俄比亚自 2011 年起推出了社区医疗保险(CBHI),以保护人们免受财务风险。然而,自付医疗支出是实现全民医保的财务障碍。在埃塞俄比亚,尤其是在 Debre Tabor 镇,对自付医疗费用的投保与未投保差异尚未进行深入研究。因此,本研究旨在评估 Debre Tabor 镇投保家庭与未投保家庭之间的医疗费用差距及其诱因:本研究使用了 2022 年 5 月至 6 月在德布雷塔博尔镇收集的主要家庭调查数据。数据收集自 825 个户主,并使用 STATA 17.0 版统计软件进行分析。采用基于 Logit 的多元分解分析来确定 CHE 的投保-未投保差异。所有分析的统计显著性均以 p 表示:非投保家庭和投保家庭的 CHE 发生率分别为 17.94% 和 5.58%。投保家庭与未投保家庭在 CHE 发生率上的差异中,分别约有 53% 和 153.20% 是由特征(禀赋)差异和特征影响(系数)造成的。户主年龄在 46 至 60 岁之间和 60 岁以上、户主的离婚和丧偶婚姻状况以及慢性健康状况是拉大 CHE 发生率差距的解释变量。然而,不寻求传统医学、家庭人口在 4 人以上以及户主年龄在 31 至 45 岁之间的变量则有助于缩小投保家庭与非投保家庭之间的 CHE 发生率差距(即由于禀赋)。此外,由于协变量效应而导致 CHE 发生率差距的变量是户主的年龄(31-45 岁)和婚姻状况、财富状况、家庭规模、家庭所有权和寻求传统药物:本研究表明,投保家庭与未投保家庭的 CHE 发生率存在显著差异。年龄、户主的婚姻状况和职业、家庭规模、是否有长期患病的家庭成员以及是否寻求传统药物是造成投保家庭和非投保家庭之间因禀赋而导致的 CHE 发病率差异的重要因素。由于协变量效应而导致 CHE 发病率差异的变量是户主的年龄和婚姻状况、财富状况、家庭规模、家庭所有权和寻求传统药物。因此,政策制定者需要重视提高家庭保险覆盖率,并在埃塞俄比亚,特别是德布雷塔博镇,提供负担得起的医疗服务。
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引用次数: 0
Economic analysis of digital motor rehabilitation technologies: a systematic review. 数字运动康复技术的经济分析:系统综述。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-17 DOI: 10.1186/s13561-024-00523-5
Koffi Adzinyo Agbemanyole, Kokouvi Geovani Agbohessou, Christelle Pons, Philippe Lenca, Olivier Rémy-Néris, Myriam Le Goff-Pronost

Rehabilitation technologies offer promising opportunities for interventions for patients with motor disabilities. However, their use in routine care remains limited due to their high cost and persistent doubts about their cost-effectiveness. Providing solid evidence of the economic efficiency of rehabilitation technologies would help dispel these doubts in order to better take advantage of these technologies. In this context, this systematic review aimed to examine the cost-effectiveness of rehabilitation interventions based on the use of digital technologies. In total, 660 articles published between 2011 and 2021 were identified, of which eleven studies met all the inclusion criteria. Of these eleven studies, seven proved to be cost-effective, while four were not. Four studies used cost-utility analyses (CUAs) and seven used cost-minimization analyses (CMAs). The majority (ten studies) focused on the rehabilitation of the upper and/or lower limbs after a stroke, while only one study examined the rehabilitation of the lower limbs after knee arthroplasty. Regarding the evaluated devices, seven studies analyzed the cost-effectiveness of robotic rehabilitation and four analyzed rehabilitation with virtual reality.The assessment of the quality of the included studies using the CHEERS (Consolidated Health Economic Evaluation Reporting Standards) suggested that the quality was related to the economic analysis method: all studies that adopted a cost-utility analysis obtained a high quality score (above 80%), while the quality scores of the cost-minimization analyses were average, with the highest score obtained by a CMA being 72%. The average quality score of all the articles was 75%, ranging between 52 and 100. Of the four studies with a considering score, two concluded that there was equivalence between the intervention and conventional care in terms of cost-effectiveness, one concluded that the intervention dominated, while the last one concluded that usual care dominated. This suggests that even considering the quality of the included studies, rehabilitation interventions based on digital technologies remain cost-effective, they improved health outcomes and quality of life for patients with motor disorders while also allowing cost savings.

康复技术为运动障碍患者的干预提供了大有可为的机会。然而,由于康复技术成本高昂,其成本效益一直受到质疑,因此在日常护理中的应用仍然有限。提供康复技术经济效益的可靠证据将有助于消除这些疑虑,从而更好地利用这些技术。在此背景下,本系统综述旨在研究基于数字技术使用的康复干预措施的成本效益。本次系统性综述共筛选出 2011 年至 2021 年间发表的 660 篇文章,其中有 11 项研究符合所有纳入标准。在这 11 项研究中,7 项被证明具有成本效益,4 项不具成本效益。四项研究使用了成本效用分析(CUAs),七项使用了成本最小化分析(CMA)。大多数研究(10 项)侧重于中风后上肢和/或下肢的康复,只有一项研究对膝关节置换术后下肢的康复进行了研究。使用CHEERS(卫生经济评估综合报告标准)对纳入研究的质量进行评估后发现,研究质量与经济分析方法有关:所有采用成本效用分析的研究都获得了较高的质量分数(80%以上),而成本最小化分析的质量分数一般,CMA获得的最高分数为72%。所有文章的平均质量得分为 75%,介于 52 分和 100 分之间。在四项考虑得分的研究中,有两项研究认为干预措施与常规护理的成本效益相当,一项研究认为干预措施占主导地位,最后一项研究认为常规护理占主导地位。这表明,即使考虑到所纳入研究的质量,基于数字技术的康复干预仍然具有成本效益,它们改善了运动障碍患者的健康状况和生活质量,同时还能节约成本。
{"title":"Economic analysis of digital motor rehabilitation technologies: a systematic review.","authors":"Koffi Adzinyo Agbemanyole, Kokouvi Geovani Agbohessou, Christelle Pons, Philippe Lenca, Olivier Rémy-Néris, Myriam Le Goff-Pronost","doi":"10.1186/s13561-024-00523-5","DOIUrl":"10.1186/s13561-024-00523-5","url":null,"abstract":"<p><p>Rehabilitation technologies offer promising opportunities for interventions for patients with motor disabilities. However, their use in routine care remains limited due to their high cost and persistent doubts about their cost-effectiveness. Providing solid evidence of the economic efficiency of rehabilitation technologies would help dispel these doubts in order to better take advantage of these technologies. In this context, this systematic review aimed to examine the cost-effectiveness of rehabilitation interventions based on the use of digital technologies. In total, 660 articles published between 2011 and 2021 were identified, of which eleven studies met all the inclusion criteria. Of these eleven studies, seven proved to be cost-effective, while four were not. Four studies used cost-utility analyses (CUAs) and seven used cost-minimization analyses (CMAs). The majority (ten studies) focused on the rehabilitation of the upper and/or lower limbs after a stroke, while only one study examined the rehabilitation of the lower limbs after knee arthroplasty. Regarding the evaluated devices, seven studies analyzed the cost-effectiveness of robotic rehabilitation and four analyzed rehabilitation with virtual reality.The assessment of the quality of the included studies using the CHEERS (Consolidated Health Economic Evaluation Reporting Standards) suggested that the quality was related to the economic analysis method: all studies that adopted a cost-utility analysis obtained a high quality score (above 80%), while the quality scores of the cost-minimization analyses were average, with the highest score obtained by a CMA being 72%. The average quality score of all the articles was 75%, ranging between 52 and 100. Of the four studies with a considering score, two concluded that there was equivalence between the intervention and conventional care in terms of cost-effectiveness, one concluded that the intervention dominated, while the last one concluded that usual care dominated. This suggests that even considering the quality of the included studies, rehabilitation interventions based on digital technologies remain cost-effective, they improved health outcomes and quality of life for patients with motor disorders while also allowing cost savings.</p>","PeriodicalId":46936,"journal":{"name":"Health Economics Review","volume":"14 1","pages":"52"},"PeriodicalIF":2.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11253330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141628091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"经济学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social costs associated with fibromyalgia in Spain. 西班牙与纤维肌痛相关的社会成本。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-13 DOI: 10.1186/s13561-024-00527-1
J Oliva-Moreno, C Vilaplana-Prieto

Background: Fibromyalgia is a chronic rheumatic disease of unknown aetiology, highly disabling and mainly affecting women. The aim of our work is to estimate, on a national scale, the economic impact of this disease on the employment of patients and non-professional (informal) care dimension.

Methods: Survey on Disabilities, Autonomy and Dependency carried out in Spain in 2020/21 was used to obtain information on disabled individuals with AD and their informal caregivers. Six estimation scenarios were defined as base case, depending on whether the maximum daily informal caregiving time was censored or not, and on the approach chosen for the valuation of informal caregiving time (contingent valuation and replacement time). Another six conservative scenarios were developed using the minimum wage for the estimation of labour losses.

Results: Our estimates range from 2,443.6 (willingness to pay, censored informal care time) to 7,164.8 million euros (replacement cost, uncensored informal care time) (base year 2021). Multivariate analyses identified that the degree of dependency of the person suffering from fibromyalgia is the main explanatory variable for both the probability of being employed and the time spent in informal care. Conservative scenarios estimates range from 1,807 to 6,528 million euros.

Conclusions: The high economic impact revealed should help to position a health problem that is relatively unknown in society and for which there are significant research and care gaps to be filled.

背景:纤维肌痛是一种病因不明的慢性风湿病,致残率高,主要影响女性。我们的工作旨在估算这种疾病在全国范围内对患者就业和非专业(非正式)护理方面的经济影响:方法:利用 2020/21 年在西班牙开展的 "残疾、自主性和依赖性调查",获取患有注意力缺失症的残疾人及其非正规护理人员的信息。根据是否对每日最长非正规护理时间进行删减,以及对非正规护理时间的估价方法(或有估价和替代时间),确定了六种估算方案作为基本情况。另外六种保守方案使用最低工资估算劳动力损失:我们的估算范围从 24.436 亿欧元(支付意愿,经调查的非正规护理时间)到 71.648 亿欧元(替代成本,未经调查的非正规护理时间)(基准年为 2021 年)。多变量分析表明,纤维肌痛患者的依赖程度是就业概率和非正式护理时间的主要解释变量。保守估计从 18.07 亿欧元到 65.28 亿欧元不等:结论:所揭示的高经济影响应有助于对这一在社会上相对不为人知的健康问题进行定位,因为该问题在研究和护理方面还有很大的差距有待填补。
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引用次数: 0
Untangling the corruption maze: exploring the complexity of corruption in the health sector. 解开腐败迷宫:探索卫生部门腐败的复杂性。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-12 DOI: 10.1186/s13561-024-00530-6
Margit Sommersguter-Reichmann, Gerhard Reichmann

Background: Healthcare corruption poses a significant threat to individuals, institutions, sectors, and states. Combating corruption is paramount for protecting patients, maintaining the healthcare system's integrity, and preserving public trust. As corruption evolves, takes new forms, and adapts to changing socio-political landscapes, understanding its manifestations is critical to developing effective anti-corruption strategies at individual and institutional levels.

Objective: The aim was to comprehensively collate the manifestations of different types of corruption in healthcare to illustrate prevailing patterns and trends and to provide policymakers, practitioners, and researchers with practical insights to inform research agendas, regulatory and governance strategies, and accountability measures.

Method: We conducted a narrative review of scientific articles published between 2013 and 2022 using keyword searches in SCOPUS and EBSCO. We utilized the corruption typology proposed by the European Union and Thompson's Institutional Corruption Framework to systematically identify manifestations across different corruption types. The Prisma scheme was employed to document the selection process and ensure reproducibility.

Findings: Bribery in medical service provision was the most frequently investigated form of corruption, revealing rather uniform manifestations. Misuse of high-level positions and networks and institutional corruption also received considerable attention, with a wide range of misconduct identified in institutional corruption. Extending the analysis to institutional corruption also deepened the understanding of misconduct in the context of improper marketing relations and highlighted the involvement of various stakeholders, including academia. The pandemic exacerbated the vulnerability of the healthcare sector to procurement corruption. Also, it fostered new types of misconduct related to the misuse of high-level positions and networks and fraud and embezzlement of medical drugs, devices, and services.

Conclusions: The review spotlights criminal actions by individuals and networks and marks a notable shift towards systemic misconduct within specific types of corruption. The findings highlight the necessity of customized anti-corruption strategies throughout the healthcare sector. These insights are crucial for policymakers, practitioners, and researchers in guiding the formulation of legal frameworks at local and global levels, governance strategies, and research priorities.

背景:医疗腐败对个人、机构、部门和国家构成重大威胁。打击腐败对于保护患者、维护医疗保健系统的完整性和维护公众信任至关重要。随着腐败现象的演变、新形式的出现以及社会政治环境的不断变化,了解其表现形式对于在个人和机构层面制定有效的反腐败战略至关重要:目的:旨在全面整理医疗保健领域不同类型腐败的表现形式,以说明当前的模式和趋势,并为政策制定者、从业人员和研究人员提供实用的见解,为研究议程、监管和治理策略以及问责措施提供依据:我们利用 SCOPUS 和 EBSCO 中的关键词搜索,对 2013 年至 2022 年间发表的科学文章进行了叙述性综述。我们利用欧盟提出的腐败类型学和汤普森的机构腐败框架来系统地识别不同腐败类型的表现形式。我们采用了 Prisma 方案来记录选择过程并确保可重复性:医疗服务提供中的贿赂是最常被调查的腐败形式,其表现形式相当统一。滥用高级职位和网络以及机构腐败也受到了相当大的关注,在机构腐败中发现了各种各样的不当行为。将分析扩展到机构腐败还加深了对不当营销关系背景下不当行为的理解,并强调了包括学术界在内的各利益攸关方的参与。大流行病加剧了医疗保健部门在采购腐败方面的脆弱性。此外,它还助长了与滥用高级职位和网络以及欺诈和贪污医疗药品、设备和服务有关的新型不当行为:本次审查突出了个人和网络的犯罪行为,并标志着在特定类型的腐败中系统性不当行为的显著转变。研究结果突出表明,有必要在整个医疗保健领域制定量身定制的反腐败战略。这些见解对于政策制定者、从业人员和研究人员在指导制定地方和全球层面的法律框架、治理战略和研究重点方面至关重要。
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引用次数: 0
Correction: A microcosting approach for planning and implementing community‑based mental health prevention programs: what does it cost? 更正:规划和实施社区心理健康预防计划的微观成本计算方法:成本是多少?
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-10 DOI: 10.1186/s13561-024-00524-4
Sharmily Roy, Henry Shelton Brown, Lisa Sanger Blinn, Sarah Carter Narendorf, Jane E Hamilton
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引用次数: 0
Cost-effectiveness of immune checkpoint inhibitors as a first-line therapy for advanced hepatocellular carcinoma: a systematic review. 免疫检查点抑制剂作为晚期肝细胞癌一线疗法的成本效益:系统综述。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-05 DOI: 10.1186/s13561-024-00526-2
Hongyu Gong, Siew Chin Ong, Fan Li, Yan Shen, Zhiying Weng, Keying Zhao, Zhengyou Jiang, Meng Wang

Since 2017, immune checkpoint inhibitors (ICIs) have been available for the treatment of advanced hepatocellular carcinoma (HCC) or unresectable HCC, but their adoption into national medical insurance programs is still limited. Cost-effectiveness evidence can help to inform treatment decisions. This systematic review aimed to provide a critical summary of economic evaluations of ICIs as a treatment for advanced HCC and identify key drivers (PROSPERO 2023: CRD42023417391). The databases used included Scopus, Web of Science, PubMed, Embase, and Cochrane Central. Economic evaluations of ICIs for the treatment of advanced HCC were included. Studies were screened by two people. Of the 898 records identified, 17 articles were included. The current evidence showed that ICIs, including atezolizumab plus bevacizumab, sintilimab plus bevacizumab/bevacizumab biosimilar, nivolumab, camrelizumab plus rivoceranib, pembrolizumab plus lenvatinib, tislelizumab, durvalumab, and cabozantinib plus atezolizumab, are probably not cost-effective in comparison with tyrosine kinase inhibitors or other ICIs. The most influential parameters were price of anticancer drugs, hazard ratios for progression-free survival and overall survival, and utility for health statest. Our review demonstrated that ICIs were not a cost-effective intervention in advanced HCC. Although ICIs can significantly enhance the survival of patients with advanced HCC, decision-makers should consider the findings of economic evaluations and affordability before adoption of new therapies.

自2017年起,免疫检查点抑制剂(ICIs)开始用于治疗晚期肝细胞癌(HCC)或无法切除的HCC,但其在国家医疗保险计划中的应用仍然有限。成本效益证据有助于为治疗决策提供依据。本系统综述旨在对 ICIs 作为晚期 HCC 治疗方法的经济评估进行批判性总结,并确定关键驱动因素(PROSPERO 2023:CRD42023417391)。使用的数据库包括 Scopus、Web of Science、PubMed、Embase 和 Cochrane Central。纳入了对 ICIs 治疗晚期 HCC 的经济评估。研究由两人进行筛选。在确定的 898 条记录中,共纳入了 17 篇文章。目前的证据显示,与酪氨酸激酶抑制剂或其他 ICIs 相比,ICIs(包括阿特珠单抗联合贝伐单抗、辛替利单抗联合贝伐单抗/贝伐单抗生物类似物、尼沃单抗、卡麦珠单抗联合利伐沙尼、pembrolizumab 联合来伐替尼、tislelizumab、durvalumab 和 cabozantinib 联合阿特珠单抗)可能不具有成本效益。最有影响的参数是抗癌药物的价格、无进展生存期和总生存期的危险比以及健康状况的效用。我们的研究表明,对晚期 HCC 进行干预,ICIs 并不具有成本效益。虽然 ICIs 能显著提高晚期 HCC 患者的生存率,但决策者在采用新疗法之前应考虑经济评估结果和经济承受能力。
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引用次数: 0
Cost-benefit analysis of haemodialysis in patients with end-stage kidney disease in Abuja, Nigeria. 尼日利亚阿布贾终末期肾病患者血液透析的成本效益分析。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-07-03 DOI: 10.1186/s13561-024-00529-z
Yakubu Adole Agada-Amade, Daniel Chukwuemeka Ogbuabor, Eric Obikeze, Ejemai Eboreime, Obinna Emmanuel Onwujekwe

Background: Significant gaps in scholarship on the cost-benefit analysis of haemodialysis exist in low-middle-income countries, including Nigeria. The study, therefore, assessed the cost-benefit of haemodialysis compared with comprehensive conservative care (CCC) to determine if haemodialysis is socially worthwhile and justifies public funding in Nigeria.

Methods: The study setting is Abuja, Nigeria. The study used a mixed-method design involving primary data collection and analysis of secondary data from previous studies. We adopted an ingredient-based costing approach. The mean costs and benefits of haemodialysis were derived from previous studies. The mean costs and benefits of CCC were obtained from a primary cross-sectional survey. We estimated the benefit-cost ratios (BCR) and net benefits to determine the social value of the two interventions.

Results: The net benefit of haemodialysis (2,251.30) was positive, while that of CCC was negative (-1,197.19). The benefit-cost ratio of haemodialysis was 1.09, while that of CCC was 0.66. The probabilistic and one-way sensitivity analyses results demonstrate that haemodialysis was more cost-beneficial than CCC, and the BCRs of haemodialysis remained above one in most scenarios, unlike CCC's BCR.

Conclusion: The benefit of haemodialysis outweighs its cost, making it cost-beneficial to society and justifying public funding. However, the National Health Insurance Authority requires additional studies, such as budget impact analysis, to establish the affordability of full coverage of haemodialysis.

背景:包括尼日利亚在内的中低收入国家在血液透析的成本效益分析方面存在巨大的学术空白。因此,本研究评估了血液透析与全面保守治疗(CCC)相比的成本效益,以确定血液透析在尼日利亚是否具有社会价值,是否有理由获得公共资助:研究地点:尼日利亚阿布贾。研究采用混合方法设计,包括收集原始数据和分析以往研究的二手数据。我们采用了基于成分的成本计算方法。血液透析的平均成本和效益来自以往的研究。CCC 的平均成本和效益来自一项横断面初步调查。我们估算了效益成本比(BCR)和净效益,以确定两种干预措施的社会价值:结果:血液透析的净收益(2,251.30)为正,而 CCC 的净收益(-1,197.19)为负。血液透析的效益成本比为 1.09,而 CCC 的效益成本比为 0.66。概率分析和单向敏感性分析结果表明,血液透析的成本效益高于 CCC,而且在大多数情况下,血液透析的 BCR 仍高于 1,这与 CCC 的 BCR 不同:结论:血液透析的益处大于其成本,对社会而言具有成本效益,因此有理由获得公共资助。然而,国家医疗保险局需要进行更多的研究,如预算影响分析,以确定全面覆盖血液透析的可负担性。
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引用次数: 0
Exploring unmet healthcare needs and associated inequalities among middle-aged and older adults in Eastern China during the progression toward universal health coverage. 探索华东地区中老年人在全民医保进程中未得到满足的医疗需求及相关的不平等现象。
IF 2.7 3区 经济学 Q1 ECONOMICS Pub Date : 2024-06-27 DOI: 10.1186/s13561-024-00521-7
Yunhan Wang, Nan Jiang, Haiya Shao, Zhonghua Wang

Background: Given the rapid population aging in China, achieving universal health coverage (UHC) presents a primary challenge in addressing unmet healthcare needs and associated inequalities among middle-aged and older adults. Several studies have focused on healthcare utilization and its inequalities, but little attention has been paid to the inequality in unmet healthcare needs. This study aimed to analyze the inequalities in unmet the healthcare needs of middle-aged and older adults in eastern China during the progression toward UHC.

Methods: Data were obtained from the fourth, fifth, and sixth National Health Service Survey (NHSS) of Jiangsu Province, located in eastern China, during the years 2008, 2013, and 2018, respectively. Logistic regression models were used to assess the associated factors of unmet healthcare needs. The inequality was measured according to the concentration index (CI) and its decomposition.

Results: In this study, we found that 12.86%, 2.22%, and 48.89% of middle-aged and older adults reported unmet needs for outpatient and inpatient services and physical examinations, respectively. The prevalence of unmet outpatient needs increased from 2008 to 2018, while the prevalence of unmet inpatient services was lower but maintained. The prevalence of unmet needs for physical examinations among middle-aged and older adults markedly decreased since 2008. Rural areas had a higher prevalence of unmet needs for inpatient services and physical examinations than urban areas. Unmet healthcare needs were more prevalent among the poor. The pro-poor inequalities of unmet healthcare needs have been mitigated during the progression toward UHC; however, they remain predominant among rural middle-aged and older adults for outpatient and inpatient services. Socioeconomic factors significantly influenced unmet healthcare needs and contributed to their inequalities.

Conclusions: The findings characterize the prevalence and inequality of unmet healthcare need among middle-aged and older adults in eastern China during the progression toward UHC. Policy interventions should be actively advocated to effectively mitigate the unmet healthcare needs and address the associated inequalities.

背景:鉴于中国人口的快速老龄化,实现全民医保(UHC)是解决中老年人未得到满足的医疗需求和相关不平等问题的首要挑战。已有多项研究关注了医疗保健利用率及其不平等问题,但很少有人关注未满足的医疗保健需求的不平等问题。本研究旨在分析华东地区中老年人在向全民医保迈进的过程中未得到满足的医疗需求的不平等现象:数据来源于中国东部地区江苏省分别于 2008 年、2013 年和 2018 年进行的第四次、第五次和第六次国家卫生服务调查(NHSS)。采用逻辑回归模型评估未满足医疗需求的相关因素。根据集中指数(CI)及其分解来衡量不平等程度:在这项研究中,我们发现分别有 12.86%、2.22% 和 48.89% 的中老年人报告其门诊、住院服务和体检需求未得到满足。从 2008 年到 2018 年,门诊需求未得到满足的流行率有所上升,而住院服务需求未得到满足的流行率较低,但仍保持不变。自 2008 年以来,中老年人体检需求未得到满足的流行率明显下降。与城市地区相比,农村地区住院服务和体检需求未得到满足的比例更高。未满足的医疗保健需求在贫困人口中更为普遍。在向全民健康计划迈进的过程中,未满足的医疗保健需求对贫困人口造成的不平等有所缓解;但在农村中老年人中,未满足的门诊和住院服务需求仍占主导地位。社会经济因素在很大程度上影响了未满足的医疗保健需求,并导致了这些需求的不平等:结论:研究结果表明,在实现全民医保的过程中,华东地区中老年人未满足医疗需求的普遍性和不平等性。应积极倡导政策干预,以有效缓解未满足的医疗需求,并解决相关的不平等问题。
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引用次数: 0
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Health Economics Review
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