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Societal cost-of-illness analysis of self-injection of biologics for patients with rheumatoid arthritis in Japan using claims, surveys, and national statistics. 使用索赔、调查和国家统计数据对日本类风湿性关节炎患者自我注射生物制剂的社会疾病成本进行分析。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-19 DOI: 10.1186/s13561-025-00710-y
Kazuhiko Takahata, Eiichi Tanaka, Ryoko Sakai, Manabu Akazawa
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引用次数: 0
Health economic evaluations of fecal microbiota transplantation for non-clostridioides difficile related diseases: a systematic review. 粪便菌群移植治疗非艰难梭菌相关疾病的健康经济评价:系统综述。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-16 DOI: 10.1186/s13561-025-00698-5
Qiran Wei, Yingcheng Wang, Mingjun Rui, Joyce H S You
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引用次数: 0
Cost-benefit analysis of pre-entry tuberculosis screening for incoming migrants to Japan: a focus on Nepalese migrants. 日本入境移民入境前肺结核筛查的成本效益分析:以尼泊尔移民为重点。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-13 DOI: 10.1186/s13561-025-00709-5
Yoko Iwaki, Takayuki Hayashi, Shuhei Nomura, Shoko Shimamura, Rohita Gauchan, Michael C Huang

Objectives: Nepalese students in Japan surged from under 1,000 in 2008 to over 29,000 by 2019, driven by Japan's strategy of using student visas to fill unskilled labor gaps. This study examined the cost and benefit impact of the introduction of pre-entry tuberculosis (TB) screening policy, including testing and treatment for Japan and Nepal from 2014 to 2018.

Methods: This study used anonymous data of TB statistics of diagnosis and treatment from the Nepal Demographic and Health Survey and from Japan's Legal Affairs Bureau and Tuberculosis Surveillance Center. We used social cost-benefit analysis to examine the effect of the pre-entry TB screening policy on visas of Nepalese workers and students to Japan. Total cost, total benefit and net benefit for both countries were compared for the policy scenarios "With" and "Without", using net present value (NPV). In order to address parameter differences for uncertainty, we conducted sensitivity analysis using the Monte Carlo simulation with secondary transmission rate.

Results: Between 2014 and 2018 in Japan, net present value (NPV) of Nepalese students increased from USD 1.9 million to USD 3.1 million; likewise, NPV of Nepalese workers grew from USD 1.1 million to USD 3.2 million. From the perspective of Japan, the increase in NPV was greater than zero, meaning that the implementation of the policy could produce a benefit for Japan regarding prevention of an increase in new TB cases. The total NPV was USD -51.6 million, as pre-entry screening and treatment costs are incurred by both emigrants and the national health system.

Conclusions: Implementing a pre-entry TB screening policy for foreign migrants from high-burden countries such as Nepal could yield cost savings by reducing the incidence of newly diagnosed and potentially transmissible TB cases. Strong collaboration could ensure the follow-up and incentive for burden sharing of the implementation cost.

目标:受日本利用学生签证填补非熟练劳动力缺口的战略推动,在日本的尼泊尔学生从2008年的不到1000人激增至2019年的2.9万多人。本研究考察了引入入境前结核病筛查政策的成本和效益影响,包括2014年至2018年日本和尼泊尔的检测和治疗。方法:本研究采用尼泊尔人口与健康调查和日本法律事务局和结核病监测中心提供的结核病诊断和治疗统计匿名数据。我们使用社会成本效益分析来检验入境前结核病筛查政策对尼泊尔工人和学生赴日签证的影响。使用净现值(NPV)比较了两国在“有”和“没有”政策情景下的总成本、总收益和净收益。为了解决不确定性的参数差异,我们使用蒙特卡罗模拟进行了二次传输速率的灵敏度分析。结果:2014年至2018年,尼泊尔学生在日本的净现值(NPV)从190万美元增加到310万美元;同样,尼泊尔工人的净现值从110万美元增加到320万美元。从日本的角度来看,净现值的增加大于零,这意味着该政策的实施可以为日本在预防新发结核病病例增加方面带来好处。由于入境前筛查和治疗费用由移民和国家卫生系统共同承担,净现值总额为5160万美元。结论:对来自尼泊尔等高负担国家的外国移民实施入境前结核病筛查政策,可以减少新诊断和潜在传染性结核病病例的发病率,从而节省成本。强有力的合作可以确保后续行动和鼓励分担执行费用的负担。
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引用次数: 0
Systematic review of health economic evaluation of robot-assisted hip and knee arthroplasty. 机器人辅助髋关节和膝关节置换术的健康经济评价系统综述。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-13 DOI: 10.1186/s13561-025-00701-z
Yajing Gao, Yi Yang, Zhuofu Li, Bai Zang, Chengfengyi Yang, Feifei Zhou, Qiaoqin Wan
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引用次数: 0
Selecting risk adjusters with penalized regression and expert judgment: evidence from Colombia. 采用惩罚回归和专家判断选择风险调整者:来自哥伦比亚的证据。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-13 DOI: 10.1186/s13561-025-00689-6
Camilo Arias

Risk adjustment formulas are essential in health insurance markets, as they mitigate risk selection incentives by aligning revenues with expected healthcare expenses based on enrollee characteristics. However, current formulas can underpredict spending for certain groups, leading to under-compensation for insurers and potentially affecting fairness, quality, and access to care. Many countries are exploring the addition of new variables to improve accuracy, but this can also weaken incentives for cost control. This paper illustrates a methodology approach to risk adjuster selection by using a penalized regression framework that explicitly incorporates the potential downsides of including specific variables. Drawing on a large dataset of over 10 million Colombian health insurance enrollees, we combine statistical estimation with expert assessment of each variable's susceptibility to gaming to construct a specification that limits gaming and maintains predictive accuracy.

风险调整公式在健康保险市场中是必不可少的,因为它们通过将收入与基于注册者特征的预期医疗费用相一致来减轻风险选择激励。然而,目前的公式可能会低估某些群体的支出,导致保险公司的补偿不足,并可能影响公平性、质量和获得医疗服务的机会。许多国家正在探索增加新的变量以提高准确性,但这也可能削弱成本控制的动力。本文通过使用惩罚回归框架来说明风险调整者选择的方法学方法,该框架明确地结合了包括特定变量的潜在缺点。利用超过1000万哥伦比亚健康保险注册者的大型数据集,我们将统计估计与每个变量对游戏敏感性的专家评估结合起来,构建了一个限制游戏并保持预测准确性的规范。
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引用次数: 0
Burden or benefit? Unveiling the impact of out-of-pocket health expenditures in Somalia's healthcare system. 负担还是利益?揭示自付医疗支出对索马里医疗系统的影响。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-12 DOI: 10.1186/s13561-025-00703-x
Khalid Mohamed Mohamud, Said Yusuf Warei, Ali Hajji Adam Abubakr
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引用次数: 0
The economic impact of retinal diseases for which gene therapy is emerging: a systematic literature review. 基因治疗正在兴起的视网膜疾病的经济影响:系统的文献综述。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-07 DOI: 10.1186/s13561-025-00707-7
Claire Willmington, Ann Kirby, Aileen Murphy
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引用次数: 0
Beyond seed funding: why Nigerian digital health startups struggle to grow. 除了种子融资:尼日利亚数字医疗创业公司为何难以成长。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-12-05 DOI: 10.1186/s13561-025-00708-6
Ubalaeze Solomon Elechi, Chibuzo Okechukwu Onah, Mohamed Albert Tarawallie, Ironuru Ifeanyi

Nigeria's growing digital health startup ecosystem has a lot of potential to fill in gaps in healthcare delivery, but many of these businesses fail to get off the ground after getting initial funding. This narrative review examines funding patterns from 2019 to 2025 and investigates why seed-stage investment often fails to translate into scaled impact. Investment reports, case studies of prominent Nigerian health-tech startups, and comparative insights from peer markets were synthesized. The analysis finds that despite a surge of seed funding and a record venture capital peak in 2021, few Nigerian digital health startups convert initial success into sustainable growth. Constraining factors include regulatory hurdles, infrastructural deficiencies, market trust barriers, talent gaps, and systemic health-sector limitations, challenges that mere capital infusion cannot overcome. Case narratives (e.g., Helium Health's regional expansion and 54gene's post-pandemic collapse) illustrate these dynamics. Key mechanisms to bridge the "post-seed" gap are discussed, ranging from strategic public-private partnerships to specialized follow-on funds, with lessons drawn from ecosystems like Kenya and India. Strengthening support beyond seed stages and addressing non-financial frictions will be crucial for Nigerian health-tech innovators to realize their full scale-up potential.

尼日利亚不断增长的数字医疗创业生态系统有很大的潜力来填补医疗保健服务的空白,但其中许多企业在获得初始资金后未能起步。本文考察了2019年至2025年的融资模式,并调查了种子期投资往往无法转化为规模影响的原因。综合了投资报告、尼日利亚著名医疗技术初创企业的案例研究以及来自同行市场的比较见解。分析发现,尽管种子资金激增,风险资本在2021年达到创纪录的峰值,但很少有尼日利亚数字健康初创公司将最初的成功转化为可持续增长。制约因素包括监管障碍、基础设施缺陷、市场信任障碍、人才缺口和系统性卫生部门限制,这些挑战仅靠资本注入是无法克服的。案例叙述(例如,Helium Health的区域扩张和54gene的大流行后崩溃)说明了这些动态。讨论了弥合“种子期后”差距的关键机制,从战略公私伙伴关系到专门的后续基金,并借鉴了肯尼亚和印度等生态系统的经验教训。加强种子阶段之后的支持和解决非金融摩擦对于尼日利亚卫生技术创新者充分发挥其扩大规模的潜力至关重要。
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引用次数: 0
Physician agency in China: evidence from physicians' responses to financial pressure during the COVID-19 pandemic. 中国医生代理:来自2019冠状病毒病大流行期间医生应对资金压力的证据
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-11-27 DOI: 10.1186/s13561-025-00692-x
Qi Zhang

This paper examines how rural primary care physicians in China adjusted their practice patterns to pandemic-related financial pressures under a capitated global-budget model. Using township-hospital data, we find increased prescribing of Traditional Chinese Medicine (TCM) decoction pieces, with effects concentrated among habitual prescribers rather than converting occasional users into regular prescribers. Physicians also reduced both the number of drugs prescribed and the volume of services provided to cost-sharing outpatients, producing a 5% decline in average insurance payments per outpatient visit and potentially generating a greater surplus within the global-budget pool. By contrast, we observe no significant changes for self-paying outpatients, suggesting limited scope for physician-induced demand. These results underscore the role of physician agency in healthcare provision and highlight the importance of aligning financial incentives with policy goals. While drug reforms and managed-care models have contained expenditures, challenges remain in achieving adequate coverage for rural residents.

本文研究了中国农村初级保健医生如何在资本化全球预算模型下调整其实践模式以适应与大流行相关的财务压力。利用乡镇医院的数据,我们发现中药饮片的处方增加了,效果集中在习惯性处方者身上,而不是将偶尔的使用者转化为定期处方者。医生们还减少了处方药物的数量和为费用分摊的门诊病人提供的服务数量,使每次门诊就诊的平均保险支付下降了5%,并可能在全球预算池中产生更大的盈余。相比之下,我们观察到自费门诊患者没有显著变化,表明医生诱导需求的范围有限。这些结果强调了医生代理在医疗保健服务中的作用,并强调了将财政激励与政策目标相结合的重要性。虽然药品改革和管理式医疗模式控制了支出,但在实现农村居民的充分覆盖方面仍然存在挑战。
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引用次数: 0
Overview of the Japanese Rapid Introduction Premium as a drug pricing framework to enhance patient access to innovative drugs. 概述日本快速引进保费作为药物定价框架,以提高患者获得创新药物。
IF 3.3 3区 经济学 Q1 ECONOMICS Pub Date : 2025-11-27 DOI: 10.1186/s13561-025-00705-9
Kento Takamura, Gai Jinnai, Yuki Niwa, Masuo Kondoh

The pricing of new drugs plays a critical role in patient access by influencing where and when pharmaceutical companies choose to launch their products. The United States (US) operates a predominantly market-based pricing system, in which pharmaceutical companies set and manage drug prices under private health insurance. In contrast, Japan has a government-regulated drug pricing system under its National Health Insurance (NHI). On average, drug prices in the US are 3.2 times higher than those in Japan. The US system facilitates faster patient access to new drugs through rapid market entry, whereas market entry in Japan has often been delayed. To address this issue, the Japanese government introduced the Rapid Introduction Premium in April 2024, aiming to promote earlier launches of new drugs by narrowing the price gap with higher-priced markets such as the US. In this review, we provide an overview of the new drug pricing framework associated with the Rapid Introduction Premium.

新药的定价通过影响制药公司选择在何时何地推出其产品,在患者获取方面发挥着关键作用。美国实行一种主要以市场为基础的定价制度,在这种制度下,制药公司根据私人健康保险制定和管理药品价格。相比之下,日本在其国民健康保险(NHI)下有一个政府监管的药品定价体系。平均而言,美国的药品价格是日本的3.2倍。美国的制度通过快速进入市场促进患者更快地获得新药,而日本的市场进入经常被推迟。为了解决这一问题,日本政府于2024年4月推出了快速推出保费,旨在通过缩小与美国等价格较高的市场的价格差距,促进新药早日上市。在这篇综述中,我们概述了与快速引入保费相关的新药定价框架。
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Health Economics Review
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