IDCases最新文献

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Saved by My Specs: Incidental central retinal vein occlusion uncovering infective endocarditis – A case report 偶然的视网膜中央静脉阻塞发现感染性心内膜炎- 1例报告

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2025-12-26 DOI: 10.1016/j.idcr.2025.e02484

Daniel Broderick , Ciara Murray , Padraig McGettrick , James Woo , Emer Kilbride , James McCarthy , Yvonne O’Meara , Varisha Shahzad , Carlos Mejia-Chew

We describe a case of a 74-year-old man with a history of bioprosthetic aortic valve replacement who was diagnosed with Granulicatella adiacens (G. adiacens) infective endocarditis (IE) following an incidental finding of central retinal vein occlusion (CRVO) during a routine optician visit. Despite minimal symptoms on presentation, blood cultures grew G. adiacens, and imaging revealed a 1 × 1.2 cm aortic valve vegetation plus splenic and cerebral embolic complications. Management was complicated by drug-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, microangiopathic thrombocytopenia, anaemia, and possible subacute glomerulonephritis, leading to deferral of surgery until haematological parameters improved. Following a 9-week antibiotic course and stabilisation of platelet counts, he underwent a successful redo aortic valve replacement, highlighting the indolent yet clinically significant nature of G. adiacens IE and the importance of thorough, multidisciplinary care in complex prosthetic valve infections.

我们描述了一个病例74岁的男子与生物假体主动脉瓣置换术的历史，谁被诊断为肉芽肿（G. adiacens）感染性心内膜炎（IE）后偶然发现视网膜中央静脉闭塞（CRVO）在常规验光。尽管出现时症状轻微，但血培养培养出了棘球蚴，影像学显示主动脉瓣1 × 1.2 cm赘生物，并伴有脾和脑栓塞并发症。治疗伴有药物性药物性皮疹伴嗜酸性粒细胞增多和全身症状（DRESS）综合征、微血管病性血小板减少症、贫血和可能的亚急性肾小球肾炎，导致手术推迟至血液学参数改善。经过9周的抗生素治疗和血小板计数稳定后，他进行了成功的主动脉瓣置换术，强调了G. adiacens IE的惰性但临床意义重大的性质，以及在复杂的人工瓣膜感染中进行全面、多学科护理的重要性。

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引用次数: 0

Ictero-hemorrhagic leptospirosis -Weil’s disease 出血性钩端螺旋体病-威尔氏病。

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-02-10 DOI: 10.1016/j.idcr.2026.e02515

Johannes Heine , Benedikt Selbertinger , Benedicta Binder , Nadine Theissen , Stephan Schmid , Patricia Mester , Martina Müller , Vlad Pavel

引用次数: 0

Rare co-occurrence of colon cancer and Gastrodiscoides hominis in a human host: A case report and literature review 结肠癌和人腹盘虫在人类宿主中罕见共存：1例报告并文献复习。

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-02-13 DOI: 10.1016/j.idcr.2026.e02522

Sandhya Chaurasiya , Tuhina Banerjee , Aakash Shah , Anurag Tiwari

A rising but underappreciated public health concern, gastrodiscoidiasis, is caused by a food-borne intestinal trematode. We report molecular identification of the parasite Gastrodiscoides hominis, from a patient of colon cancer, based on conserved ribosomal and mitochondrial DNA. Phylogeny revealed closed genetic relatedness with other Indian isolates.

胃盘虫病是一种由食源性肠道吸虫引起的日益严重但未得到充分重视的公共卫生问题。我们报告的分子鉴定寄生虫人腹盘虫，从病人的结肠癌，基于保守的核糖体和线粒体DNA。系统发育显示与其他印度分离株有密切的遗传亲缘关系。

引用次数: 0

Myiasis as a portal for fatal sepsis with Proteus vulgaris bacteremia 蝇蛆病作为致命败血症与普通变形杆菌菌血症的入口。

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-02-19 DOI: 10.1016/j.idcr.2026.e02531

Kazushi Takayama, Yuko Ono, Taku Oshima

引用次数: 0

Fournier’s gangrene caused by Pediococcus damnosus – A case report and review of the literature 沙棘Pediococcus damnosus致Fournier坏疽1例报告及文献复习

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.idcr.2026.e02496

Osamu Okamoto , Kayo Yokoyama , Teruko Suematsu , Kosuke Akishino , Sekinori Munemoto , Yoshitaka Kai

The anaerobic bacterium Pediococcus damnosus is known to be associated with beer or wine spoilage in breweries, and human infection with Pediococcus damnosus has never been reported. A man with severe diabetes mellitus and diabetic nephropathy consulted our clinic because of painful swelling of the scrotal skin and a fever. The patient was diagnosed with Fournier’s gangrene, and Pediococcus damnosus was exclusively isolated from the exudate. Finally, one of the testes became necrotic and was excised. This is the first case of human infection by Pediococcus damnosus and primary skin infection due to Pediococcus species.

厌氧细菌丹诺球菌已知与啤酒厂的啤酒或葡萄酒变质有关，人类感染丹诺球菌从未报道过。一名患有严重糖尿病及糖尿病肾病的男子，因阴囊皮肤肿胀疼痛及发烧而求诊。患者被诊断为富尼耶坏疽，从渗出液中完全分离出沙棘球球菌。最后，其中一个睾丸坏死并被切除。这是首例人类感染沙棘球绦虫和由球绦虫引起的原发性皮肤感染病例。

引用次数: 0

Aggressive Pasteurella multocida rhinosinusitis with orbital extension in a patient with liver cirrhosis: A case report and literature review 肝硬化患者侵袭性多杀性巴氏杆菌性鼻窦炎伴眼眶扩张1例报告并文献复习

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-03-12 DOI: 10.1016/j.idcr.2026.e02549

Kohei Kawabata , Daichi Murakami , Mai Miyamoto , Taku Fujishiro , Takuma Okada , Chishin Yohda , Fumiya Kitamura , Ryo Ueda , Muneki Hotomi , Masamitsu Kono

Pasteurella multocida often causes skin and soft tissue infections associated with animal bites and scratches. However, aggressive respiratory tract infections without animal exposure have been reported in immunocompromised hosts. We report the case of a Japanese woman in her early 80 s with liver cirrhosis that developed acute rhinosinusitis caused by P. multocida without animal-related wounds. She presented with swelling and redness of the left eyelid, and subsequently developed decreased vision and impaired eye movement. Imaging studies revealed an ethmoid sinus abscess with a bony defect of the medial orbital wall and extension into the orbit. Emergency drainage by endoscopic sinus surgery led to complete resolution of the decreased vision and impaired eye movement. A strain of P. multocida was identified from the purulent discharge. To the best of our knowledge, this is the first reported case of aggressive Pasteurella rhinosinusitis with orbital extension. It suggests that P. multocida can cause invasive rhinosinusitis in immunocompromised hosts such as those with liver cirrhosis, and it demonstrates a potential osteolytic effect upon the paranasal bony structure.

多杀性巴氏杆菌经常引起与动物咬伤和抓伤有关的皮肤和软组织感染。然而，在免疫功能低下的宿主中，没有动物接触的侵袭性呼吸道感染也有报道。我们报告一位80岁出头的日本女性 ，她的肝硬化发展为由多杀性假单胞菌引起的急性鼻窦炎，没有动物相关伤口。患者表现为左眼睑红肿，随后出现视力下降和眼球运动障碍。影像学检查显示筛窦脓肿伴眶内壁骨缺损并向眶内延伸。内窥镜鼻窦手术急诊引流可完全解决视力下降和眼球运动障碍。从脓性分泌物中鉴定出一株多杀假单胞菌。据我们所知，这是第一例侵袭性巴斯德氏菌性鼻窦炎伴眼眶扩张。提示多杀假单胞菌可引起肝硬化等免疫功能低下宿主的侵袭性鼻窦炎，并对鼻副骨结构具有潜在的溶骨作用。

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引用次数: 0

Anti-NMDA receptor encephalitis in the setting of inherited chromosomally integrated human herpesvirus 6B (iciHHV-6B): A case report 遗传染色体整合型人疱疹病毒6B （iciHHV-6B）患者抗nmda受体脑炎1例报告

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-02-19 DOI: 10.1016/j.idcr.2026.e02526

Annie M. Geiger , William J. House , Armando Paez

Human herpesvirus 6 (HHV-6) is a ubiquitous DNA virus most frequently associated with roseola infantum and implicated in encephalitis among immunocompromised patients. Notably, it can integrate into human telomeres, contributing to diagnostic complexities. Although herpes simplex virus is a recognized trigger of autoimmune encephalitis, a comparable relationship for HHV-6 remains unconfirmed. We present a case of a previously healthy 19-year-old woman who presented with altered mental status. Lumbar puncture revealed HHV-6 by polymerase chain reaction (PCR) in the cerebrospinal fluid (CSF), and brain magnetic resonance imaging (MRI) findings were normal. Further testing confirmed anti- N-methyl-D-aspartate (NMDA) receptor antibodies in the serum and CSF. HHV-6 serum viral load testing resulted in over 2 million copies/mL, and chromosomal integration of HHV-6 was later confirmed. Four months after diagnosis, the patient’s cognition was approaching their prior baseline. This case underscores the importance of investigating alternative etiologies of encephalitis in immunocompetent patients with detectable HHV-6 DNA in the CSF. Our report further highlights a potential association between HHV-6B and anti-NMDA receptor encephalitis, even under chromosomal integration.

人类疱疹病毒6 （HHV-6）是一种普遍存在的DNA病毒，最常与婴儿红疹相关，并与免疫功能低下患者的脑炎有关。值得注意的是，它可以整合到人类端粒中，从而增加了诊断的复杂性。虽然单纯疱疹病毒是公认的自身免疫性脑炎的诱因，但与HHV-6的类似关系仍未得到证实。我们提出一个以前健康的19岁妇女谁提出了改变精神状态的情况。腰椎穿刺脑脊液（CSF）经聚合酶链反应（PCR）检出HHV-6，脑磁共振（MRI）检查结果正常。进一步检测证实血清和脑脊液中存在抗n -甲基- d -天冬氨酸（NMDA）受体抗体。HHV-6血清病毒载量检测结果超过200万拷贝/mL，随后证实了HHV-6染色体整合。诊断后4个月，患者的认知能力接近之前的基线。该病例强调了在脑脊液中检测到HHV-6 DNA的免疫功能正常患者中调查脑炎其他病因的重要性。我们的报告进一步强调了HHV-6B和抗nmda受体脑炎之间的潜在关联，即使在染色体整合下也是如此。

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引用次数: 0

Mycobacterium abscessus lumbar osteomyelitis: A rare and challenging case with review of literature 脓肿分枝杆菌腰椎骨髓炎：一个罕见且具有挑战性的病例与文献回顾

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.idcr.2026.e02495

Mohammed S. Zaman , Rootul Kakadia , Abhinav Kakuturu , Moamen Al Zoubi

A 65-year-old male presented with a three-month history of back pain, increased urinary frequency and lower extremity edema. MRI spine suggested discitis/osteomyelitis at L3-L4 (Fig. 1), and blood cultures and lumbar biopsy grew gram-positive bacilli. Despite IV antibiotics, the patient continued to experience back pain. Subsequent cultures identified Mycobacterium abscessus. He was initially treated with IV amikacin, IV meropenem, IV tigecycline, and oral linezolid. He also underwent L3-L4 discectomy, fusion, and posterior L2-L5 fusion with drain placement. He was discharged on IV tigecycline, imipenem, amikacin, and oral linezolid, later transitioning to oral omadacycline, azithromycin, and linezolid (Table 1). This case illustrates the challenges of managing Mycobacterium abscessus (MAB) infections, which require a multi-drug approach due to intrinsic and acquired antibiotic resistance. Therapy should begin with in-vitro guided IV antibiotics and transition to oral drugs for the continuation phase, optimizing therapeutic efficacy and overcoming resistance mechanisms.

65岁男性，有三个月的背痛病史，尿频增加，下肢水肿。脊柱MRI提示L3-L4椎间盘炎/骨髓炎（图1），血培养和腰椎活检显示革兰氏阳性杆菌。尽管静脉注射了抗生素，病人仍然感到背部疼痛。随后的培养鉴定为脓肿分枝杆菌。他最初接受阿米卡星、美罗培南、替加环素和口服利奈唑胺的治疗。他还接受了L3-L4椎间盘切除术、融合术和后路L2-L5融合术并放置引流管。出院时给予静脉滴注替加环素、亚胺培南、阿米卡星和口服利奈唑胺，后来转为口服奥马达环素、阿奇霉素和利奈唑胺（表1）。该病例说明了管理脓肿分枝杆菌（MAB）感染的挑战，由于固有和获得性抗生素耐药性，需要多种药物治疗。治疗应从体外引导静脉注射抗生素开始，并在持续阶段过渡到口服药物，以优化治疗效果并克服耐药机制。

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引用次数: 0

Misleading presentation of tuberculosis in a child with CGD revealing invasive aspergillosis: A molecularly confirmed case CGD患儿结核的误导表现显示侵袭性曲霉病：一个分子确诊病例

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-01-21 DOI: 10.1016/j.idcr.2026.e02499

Marjan Aghajani , Nima Parvaneh , Shahram Mahmoudi , Mahmoud Khansari , Fuad Haghighat , Kimia Kamali Sarvestani , Romina Ghazi Mirsaid , Hasti Kamali Sarvestani

Background and Purpose

Patients with chronic granulomatous disease (CGD) are susceptible to serious infections including, invasive aspergillosis (IA), which remains a major cause of morbidity and mortality. The diagnosis and management are often challenging due to overlapping clinical features and variable treatment responses.

Case report

Here we report a 4-year-old girl with CGD who admitted with cellulitis, a chest wall abscess, and fever. She had a history of recurrent pneumonia since infancy and a prior diagnosis of tuberculosis (TB). Despite broad-spectrum antibacterial, her condition did not improve. Direct microscopic and macroscopic investigations revealed fungal infection with Aspergillus species.

Conclusion

Molecular identification confirmed the isolates as A. fumigatus. According to the antifungal susceptibility testing, amphotericin B and posaconazole demonstrated strongest activity and the patient was successfully treated by liposomal amphotericin B (50 mg/day) and caspofungin (35 mg/day).

背景和目的慢性肉芽肿病（CGD）患者易受严重感染，包括侵袭性曲霉病（IA），这仍然是发病率和死亡率的主要原因。由于重叠的临床特征和不同的治疗反应，诊断和管理往往具有挑战性。病例报告：我们报告一名4岁的CGD女孩，她因蜂窝组织炎，胸壁脓肿和发烧而入院。她自婴儿期就有复发性肺炎病史，既往诊断为结核病。尽管使用了广谱抗菌药物，她的病情并没有好转。直接的显微和宏观调查显示真菌感染的曲霉种类。结论经分子鉴定，分离物为烟螨。抗真菌药敏试验两性霉素B和泊沙康唑活性最强，经两性霉素B脂质体（50 mg/d）和卡泊芬金（35 mg/d）治疗成功。

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引用次数: 0

Subretinal parasitic lesion mimicking viral retinitis managed with combined medical therapy and laser photocoagulation 模拟病毒性视网膜炎的视网膜下寄生病变采用药物治疗和激光光凝治疗

IF 1 Q4 INFECTIOUS DISEASES

IDCases

Pub Date : 2026-01-01 Epub Date: 2026-03-09 DOI: 10.1016/j.idcr.2026.e02543

Thanh Ngoc Tran , Hai Xuan Ho , Thoa Thi Doan , Hong Son Cung

Parasitic infections can present with variable manifestations and may mimic viral retinitis, particularly when intraocular inflammation is prominent. We report a case of a 54-year-old woman experiencing worsening blurred vision in her right eye for over a month. She was previously diagnosed with acute retinal necrosis and treated with corticosteroids and acyclovir, but her condition continued to decline. Fundus examination showed dense vitritis and an ill-defined area of retinitis along the superior temporal arcade. Serologic tests were positive for Toxocara IgG and Toxoplasma gondii IgG, while PCR testing of aqueous humor for viral pathogens was negative. Antihelminthic therapy was initiated, resulting in gradual improvement in media clarity and revealing a subretinal parasitic lesion within the area of retinitis. Once confirmed to be extramacular, focal laser photocoagulation was performed. During follow-up, intraocular inflammation subsided, the subretinal parasite fragmented, and best-corrected visual acuity improved to 20/25 and remained stable. This case highlights that parasitic infections should be considered in the differential diagnosis of infectious uveitis that does not respond to initial treatment in regions where parasitic infections are common. Combining focal laser photocoagulation with medical therapy may help control inflammation and preserve vision when a distinct extramacular subretinal parasite is detected.

寄生虫感染表现多样，可模仿病毒性视网膜炎，特别是当眼内炎症突出时。我们报告一例54岁的妇女，她的右眼视力模糊恶化了一个多月。她之前被诊断为急性视网膜坏死，并接受了皮质类固醇和阿昔洛韦治疗，但她的病情继续恶化。眼底检查显示密集的玻璃体炎和沿颞上拱廊的模糊区域视网膜炎。弓形虫IgG和刚地弓形虫IgG血清学检测阳性，房水病毒病原体PCR检测阴性。开始抗蠕虫治疗，导致介质清晰度逐渐改善，并显示视网膜炎区域内的视网膜下寄生病变。一旦确诊为黄斑外病变，进行病灶激光光凝治疗。随访期间，眼内炎症消退，视网膜下寄生虫碎裂，最佳矫正视力提高至20/25，保持稳定。该病例强调，在寄生虫感染常见的地区，在对初始治疗无效的传染性葡萄膜炎进行鉴别诊断时，应考虑寄生虫感染。当检测到明显的黄斑外视网膜下寄生虫时，将病灶激光光凝与药物治疗相结合可能有助于控制炎症和保护视力。

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