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Quantitative Evaluation of Zygomatic Buttress, Ramal, and Symphysis Onlay Grafts in Ridge Augmentation Prior to Implant Placement. 在植入前对颧支撑、颧弓和联合嵌板移植物进行脊隆的定量评估。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2024-05-31 DOI: 10.1007/s12663-024-02192-7
John Vanlalrinawma Fanai, Jigar Dhuvad, Sonal Anchlia, Utsav Bhatt, Bhagya Trivedi, Hitarthi Jogani

Background: Dental implants require an adequate amount of bone volume for successful and good prosthetic support. However, in severe alveolar bone width deficiency, onlay grafts from intraoral donor sites like zygomatic buttress, ramus and symphysis may be taken.

Method: A prospective comparative study was conducted on 30 patients with upper and lower anterior edentulous arches of width less than 4 mm. They were evaluated for the efficacy of three types of onlay grafts for ridge augmentation prior to implant placement. Patients were randomly divided into Group 1 (Ramal), Group 2 (Symphysis) and Group 3 (Zygomatic buttress) grafts of n = 10 each. The grafts were evaluated in terms of bone width, pain, mouth opening, teeth vitality, neurosensory loss and patient satisfaction score till 6 months follow-up.

Findings: Graft uptakes were good in all three groups with maximum width gained in the symphysis group. More postoperative complications (reduced mouth opening, swelling, paresthesia, mobility) occurred in the ramal graft group.

Conclusion: The use of autogenous onlay bone grafts from intra-oral donor sites provides promising results with reduced operative time for augmenting atrophic ridge prior to implant placement, but the symphysis graft provides the maximum bone width to accommodate the dental implant, with minimal complications.

背景:牙种植体需要足够的骨体积,以获得成功和良好的假体支持。然而,在严重的牙槽骨宽度不足的情况下,可以采用口腔内供体部位(如颧支、支和联合)的移植。方法:对30例上、下无牙弓宽度小于4mm的患者进行前瞻性对比研究。他们评估了三种类型的嵌体移植物在种植体放置之前的嵴增强效果。将患者随机分为组1 (Ramal)、组2(联合)、组3(颧扶壁),每组10例。随访6个月,对移植物的骨宽、疼痛、开口、牙齿活力、神经感觉丧失和患者满意度评分进行评价。结果:三组植骨摄取均良好,联合组植骨宽度最大。植牙组术后并发症(开口减小、肿胀、感觉异常、活动能力)较多。结论:在种植体植入前,使用口腔内供体自体贴体骨移植物可以减少萎缩脊的手术时间,但联合移植物提供了最大的骨宽度来容纳牙种植体,并发症最少。
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引用次数: 0
Prevalence of the Huschke Foramen in Colombian Population: An Important Anatomic Alteration for the Planning of TMJ Arthroscopy. 哥伦比亚人群中Huschke孔的患病率:TMJ关节镜检查计划的重要解剖学改变。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2024-08-27 DOI: 10.1007/s12663-024-02271-9
Luis Vicente Gonzalez, Juan Pablo López, María Paula Orjuela, Michel Hernandez-Restrepo, Mitchell Calvin Balentien

Background: Ignoring this anatomic structure would have implications for iatrogenic perforation with the trocar toward the FH during the initial blind drilling or due to the diffusion of the infusion liquid toward the middle ear.

Purpose: To analyze the prevalence of the FH in an institutional population with a high incidence of TMD to provide further guidelines in diagnosing this anomaly and the planification of TMJ arthroscopy.

Materials and methods: A retrospective tomographic study was conducted at the ENT-Oral and Maxillofacial and Radiology Department of the Hospital Universitario la Samaritana in Bogotá, Colombia. Inclusion criteria were patients over 18 years of age who had complementary exams such as ear, face, paranasal sinus, and/or TMJ tomography. Exclusion criteria were history of direct trauma to the external auditory canal in the medical history, patients with craniofacial syndromes, congenital anomalies, and/or history of cranial, mandibular, or temporal fractures. Two radiologists were part of the evaluators of the CT images who conducted the measures in the axial tomographic section and established the presence of the tympanic defect.

Results: A sample size of 139 medical records of patients, where females represent n: 101 (72.6%) and males represent n: 38 (27.4%). The average age was 43 years ± 18 years. Among the studied population, a total of five FH were detected, corresponding to a prevalence of 3.6% (95% CI 1.5-8.1%). The average size of the defect was 3.52 mm ± 1.1 mm. All the patients had TMJ-related symptoms, but none of them reported otalgia.

Conclusion: The initial evaluation of each patient must be addressed to assess the integrity of the tympanic bone. In this study, the defects size was smaller than others previously reported. However, diffusion through the tympanic defect could spread the lavage substance into the middle ear during TMJ arthroscopic surgery.

背景:忽略这种解剖结构可能会导致套管针在初始盲钻孔时或由于输液液向中耳扩散而向FH方向发生医源性穿孔。目的:分析在TMD高发的机构人群中FH的患病率,为该异常的诊断和TMJ关节镜平化提供进一步的指导。材料和方法:回顾性断层扫描研究在哥伦比亚波哥大萨玛利亚大学医院门诊部口腔颌面和放射科进行。纳入标准是18岁以上的患者,并进行了补充检查,如耳部、面部、副鼻窦和/或TMJ断层扫描。排除标准为病史中有外耳道直接创伤史、颅面综合征、先天性异常和/或颅、下颌或颞部骨折史。两名放射科医生是CT图像评估人员的一部分,他们在轴向断层扫描中进行了测量,并确定了鼓室缺损的存在。结果:样本量为139份患者病历,其中女性占n: 101(72.6%),男性占n: 38(27.4%)。平均年龄43岁±18岁。在研究人群中,共检测到5例FH,患病率为3.6% (95% CI 1.5-8.1%)。缺陷的平均尺寸为3.52 mm±1.1 mm。所有患者都有颞下颌关节相关症状,但没有人报告有耳痛。结论:每位患者的初步评估必须考虑鼓室骨的完整性。在这项研究中,缺陷的大小比其他先前报道的要小。然而,在TMJ关节镜手术中,通过鼓室缺损的扩散可使灌洗物扩散到中耳。
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引用次数: 0
Adenoid Ameloblastoma: A Case Report on this Newly Recognized Under-Treated Odontogenic Tumour. 腺样成釉细胞瘤:一例新发现的治疗不足的牙源性肿瘤。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-07-03 DOI: 10.1007/s12663-025-02592-3
Fadi Titinchi, Moegamat Sallies, Johan Opperman

Introduction: Adenoid ameloblastoma (AdAM) is a rare epithelial odontogenic tumour recently included in the 5th World Health Organization classification of head and neck tumours as a separate tumour from conventional ameloblastoma. It presents diagnostic and management challenges due to its morphological overlapping features with adenomatoid odontogenic tumour (AOT) and conventional ameloblastoma.

Case report: A 32-year-old female with neurofibromatosis type I presented with a 4-month history of right-sided facial swelling. Clinical examination revealed a firm, expansive mass in the right anterior mandibular region with associated tooth mobility. Radiographic evaluation demonstrated a well-demarcated unilocular radiolucency mimicking a cystic lesion. Histological examination revealed an epithelial odontogenic neoplasm composted of nests of ovoid to spindle-shaped cells demonstrating pseudo-duct-like spaces, cribriform areas and a whirling pattern with deposition of dentinoid material. These features confirmed the diagnosis of AdAM. The tumour was resected and immediately reconstructed with a fibula free flap. The patient remains diseases-free 2 years post-surgery.

Conclusion: There are some overlapping clinico-pathological features of this tumour with AOT, which has led to inadequate surgical management previously with high recurrence rates. Emphasis should be placed on identifying all histopathological features described to arrive at an accurate diagnosis. Surgical treatment of AdAM should be radical resection despite its clinical and radiographic presentation mimicking the less aggressive AOT.

腺样成釉细胞瘤(AdAM)是一种罕见的上皮性牙源性肿瘤,最近被列入世界卫生组织第五次头颈部肿瘤分类,作为一种独立于常规成釉细胞瘤的肿瘤。由于其形态学特征与腺瘤样牙源性肿瘤(AOT)和常规成釉细胞瘤重叠,因此给诊断和治疗带来了挑战。病例报告:一名32岁女性神经纤维瘤病I型提出了4个月的历史,右侧面部肿胀。临床检查显示在右下颌前区有一个坚固、膨胀的肿块,伴有牙齿活动。x线检查显示有清晰的单眼放射透光度,类似囊性病变。组织学检查显示一上皮性牙源性肿瘤,由卵圆形巢到纺锤形细胞组成,显示假导管样空间、筛网状区域和牙本质样物质沉积的旋转模式。这些特征证实了AdAM的诊断。肿瘤被切除并立即用腓骨游离皮瓣重建。患者术后2年无疾病。结论:AOT有一些重叠的临床病理特征,导致手术治疗不充分,复发率高。重点应放在识别所描述的所有组织病理学特征,以达到准确的诊断。手术治疗应该是根治性切除,尽管它的临床和影像学表现与不那么积极的AOT相似。
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引用次数: 0
Comparative Evaluation of Conventional (Static) Versus Dynamic Elastic Therapy for Closed Treatment of Unilateral Mandibular Sub-Condylar Fractures: A Randomized Controlled Trial. 常规(静态)与动态弹性疗法对单侧下颌髁下骨折闭合治疗的比较评价:一项随机对照试验。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2024-10-09 DOI: 10.1007/s12663-024-02342-x
Amrish Bhagol, Neetu Raj, Ankita Dahiya, Virendra Singh, Deepti Chhikara, Aakash Britto

Background: The treatment of mandibular sub-condyle fractures is controversial. Guiding elastics play an important role in managing sub-condylar fractures, as their rationale revolves around the vector and traction alteration of the fractured ends.

Purpose: This study aims to compare the outcomes of conventional closed treatment and dynamic elastic therapy for the treatment of unilateral mandibular sub-condylar fractures.

Study design: The study design was a double-blinded prospective randomized controlled trial. Patients ≥ 18 years of age, with unilateral sub-condylar fractures with or without associated mandibular fractures, were randomized into experimental and control groups.

Predictor: The predictor variable was the type of method used for fracture management, either conventional way or dynamic elastic therapy.

Main outcome variables: Primary outcome variables were post-treatment occlusion, mouth opening, deviation, and patient satisfaction level scores and secondary outcome variables were protrusion, laterotrusive and mediotrusive movements, Ramal height, degree of displacement, and complications.

Covariates: Age, etiology, and site of the associated mandibular fracture were the covariates.

Analyses: Data were analyzed using the Student's t test, ANOVA followed by post hoc test, and frequencies were compared using the chi-square test. For all the statistical tests, p < 0.05 was considered to be statistically significant.

Results: The study incorporated 34 patients, out of which 22 had sub-condylar fractures along with associated mandibular fractures, and the rest 12 were isolated. There were no significant differences between the two groups in terms of occlusion, mouth opening, Ramal height, mediotrusion, and laterotrusion, and degree of the displaced condyle. (p > 0.05). Among the GOHAI scale questions, used for patient satisfaction score assessment, question 10 produced a highly statistically significant p value < 0.001 (p value- 0.006). There is a statistically non-significant difference seen (p > 0.05) for the values of all variables between the groups, except for the protrusion baseline with higher values in the conventional group (p = 0.044) and deviation baseline with higher values in the dynamic elastic therapy group. (p = 0.018).

Conclusions: Both treatment options provide satisfactory results for the management of sub-condylar fractures but novel guiding elastic therapy has few advantages over conventional elastic therapy such as improved treatment satisfaction.

背景:下颌髁下骨折的治疗存在争议。引导弹性在治疗髁下骨折中起着重要的作用,因为其原理是围绕骨折端的矢量和牵引改变。目的:比较常规封闭治疗与动态弹性治疗治疗单侧下颌髁下骨折的疗效。研究设计:研究设计为双盲前瞻性随机对照试验。年龄≥18岁,单侧髁下骨折伴或不伴下颌骨骨折的患者随机分为实验组和对照组。预测因素:预测变量是用于骨折处理的方法类型,是常规方法还是动态弹性治疗。主要结果变量:主要结果变量为治疗后咬合、开口、偏差和患者满意度评分,次要结果变量为突出、侧突和中突运动、Ramal高度、移位程度和并发症。协变量:年龄、病因和相关的下颌骨折部位为协变量。数据分析采用学生t检验,方差分析后进行事后检验,频率比较采用卡方检验。结果:本研究纳入34例患者,其中22例为髁下骨折合并下颌骨骨折,其余12例为孤立性骨折。两组患者在咬合、开口、腓骨高度、中突和侧突以及髁突移位程度方面均无显著差异。(p < 0.05)。在用于患者满意度评分评估的GOHAI量表问题中,问题10产生了高度统计学显著的p值(p值- 0.006)。除常规组突出基线值较高(p = 0.044)、动态弹性治疗组偏差基线值较高外,各组间各变量值差异均无统计学意义(p < 0.05)。(p = 0.018)。结论:两种治疗方法治疗髁下骨折均有满意的效果,但新型导向弹性治疗在提高治疗满意度等方面与传统弹性治疗相比优势不大。
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引用次数: 0
The Clear Cell Odontogenic Carcinoma: Case Report of a Rare Jaw Malignancy. 透明细胞牙源性癌:1例罕见颌骨恶性肿瘤。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-07-11 DOI: 10.1007/s12663-025-02590-5
Vasco Starke, Markus Merkl, Lukas Grössing, Mauro Pau, Wolfgang Zemann

Clear cell odontogenic carcinoma is a very rare malignant tumor of the jaw. Diagnosis and treatment may be challenging as the tumor grows locally aggressive and infiltrative with possible metastatic spread, while the clinical presentation varies, and the definitive diagnosis can only be confirmed by immunohistopathology. The case of a 25-year-old male patient with clear cell odontogenic carcinoma of the mandible is presented. Therapeutic treatment included primary surgical resection with bilateral removal of cervical lymph nodes followed by a two-stage reconstruction approach. Continuous follow-up over 7.5 years showed no signs of tumor recurrence.

透明细胞牙源性癌是一种非常罕见的颌骨恶性肿瘤。诊断和治疗可能具有挑战性,因为肿瘤局部具有侵袭性和浸润性,并可能转移扩散,而临床表现各不相同,最终诊断只能通过免疫组织病理学证实。病例25岁的男性患者与透明细胞牙源性癌的下颌骨提出。治疗方法包括初级手术切除双侧颈部淋巴结,然后进行两期重建。连续随访7.5年未见肿瘤复发迹象。
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引用次数: 0
The Restoration of Lower Facial Width in Trifocal Mandibular Fractures Using Pre-fabricated Inter-Occlusal Splint: A Clinical Study. 应用预制咬合间夹板修复下颌三瓣骨折下面宽的临床研究。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-05-31 DOI: 10.1007/s12663-025-02557-6
P Elavenil, Radhika Menon, M Thilagavathy, V Ananthanarayanan, V B Krishnakumar Raja

Purpose: Trifocal (bilateral condyle and anterior mandible) fractures of mandible lead to increased lower facial width. The methods currently described in literature are associated with limitations and offer less predictable intra-operative guidance. This study was designed to evaluate the effectiveness of pre-fabricated inter-occlusal splints in restoring the lower facial width.

Materials and methods: A retrospective cohort study was designed involving patients who were treated for trifocal fractures. Pre-fabricated inter-occlusal splint had been used during reduction and stabilization/fixation of symphysis/condyle fracture to establish the lower facial width. Data were collected from clinical records (photographs and case sheets) and computed tomographic (CT) images. Study variables included clinical parameters such as inter-gonial width, lower facial height, mouth opening, and occlusion. Radiological (CT) parameters were inter-gonial width and inter-molar width. Data analysis was done by SPSS (V 26) using Shapiro-Wilk test and paired t test.

Results: A total of nine patients (eight males and one female) with mean age of 27.2 (SD ± 8.47) years were included in the study. The study showed statistically significant decrease (p value-0.001) in inter-gonial width (clinical and radiological), lower facial height, and inter-molar width after treatment. All patients demonstrated improved mouth opening (p value-0.001) and corrected dental occlusion.

Conclusion: The intra-operative use of splints is effective in restituting lower facial width in the management of trifocal fractures. The technique is simple and predictable.

目的:下颌骨三焦(双侧髁和前下颌)骨折导致下面部宽度增加。目前文献中描述的方法存在局限性,术中指导的可预见性较差。本研究旨在评估预制咬合间夹板在恢复下面部宽度方面的有效性。材料和方法:设计了一项回顾性队列研究,纳入了接受三灶性骨折治疗的患者。在联合/髁骨折复位和稳定/固定期间使用预制咬合间夹板来确定下面部宽度。数据收集自临床记录(照片和病例表)和计算机断层扫描(CT)图像。研究变量包括临床参数,如骨间宽度、下面部高度、张嘴和咬合。CT影像学参数为角骨间宽度和磨牙间宽度。数据分析采用SPSS (v26)软件,采用Shapiro-Wilk检验和配对t检验。结果:共纳入9例患者,男8例,女1例,平均年龄27.2 (SD±8.47)岁。研究显示,治疗后的骨间宽度(临床和影像学)、下面部高度和磨牙间宽度均有统计学意义(p值0.001)的降低。所有患者均表现出改善的张嘴(p值0.001)和矫正的牙合。结论:术中使用夹板可有效地恢复三焦性骨折的下面部宽度。这项技术简单且可预测。
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引用次数: 0
Efficacy of Oral and Intralesional Pentoxifylline in Grade II and Grade III Oral Submucous Fibrosis: a Systematic Review. 口服和病灶内己酮可可碱治疗II级和III级口腔黏膜下纤维化的疗效:系统综述。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1007/s12663-025-02728-5
Seema Dengra, Nitin Bhola, Anand Nikunj, Bathri Elangovan
<p><strong>Purpose: </strong>Oral submucous fibrosis (OSMF) is a debilitating oral disease. The underlying cause of its pathogenesis is progressive loss of vascularity in the diseased mucosa resulting in epithelial atrophy. Various non-surgical treatment modalities have been prescribed in various literatures, but due to the multifactorial nature of the disease no single treatment has been advocated. Various intralesional injections in combination with oral medications have been advocated for the treatment. Currently, pentoxifylline is reported to have satisfactory results in the management of OSMF due to its immune modulation, alteration of fibroblast physiology, rheologic modification and anti-inflammatory property. Among these, oral pentoxifylline in combination with intralesional injections of dexamethasone and hyaluronidase have shown promising results. There is very less evidence of intralesional pentoxifylline use in the treatment of OSMF. The present study conducted a systematic review to find the efficacy of oral and intralesional pentoxifylline in grade II and grade III oral submucous fibrosis.</p><p><strong>Methods: </strong>This review followed the principles of systematic reviews. We conducted a comprehensive literature search of 5 databases according to PRISMA guidelines. Research articles published in English from 2006 till 2022 were reviewed. The keywords consisted of OSMF, oral, intralesional, pentoxifylline, dexamethasone, and routes of administration. In this study, Rayyan online software was used to identify and eliminate duplicate articles, and another reviewer was invited to screen the articles independently. The included articles' data were extracted, and conclusions were drawn after cross-comparison. Primary outcomes assessed were objective changes, like an increase in interincisal distance, and subjective changes, including a reduction in pain and burning sensation using the visual analog scale (VAS) and cheek flexibility. Secondary outcomes assessed were subjective or objective changes, which included any side effects of intervention and subjective changes in quality of life.</p><p><strong>Results: </strong>Ninety articles were identified through the database search, and an additional study was identified through the other sources. After screening the articles based on the inclusion criteria, 52 articles were excluded due to non-compliance of adequate data according to the specified criteria. 38 full-text articles were assessed, and finally, 16 articles were included in qualitative synthesis.</p><p><strong>Conclusion: </strong>The therapeutic benefits of oral pentoxifylline are unclear in terms of patient compliance as well as the side effects that may result due to its route of administration as compared to intralesional pentoxifylline combined with other intralesional steroids, where the effect will be seen in local tissues with nil or minimal side effects. Hereby proves beneficial in improving the symptoms of the disea
目的:口腔黏膜下纤维化(OSMF)是一种使人衰弱的口腔疾病。其发病机制的根本原因是病变粘膜血管的逐渐丧失导致上皮萎缩。在各种文献中已经规定了各种非手术治疗方式,但由于疾病的多因素性质,没有单一的治疗方法被提倡。各种病灶内注射与口服药物相结合已被提倡用于治疗。目前,己酮茶碱由于其免疫调节、成纤维细胞生理改变、流变学改变和抗炎特性,在OSMF的治疗中有令人满意的结果。其中,口服己酮可可碱联合局部注射地塞米松和透明质酸酶已显示出良好的效果。很少有证据表明,局部使用己酮茶碱治疗OSMF。本研究进行了系统回顾,以发现口服和局部内己酮茶碱治疗II级和III级口腔黏膜下纤维化的疗效。方法:本综述遵循系统综述的原则。我们根据PRISMA指南对5个数据库进行了全面的文献检索。回顾了2006年至2022年发表的英文研究论文。关键词为OSMF、口服、局部、己酮可可碱、地塞米松、给药途径。本研究采用Rayyan在线软件识别和消除重复文章,并邀请另一位审稿人独立筛选文章。提取纳入文献的资料,交叉比较得出结论。评估的主要结果是客观变化,如内脏距离的增加,以及主观变化,包括使用视觉模拟量表(VAS)和脸颊灵活性减少疼痛和烧灼感。评估的次要结果是主观或客观的变化,包括干预的任何副作用和生活质量的主观变化。结果:通过数据库检索确定了90篇文章,并通过其他来源确定了另外一项研究。根据纳入标准筛选文献后,52篇文献因资料不符合规定标准而被排除。评估了38篇全文文章,最后将16篇文章纳入定性综合。结论:与己酮茶碱与其他局灶内类固醇联合使用相比,口服己酮茶碱的治疗效果在患者依从性和可能因其给药途径而产生的副作用方面尚不清楚,后者的作用将在局部组织中出现,副作用为零或最小。由此证明对改善疾病症状是有益的。
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引用次数: 0
Trapezoid Genioplasty: A New Technique. 梯形颏成形术:一项新技术。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-10-05 DOI: 10.1007/s12663-025-02768-x
Eren Pera, Lina Aljumaili
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引用次数: 0
Molecular Mechanisms of Preventable Causes of Oral Cancer and Precancer Through Polymorphism in DNA Base Excision Repair Genes in Patients with Tobacco Products Habits. 烟草制品习惯患者DNA碱基切除修复基因多态性研究口腔癌和癌前病变可预防原因的分子机制
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2024-08-01 DOI: 10.1007/s12663-024-02294-2
Ezhilarasi Sundaram, Shadab Mohammad, Rakesh Kumar Singh, Vibha Singh, Mohammad Kaleem Ahmad, Amiya Agrawal, Arunesh Kumar Tiwari, Anveshika Manoj

Introduction: The 'progression model' of oral carcinogenesis emphasizes that initial irreversible genotypic damage produces tissue disorganization and dysmaturation which, if allowed to progress, leads invariably towards invasive oral squamous cell carcinoma. Recognition of these genotypic changes is fundamental for a successful management strategy. Genetic studies have confirmed the role of pro-carcinogens present in tobacco and alcohol contributing to DNA damage and genotoxicity. Many molecular epidemiological studies have evaluated the association of head and neck cancer with polymorphisms in DNA repair genes. Our study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of DNA repair genes OGG1 Ser326Cys, APE1-Asp148Glu, XRCC1- Arg194Trp, XRCC1-Arg280His, XRCC1-Arg399Gln, ADPRT-V762A, APEX1-D148E, LIG3-R780H, MUTYH-Tyr165Cys and the risk of oral squamous cell carcinoma and oral precancerous lesions.

Materials and method: Our study included two patient groups. Group I (n = 58) included patients with leukoplakia, oral submucous fibrosis and biopsy-proven oral squamous cell carcinoma. Group II (n = 58) included patients who had no clinically detectable lesions. Patients in both groups had tobacco chewing and smoking history. Blood samples were collected, and gene polymorphisms were identified using PCR-RFLP technique.

Results and discussion: Our study results revealed a statistically significant association between gene polymorphisms OGG1-Ser326Cys (p = 0.008), XRCC1-Arg194Trp (p = 0.009), XRCC1-Arg399Gln (p < 0.001), APEX1-Asp148Glu (p < 0.001) and the occurrence of leukoplakia, OSMF and OSCC.

口腔癌发生的“进展模型”强调,最初不可逆的基因型损伤会产生组织紊乱和不成熟,如果任由其发展,必然导致侵袭性口腔鳞状细胞癌。认识到这些基因型变化是成功管理策略的基础。遗传学研究已经证实,烟草和酒精中存在的致癌物会导致DNA损伤和遗传毒性。许多分子流行病学研究已经评估了头颈癌与DNA修复基因多态性的关系。本研究旨在探讨DNA修复基因OGG1 Ser326Cys、APE1-Asp148Glu、XRCC1- Arg194Trp、XRCC1- arg280his、XRCC1- arg399gln、ADPRT-V762A、APEX1-D148E、LIG3-R780H、MUTYH-Tyr165Cys的单核苷酸多态性与口腔鳞状细胞癌和口腔癌前病变风险的关系。材料和方法:我们的研究包括两组患者。I组(n = 58)包括白斑、口腔黏膜下纤维化和活检证实的口腔鳞状细胞癌患者。II组(n = 58)包括无临床可检测病变的患者。两组患者均有咀嚼烟草和吸烟史。采集血样,采用PCR-RFLP技术鉴定基因多态性。结果与讨论:我们的研究结果显示,基因多态性OGG1-Ser326Cys (p = 0.008)、XRCC1-Arg194Trp (p = 0.009)、XRCC1-Arg399Gln (p < 0.001)、APEX1-Asp148Glu (p < 0.001)与白斑、OSMF和OSCC的发生有统计学意义。
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引用次数: 0
Use of a Non-Invasive Ventilation Mask as a Guard During the Initial Postoperative Period Following Reduction of an Isolated Zygomatic Arch Fracture: A Technical Note. 在孤立性颧弓骨折复位术后初期使用无创通气面罩作为保护:技术说明。
IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1007/s12663-025-02437-z
Uday Kiran Uppada

Purpose: To propose a novel and viable modality for guarding an isolated zygomatic arch fracture following reduction in the initial postoperative phase.

Method: A silicone non-invasive ventilation mask is used efficiently as a guard during the initial postoperative period following reduction of an isolated zygomatic arch fracture.

Results: The use of a non-invasive ventilation mask as a guard is safe and versatile. However, it can be employed only in clinical situations where there are no other associated injuries or fractures of the facial skeleton.

Conclusion: The non-invasive ventilation mask is easy to use, less traumatic to the patient in addition to the fact that it aids in guarding an isolated zygomatic arch fracture following reduction during the initial postoperative phase.

目的:提出一种新颖可行的方法来保护孤立性颧弓骨折术后复位后的初始阶段。方法:在孤立性颧弓骨折复位后的术后初期,使用硅胶无创通气面罩作为有效的保护。结果:使用无创通气面罩作为防护是安全的,用途广泛。然而,它只能在没有其他相关损伤或面部骨骼骨折的临床情况下使用。结论:无创通气面罩使用方便,对患者创伤小,有助于在术后初始阶段保护孤立性颧弓骨折复位。
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Journal of Maxillofacial & Oral Surgery
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