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A nucleosome switch primes Hepatitis B Virus infection. 核糖体开关启动了乙型肝炎病毒感染。
3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-06-12 DOI: 10.1101/2023.03.03.531011
Nicholas A Prescott, Andrés Mansisidor, Yaron Bram, Tracy Biaco, Justin Rendleman, Sarah C Faulkner, Abigail A Lemmon, Christine Lim, Pierre-Jacques Hamard, Richard P Koche, Viviana I Risca, Robert E Schwartz, Yael David

Chronic hepatitis B virus (HBV) infection is an incurable global health threat responsible for causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. The viral X gene must be expressed immediately upon infection to induce degradation of the host silencing factor, Smc5/6. However, the relationship between cccDNA chromatinization and X gene transcription remains poorly understood. Establishing a reconstituted viral minichromosome platform, we found that nucleosome occupancy in cccDNA drives X transcription. We corroborated these findings in cells and further showed that the chromatin destabilizing molecule CBL137 inhibits X transcription and HBV infection in hepatocytes. Our results shed light on a long-standing paradox and represent a potential new therapeutic avenue for the treatment of chronic HBV infection.

慢性乙型肝炎病毒(HBV)感染是一种无法治愈的全球性健康威胁,可导致肝病和肝细胞癌。在感染发生过程中,HBV 会建立一个独立的小染色体,由病毒共价闭合环状 DNA(cccDNA)基因组和宿主组蛋白组成。病毒 X 基因必须在感染后立即表达,以诱导宿主沉默因子 Smc5/6 的降解。然而,人们对cccDNA染色质化与X基因转录之间的关系仍然知之甚少。通过建立一个重组病毒小染色体平台,我们发现cccDNA中的核小体占据驱动了X基因的转录。我们在细胞中证实了这些发现,并进一步表明染色质去稳定分子 CBL137 可抑制肝细胞中的 X 转录和 HBV 感染。我们的研究结果揭示了一个长期存在的悖论,为治疗慢性 HBV 感染提供了一条潜在的新治疗途径。
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引用次数: 0
State temporary assistance for needy families policies and high school diploma or equivalent attainment among mothers following a nonmarital birth: An event history analysis 州贫困家庭临时援助政策和非婚生育母亲的高中文凭或同等学历:事件史分析
IF 1.2 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-06-02 DOI: 10.1111/ijsw.12683
Sehun Oh, Melissa Radey, Briana Smith, Daniel A. Powers

This study examines high school diploma or equivalent (HS/E) attainment by mothers who had a nonmarital birth (“unmarried mothers”) and the associations between state-level Temporary Assistance for Needy Families (TANF) policies and their postnatal HS/E attainment. Using an analytic sample of 1154 unmarried mothers without HS/E from the restricted-use Future of Families and Child Wellbeing Study, we tracked postnatal HS/E attainment patterns for 15 years, and conducted discrete-time event history analysis with mixed effects to test the relationships between states' TANF policies and postnatal HS/E attainment. Only 35.1% of the sample attained HS/E after childbirth, while nearly half of mothers who attained HS/E were not able to do so within 3 years of childbirth. A $100 higher maximum monthly benefit amount is associated with 86.1% higher odds of postnatal HS/E attainment, indicating the need to consider increasing TANF benefit amounts as a means to promote educational attainment among unmarried mothers with educational disadvantages.

本研究探讨了非婚生育母亲("未婚母亲")的高中文凭或同等学历(HS/E)获得情况,以及州级贫困家庭临时援助(TANF)政策与她们产后 HS/E 获得情况之间的关联。我们从限制使用的 "家庭未来与儿童福祉研究"(Future of Families and Child Wellbeing Study)中抽取了 1154 名没有获得 HS/E 的未婚母亲作为分析样本,对她们产后获得 HS/E 的模式进行了长达 15 年的追踪,并采用混合效应的离散时间事件历史分析方法来检验各州的 TANF 政策与产后获得 HS/E 之间的关系。只有 35.1% 的样本在产后达到了 HS/E,而将近一半达到 HS/E 的母亲在产后 3 年内未能达到。每月最高补助金额增加 100 美元,产后达到 HS/E 的几率就会增加 86.1%,这表明有必要考虑增加 TANF 补助金额,以此来提高教育条件不利的未婚母亲的受教育程度。
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引用次数: 0
Social safety net features in East Asia: A comparative analysis using the model family approach 东亚社会安全网的特点:利用示范家庭法进行比较分析
IF 1.2 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-05-20 DOI: 10.1111/ijsw.12678
Julia Shu-Huah Wang, Aya Abe, Ji Young Kang, Inhoe Ku, Irene Y. H. Ng, Chenhong Peng, Xi Zhao

East Asian (EA) social welfare has been described as productivist, where social policies are subordinate to economic development. However, EA comparative studies often focus on a few select social policies and seldom examine welfare programs as a bundle. We contribute to the depiction of divergent features of EA safety nets by exploring welfare content (generosity, coverage, protective vs. productive, and work incentives) and welfare outcomes (poverty reduction and income redistribution) for lower-income populations in the largest city in mainland China, Hong Kong, Japan, Singapore, South Korea, and Taiwan. We collected model family (MF) data and analyzed the data through descriptive statistics and regression models. We found that Taiwan and Hong Kong, followed by Japan, have more generous programs for reducing poverty, while Korea focuses on productive programs; Singapore offers wide coverage and strong work incentives for low-income families yet lags behind in generosity; and China appears to be a laggard in welfare provision in the region. Our findings reveal heterogeneity within EA welfare systems, and our synthesis of welfare features using MF data offers a promising, innovative strategy for conducting comparative research in regions with limited comparable data.

东亚(EA)的社会福利被描述为生产主义,即社会政策从属于经济发展。然而,东亚比较研究通常只关注少数几项选定的社会政策,而很少将福利项目作为一个整体来研究。我们探讨了中国大陆、香港、日本、新加坡、韩国和台湾最大城市低收入人群的福利内容(慷慨程度、覆盖范围、保护性与生产性以及工作激励)和福利结果(减贫和收入再分配),从而为描述经济适用房安全网的不同特征做出了贡献。我们收集了示范家庭(MF)数据,并通过描述性统计和回归模型对数据进行了分析。我们发现,台湾和香港的减贫项目更为慷慨,其次是日本,而韩国则侧重于生产性项目;新加坡为低收入家庭提供了广泛的覆盖面和强有力的工作激励,但在慷慨程度上却落后于其他国家;而中国似乎是该地区福利提供方面的落后者。我们的研究结果揭示了东亚地区福利制度的异质性,我们利用多边基金数据对福利特征进行的综合分析,为在可比数据有限的地区开展比较研究提供了一种前景广阔的创新策略。
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引用次数: 0
What if it is not just an additional income? Poverty risks of non‐standard employment histories in Germany 如果不只是额外收入呢?德国非标准工作经历的贫困风险
IF 1.9 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-05-08 DOI: 10.1111/ijsw.12676
Fridolin Wolf
While the poverty risks associated with transitions to and from different forms of non‐standard employment (NSE) have been studied extensively, poverty research on NSE histories remains fuzzy. Therefore, this study focuses on persons with NSE histories whose earnings contribute significantly to the household income, asking to what extent they are exposed to income poverty risks during their main career phase and examining the role of employment, family and sociodemographic characteristics. Employment histories were observed over 10 years using German Socio‐Economic Panel data from 2001 to 2020. A sequence cluster analysis identified four NSE clusters with increased poverty risks, namely, those with increasing and permanent low‐part‐time work, those who were mainly temporary agency‐employed or had long episodes of fixed‐term employment. Multivariate regressions considering employment‐specific, care‐related and sociodemographic characteristics revealed a network of cumulative disadvantages related to gender, occupational position, care obligations and structural disadvantages for those clusters.
虽然与不同形式的非标准就业(NSE)过渡相关的贫困风险已被广泛研究,但有关非标准就业历史的贫困研究仍然模糊不清。因此,本研究将重点放在有非标准就业经历且收入对家庭收入有重大贡献的人身上,询问他们在主要职业生涯阶段面临收入贫困风险的程度,并研究就业、家庭和社会人口特征的作用。利用 2001 年至 2020 年的德国社会经济面板数据,对 10 年的就业历史进行了观察。通过序列聚类分析,确定了贫困风险增加的四个 NSE 聚类,即从事越来越多的长期低兼职工作的聚类、主要从事临时中介工作的聚类或长期从事固定期限工作的聚类。考虑到特定就业、与护理相关和社会人口特征的多变量回归显示,这些群组存在与性别、职业地位、护理义务和结构性劣势相关的累积劣势网络。
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引用次数: 0
Welfare conditionality in Latin America's conditional cash transfers: Models and trends 拉丁美洲有条件现金转移中的福利条件:模式和趋势
IF 1.2 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-05-07 DOI: 10.1111/ijsw.12677
Florencia Antía, Cecilia Rossel, Sofía Karsaclian

To what extent have Latin America's Conditional Cash Transfer (CCT) programs adopted different forms of conditionality? What are the main features of this variation, if any? In this article, we show that conditionalities vary across Latin America's CCTs and across time within programs. Drawing on existing conceptualizations of welfare conditionality and a novel, purpose-built dataset covering 16 countries from 1997 to 2019, we analyze the evolution and variation in the design of welfare conditionality in the region. We find that conditionalities among Latin America's CCTs exhibit many different types and also vary significantly in how the program's main attributes—behavioral requirements, monitoring, and sanctioning rules—combine and evolve across time in each program. These combinations show that governments do not consistently produce “pure” CCT models but instead use conditionality features in many different ways and also adjust them over time, frequently to make more explicit what they expect from CCT recipients.

拉丁美洲的有条件现金转移(CCT)计划在多大程度上采用了不同形式的条件性?如果有的话,这种差异的主要特征是什么?在本文中,我们将说明在拉丁美洲的有条件现金转移项目中,以及在项目内部的不同时期,条件性是各不相同的。借鉴现有的福利附加条件概念和一个涵盖 16 个国家(从 1997 年到 2019 年)的新型专用数据集,我们分析了该地区福利附加条件设计的演变和变化。我们发现,拉美国家的 CCTs 中的附加条件表现出多种不同类型,而且在每个项目中,项目的主要属性--行为要求、监督和制裁规则--的组合和随时间演变的方式也大不相同。这些组合表明,各国政府并没有始终如一地制定 "纯粹的" CCT 模式,而是以多种不同的方式使用条件性特征,并随着时间的推移对其进行调整,经常是为了更加明确地表达他们对 CCT 受惠者的期望。
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引用次数: 0
Poverty and public works: Evidence from Hungary 贫困与公共工程:匈牙利的证据
IF 1.2 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-05-02 DOI: 10.1111/ijsw.12673
Claudia Colombarolli, András Gábos

This paper investigates how being employed in public works exposes workers and their households to poverty. Public works consist of centrally planned and financed works targeting long-term unemployed or inactive. Evidence is primarily negative concerning improved employment trajectories, while we still know little about the poverty outcomes. To examine this, we draw on the 2014–2019 cross-sectional data of the EU-SILC survey for Hungary. Hungary has invested significantly in these programmes over the last few years, and since 2014, it has provided a unique opportunity to access income and public works information within EU-SILC. Results highlight the relevance of both quantity and quality of employment. Public workers are better off than long-term unemployed. However, they show higher poverty risk than non-public workers (about twice as much). Living with non-public workers substantially reduces their poverty risk, while households of only public workers struggle more to avoid poverty.

本文探讨了受雇于公共工程如何使工人及其家庭陷入贫困。公共工程由中央计划和资助的工程组成,目标群体是长期失业者或非经济活动者。有关改善就业轨迹的证据主要是负面的,而我们对贫困结果仍然知之甚少。为了研究这个问题,我们利用了欧盟-SILC 调查中有关匈牙利的 2014-2019 年横截面数据。在过去几年中,匈牙利在这些计划中投入了大量资金,自 2014 年以来,它为获取 EU-SILC 中的收入和公共工程信息提供了一个独特的机会。结果凸显了就业数量和质量的相关性。与长期失业者相比,公共工程人员的境况要好一些。然而,他们比非公有制工人面临更高的贫困风险(约为后者的两倍)。与非公职人员共同生活会大大降低他们的贫困风险,而只有公职人员的家庭则更难避免贫困。
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引用次数: 0
The quest for standardisation in adult social work: Municipal guidelines and premises for professional discretion 追求成人社会工作的标准化:市政指南和专业自由裁量权的前提
IF 1.2 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-04-30 DOI: 10.1111/ijsw.12674
Sara Wittberg, Annika Taghizadeh Larsson, Anna Olaison

Little is known about how the tools and guidelines, which are central to current social work practice, are designed. The purpose of this article is to improve understanding of the conditions for social workers' discretion by analysing how the municipal responsibility to meet individual needs is circumscribed in local guidelines for needs assessment in Swedish elder care. The paper applies framing theory to the analysis of guidelines in 51 municipalities and maps the prevalence of guidelines. Framing theory highlights how different designs of local guidelines can create varying premises for the discretion of social workers. By illustrating how the guidelines provide social workers with the necessary guidance on how to interpret the law by circumscribing their discretion in standardised, and varying, ways, the findings point to the importance of further research on how the quest for standardisation in adult social work through local guidelines influences social workers' assessments in practice.

人们对作为当前社会工作实践核心的工具和指南是如何设计的知之甚少。本文旨在通过分析瑞典老年人护理需求评估的地方指南是如何限定市政当局满足个人需求的责任的,从而加深对社会工作者自由裁量权条件的理解。本文运用框架理论对 51 个城市的指导方针进行了分析,并绘制了指导方针的普及地图。框架理论强调了地方指导方针的不同设计如何为社会工作者的自由裁量权创造不同的前提。通过说明指导原则如何以标准化和不同的方式限制社会工作者的自由裁量权,从而为社会工作者解释法律提供必要的指导,研究结果指出了进一步研究通过地方指导原则寻求成人社会工作标准化如何影响社会工作者实践评估的重要性。
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引用次数: 0
The role of social transfers in reducing the poverty risk for larger families in the European Union 社会转移在降低欧盟人口较多家庭的贫困风险方面的作用
IF 1.9 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-04-29 DOI: 10.1111/ijsw.12675
Ilari Ilmakunnas, Lauri Mäkinen, Aapo Hiilamo
Child poverty is impacted to a great extent by family demography, with large families and single parents having a greater risk of being poor. Using the EU‐SILC microdata, we examine the extent to which social transfers reduce the risk of poverty among large families compared with smaller families in 29 European countries. Large families are defined as families with three or more children. First, we look at the reduction of poverty rates before and after the social transfers for large and small families. Second, we examine which types of social benefits are of most importance in alleviating poverty of large families. Poverty threshold is set at 60% of the national equivalent disposable income. In addition to poverty rates, poverty gaps are analysed. Results show that European countries seem to have different kinds of profiles in terms of overall child poverty reduction and whether the reduction is stronger among large families.
儿童贫困在很大程度上受到家庭人口结构的影响,大家庭和单亲家庭的贫困风险更大。我们利用 EU-SILC 微观数据,研究了在 29 个欧洲国家中,与较小的家庭相比,社会转移在多大程度上降低了大家庭的贫困风险。大家庭是指有三个或三个以上子女的家庭。首先,我们研究了社会转移支付前后大家庭和小家庭贫困率的下降情况。其次,我们研究哪类社会福利对缓解大家庭的贫困最为重要。贫困线设定为全国等值可支配收入的 60%。除了贫困率,我们还分析了贫困差距。结果表明,欧洲各国在整体减少儿童贫困以及大家庭是否更容易减少贫困方面似乎有着不同的特点。
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引用次数: 0
Savings trajectories and cohort differences among older Chinese couples 中国老年夫妇的储蓄轨迹和组群差异
IF 1.2 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-04-17 DOI: 10.1111/ijsw.12672
Lu Chen, Wenjuan Zhang

Based on longitudinal data from four waves (2011, 2013, 2015, and 2018) of the China Health and Retirement Longitudinal Study, we examined savings and savings changes among older couples in China using hierarchical linear models, explored any cohort differences, and analyzed the effects of the accessibility of the employee pension and the number of children on parents' savings. The results indicate that the savings of older couples continued to increase in old age, but the growth slowed down with age. For the cohort born before 1940, savings declined in later years. The cohorts born after 1940 had higher savings, but their savings grew less in later years. Older adults with access to the employee pension saved more and faster. Older adults with more than two children had lower savings, while those from younger cohorts were less impacted.

基于中国健康与退休纵向研究四次波次(2011、2013、2015 和 2018 年)的纵向数据,我们使用层次线性模型考察了中国老年夫妇的储蓄和储蓄变化,探讨了任何队列差异,并分析了职工养老金可及性和子女数量对父母储蓄的影响。结果表明,老年夫妇的储蓄在老年时期持续增长,但增长速度随着年龄的增长而放缓。对于 1940 年前出生的人群,储蓄在晚年有所下降。1940 年后出生的人群储蓄较高,但晚年储蓄增长较少。可以领取职工养老金的老年人储蓄得更多、更快。有两个以上子女的老年人储蓄较少,而较年轻组群的老年人受到的影响较小。
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引用次数: 0
WeChat use and social participation among community-dwelling adults with severe mental disorders: A mixed-methods study 居住在社区的严重精神障碍成人的微信使用和社会参与情况:混合方法研究
IF 1.2 3区 社会学 Q3 SOCIAL WORK Pub Date : 2024-04-11 DOI: 10.1111/ijsw.12671
Ying Li

The social media platform WeChat is increasingly used by individuals with severe mental disorders (SMDs). However, few studies have examined WeChat use of adults with SMDs and its association with social participation in the Chinese context. This mixed-methods study examined the effects of WeChat use on this population's social participation. The results indicate that WeChat use was positively and significantly associated with social participation among older adults with SMDs, helping them maintain contact with family, relatives, friends, community residents, and mental health professionals. Owing to different life stages and associated social expectations, younger adults with SMDs were mainly concerned with employment or family obligations and were less likely to use WeChat for social interactions with friends and community residents. WeChat can be a useful tool to encourage social participation among older adults with SMDs; age-related expectations for participation need to be considered in the design and delivery of intervention services.

越来越多的严重精神障碍(SMDs)患者使用微信这一社交媒体平台。然而,很少有研究考察过患有严重精神障碍的成年人使用微信的情况及其与在中国的社会参与度之间的关系。这项混合方法研究考察了微信的使用对这一人群社会参与的影响。结果表明,微信的使用与患有 SMD 的老年人的社会参与有显著的正相关,有助于他们与家人、亲戚、朋友、社区居民和心理健康专业人员保持联系。由于不同的人生阶段和相关的社会期望,患有 SMD 的年轻成年人主要关注就业或家庭义务,较少使用微信与朋友和社区居民进行社交互动。微信可以成为鼓励患有精神障碍的老年人参与社交的有用工具;在设计和提供干预服务时,需要考虑与年龄相关的参与期望。
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引用次数: 0
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International Journal of Social Welfare
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