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A epidemiologia das fraturas por fragilidade óssea em uma população de mulheres brasileiras na pósmenopausa residentes na cidade de Chapecó/SC 居住在chapeco /SC市的巴西绝经后妇女因骨脆性骨折的流行病学
IF 1.2 Q3 Medicine Pub Date : 2010-07-01 DOI: 10.1590/S0100-72032010000700010
Patricia Pereira de Oliveira, Lizanka P.F. Marinheiro, Maria Celeste Osório Wender
Introduction: Osteoporosis and fractures have become one of the most public health problems in the world, affecting mostly women after menopause. Bone densitometry (BD) was established as the gold standard for diagnosis and monitoring of osteoporosis, but the quantitative ultrasound of the calcaneus (QUS) is able to estimate the risk for fractures in a similar way.Objectives: 1) To compare the recommendations in the international and national guidelines; 2) To verify the prevalence of vertebral fracture by bone fragility in the Chapecó city and relate it to clinical factors; 3) To verify the prevalence of women with fracture risk estimated by the QUS and its association with risk factors. 4) To check the power discrimination of this kind of QUC to discriminate vertebral fractures. Methodology: To achieve the first objective was to elaborate an article with critical analysis on the recommendations of international and national consensus for BD. For the other three objectives was developed one cross-sectional study. The population was selectioned by random sampling of white elderly post-menopausal women living in Chapecó. All answered a structured questionnaire between May and December 2007, and have done spine radiography (SR) and/or QUS. Results: The critical analysis about different consensus, we observed that in recent years there has been an effort to improve the referral recommendations and analysis of results of BD, and to unify them. In the cross-sectional studies, we observed: a) about the prevalence of vertebral fractures, the sample consisted of 186 women. Of these, 48.9% had asymptomatic vertebral fractures, with higher prevalence in T11-12 and L4-5. Sedentary lifestyle (OR 2.59, IC 1,18-5,67) and age (OR 3.14, CI 1,47-6,71 for women between 70 and 79 years, and OR 19.89 IC 2,35-168,58 for women aged over 80 years) were risk factors for fracture; b) about the prevalence of fracture risk estimated by the QUS, we studied 168 women with a mean age of 69.56 ± 6.27 years; 81% of the study population had abnormal test, 41% considered higher risk. Women with abnormal tests had lower weight, height and BMI, and had lower values of SOS, BUA, BQI and T-score. After adjustment, BMI remained significant for QUS changed (OR = 3.37, CI 1,199,56, p = 0.02) and previous history of fractures of the QUC to the greatest risk (OR = 4.44 CI 1,16-16,96, p = 0.03); c) about the QUS we observed 87.8% of sensitivity and 28% of specificity if abnormal QUS, and 80% and 45% for the largest range of risk of QUS, respectively. The AUC was more significant for SOS and BUA. Conclusions: Our study shows good sensitivity of the equipment of QUC Sonost 2000 to screen elderly female population. The prevalence of risk for fractures by QUS and vertebral fractures by SR was higher than other Brazilian studies. This shows the need for adaptive public policies for each region of this country. So, we suggest the realization of SR and/or QUS for screening and prevention of fract
骨质疏松和骨折已成为世界上最严重的公共卫生问题之一,主要影响绝经后妇女。骨密度测定(BD)被确立为骨质疏松症诊断和监测的金标准,但跟骨定量超声(QUS)也能以类似的方式估计骨折的风险。目的:1)比较国际和国家指南中的建议;2)验证Chapecó城市因骨脆性导致椎体骨折的患病率,并将其与临床因素联系起来;3)验证QUS估计的女性骨折风险患病率及其与危险因素的关系。4)检验该类QUC对椎体骨折的鉴别能力。方法:为了实现第一个目标,我们将详细阐述一篇文章,对国际和国家共识的BD建议进行批判性分析。为了实现其他三个目标,我们进行了一项横断面研究。人口是通过随机抽样选择居住在Chapecó的白人老年绝经后妇女。所有人都在2007年5月至12月期间回答了一份结构化问卷,并做了脊柱x线摄影(SR)和/或QUS。结果:通过对不同共识的批判性分析,我们观察到,近年来人们一直在努力改进BD的转诊建议和结果分析,并将其统一起来。在横断面研究中,我们观察到:a)关于椎体骨折的患病率,样本由186名女性组成。其中48.9%为无症状椎体骨折,T11-12和L4-5发生率较高。久坐不动的生活方式(OR为2.59,ic1,18 -5,67)和年龄(70 - 79岁女性的OR为3.14,ic1,47 -6,71, 80岁以上女性的OR为19.89,ic2,35 -168,58)是骨折的危险因素;b)关于QUS估计的骨折风险患病率,我们研究了168名女性,平均年龄为69.56±6.27岁;81%的研究人群检测异常,41%的研究人群高危。检查结果异常的女性体重、身高、BMI均较低,SOS、BUA、BQI、t评分均较低。调整后,BMI对QUC发生改变(OR = 3.37, CI 1,199,56, p = 0.02)和既往QUC骨折史的风险最大(OR = 4.44, CI 1,16-16,96, p = 0.03);c)关于QUS,我们观察到异常QUS的敏感性为87.8%,特异性为28%,最大QUS风险范围分别为80%和45%。SOS和BUA的AUC更为显著。结论:QUC Sonost 2000对老年女性人群筛查具有良好的敏感性。QUS导致骨折和SR导致椎体骨折的发生率高于其他巴西研究。这表明需要为该国的每个区域制定适应性的公共政策。因此,我们建议实现SR和/或QUS来筛查和预防骨折,因为这种方法比BD更经济、更容易获得。在分析关于BD的共识时,我们看到了改进和统一它们的努力。尽管发生了这些变化,但以这种方式使用的机器的技术进步以及对骨质疏松症的研究给了我们未来几年更多变化的希望。
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引用次数: 1
Métodos de barreira na prevenção de aderências peritoniais em videolaparoscopia: estudo em coelhas 腹腔镜中屏障预防腹膜粘连的方法:兔子的研究
IF 1.2 Q3 Medicine Pub Date : 2010-07-01 DOI: 10.1590/S0100-72032010000700012
Rosi Pereira Balbinotto
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引用次数: 0
5-Fluorouracil tópico para tratamento do condiloma genital em pacientes não imunocomprometidos 5-氟尿嘧啶外用治疗非免疫功能低下患者生殖器尖锐湿疣
IF 1.2 Q3 Medicine Pub Date : 2010-07-01 DOI: 10.1590/S0100-72032010000700011
Claudio Sérgio Batista
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引用次数: 1
Aspects obstetrics, social-demographic and psychosocial of puerpera teenagers assisted by the Health System, in the municipality of Muriaé (Zona da Mata Mineira) in the state of Minas Gerais, Brazil 在巴西米纳斯吉拉斯州穆里亚瓦伊市(Zona da Mata Mineira),由卫生系统协助的产妇青少年的产科、社会人口和社会心理方面
IF 1.2 Q3 Medicine Pub Date : 2010-07-01 DOI: 10.1590/S0100-72032010000700009
Carlos Wilson Dala Paula Abreu Abreu
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引用次数: 3
Complicações maternas decorrentes das cirurgias endoscópicas em Medicina fetal 胎儿医学内镜手术引起的产妇并发症
IF 1.2 Q3 Medicine Pub Date : 2010-06-01 DOI: 10.1590/S0100-72032010000600002
C. F. A. Peralta, Lourenço Sbragia, Eloisa Pedroso de Barros Corrêa-Silva, G. H. Y. Oh, A. Braga, Débora Alessandra de Castro Gomes, R. Barini
PURPOSE: to describe the maternal complications due to therapeutic endoscopic procedures in fetal Medicine performed at an university center in Brazil. METHODS: retrospective observational study including patients treated from April 2007 to May 2010 who underwent laser ablation of placental vessels (LAPV) for severe twin-twin transfusion syndrome (TTTS); fetal tracheal occlusion (FETO) and endoscopic removal of tracheal balloon in cases of severe congenital diaphragmatic hernia (CDH); LAPV with or without bipolar coagulation of the umbilical cord in cases of twin reversed arterial perfusion (TRAP) sequence. The main variables described for each disease/type of surgery were maternal complications and neonatal survival (discharge from nursery). RESULTS: fifty-six patients underwent 70 procedures: Severe TTTS (34 patients; 34 surgeries); severe CDH (16 patients; 30 surgeries), and TRAP sequence (6 patients; 6 surgeries). Among 34 women who underwent LAPV for TTTS, two (2/34=5.9%) experienced amniotic fluid leakage to the peritoneal cavity and seven (7/34=20.6%) miscarried after the procedure. Survival of at least one twin was 64.7% (22/34). Among 30 interventions performed in cases of CDH, there was amniotic fluid leakage into the maternal peritoneal cavity in one patient (1/30=3.3%) and premature preterm rupture of membranes after three (3/30=30%) fetoscopies for removal of the tracheal balloon. Infant survival with discharge from nursery was 43.8% (7/16). Among six cases of TRAP sequence, there was bleeding into the peritoneal cavity after surgery in one patient (1/6=16.7%) and neonatal survival with discharge from nursery was 50% (3/6). CONCLUSIONS: in agreement with the available data in literature, at our center, the benefits related to therapeutic endoscopic interventions for TTTS, CDH and TRAP sequence seem to overcome the risks of maternal complications, which were rarely considered severe.
目的:描述在巴西一所大学中心进行的胎儿医学治疗性内窥镜手术引起的产妇并发症。方法:回顾性观察研究,纳入2007年4月至2010年5月因严重双胎输血综合征(TTTS)接受激光消融胎盘血管(LAPV)治疗的患者;胎儿气管阻塞(FETO)和内镜下气管球囊切除在重度先天性膈疝(CDH)中的应用;双动脉反向灌注(TRAP)序列的LAPV伴或不伴双极性脐带凝血的情况。每种疾病/手术类型描述的主要变量是产妇并发症和新生儿存活率(从托儿所出院)。结果:56例患者共进行了70次手术:重度TTTS(34例;34手术);重度CDH(16例;30例手术)和TRAP序列(6例;6手术)。在34例因TTTS接受LAPV的妇女中,2例(2/34=5.9%)发生羊水漏至腹腔,7例(7/34=20.6%)术后流产。至少一个双胞胎的生存率为64.7%(22/34)。在对CDH病例进行的30例干预中,1例(1/30=3.3%)出现羊水漏入母体腹腔,3例(3/30=30%)胎儿镜取出气管球囊后出现胎膜早破。婴儿出院存活率为43.8%(7/16)。6例TRAP序列患者中,术后腹腔出血1例(1/6=16.7%),新生儿出院存活率为50%(3/6)。结论:与现有文献数据一致,在我们中心,TTTS、CDH和TRAP序列的治疗性内镜干预的益处似乎克服了母体并发症的风险,这些风险很少被认为是严重的。
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引用次数: 2
Polimorfismo do gene dos receptores de progesterona e o aborto espontâneo de repetição 孕酮受体基因多态性与重复流产
IF 1.2 Q3 Medicine Pub Date : 2010-05-01 DOI: 10.1590/S0100-72032010000500005
Évelyn Traina, S. Daher, Camila Sommerauer Franchim, Juliana Aoki Fuziy, A. F. Moron, Priscilla Chamelete Andrade Banzato, R. Mattar
PURPOSE: to assess a possible association between polymorphism of the progesterone receptor gene (PROGINS) and recurrent spontaneous abortion (RSA). METHODS: in this case-control study, 85 women with at least three previous spontaneous abortions without an identifiable cause (RSA Group) and 157 women with at least two previous term pregnancies without pathologies and no previous miscarriage (Control Group) were selected. An amount of 10 mL of peripheral blood was collected by venipuncture and genomic DNA was extracted by the DTAB/CTAB method, followed by the polymerase chain reaction (PCR) under specific conditions for this polymorphism and by amplification by 2% agarose gel electrophoresis. The bands were visualized with an ultraviolet light transilluminator and the gels were photographed. Differences in the PROGINS genotype and allele frequencies between groups were analyzed by the χ2 test, with the level of significance set at p<0.05. The Odds Ratio (OR) was also used, with 95% confidence intervals 95%CI. RESULTS: PROGINS genotypic frequencies were 72.3% T1T1 and 27.7% T1T2 for the RSA group and 764% T1T1, 22.3% T1T2 and 1.3% T2T2 for the control group. There were no differecnes between groups when the genotype and allele frequencies were analyzed: respectively p=0.48 (OR: 0.8) and p=0.65 (OR: 0.9). CONCLUSIONS: our results suggest that PROGINS polymorphism is not associated with RSA.
目的:评估黄体酮受体基因多态性(PROGINS)与复发性自然流产(RSA)之间的可能关联。方法:在本病例对照研究中,85例既往至少有三次无明确原因自然流产的妇女(RSA组)和157例既往至少有两次足月妊娠无病理且无流产的妇女(对照组)被选中。静脉穿刺采集外周血10 mL, DTAB/CTAB法提取基因组DNA,在特定条件下对该多态性进行聚合酶链反应(PCR),并进行2%琼脂糖凝胶电泳扩增。用紫外透光器观察这些条带,并对凝胶进行拍照。PROGINS基因型及等位基因频率组间差异采用χ2检验,差异水平p<0.05。比值比(OR)也被使用,95%置信区间为95% ci。结果:RSA组T1T1基因型频率为72.3%,T1T2基因型频率为27.7%;对照组T1T1基因型频率为764%,T1T2基因型频率为22.3%,T2T2基因型频率为1.3%。基因型和等位基因频率组间差异无统计学意义:p=0.48 (OR: 0.8)和p=0.65 (OR: 0.9)。结论:我们的研究结果表明PROGINS多态性与RSA无关。
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引用次数: 0
Qualidade de vida de mulheres com dor pélvica crônica: um estudo de corte transversal analítico 慢性盆腔疼痛女性的生活质量:一项分析横断面研究
IF 1.2 Q3 Medicine Pub Date : 2010-05-01 DOI: 10.1590/S0100-72032010000500008
Priscilla Rodrigues Barcelos, D. M. Conde, José Miguel de Deus, Edson Zangiacomi Martinez
OBJETIVOS: comparar a qualidade de vida (QV) de mulheres com e sem dor pelvica cronica (DPC) e investigar os fatores associados a QV de mulheres com DPC. METODOS: conduziu-se estudo de corte transversal, incluindo 30 mulheres com DPC e 20 sem DPC. Foram avaliadas caracteristicas sociodemograficas e clinicas. A QV foi investigada pelo questionario SF-36, que apresenta oito dominios: capacidade funcional, aspectos fisicos, dor, estado geral de saude, vitalidade, aspectos sociais, aspectos emocionais e saude mental. Esses dominios podem ser resumidos em dois sumarios: sumario do componente fisico (SCF) e sumario do componente mental (SCM). A intensidade da dor foi pesquisada, aplicando-se a escala visual analogica. Utilizou-se analise de regressao linear para comparacao dos escores de QV entre mulheres com e sem DPC e para identificacao dos fatores associados a QV de mulheres com DPC. RESULTADOS: a media de idade das mulheres com e sem DPC foi de 35,2±7,5 e de 36±9,3 anos (p=0,77), respectivamente. Mulheres com DPC apresentaram menor renda familiar mensal (p=0,04) e maior prevalencia de dismenorreia (87 versus 40%; p<0,01) e depressao (30 versus 5%; p=0,04) quando comparadas aquelas sem DPC. Na analise ajustada por potenciais variaveis confundidoras, mulheres com DPC apresentaram menores escores de QV nos dominios dor (p<0,01) e aspectos sociais (p<0,01). Depressao associou-se negativamente ao dominio aspectos emocionais (p=0,05) e ao SCM (p=0,03), enquanto intensidade da dor relacionou-se negativamente ao dominio dor (p<0,01) da QV de mulheres com DPC. CONCLUSOES: mulheres com DPC apresentaram pior QV quando comparadas a mulheres sem DPC. Depressao e intensidade da dor relacionaram-se negativamente a QV de mulheres com DPC. Dessa forma, a avaliacao e o tratamento de sintomas depressivos e da dor devem estar entre as prioridades que objetivem melhorar a QV de mulheres com DPC.
目的:比较有无慢性盆腔疼痛(cpd)女性的生活质量(qol),并调查与慢性盆腔疼痛女性生活质量相关的因素。方法:我们进行了一项横断面研究,包括30名患有cpd的女性和20名没有cpd的女性。评估社会人口学和临床特征。采用SF-36问卷对生活质量进行调查,包括八个领域:功能能力、身体方面、疼痛、一般健康状况、活力、社会方面、情感方面和心理健康。这些领域可以总结为两个总结:物理成分总结(SCF)和心理成分总结(SCM)。采用视觉模拟量表对疼痛强度进行研究。我们使用线性回归分析来比较有和没有cpd的女性的生活质量评分,并确定与cpd女性生活质量相关的因素。结果:有无cpd女性的平均年龄分别为35.2±7.5岁和36±9.3岁(p= 0.77)。患有cpd的女性家庭月收入较低(p= 0.04),痛经患病率较高(87 vs . 40%; p= 0.04)p< 0.01)和抑郁(30 vs 5%;p= 0.04)与没有cpd的患者相比。在潜在混淆变量调整分析中,患有cpd的女性在疼痛领域(p< 0.01)和社会方面(p< 0.01)的生活质量得分较低。抑郁与情绪领域(p= 0.05)和SCM (p= 0.03)呈负相关,而疼痛强度与cpd女性生活质量的疼痛领域(p< 0.01)呈负相关。结论:患有cpd的女性比没有cpd的女性生活质量更差。抑郁和疼痛强度与cpd女性的生活质量呈负相关。因此,评估和治疗抑郁症状和疼痛应该是改善cpd女性生活质量的优先事项之一。
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引用次数: 18
Alterações morfológicas das fibras tipos I e II do músculo estriado uretral de ratas prenhes diabéticas 糖尿病妊娠大鼠尿道横纹肌I型和II型纤维的形态学改变
IF 1.2 Q3 Medicine Pub Date : 2010-03-01 DOI: 10.1590/S0100-72032010000300009
G. Marini
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引用次数: 2
Detecção precoce do câncer de mama: conhecimento e prática de mulheres e profissionais da Estratégia de Saúde da Família em Dourados/MS 乳腺癌的早期发现:杜拉多斯/MS妇女和家庭保健战略专业人员的知识和实践
IF 1.2 Q3 Medicine Pub Date : 2010-03-01 DOI: 10.1590/S0100-72032010000200010
A. Batiston
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引用次数: 5
Efeito da terapia hormonal sobre a resposta imune no climatério 激素治疗对更年期免疫反应的影响
IF 1.2 Q3 Medicine Pub Date : 2010-03-01 DOI: 10.1590/S0100-72032010000300010
Alexandre Maitelli
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引用次数: 1
期刊
Revista Brasileira de Ginecologia e Obstetricia
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