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Early Detection of Oral Potentially Malignant Disorders: A Review on Prospective Screening Methods with Regard to Global Challenges. 口腔潜在恶性疾病的早期检测:应对全球挑战的前瞻性筛查方法综述
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-02-01 Epub Date: 2022-04-15 DOI: 10.1007/s12663-022-01710-9
Neda Haj-Hosseini, Joakim Lindblad, Bengt Hasséus, Vinay Vijaya Kumar, Narayana Subramaniam, Jan-Michaél Hirsch

Oral cancer is a cancer type that is widely prevalent in low-and middle-income countries with a high mortality rate, and poor quality of life for patients after treatment. Early treatment of cancer increases patient survival, improves quality of life and results in less morbidity and a better prognosis. To reach this goal, early detection of malignancies using technologies that can be used in remote and low resource areas is desirable. Such technologies should be affordable, accurate, and easy to use and interpret. This review surveys different technologies that have the potentials of implementation in primary health and general dental practice, considering global perspectives and with a focus on the population in India, where oral cancer is highly prevalent. The technologies reviewed include both sample-based methods, such as saliva and blood analysis and brush biopsy, and more direct screening of the oral cavity including fluorescence, Raman techniques, and optical coherence tomography. Digitalisation, followed by automated artificial intelligence based analysis, are key elements in facilitating wide access to these technologies, to non-specialist personnel and in rural areas, increasing quality and objectivity of the analysis while simultaneously reducing the labour and need for highly trained specialists.

口腔癌是中低收入国家广泛流行的一种癌症,死亡率高,治疗后患者的生活质量差。癌症的早期治疗可提高患者的生存率,改善生活质量,降低发病率,改善预后。为实现这一目标,最好能利用可在偏远和资源匮乏地区使用的技术对恶性肿瘤进行早期检测。这些技术应价格低廉、准确、易于使用和解释。本综述从全球角度出发,以口腔癌高发的印度人口为重点,调查了有可能在初级卫生保健和普通牙科实践中应用的不同技术。审查的技术包括基于样本的方法,如唾液和血液分析以及刷状活检,以及更直接的口腔筛查,包括荧光、拉曼技术和光学相干断层扫描。数字化和基于人工智能的自动分析是促进非专业人员和农村地区广泛使用这些技术的关键因素,可提高分析的质量和客观性,同时减少劳动力和对训练有素的专家的需求。
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引用次数: 0
An Overview of Systematic Reviews on the Surgical Management of Obstructive Sleep Apnoea. 阻塞性睡眠呼吸暂停手术治疗系统综述》。
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-11-17 DOI: 10.1007/s12663-023-02051-x
Vivekanand Kattimani, Elavenil Panneerselvam, Rahul Tiwari, Gnana Sarita Kumari Panga, Roopa Rani Sreeram

Background: Obstructive Sleep Apnoea (OSA) is a common sleep disorder marked by partial or total obstruction of the upper airway while a person is asleep leading to breathing difficulty, reduced oxygenation and frequent awakenings. This condition affects the general health significantly compromising quality of life. The objective of this overview  is to thoroughly assess the systematic reviews on current surgical therapies for the management of OSA in terms of patient outcomes.

Methods: A thorough literature search was performed from inception till 31st December 2022 using PubMed, and Cochrane databases. Studies evaluating the effectiveness and safety of different surgical techniques for the management of OSA were considered. The quality of articles was assessed using AMSTAR (A MeaSurement Tool to Assess systematic Reviews) and Glenny et al. checklist.

Results: Out of eighteen studies, only seven studies met the inclusion and exclusion criteria. Results showed that the majority of studies were in the pediatric age group except one systematic  review which assessed the adult age group.

Conclusion: None of the published articles had compared all surgical procedures based on the standard evaluating procedure nor followed all reporting guidelines in the primary studies. For better implementation, further multi center studies are warranted with unique reporting criteria and guidelines about pre- as well as post-operative phases. Future research should concentrate on contrasting strategies, combination therapies, and evaluating long-term effects.

Supplementary information: The online version contains supplementary material available at 10.1007/s12663-023-02051-x.

背景:阻塞性睡眠呼吸暂停(OSA)是一种常见的睡眠障碍,主要表现为睡眠时上气道部分或全部阻塞,导致呼吸困难、氧合作用降低和频繁觉醒。这种疾病会严重影响一般人的健康,降低生活质量。本综述旨在从患者疗效的角度全面评估目前治疗 OSA 的手术疗法的系统性综述:方法:使用 PubMed 和 Cochrane 数据库对从开始到 2022 年 12 月 31 日的文献进行了全面检索。研究考虑了对不同手术技术治疗 OSA 的有效性和安全性进行评估的研究。文章质量采用 AMSTAR(评估系统性综述的评估工具)和 Glenny 等人的核对表进行评估:在 18 项研究中,只有 7 项研究符合纳入和排除标准。结果显示,除了一篇评估成人年龄组的系统综述外,大多数研究都是针对儿科年龄组的:结论:已发表的文章中,没有一篇是根据标准评估程序对所有外科手术进行比较的,也没有一篇是在主要研究中遵循所有报告指南的。为了更好地实施,有必要进一步开展多中心研究,并制定独特的报告标准和术前术后指南。未来的研究应侧重于对比策略、联合疗法和长期效果评估:在线版本包含补充材料,可在 10.1007/s12663-023-02051-x 上获取。
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引用次数: 0
Reproducibility of Computerized Cephalometric Analysis Software Compared with Conventional Manual Tracing for Analyzing Skeletal Stability After Orthognathic Surgery. 在分析正颌外科手术后骨骼稳定性方面,计算机化头颅测量分析软件与传统手动描记法的再现性比较。
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-11-26 DOI: 10.1007/s12663-023-02071-7
Phu Hnin Thet, Boosana Kaboosaya

Objective: This study aimed to compare the difference between analyzing skeletal stability after orthognathic surgery by lateral cephalogram measurement created from Dolphin software (version 11.95) compared with the manual technique.

Methods: Twenty-eight patients who underwent mandibular setback surgery (BSSRO) were randomly selected between 2015 and 2021. Serial lateral cephalograms were analyzed at four different time sets postoperatively, and a total of 112 cephalometric radiographs were obtained. Horizontal measurement (BX), vertical measurement (BY), and 3 angular measurements (SNB, ANB, and Gonial angle) were analyzed by manual tracing and Dolphin software by 2 examiners. The intraclass correlation coefficient determined the intra-rater reliability. Parameter differences between timelines were observed for skeletal stability, and mean values between methods were compared using the Student's t-test.

Results: Both examiners were generally consistent in the repeated measurements (ICCs of the manual method ranged from 0.926 to 0.994, and the digital method ranged from 0.719 to 0.956). All variables represented skeletal stability at T0-T1, T0-T2, and T0-T3 showed no statistically significant differences between methods except ANB (T0-T1; p value = 0.009).

Conclusions: Computerized cephalometric analysis software is relatively reproducible for assessing skeletal changes after orthognathic surgery and can be used routinely in follow-up.

研究目的本研究旨在比较通过Dolphin软件(11.95版)创建的侧向头影测量分析正颌手术后骨骼稳定性与人工技术的差异:随机选取2015年至2021年期间接受下颌后缩手术(BSSRO)的28名患者。对术后四个不同时间段的连续头颅侧位片进行分析,共获得 112 张头颅X光片。水平测量(BX)、垂直测量(BY)和 3 个角度测量(SNB、ANB 和 Gonial 角)由 2 名检查员通过手动描记和 Dolphin 软件进行分析。类内相关系数确定了评分者内部的可靠性。在骨骼稳定性方面,观察了不同时间段的参数差异,并使用学生 t 检验比较了不同方法的平均值:结果:两位检查者在重复测量中的表现基本一致(人工方法的 ICC 为 0.926 至 0.994,数字方法的 ICC 为 0.719 至 0.956)。除了 ANB(T0-T1;P 值 = 0.009)外,T0-T1、T0-T2 和 T0-T3 时代表骨骼稳定性的所有变量在统计学上没有显著差异:结论:计算机头颅测量分析软件在评估正颌手术后的骨骼变化方面具有较高的可重复性,可在随访中常规使用。
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引用次数: 0
The Relation Between Mandibular Relapse and the Postoperative Mandibular Ramus Rotation Following BSSO Setback. 下颌骨复发与BSSO术后下颌支旋转的关系
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2022-07-18 DOI: 10.1007/s12663-022-01760-z
Phathaitip Wittayakornlerk, Yutthasak Kriangcherdsak, Pattamawan Manosuthi

Objectives: This retrospective study aimed to determine the angulation changes of the proximal segment following bilateral sagittal split osteotomy (BSSO) setback and its correlation with the amount of immediate postoperative surgical movement. The correlation between postoperative relapse of the distal and proximal segment at six months postoperatively was also evaluated.

Materials and methods: The CBCT-generated lateral cephalometric images of 39 patients who underwent BSSO setback with or without Le Fort I osteotomy were evaluated preoperatively (T0), immediately postoperative (T1), and six months postoperatively (T2).

Results: The mean surgical setback was 7.28 ± 4.45 mm at B point. The proximal segment's immediate postoperative mean posterior rotation was 2.13 ± 3.59 degrees. Six months after the operation, the mean distal segment relapse was 0.89 ± 3.03 mm at B point. The proximal segment relapse was 0.81 ± 1.63 degrees. A significant moderate correlation was found (P < 0.05) between the surgical movement and the immediate postoperative proximal segment rotation and between the surgical movement and the distal segment relapse. A significant correlation was found between the distal segment relapse and the average and left proximal segment relapse. There was no significant correlation between immediate postoperative proximal segment rotation and distal segment relapse.

Conclusion: The immediate postoperative posterior rotation of the proximal segment had a negligible effect on mandibular relapse. The amount of surgical movement, on the other hand, was more related to distal segment relapse. The intraoperative proximal segment rotation should thus be minimized in cases with a significant surgical setback.

研究目的这项回顾性研究旨在确定双侧矢状面劈开截骨术(BSSO)后近端节段的角度变化及其与术后即刻手术移动量的相关性。此外,还评估了术后 6 个月远端和近端节段复发的相关性:对 39 例接受或未接受 Le Fort I 截骨术的 BSSO 后移患者的 CBCT 头侧造影图像进行术前(T0)、术后即刻(T1)和术后 6 个月(T2)评估:B 点的平均手术后移量为 7.28 ± 4.45 毫米。近节段术后即刻的平均后旋度为 2.13 ± 3.59 度。术后 6 个月,远端节段在 B 点的平均复发率为 0.89 ± 3.03 毫米。近节段复位为 0.81 ± 1.63 度。两者之间存在明显的中度相关性(P术后立即后旋近段对下颌复发的影响微乎其微。另一方面,手术移动量与远段复发的关系更大。因此,在手术复发严重的病例中,应尽量减少术中近节旋转。
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引用次数: 0
Original Location of Congenital Nasal Sinus "Midcolumella": A Modified Inverted V Incision Technique. 先天性鼻窦 "Midcolumella "的原始位置:改良倒 V 切口技术。
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-11-24 DOI: 10.1007/s12663-023-02032-0
Majid Ismayilzade, Mahmut Tekecik, Arda Soylu, Hayri Ahmet Burak Nurşen, Bilsev Ince, Mehmet Dadacı

Among the rare congenital malformations, congenital nasal sinuses with blind end are extremely unusual. To the best of our knowledge, a sinus located in the midcolumellar region has not been reported yet. Since there is no consensus about the treatment of midcolumellar sinus, to manage the case as individually as possible was our priority. Considering the patient's age, aesthetic concerns, and requirement of septorhinoplasty in the future, the known inverted V incision was modified to provide surgical excision without any extra scar in the midcolumellar line. This report emphasizes a patient-specific treatment of a 15-year-old female patient presented for congenital sinus in the midcolumellar area.

Supplementary information: The online version contains supplementary material available at 10.1007/s12663-023-02032-0.

在罕见的先天性畸形中,带有盲端的先天性鼻窦极为罕见。据我们所知,位于蝶窦中部的鼻窦尚未见报道。由于目前还没有关于蝶窦中段治疗的共识,我们的首要任务是尽可能个性化地处理该病例。考虑到患者的年龄、对美观的关注以及将来进行鼻中隔成形术的要求,我们对已知的倒 V 形切口进行了改良,使手术切除时不会在颊中线留下任何额外的疤痕。本报告强调了对一名因额中部先天性鼻窦而就诊的 15 岁女性患者的特殊治疗方法:在线版本包含补充材料,可在 10.1007/s12663-023-02032-0获取。
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引用次数: 0
Management of Short Face Syndrome with Masseter Muscle Hypertrophy: A Surgery-First Approach. 短脸综合征伴咬肌肥大的治疗:手术优先的方法
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-04-25 DOI: 10.1007/s12663-023-01921-8
Ashwina S Banari, Sanjeev Datana, A N Kunal, Yuvraj Issar

Short face syndrome (SFS) is a condition with a clinical impression of deficient lower anterior facial height, which is an esthetic disharmony based on vertical facial proportions rather than absolute dimensions. Masseter hypertrophy is one of the etiologic factors in which there is an enlargement of unilateral or bilateral masseter muscles. Clinically, it presents as a quadrangular face characterized by bulging of the mandibular angle giving a muscular appearance. Despite the muscular origin, surgery should be aimed toward bony reduction (osteoplasty) followed by supplemented myotomy. This case report addresses one such case of SFS treated with surgery-first approach and supplemented myotomy with a 1-year follow-up. The esthetic facial profile, pleasant smile and overall good treatment outcome remained stable 1 year after orthognathic surgery and orthodontic treatment.

短脸综合征(SFS)是一种临床表现为面部前下方高度不足的疾病,是一种基于面部垂直比例而非绝对尺寸的美学不协调。颌下肌肥大是单侧或双侧颌下肌肥大的病因之一。临床表现为四角形脸,下颌角隆起,给人以肌肉发达的感觉。尽管病因是肌肉性的,但手术的目的应该是削骨(骨整形术),然后辅以肌肉切除术。本病例报告介绍了一例采用先手术后辅助肌切开术治疗的 SFS 病例,并进行了为期 1 年的随访。患者在接受正颌手术和正畸治疗 1 年后,面部轮廓美观,笑容怡人,整体治疗效果良好。
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引用次数: 0
Facial Asymmetry-Demystifying the Entity. 面部不对称--解密实体。
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-12-05 DOI: 10.1007/s12663-023-02053-9
Nalla Viveka Vardhan Reddy, Abhinand Potturi, Ritesh Rajan, Dinesh Jhawar, Y W Bharath Bhushan, Anitha Pasupuleti

Introduction/background: Perfect facial symmetry has always been considered a hallmark of beauty, but, is almost elusive in nature. However, clinically evident skeletal facial asymmetry on the other hand is quite common, which can result from congenital deformities, developmental abnormalities, secondary to maxillofacial trauma and it is an entity maxillofacial surgeons deal with on a regular basis. Surgical correction of facial asymmetry is challenging, as it not only involves the correction of the skeletal asymmetry for an aesthetic outcome, but, also the improvement of the soft tissue drape and dental occlusal harmony. This results in rehabilitation of functional components of orofacial complex like speech, deglutition and phonation.

Objective: With this paper, we intend to throw a light on this challenging aspect of maxillofacial surgery, along with giving the next generation of maxillofacial surgeons a direction to explore the topic further.

Conclusion: Meticulous evaluation and diagnosis of the patient's problems with latest diagnostic methods like 3-dimensional imaging and surgical treatment with orthognathic surgery, gap arthroplasty or distraction osteogenesis, utilizing cutting edge 3-D virtual planning will result in better outcomes.This review will collate the information available in the literature, along with the authors' recommendations for better planning and execution of this challenging puzzle of facial asymmetry.

简介/背景:完美的面部对称一直被认为是美的标志,但在本质上却几乎难以捉摸。然而,临床上明显的面部骨骼不对称却很常见,这可能是先天畸形、发育异常或继发于颌面外伤造成的,也是颌面外科医生经常处理的问题。面部不对称的手术矫正具有挑战性,因为它不仅涉及骨骼不对称的矫正以达到美学效果,还涉及软组织悬垂性和牙齿咬合和谐性的改善。这将导致口颌复合体功能部分的康复,如语言、脱颌和发音:本文旨在阐明颌面外科手术中这一具有挑战性的方面,同时为下一代颌面外科医生提供一个进一步探索这一课题的方向:通过三维成像等最新诊断方法对患者的问题进行细致的评估和诊断,并采用正颌外科手术、间隙关节成形术或牵引成骨术等手术治疗方法,利用最先进的三维虚拟规划技术,将取得更好的疗效。本综述将整理文献中的信息,并结合作者的建议,以更好地规划和实施面部不对称这一具有挑战性的难题。
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引用次数: 0
Treatment Modalities to Achieve Nasal Symmetry in Unilateral Cleft Lip/Nasal Deformity: An Objective and Comparative Evaluation. 实现单侧唇裂/鼻畸形患者鼻部对称的治疗方法:客观和比较评估。
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-11-19 DOI: 10.1007/s12663-023-02039-7
K Mustafa, Shehzana Fatima, M V Ashith, Jay Nandkishor Goyal, Amrutha Varshini, Aafreen Aftab

Introduction: Primary cleft lip repair techniques do not address the nasal deformity adequately resulting in nasal asymmetry. Maneuvers employed to minimize this have varying degrees of success.

Aim: To assess the outcome of different treatment modalities employed to establish nasal symmetry in unilateral cleft lip.

Methods: 100 patients with complete unilateral cleft lip/ palate operated for primary cheiloplasty with modified Millard's rotation advancement technique were divided into five groups. Group 1: lip repair alone, Group 2: NAM followed by lip repair, Group 3: lip repair followed by placement of conformers, Group 4: NAM followed by lip repair and placement of conformers, Group 5: lip repair with semi-open rhinoplasty. Objective assessment was done using measurable parameters after 12 months post-operatively on a 1:1 standard photograph.

Results: Group 5 showed statistical significance in all parameters assessed. Progressive improvement in nasal symmetry was noted from Group 1 to Group V.

Conclusion: In our study, group V, i.e., modified Millard's repair with semi-open rhinoplasty improved the results in terms of all the objective parameters assessed. The results of the other groups showed improvement though not consistent in all parameters. Naso-alveolar molding is an effective adjunct. Additionally, nasal conformers proved to be of great value in retaining the results obtained post-surgery.

简介初级唇裂修复技术不能充分解决鼻部畸形问题,导致鼻部不对称。目的:评估不同治疗方法对单侧唇裂患者鼻部对称性的影响。方法:100 名完全性单侧唇裂/腭裂患者被分为五组,分别接受改良米拉德旋转推进技术的初级唇腭裂成形术。第 1 组:单纯唇修复术;第 2 组:NAM 后进行唇修复术;第 3 组:唇修复术后放置保形器;第 4 组:NAM 后进行唇修复术并放置保形器;第 5 组:唇修复术后半开鼻整形术。术后 12 个月后,在 1:1 标准照片上使用可测量的参数进行客观评估:结果:第 5 组在所有评估参数上均显示出统计学意义。结论:在我们的研究中,第五组即第一组和第五组的鼻对称性都得到了改善:结论:在我们的研究中,第五组,即改良米拉德修补术和半开放式鼻整形术,在所有客观评估参数方面均有改善。其他各组的结果虽然在所有参数上都有改善,但并不一致。鼻齿槽成型是一种有效的辅助方法。此外,鼻部塑形器在保持术后效果方面也具有重要价值。
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引用次数: 0
Condylar Hyperplasia: Case Report and Literature Review. 髁突增生症病例报告及文献复习
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-01-06 DOI: 10.1007/s12663-022-01834-y
Avapati Pravallika, Col Suresh Menon, M E Sham, S Archana, Sheron Mathews

Condylar hyperplasia is a rare pathology characterised by excessive bone growth that presents virtually unilaterally, resulting in facial asymmetry. The aetiology of this disorder is not well understood. This pathology has been reported to be a rare entity with very few cases being reported in the literature, mostly seen between 11 and 30 years of age, with males and females being equally affected and having no predominance to the left or right side. It has also been reported to be a self-limiting condition, that is, the active growth can cease at any point in time. We report two cases of unilateral condylar hyperplasia in 24- and 19-year-old male and female patients, where the first was treated by condylectomy and BSSO, and the latter was treated by high condylectomy and recontouring of the mandible.

髁状突增生症是一种罕见的病症,其特点是骨质过度生长,几乎单侧发病,导致面部不对称。这种疾病的病因尚不十分清楚。据报道,这种病症非常罕见,文献中仅有极少数病例报道,患者年龄大多在 11 至 30 岁之间,男性和女性患者人数相当,且不分左右。也有报道称,该病是一种自限性疾病,即主动生长可在任何时候停止。我们报告了两例单侧髁状突增生病例,患者分别为 24 岁和 19 岁,前者采用髁状突切除术和 BSSO 治疗,后者采用高位髁状突切除术和下颌骨修整术治疗。
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引用次数: 0
Ocular Hypertelorism: Principles and Management. 眼球突出症:原理与管理。
IF 0.9 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2023-12-01 Epub Date: 2023-11-24 DOI: 10.1007/s12663-023-02057-5
Srinivas Gosla Reddy, Adity Bansal, Hermann F Sailer, Likith V Reddy, Ghali E Ghali, Varsha Haridas Upadya

Background: Ocular hypertelorism (OH) was initially considered as un-differentiated congenital cranio-facial deformity, however, I.T Jackson mentioned it as teleorbitism, considering it as increase in the inter-canthal width, inter-pupillary as well as inter-orbital distance as a result of lateralization of the orbital complex in total. Furthermore, Sailer further refined it and included the distance from the lateral orbital wall, i.e. he denoted increased inter-orbital distance along with the distance between lateral orbital walls as true hypertelorism. This condition is rare and is seen in association with midline congenital defects affecting the cranio-facial region.

Classification and review of cases: The ideal time for the OH correction is usually between 5 and 8 years of age. However, the management of OH is complex, and several techniques have been described in literature for the same. Here, we describe our classification of OH, along with the evolution of the surgical aspects, the key treatment principles we follow, together with the types of the osteotomies and their indications. Furthermore, we delineate the four main principles that we have set for OH management.

Results: Though the improvement in appearance is seen immediately post-surgery, however, this challenging surgery faces a multitude and common postoperative complications which have been represented in this article. The surgeon needs both the technical expertise and an inclination towards aesthetics for the execution of such procedures.

Conclusion: It is preferred that the management of OH should be individualized as per the stage of the craniofacial growth and the psychosocial needs of the patient and the parents.

背景:眼球突出症(OH)最初被认为是一种未分化的先天性颅面畸形,但杰克逊(I.T Jackson)将其称为 "远距眼球突出症"(teleorbitism),认为眼球突出症是由于眼眶复合体整体偏向一侧而导致的眶间宽、瞳孔间和眶间距的增加。此外,赛勒还对其进行了进一步的完善,将眼眶外侧壁的距离也包括在内,即他将眼眶间距离的增加以及眼眶外侧壁之间距离的增加视为真正的眼球突出。这种情况很少见,多见于影响颅面部的中线先天缺陷:OH的理想矫正时间通常在5至8岁之间。然而,OH 的治疗非常复杂,文献中描述了多种治疗方法。在此,我们将介绍我们对OH的分类、手术方面的演变、我们遵循的主要治疗原则、截骨术的类型及其适应症。此外,我们还阐述了我们为OH治疗制定的四项主要原则:虽然手术后外观立即得到改善,但这种具有挑战性的手术面临着多种常见的术后并发症,本文对此进行了介绍。外科医生需要同时具备专业技术知识和审美倾向,才能完成此类手术:颅颌面发育阶段以及患者和家长的社会心理需求决定了对颅颌面发育不良的治疗应因人而异。
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引用次数: 0
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