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Common Tumour at a Rare Site: Colloid Goitre with Degenerative Changes in Cheek. 罕见部位的常见肿瘤:脸颊胶质甲状腺肿大伴退行性改变
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2021-01-15 DOI: 10.1007/s12663-020-01500-1
Gyanaranjan Sahu, Amanjot Kaur, P G Gigi

Ectopic thyroid gland is a rare entity resulting from embryological aberration. We present a rare case of colloid goitre with degenerative changes which appeared as cheek swelling in a euthyroid adult male.

异位甲状腺是一种罕见的胚胎畸变所致的疾病。我们提出一个罕见的胶质甲状腺肿与退行性改变,出现在一个甲状腺功能正常的成年男性脸颊肿胀。
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引用次数: 0
Sub-Sigmoid Osteotomy for Transoral Removal of Ectopic Tooth From Mandibular Ramus and Sigmoid Region. 乙状突下截骨术经口切除下颌骨支及乙状突区异位牙。
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1007/s12663-024-02331-0
Anshul J Rai, Babu Lal, Jitendra Kumar, Vinisha Agrawal, Zenish Rameshbhai Bhatti

Purpose: This study proposes a novel intraoral approach combined with sub-sigmoid osteotomy to effectively and safely remove of ectopic third molar teeth without complications.

Methods: The procedure included a sub-sigmoid osteotomy to expose and remove the ectopic tooth, followed by fixation of the osteotomized coronoid with titanium plates. Preoperative cone beam computed tomography (CBCT) was used for precise tooth localization.

Results: The ectopic third molar was successfully removed with minimal bone removal. One intraoperative complication, a bad split of the anterior ramus, was observed but managed effectively. Postoperative healing was uneventful, with no nerve injury, infection, or reduced mouth opening.

Conclusion: The transoral sub-sigmoid osteotomy technique is a reproducible, effective method for ectopic third molar removal, avoiding extraoral scars, nerve damage, and extensive dissection. Preoperative planning using CBCT is essential to prevent complications, making this technique a valuable alternative to traditional approaches.

目的:提出一种新的口腔内入路联合乙状结肠下截骨术,有效、安全、无并发症地切除异位第三磨牙。方法:采用乙状骨下截骨术暴露并切除异位牙,然后用钛板固定截骨的冠状骨。术前使用锥形束ct (CBCT)进行牙齿精确定位。结果:成功拔除异位第三磨牙,除骨量最小。一个术中并发症,严重的前支分裂,被观察到,但有效地处理。术后愈合顺利,无神经损伤、感染或开口缩小。结论:经口乙状结肠下截骨术是一种可重复、有效的异位第三磨牙切除方法,避免了口外瘢痕、神经损伤和大面积剥离。术前规划使用CBCT是必不可少的,以防止并发症,使该技术有价值的替代传统方法。
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引用次数: 0
Maxillomandibular Fixation Verses Open Reduction and Internal Fixation in Mandibular Fractures-Effect on Pulmonary Functions. 上颌下颌固定与切开复位内固定治疗下颌骨骨折对肺功能的影响。
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1007/s12663-024-02327-w
Pallavi Gupta, Jeevan Lata, Nitin Verma, Sharad Gowda

Introduction: Mandibular fractures have significant influence on oropharyngeal and laryngopharyngeal portions of the upper airway. They can be managed by MMF or ORIF.

Aim & objectives: To quantify and compare the effects of MMF with ORIF on the pulmonary functions of the patients undergoing treatment for mandibular fractures.

Method: Total 42 patients with isolated mandibular fractures were randomly divided into two treatment groups. Group A comprised of 21 patients planned for ORIF under LA and Group B comprised of 21 patients planned for MMF under LA. Pulmonary function tests (PFT) were done in all participants preoperatively 24 h before, postoperatively after 24 h, 1 week, 4 weeks and 6 weeks using spirometry. FVC, FEV1, FEV1/FVC, and PEFR were determined and compared.

Results: PFT values in both the groups were comparable preoperatively 24 h before and were significantly lower than their predicted values showing adverse effect of mandibular fractures on airways. Postoperatively after 24 h, 1 week and four weeks, PFT values were significantly lower in group B (MMF) than in group A (ORIF). At six weeks postoperatively, when MMF was removed, there was no statistically significant difference in PFT values of both the groups.

Conclusion: Mandibular fracture patients presented with abnormal PFT values. Patients treated by MMF had obstructive pulmonary pattern, while those treated by ORIF had normal pulmonary pattern concluding that MMF can be dangerous to the patients with limited respiratory reserve and the use of ORIF in pulmonary comorbidity is justified.

Supplementary information: The online version contains supplementary material available at 10.1007/s12663-024-02327-w.

下颌骨骨折对上气道口咽部和喉咽部有显著影响。它们可以通过MMF或ORIF进行管理。目的:量化并比较MMF与ORIF对下颌骨骨折患者肺功能的影响。方法:42例孤立性下颌骨骨折患者随机分为两组。A组包括21名计划在LA下进行ORIF治疗的患者,B组包括21名计划在LA下进行MMF治疗的患者。所有受试者术前24小时、术后24小时、1周、4周和6周均采用肺量测定法进行肺功能测试(PFT)。测定FVC、FEV1、FEV1/FVC、PEFR并进行比较。结果:两组患者术前24 h PFT值具有可比性,且明显低于预期值,显示下颌骨折对气道的不良影响。术后24 h、1周和4周,B组(MMF)的PFT值明显低于A组(ORIF)。在术后6周,当MMF被移除时,两组的PFT值无统计学差异。结论:下颌骨骨折患者PFT值异常。MMF治疗的患者为阻塞性肺型,而ORIF治疗的患者为正常肺型,结论是MMF对呼吸储备有限的患者有危险,ORIF用于肺部合并症是合理的。补充信息:在线版本包含补充资料,提供地址:10.1007/s12663-024-02327-w。
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引用次数: 0
Management of Aesthetical and Functional Complications after Total Parotidectomy. First Long-Term Experiences with Dermal Matrix Surgimend ® in Patient Affected by Malignant Parotid Tumors. 腮腺全切除术后美学及功能并发症的处理。恶性腮腺肿瘤患者真皮基质手术的首次长期经验
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2022-07-23 DOI: 10.1007/s12663-022-01761-y
Paola Bonavolonta, Giorgio Iaconetta, Giovanni Improda, Cristiana Germano, Gerardo Borriello, Federica Goglia, Vincenzo Abbate, Pasquale Piombino, Luigi Califano, Giovanni Dell'Aversana Orabona

Background: This is an observational cohort study on patients affected by malignant parotid tumors treated with total parotidectomy. The aim of our work is to analyze and compare the effects and complications after parotidectomy, using or not SurgiMend ®.

Methods: 40 patients were retrospectively enrolled between September 2014 and June 2020. Basing on the placement of SurgiMend ® for parotid lodge reconstruction, the samples were divided into two groups. Thus, the incidence rate of complications after the surgical procedure was analyzed between the two groups.

Results: Patients in whom SurgiMend ® was used reported a lower rate of complications. The ANOVA test (p = 0.05) revealed a significant difference of Vancouver Scar Scale (VSS) between the two groups, representation as vascularity and pigmentation improvement, changing scar color, scar height reduction, and increased pliability.

Conclusion: Although many techniques are available to fill the parotidectomy defect, improve facial contour and prevent Frey's syndrome, the use of SurgiMend ® matrix is one of most effective and reliable method to address these complications, with the advantage of decreased operative time due to not require an additional surgical donor site.

背景:这是一项对恶性腮腺肿瘤行腮腺全切除术的观察性队列研究。我们的工作目的是分析和比较腮腺切除术后使用或不使用SurgiMend®的效果和并发症。方法:2014年9月至2020年6月回顾性纳入40例患者。根据使用SurgiMend®进行腮腺腔重建的位置,将样本分为两组。分析两组患者术后并发症的发生率。结果:使用SurgiMend®的患者并发症发生率较低。方差分析(p = 0.05)显示两组之间温哥华疤痕量表(VSS)有显著差异,表现为血管和色素沉着改善,疤痕颜色改变,疤痕高度降低,柔韧性增加。结论:虽然有许多技术可用于填补腮腺切除术缺损,改善面部轮廓和预防Frey综合征,但使用SurgiMend®基质是解决这些并发症最有效和可靠的方法之一,其优点是由于不需要额外的手术供区而缩短了手术时间。
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引用次数: 0
Knowledge and Perception of Oral and Maxillofacial Surgery as a Specialty Amongst Dental and Medical Students at a Public University in the Gulf Cooperation Council (GCC): A Comparative Study. 海湾合作委员会(GCC)一所公立大学牙科和医学生对口腔颌面外科专业的知识和认知:一项比较研究
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2021-01-16 DOI: 10.1007/s12663-020-01491-z
Mohammad Kamal, Mohammad Abdulwahab, Ahmed Al-Zaid

Purpose: Awareness about the oral and maxillofacial surgery (OMFS) specialty in the Gulf Cooperation Council has increased in recent years with the expanding scope of practice of the specialty. Nevertheless, the perception of OMFS has not yet been investigated among healthcare students. The aim of this study was to compare the perceptions and knowledge of dental and medical students about OMFS.

Materials and methods: A cross-sectional study evaluating 100 dental and 100 medical students attending Kuwait University was conducted using a previously validated survey instrument. Students were instructed to select the most appropriate specialist to treat certain procedures across four disciplines: reconstruction, trauma, pathology and cosmetic procedures. Student year groups were compared statistically using Fisher's exact test.

Results: The responses of both student groups showed disparities, with dental students showing overwhelmingly more awareness of the practice of OMFS. OMFS was preferred overall for most clinical scenarios in trauma (p < 0.001), pathology (p < 0.001), and reconstructive surgery (p < 0.001). Plastic surgery was preferred for cosmetic surgeries (p < 0.001).

Conclusion: Our findings prompt us to revisit our dental and medical school's curriculum to increase the educational content related to OMFS procedures. Additional healthcare promotional campaigns and clinical awareness regarding OMFS are needed among healthcare professionals, university clinics and medical venues.

目的:近年来,随着口腔颌面外科(OMFS)专业的执业范围不断扩大,海湾合作委员会对该专业的认识有所提高。然而,尚未调查卫生保健专业学生对OMFS的看法。本研究的目的是比较牙科和医科学生对OMFS的认知和知识。材料和方法:对科威特大学的100名牙科学生和100名医科学生进行了横断面研究,使用了一种经过验证的调查工具。学生们被要求选择最合适的专家来治疗四个学科的某些手术:重建、创伤、病理和美容手术。学生年级组使用Fisher精确检验进行统计比较。结果:两个学生群体的反应存在差异,牙科学生对OMFS的实践表现出压倒性的更多认识。结论:我们的研究结果促使我们重新审视牙科和医学院的课程,以增加与OMFS手术相关的教育内容。医疗保健专业人员、大学诊所和医疗场所需要开展更多的医疗保健宣传活动,提高对OMFS的临床认识。
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引用次数: 0
Impacted Mandibular Third Molars Close to the Inferior Alveolar Nerve (IAN) Coronectomy: A Surgical Approach with Minimal Risk of Nerve Injury. 靠近下牙槽神经的阻生下颌第三磨牙冠切除术:一种神经损伤风险最小的手术方法。
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2024-08-12 DOI: 10.1007/s12663-024-02303-4
Lam Nguyen Le, Khue Nhut Truong, Vinh Ngoc Khanh Kim, Tan Nhat Lam, Khanh Vu Phuong Le

Aims and objectives: To evaluate the efficacy of treatment following coronectomy on mandibular third molars with inferior alveolar nerve (IAN) involvement.

Methods: A cross-sectional descriptive analysis was done on the mandibular third molars of 37 people (≥ 18 years old, 28 males, and 9 females) who needed a coronectomy and had a confirmed diagnosis of IAN in groups I, II, and III according to the classification of Q. Luo 2018, as found by CBCT.

Result: The most prevalent indication in panoramic photographs was an interruption of the canal sign's white line (45.9%). The coronectomy approach had a success rate of 100%. There were statistically significant differences in the degree of vertical and horizontal face swelling, as well as mouth opening, between the second and third postoperative days. No incidences of paresthesia were reported after surgery. The root migrated the most in the first 3 months following surgery, measuring 2.43 ± 1.08 mm. At 6 months following surgery, the root migrated by 2.95 ± 1.27 mm. At 9 months following surgery, the root migrated 3.04 ± 1.19 mm from its initial location.

Conclusion: The risk of complications after a coronectomy seems to be inadequate, at least in the immediate aftermath of the operations. Coronectomy may be required for molars that are close to the IAN. Due to the roots often receding from the IAN, a second procedure to remove the remaining roots is typically performed with minimal risk of paresthesia.

目的:探讨冠状切除术后下颌第三磨牙累及下牙槽神经的治疗效果。方法:对CBCT发现的37例(年龄≥18岁,男性28例,女性9例)需要行冠状切除术并确诊为IAN的I、II、III组患者(按Q. Luo 2018分类)的下颌第三磨牙进行横断面描述性分析。结果:全景照片中最常见的指征是管状标志白线中断(45.9%)。冠状切除术的成功率为100%。术后第2天和第3天,面部垂直和水平肿胀程度以及开口程度均有统计学差异。手术后无感觉异常发生。术后前3个月牙根偏移量最大,为2.43±1.08 mm。术后6个月,牙根偏移2.95±1.27 mm。术后9个月,根距初始位置偏移3.04±1.19 mm。结论:冠状动脉切除术后并发症的风险似乎不足,至少在手术后立即发生。对于靠近IAN的磨牙,可能需要冠状切除术。由于根通常从IAN后退,第二次手术切除剩余的根通常以最小的感觉异常风险进行。
{"title":"Impacted Mandibular Third Molars Close to the Inferior Alveolar Nerve (IAN) Coronectomy: A Surgical Approach with Minimal Risk of Nerve Injury.","authors":"Lam Nguyen Le, Khue Nhut Truong, Vinh Ngoc Khanh Kim, Tan Nhat Lam, Khanh Vu Phuong Le","doi":"10.1007/s12663-024-02303-4","DOIUrl":"https://doi.org/10.1007/s12663-024-02303-4","url":null,"abstract":"<p><strong>Aims and objectives: </strong>To evaluate the efficacy of treatment following coronectomy on mandibular third molars with inferior alveolar nerve (IAN) involvement.</p><p><strong>Methods: </strong>A cross-sectional descriptive analysis was done on the mandibular third molars of 37 people (≥ 18 years old, 28 males, and 9 females) who needed a coronectomy and had a confirmed diagnosis of IAN in groups I, II, and III according to the classification of Q. Luo 2018, as found by CBCT.</p><p><strong>Result: </strong>The most prevalent indication in panoramic photographs was an interruption of the canal sign's white line (45.9%). The coronectomy approach had a success rate of 100%. There were statistically significant differences in the degree of vertical and horizontal face swelling, as well as mouth opening, between the second and third postoperative days. No incidences of paresthesia were reported after surgery. The root migrated the most in the first 3 months following surgery, measuring 2.43 ± 1.08 mm. At 6 months following surgery, the root migrated by 2.95 ± 1.27 mm. At 9 months following surgery, the root migrated 3.04 ± 1.19 mm from its initial location.</p><p><strong>Conclusion: </strong>The risk of complications after a coronectomy seems to be inadequate, at least in the immediate aftermath of the operations. Coronectomy may be required for molars that are close to the IAN. Due to the roots often receding from the IAN, a second procedure to remove the remaining roots is typically performed with minimal risk of paresthesia.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"23 6","pages":"1462-1469"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pattern and Management of Maxillofacial Trauma in Selected Trauma Units Across Africa: A Prospective Pilot Study. 在非洲选定的创伤单位中颌面创伤的模式和管理:一项前瞻性试点研究。
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2024-09-20 DOI: 10.1007/s12663-024-02332-z
Mzubanzi Mabongo, Grace E Parkins, Timothy Aladelusi, Mohammed Adam Sheikh Abdullahi, Félicité Ngounou Ngamo, Imade J Ayo-Yusuf, Paa-Kwesi Blankson, Emmy N Nokaneng, Tshepiso Mfolo, Matthew O Boamah

Introduction: Trauma to the facial region could lead to considerable social, psychological and economic consequences. With the African region being a major contributor to global trauma events, we set out to describe the epidemiology and management of maxillofacial trauma in selected trauma units across Africa.

Materials and methods: This was a six-month prospective multicentre study carried out during March-September 2021.The study involved five major hospitals across the African continent. The patterns of maxillofacial injuries were recorded and patients managed according to local standardized operating protocols. Treatment delays and postoperative complications were recorded at review. Data analysis included descriptive statistics and regression analysis (p < 0.05). PFindings.A total of 195 patients were included in the study. The age range of patients was 1-87 years, with a mean age of 32.4 (SD =  ± 16.1). The study population consisted of 43 (22.1%) females, accounting for a Male:Female ratio of 3.5:1. Lacerations were the most common soft tissue injuries observed, while the prevalence of upper-, mid-, and lower- third fractures were 5.1%, 33.8%, and 19.5% respectively. There was loss of consciousness in 27.2%. Road crashes were the predominant aetiology of injuries, while 33.8% had concomitant injuries. About 38.3% of participants experienced treatment delays. Compared to employed patients, unemployed patients had significantly higher odds of experiencing treatment delays (OR = 3.76; 95%CI: 1.62 - 8.73).

Conclusion: With the overwhelming contribution of road crashes, measures to ensure road safety are needed to significantly reduce maxillofacial injuries in the African region, while also reducing socioeconomic inequality to timely treatment.

面部创伤可能导致相当大的社会、心理和经济后果。由于非洲地区是全球创伤事件的主要贡献者,我们开始描述非洲选定创伤单位的颌面创伤的流行病学和管理。材料和方法:这是一项为期六个月的前瞻性多中心研究,于2021年3月至9月进行。这项研究涉及非洲大陆的五家主要医院。记录颌面部损伤类型,并根据当地标准化手术方案对患者进行处理。回顾时记录治疗延误和术后并发症。数据分析包括描述性统计和回归分析(p结论:由于道路交通事故占绝大多数,因此需要采取措施确保道路安全,以显著减少非洲区域的颌面伤害,同时减少及时治疗的社会经济不平等。
{"title":"Pattern and Management of Maxillofacial Trauma in Selected Trauma Units Across Africa: A Prospective Pilot Study.","authors":"Mzubanzi Mabongo, Grace E Parkins, Timothy Aladelusi, Mohammed Adam Sheikh Abdullahi, Félicité Ngounou Ngamo, Imade J Ayo-Yusuf, Paa-Kwesi Blankson, Emmy N Nokaneng, Tshepiso Mfolo, Matthew O Boamah","doi":"10.1007/s12663-024-02332-z","DOIUrl":"https://doi.org/10.1007/s12663-024-02332-z","url":null,"abstract":"<p><strong>Introduction: </strong>Trauma to the facial region could lead to considerable social, psychological and economic consequences. With the African region being a major contributor to global trauma events, we set out to describe the epidemiology and management of maxillofacial trauma in selected trauma units across Africa.</p><p><strong>Materials and methods: </strong>This was a six-month prospective multicentre study carried out during March-September 2021.The study involved five major hospitals across the African continent. The patterns of maxillofacial injuries were recorded and patients managed according to local standardized operating protocols. Treatment delays and postoperative complications were recorded at review. Data analysis included descriptive statistics and regression analysis (<i>p</i> < 0.05). PFindings.A total of 195 patients were included in the study. The age range of patients was 1-87 years, with a mean age of 32.4 (SD =  ± 16.1). The study population consisted of 43 (22.1%) females, accounting for a Male:Female ratio of 3.5:1. Lacerations were the most common soft tissue injuries observed, while the prevalence of upper-, mid-, and lower- third fractures were 5.1%, 33.8%, and 19.5% respectively. There was loss of consciousness in 27.2%. Road crashes were the predominant aetiology of injuries, while 33.8% had concomitant injuries. About 38.3% of participants experienced treatment delays. Compared to employed patients, unemployed patients had significantly higher odds of experiencing treatment delays (OR = 3.76; 95%CI: 1.62 - 8.73).</p><p><strong>Conclusion: </strong>With the overwhelming contribution of road crashes, measures to ensure road safety are needed to significantly reduce maxillofacial injuries in the African region, while also reducing socioeconomic inequality to timely treatment.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"23 6","pages":"1620-1626"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Stage Total Lip Reconstruction Using Two Free Radial Forearm Flaps: A Case Report. 前臂游离桡骨皮瓣单期全唇重建1例。
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2023-12-01 DOI: 10.1007/s12663-023-02067-3
Swagnik Chakrabarti, Avadhut Phad, Chaitra Shetty, Abhishek Ghosh
{"title":"Single-Stage Total Lip Reconstruction Using Two Free Radial Forearm Flaps: A Case Report.","authors":"Swagnik Chakrabarti, Avadhut Phad, Chaitra Shetty, Abhishek Ghosh","doi":"10.1007/s12663-023-02067-3","DOIUrl":"https://doi.org/10.1007/s12663-023-02067-3","url":null,"abstract":"","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"23 6","pages":"1436-1439"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Analgesic Efficacy of Dexmedetomidine as an Adjuvant to Local Anaesthesia in Maxillofacial Soft Tissue Injuries: A Prospective Randomised Clinical Trial. 右美托咪定辅助局部麻醉治疗颌面部软组织损伤的镇痛效果评价:一项前瞻性随机临床试验。
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2024-02-23 DOI: 10.1007/s12663-024-02122-7
U Hemavathi, C Sreekanth, Akshay Shetty, Aparna Melethu Krishnakumari, Shreyans Sanaki Jain, Aditya Iyengar

Aims and objectives: Dexmedetomidine is a relatively new, potent, and highly selective α2-adrenergic receptor agonist used for perioperative sympatholytic, analgesia, and sedation. We conducted this study to evaluate the effects of dexmedetomidine as an adjunct to local anaesthesia for maxillofacial soft tissue injuries as day care in the emergency department on patient hemodynamics and analgesic efficacy.

Materials and methods: Eighty patients gave informed consent to participate in the study. They were divided into Groups P and D, each of which consisted of 40 participants. Patients received saline injections in Group P, and Group D received dexmedetomidine (DEX) with local anaesthesia infiltration to both groups. Hemodynamic parameters, duration of surgery, pain of first rescue analgesia, Pain score, patient satisfaction, and surgeons satisfaction were recorded and quantified using unpaired t tests or Mann-Whitney and ANOVA tests. Data and qualitative data parameters were compared using Chi-square test. A P value < 0.05 was considered significant.

Results: Our study showed statistically significant reduced heart rate, systolic, and diastolic blood pressures in DEX compared to the placebo group where none had hypotension or bradycardia in clinical settings. The dexmedetomidine group had shorter operative time and decreased need for analgesia due to lower VAS scores. Patient and surgeon satisfaction were superior in the DEX group compared to the other groups.

Conclusion: Dexmedetomidine effectively suppresses the hemodynamic stress response during minor surgical procedures. We conclude that dexmedetomidine is an effective medication to be used in the emergency room for day-care procedures, as a potent analgesic, anxiolytic providing hemodynamically stable patients, with minimal side effects. We summarise that considering the above properties of dexmedetomidine can be incorporated into ERAS (early return after surgery) protocol, making it an optimal drug of choice as an alternative to moderate sedative drugs, in managing soft tissue injuries of maxillofacial region.

目的和目的:右美托咪定是一种相对较新的、有效的、高选择性的α - 2肾上腺素能受体激动剂,用于围手术期交感神经溶解、镇痛和镇静。我们进行了这项研究,以评估右美托咪定作为局部麻醉辅助颌面部软组织损伤作为急诊科日间护理对患者血流动力学和镇痛效果的影响。材料与方法:80例患者知情同意参与研究。他们被分为P组和D组,每组40人。P组给予生理盐水注射,D组给予右美托咪定(DEX),两组均局部麻醉浸润。记录血流动力学参数、手术时间、首次抢救镇痛疼痛、疼痛评分、患者满意度和外科医生满意度,并采用非配对t检验或Mann-Whitney检验和ANOVA检验进行量化。数据与定性资料参数采用卡方检验进行比较。A P值结果:我们的研究显示,与安慰剂组相比,DEX组的心率、收缩压和舒张压有统计学意义的降低,而安慰剂组在临床环境中没有出现低血压或心动过缓。右美托咪定组手术时间较短,由于VAS评分较低,镇痛需求减少。与其他组相比,DEX组的患者和外科医生满意度更高。结论:右美托咪定可有效抑制小手术过程中的血流动力学应激反应。我们得出结论,右美托咪定是一种有效的药物,可用于急诊室的日间护理程序,作为一种有效的镇痛药,抗焦虑药,为血流动力学稳定的患者提供最小的副作用。综上所述,考虑到右美托咪定的上述特性,可以纳入ERAS(术后早期恢复)方案,使其成为治疗颌面部软组织损伤的最佳药物选择,作为中等镇静药物的替代药物。
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引用次数: 0
Local Single-Dose Teriparatide Administration for BRONJ Prevention: Insights from a Rat Model Study. 局部单剂量特立帕肽预防BRONJ:来自大鼠模型研究的见解。
IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-01 Epub Date: 2024-09-05 DOI: 10.1007/s12663-024-02301-6
Milad Etemadi Sh, Farshad Teimoori, MohammadSoroush Sehat, Seyed Mohammad Razavi, Golnaz Tajmiri

Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents significant clinical challenges with uncertain treatment outcomes. Teriparatide, a fragment of human parathyroid hormone, shows potential in prevention strategies for BRONJ.

Objective: This study investigates the impact of a single local dose of teriparatide on BRONJ prevention in an animal model.

Methods: BRONJ was induced on 26 male Wistar rats via intraperitoneal injections of 0.06 mg/kg Zoledronic acid weekly for four weeks. Following tooth extraction under general anesthesia, rats were divided into two groups: one received teriparatide via Gelatamp in the tooth socket and the other as a local injection in the vestibule. Control groups received the treatment without teriparatide. Histopathological assessments for bone remodeling, osteoclast number, inflammation, angiogenesis, and necrosis were performed after four weeks.

Results: Histopathological analysis indicated a significant improvement in bone remodeling and new bone formation in both treatment groups compared to controls, with notably better outcomes in the injection group (p = 0.01). Necrosis in the Gelatamp group was significantly higher in the control group than in the treatment group (p = 0.01), and bone formation was significantly higher in the injection group compared to the Gelatamp group (p = 0.03).

Conclusion: Local administration of teriparatide significantly enhances bone remodeling and reduces necrosis, suggesting a potential role in the prevention of BRONJ. These findings support further clinical investigation into teriparatide as a preventive strategy against BRONJ.

背景:双膦酸盐相关的颌骨骨坏死(BRONJ)具有显著的临床挑战,治疗结果不确定。特立帕肽是人甲状旁腺激素的一种片段,显示出预防BRONJ的潜力。目的:研究单次局部剂量特立帕肽对动物模型BRONJ预防的影响。方法:用0.06 mg/kg唑来膦酸每周腹腔注射诱导26只雄性Wistar大鼠BRONJ,连续4周。全身麻醉拔牙后,将大鼠分为两组,一组通过Gelatamp在牙槽内注射特立帕肽,另一组在前庭局部注射特立帕肽。对照组不给予特立帕肽治疗。4周后进行骨重塑、破骨细胞数量、炎症、血管生成和坏死的组织病理学评估。结果:组织病理学分析显示,与对照组相比,两组骨重塑和新骨形成均有显著改善,注射组疗效明显优于对照组(p = 0.01)。Gelatamp组骨坏死明显高于对照组(p = 0.01),骨形成明显高于注射组(p = 0.03)。结论:局部应用特立帕肽可显著促进骨重塑,减少骨坏死,提示其在BRONJ的预防中具有潜在作用。这些发现支持对特立帕肽作为BRONJ预防策略的进一步临床研究。
{"title":"Local Single-Dose Teriparatide Administration for BRONJ Prevention: Insights from a Rat Model Study.","authors":"Milad Etemadi Sh, Farshad Teimoori, MohammadSoroush Sehat, Seyed Mohammad Razavi, Golnaz Tajmiri","doi":"10.1007/s12663-024-02301-6","DOIUrl":"https://doi.org/10.1007/s12663-024-02301-6","url":null,"abstract":"<p><strong>Background: </strong>Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents significant clinical challenges with uncertain treatment outcomes. Teriparatide, a fragment of human parathyroid hormone, shows potential in prevention strategies for BRONJ.</p><p><strong>Objective: </strong>This study investigates the impact of a single local dose of teriparatide on BRONJ prevention in an animal model.</p><p><strong>Methods: </strong>BRONJ was induced on 26 male Wistar rats via intraperitoneal injections of 0.06 mg/kg Zoledronic acid weekly for four weeks. Following tooth extraction under general anesthesia, rats were divided into two groups: one received teriparatide via Gelatamp in the tooth socket and the other as a local injection in the vestibule. Control groups received the treatment without teriparatide. Histopathological assessments for bone remodeling, osteoclast number, inflammation, angiogenesis, and necrosis were performed after four weeks.</p><p><strong>Results: </strong>Histopathological analysis indicated a significant improvement in bone remodeling and new bone formation in both treatment groups compared to controls, with notably better outcomes in the injection group (<i>p</i> = 0.01). Necrosis in the Gelatamp group was significantly higher in the control group than in the treatment group (<i>p</i> = 0.01), and bone formation was significantly higher in the injection group compared to the Gelatamp group (<i>p</i> = 0.03).</p><p><strong>Conclusion: </strong>Local administration of teriparatide significantly enhances bone remodeling and reduces necrosis, suggesting a potential role in the prevention of BRONJ. These findings support further clinical investigation into teriparatide as a preventive strategy against BRONJ.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"23 6","pages":"1500-1507"},"PeriodicalIF":0.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142773486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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