While link prediction methods in knowledge graphs have been increasingly utilized to locate potential associations between compounds and diseases, they suffer from lack of sufficient evidence to explain why a drug and a disease may be indicated. This is especially true for knowledge graph embedding (KGE) based methods where a drug-disease indication is linked only by information gleaned from a vector representation. Complementary pathwalking algorithms can increase the confidence of drug repurposing candidates by traversing a knowledge graph. However, these methods heavily weigh the relatedness of drugs, through their targets, pharmacology or shared diseases. Furthermore, these methods can rely on arbitrarily extracted paths as evidence of a compound to disease indication and lack the ability to make predictions on rare diseases. In this paper, we evaluate seven link prediction methods on a vast biomedical knowledge graph for drug repurposing. We follow the principle of consilience, and combine the reasoning paths and predictions provided by path-based reasoning approaches with those of KGE methods to identify putative drug repurposing indications. Finally, we highlight the utility of our approach through a potential repurposing indication.
Does founding family control affect labor cost stickiness? Theoretically, labor cost stickiness is a double-sided sword: While it can be interpreted as long-term commitment to employees, it increases operating leverage, reduces operating performance, and thus jeopardizes long-term firm survival. Empirically, we find that—consistent with socioemotional wealth theory suggesting that founding family firms are more employee oriented—founding family firms exhibit greater labor costs stickiness. The pattern is more pronounced in industries with high labor turnover and high labor intensity. Furthermore, we find that abnormal high labor cost stickiness in family firms reduces profitability and non-labor investments.
We used rich Canadian administrative data linked to census records to examine the impact of firm closures and involuntary job displacement on entry into gig work. Similar to several recent studies, we identified gig workers as unincorporated self-employed freelancers, independent consultants and on-demand workers. We found that individuals displaced from closing firms are about 24% (1.1 p.p.) more likely to be gig workers in the year following the displacement year than the control group. We show that displaced workers remain strongly attached to traditional employment, and those who take up gig work often combine it with earning wages and salaries.
Current mainstream research on on-demand labor platforms primarily focuses on the discussion of algorithmic technologies while overlooking the issue of how platforms achieve stable operations in a de-employment context. Addressing this research gap, this study investigates the approaches employed by Chinese food-delivery platforms to ensure stable labor supply. Utilizing qualitative data, the research reveals that Chinese food-delivery platforms have established stability in labor supply by implementing the outsourced model, partnering with third-party staffing agencies to establish service stations, and managing couriers offline. This approach helps to balance platform and courier needs, addressing the tension between work flexibility and income stability. This research provides a case study illuminating the interplay between technology and the labor market in labor relations. Additionally, it highlights the structural forces that workers form within the internal labor market, deepening our understanding of platform management and the complexities of labor relations.
This article addresses workplace collective action. Through a discussion of instrumental and norm-driven motivations for workers' collective action, it is argued that most workers are driven mainly by instrumental motivations—meaning, that they aim to achieve certain outcomes. Consequently, the theoretical concept of instrumental collectivism from Alan Fox is utilized to explain and understand collective action. Finally, six conditions facilitating workplace collective action, including an ideational and hence constructivist element, are identified and discussed providing a more nuanced theoretical framework of workers' collective action that allows for workers' agency and refutes that instrumentalism per se leads to individualized behavior.
In 2013, mandatory worker representation on French corporate boards was enacted. We examine the way employee directors have been incorporated within the board machinery. Our empirical results indicate that employee representatives have a limited access to board committees. This result casts doubt on the ability of employee directors to significantly influence corporate governance. Consistent with this analysis, we do not find any significant impact, either positive or negative, of codetermination on firm performance.