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How opioids became “safe”: pharmaceutical splitting and the racial politics of opioid safety 阿片类药物如何变得“安全”:药物分裂和阿片类药物安全的种族政治
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-06-14 DOI: 10.1057/s41292-021-00230-y
C. Parker, H. Hansen
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引用次数: 1
Pharmaceutical innovation and its crisis: drug markets, screening, and the dialectics of value 医药创新及其危机:药品市场、筛选和价值辩证法
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-06-12 DOI: 10.1057/s41292-021-00235-7
Jean-Paul Gaudilliere

This article explores recent debates on innovation in the drug sector, focusing on the ways in which the articulation of use value and exchange value operates in the hegemonic—Northern—form of pharmaceutical capitalism. Taking the category ‘crisis of innovation’ as an entry point and engaging with the economics literature in which it has been discussed for nearly twenty years, this paper uses the vast historiography of post-WWII pharmacy to propose a critical historical understanding of the crisis. It argues that the features to which the crisis discourses point originate in the long-term contradictions between use value and exchange that affect the dominant regime of pharmaceutical innovation, i.e., the screening regime of research and development. These tensions have accumulated over the past two decades and become more visible, leading to a new reading of the present turn toward bio-capital, i.e., toward biotechnology and a more speculative (financial) economy of pharmacy. The last section of the paper discusses the theoretical implications of this hypothesis.

本文探讨了近期有关药品行业创新的争论,重点关注使用价值和交换价值在北方霸权形式的医药资本主义中的运作方式。本文以 "创新危机 "这一范畴为切入点,结合近二十年来对其进行讨论的经济学文献,利用二战后庞大的药学史料,提出了对这一危机的批判性历史理解。本文认为,危机论述所指向的特征源于使用价值与交换之间的长期矛盾,这种矛盾影响了医药创新的主导制度,即研究与开发的筛选制度。这些矛盾在过去二十年中不断累积,并变得更加明显,从而导致了对当前转向生物资本(即转向生物技术和更具投机性的(金融)制药经济)的新解读。本文最后一部分讨论了这一假设的理论意义。
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引用次数: 0
Where old is gold again: antidepressants in Nepal, 1961–2021 黄金在哪里又老了:1961-2021年尼泊尔的抗抑郁药
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-05-13 DOI: 10.1057/s41292-021-00233-9
S. Ecks
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引用次数: 0
Beyond secrecy and openness: telling a relational story about children’s best interests in donor-conceived families 超越保密与公开:讲述捐赠受孕家庭中儿童最大利益的关系故事
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-05-11 DOI: 10.1057/s41292-021-00225-9
Deborah Dempsey, Petra Nordqvist, Fiona Kelly

Over the past two decades, there has been increasing demand for openness in policy and practice relating to donor-conceived families. With the benefits of openness now widely discussed, and often legally mandated, it is timely to explore the challenges families face in enacting openness when donor assisted conception is still a complex legal and social issue. Our premise is that the difficulties associated with enacting openness should be subject to at least as much scrutiny as the secrecy of past practices. To make our case, we draw on qualitative, socio-legal and sociological research with same-sex, sole parent and heterosexual donor-conceived families in the UK and Australia. We argue that exhortations to openness about donor conception ignore important relational considerations of families if they rely on a moral discourse that being open is the right thing to do, devoid of any context about how, when and by whom this is achieved. Demands for openness need to take into account the situated care relationships of family members, the timing of and manner in which information is imparted, and the fact that this information can fundamentally disrupt or transform the family lives of those to whom it is revealed.

在过去的二十年里,人们越来越多地要求与捐献受孕家庭有关的政策和实践公开化。随着公开性的益处被广泛讨论,并经常被法律强制执行,现在是时候探讨一下,当捐献者辅助受孕仍然是一个复杂的法律和社会问题时,家庭在实行公开性时所面临的挑战。我们的前提是,与实行公开性相关的困难至少应与过去的保密做法一样受到严格审查。为了说明我们的观点,我们对英国和澳大利亚的同性、单亲和异性捐精受孕家庭进行了定性、社会法律和社会学研究。我们认为,关于开放捐卵受孕的劝告如果只依赖于公开是正确做法的道德论述,而不考虑如何、何时以及由谁来实现这一目标,就会忽视家庭的重要关系因素。对公开性的要求需要考虑到家庭成员之间的照顾关系、传递信息的时间和方式,以及这些信息可能从根本上扰乱或改变信息接收者的家庭生活这一事实。
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引用次数: 0
Genome editing: From bioethics to biopolitics 基因组编辑:从生物伦理到生物政治
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-05-05 DOI: 10.1057/s41292-021-00229-5
Robert Sparrow, Catherine Mills

While CRISPR/Cas9 has become a lightning rod for fears about humanity’s increasing capacity to engineer biological life, the mainstream of Anglo-American bioethics struggles to discern much wrong with genome editing of human beings in vitro. In this paper, we analyze the notion of biopolitics and consider what contribution it may make to debates on genome editing. We disambiguate the different senses of two key terms: ‘biopolitics’, and ‘life’, and try to show how particular authors in the biopolitics literature draw on and emphasize different versions of these concepts. In the final section of the paper, we venture some suggestions as to the contribution that a number of these approaches might make to moving beyond a focus on risk and individual liberty to address the urgent bioethical questions surrounding the use of CRISPR/Cas9 to edit the human genome.

尽管 CRISPR/Cas9 已成为人们对人类日益增强的生物工程能力感到恐惧的避雷针,但英美生物伦理学的主流却很难发现体外人类基因组编辑有什么问题。在本文中,我们分析了生物政治学的概念,并考虑了它对基因组编辑辩论可能做出的贡献。我们区分了两个关键术语的不同含义:生物政治学 "和 "生命 "这两个关键术语的不同含义,并试图说明生物政治学文献中的特定作者是如何借鉴和强调这些概念的不同版本的。在本文的最后一部分,我们大胆地提出了一些建议,希望这些方法能够超越对风险和个人自由的关注,解决围绕使用CRISPR/Cas9编辑人类基因组的紧迫的生物伦理问题。
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引用次数: 0
mtDNA tests as a vehicle for Jewish recognition of Former Soviet Union Israeli citizens: religious and political debate mtDNA测试作为犹太人承认前苏联以色列公民的工具:宗教和政治辩论
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-05-05 DOI: 10.1057/s41292-021-00228-6
N. Kirsh, Yael Hashiloni-Dolev
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引用次数: 0
Vegetative value: promissory horizons of therapeutic innovation in the global circulation of ayahuasca 植物价值:死藤水全球流通中治疗创新的前景
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-03-15 DOI: 10.1057/s41292-020-00222-4
E. Sanabria
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引用次数: 4
Tissue culture and biological time: Alexis Carrel, Henri Bergson and the plasticity of living matter 组织培养与生物时间:亚历克西斯-卡雷尔、亨利-柏格森和生命物质的可塑性
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-03-13 DOI: 10.1057/s41292-020-00224-2
Rosine Kelz

Taking the early tissue culture experiments of Alexis Carrel in the 1910s–1930s as its example, the article explores the relationship between advances in biotechnological control over living matter and a holistic ontology of life, which stresses the temporal specificity of living things. With reference to Henri Bergson, Carrel argued that physiological time depends on an organism’s relationship to its milieu. By developing a laboratory apparatus and culture media, new objects of investigation could be made to live outside the organism and be brought to behave in novel temporal ways. In difference to recent biotechnological advances, like for example genome editing, which seek to ‘engineer’ living organisms by rebuilding them from their DNA up, then, early twentieth century interventionist laboratory practices were often linked to an understanding that biological plasticity results from organismic complexity and interactions between organism and milieu. These notions contributed to shaping laboratory apparatuses and techniques; they also helped to establish an understanding of environmental control that would allow for the production of novel ‘living things’.

文章以 1910-1930 年代亚历克西斯-卡雷尔(Alexis Carrel)的早期组织培养实验为例,探讨了生物技术对生命物质控制的进步与强调生物时间特性的整体生命本体论之间的关系。卡雷尔参照亨利-柏格森(Henri Bergson)的观点,认为生理时间取决于生物体与其环境的关系。通过开发实验室设备和培养基,新的研究对象可以生活在生物体之外,并以新的时间方式表现出来。与最近的生物技术进步(如基因组编辑)不同,20 世纪早期的干预性实验室实践往往与这样一种认识相联系,即生物的可塑性来自有机体的复杂性以及有机体与环境之间的相互作用。这些理念促进了实验室设备和技术的形成;它们还有助于建立对环境控制的理解,从而生产出新颖的 "生物"。
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引用次数: 0
Beyond the making of altruism: branding and identity in egg donation websites in Spain 超越利他主义:西班牙卵子捐赠网站的品牌和身份
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-03-09 DOI: 10.1057/s41292-020-00218-0
Anna Molas, A. Whittaker
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引用次数: 5
Correction to: Concussion killjoys: CTE, violence and the brain’s becoming 更正:脑震荡扫兴:CTE,暴力和大脑的变化
IF 1.6 4区 医学 Q4 SOCIAL SCIENCES, BIOMEDICAL Pub Date : 2021-03-05 DOI: 10.1057/s41292-021-00227-7
Aryn Martin, Alasdair McMillan
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引用次数: 0
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