Pub Date : 2023-01-01DOI: 10.52368/2078-0109-2023-59-2-4-9
I.V. Bondarev, V.I. Mikhalev
The article presents the material on the study of clinical and morphological indicators of endometrial glandular-cystic hyperplasia in cows. It has been established that the share of endometrial hyperplasia glandulocystica in cows accounts for 11.4% of the total number of chronic uterine diseases. Most often, this pathology is diagnosed in cows 120 or more days after calving with an annual milk production of 6000-7000 kg. Glandular-cystic hyperplasia of the endometrium is most typical of the animals of the Red-Motley and Simmental breeds with loose keeping. Endometrial hyperplasia glandulocystica is characterized by a thickening of the uterine wall up to 6.5±0.28 mm, the presence of a cavity in the uterine horns of 3.4±0.19 mm, follicular cysts in the ovaries with a diameter of 42.5±2.8 mm. Endometrial hyperplasia glandulocystica is characterized by an increase in the height of the cells of the covering epithelium up to the height of prismatic one, growth of the uterine glands with the expansion of their lumens, an increase in height and vacuolization of the glandular epithelium. In case of glandular-cystic hyperplasia, uterine glands account for 28.6%, blood vessels – 12.3%, covering epithelium – 5.7%, which is by 1.88-1.97 times more, compared to clinically healthy animals. The height of the cells of the covering epithelium in case of this pathology is higher by 13.1%, the height of the epithelial cells of the uterine glands – by 23.4%, the thickness of the endometrium – by 1.38 times, which indicates endometrial hypertrophy.
{"title":"CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF ENDOMETRIAL HYPERPLASIA GLANDULOCYSTICA IN COWS","authors":"I.V. Bondarev, V.I. Mikhalev","doi":"10.52368/2078-0109-2023-59-2-4-9","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-4-9","url":null,"abstract":"The article presents the material on the study of clinical and morphological indicators of endometrial glandular-cystic hyperplasia in cows. It has been established that the share of endometrial hyperplasia glandulocystica in cows accounts for 11.4% of the total number of chronic uterine diseases. Most often, this pathology is diagnosed in cows 120 or more days after calving with an annual milk production of 6000-7000 kg. Glandular-cystic hyperplasia of the endometrium is most typical of the animals of the Red-Motley and Simmental breeds with loose keeping. Endometrial hyperplasia glandulocystica is characterized by a thickening of the uterine wall up to 6.5±0.28 mm, the presence of a cavity in the uterine horns of 3.4±0.19 mm, follicular cysts in the ovaries with a diameter of 42.5±2.8 mm. Endometrial hyperplasia glandulocystica is characterized by an increase in the height of the cells of the covering epithelium up to the height of prismatic one, growth of the uterine glands with the expansion of their lumens, an increase in height and vacuolization of the glandular epithelium. In case of glandular-cystic hyperplasia, uterine glands account for 28.6%, blood vessels – 12.3%, covering epithelium – 5.7%, which is by 1.88-1.97 times more, compared to clinically healthy animals. The height of the cells of the covering epithelium in case of this pathology is higher by 13.1%, the height of the epithelial cells of the uterine glands – by 23.4%, the thickness of the endometrium – by 1.38 times, which indicates endometrial hypertrophy.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135754857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52368/2078-0109-2023-59-2-25-30
D.O. Zhurov
The paper presents data on the histological structure of the gastrointestinal tract of the Mute swan (Cygnus olor). When studying the architectonics of the stomach of a swan, it was found that the wall of its glandular and muscular sections consists of 3 membranes – mucous, muscular and serous. At the same time, the mucous membrane of the glandular stomach is thick-walled, with a high density of excretory ducts of complex gastric glands per conventional unit of area. It has been established that the muscular plate of the mucous membrane of the wall of the glandular stomach is fragmented and its individual myocytes penetrate between the complex glands, which contributes to a more effective excretion of the secretion of the glands. The mucous membrane also contains a muscular layer, which, in our opinion, is associated with an abundance of secreted hydrochloric acid. This can also explain the presence in this section of the stomach of a well-developed submucosa and a thick-walled muscular membrane. The muscular layer of the mucous membrane and the submucosa are also extended to the muscular section of the stomach in swans. At the same time, the cuticle of the muscular part of the stomach is relatively thin, with superficial striation. In the small intestine, the presence of crypts on the entire surface and a denser arrangement of villi were found. This feature indicates an increased absorption surface of the small intestine and is considered as compensation for its anatomical size. The liver of the swans did not differ significantly in morphology from other representatives of the class Aves. However, in the swans, the boundaries of classical hepatic lobules were not detected in the liver, and two nuclei were often visualized in hepatocytes. Thus, the noted structural features of the digestive canal of the Mute swan are physiologically justified and are associated with the trophic specialization of the represented bird species.
{"title":"MORPHOLOGICAL STATE OF ORGANS IN THE ALIMENTARY CANAL OF THE MUTE SWAN","authors":"D.O. Zhurov","doi":"10.52368/2078-0109-2023-59-2-25-30","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-25-30","url":null,"abstract":"The paper presents data on the histological structure of the gastrointestinal tract of the Mute swan (Cygnus olor). When studying the architectonics of the stomach of a swan, it was found that the wall of its glandular and muscular sections consists of 3 membranes – mucous, muscular and serous. At the same time, the mucous membrane of the glandular stomach is thick-walled, with a high density of excretory ducts of complex gastric glands per conventional unit of area. It has been established that the muscular plate of the mucous membrane of the wall of the glandular stomach is fragmented and its individual myocytes penetrate between the complex glands, which contributes to a more effective excretion of the secretion of the glands. The mucous membrane also contains a muscular layer, which, in our opinion, is associated with an abundance of secreted hydrochloric acid. This can also explain the presence in this section of the stomach of a well-developed submucosa and a thick-walled muscular membrane. The muscular layer of the mucous membrane and the submucosa are also extended to the muscular section of the stomach in swans. At the same time, the cuticle of the muscular part of the stomach is relatively thin, with superficial striation. In the small intestine, the presence of crypts on the entire surface and a denser arrangement of villi were found. This feature indicates an increased absorption surface of the small intestine and is considered as compensation for its anatomical size. The liver of the swans did not differ significantly in morphology from other representatives of the class Aves. However, in the swans, the boundaries of classical hepatic lobules were not detected in the liver, and two nuclei were often visualized in hepatocytes. Thus, the noted structural features of the digestive canal of the Mute swan are physiologically justified and are associated with the trophic specialization of the represented bird species.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135699402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52368/2078-0109-2023-59-1-89-91
K.D. Kovaliou
Histological studies have established that the pancreatic parenchyma is represented by the acini, the wall of which consists of 6-18 cells. In the rounded acini there are from 12 to 16 acinocytes, the nuclei of which are spherical and located centrally. The elongated acini contain about 15-18 cells the nuclei of which are located at the basal part of the cell. Small acini with 5-9 acinar cells are also found, and in rare cases, acini with more than 18 acinocytes are ob-served. The size of the nucleus varies even in cells of the same type at different stages of the functioning of the same secretory cell. The muscle coat in the excretory and accessory ducts of the pancreas in the raccoon dogs is absent. Proliferation of acinocytes and differentiation of ductal cells contribute to the formation of new acini. In the functioning of acinar tissue, heterogeneity is revealed. Morphological changes in the exocrine pancreas of the raccoon dog puppies should be considered as a compensatory-adaptive reaction of the organism.
{"title":"MORPHOFUNCTIONAL CHARACTERISTICS OF THE EXOCRINE PANCREAS IN PUPPIES OF RACCOON DOG DURING THE JUVENILE PERIOD IN THE TERRITORY OF HIGH RADIOACTIVE POLLUTION","authors":"K.D. Kovaliou","doi":"10.52368/2078-0109-2023-59-1-89-91","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-1-89-91","url":null,"abstract":"Histological studies have established that the pancreatic parenchyma is represented by the acini, the wall of which consists of 6-18 cells. In the rounded acini there are from 12 to 16 acinocytes, the nuclei of which are spherical and located centrally. The elongated acini contain about 15-18 cells the nuclei of which are located at the basal part of the cell. Small acini with 5-9 acinar cells are also found, and in rare cases, acini with more than 18 acinocytes are ob-served. The size of the nucleus varies even in cells of the same type at different stages of the functioning of the same secretory cell. The muscle coat in the excretory and accessory ducts of the pancreas in the raccoon dogs is absent. Proliferation of acinocytes and differentiation of ductal cells contribute to the formation of new acini. In the functioning of acinar tissue, heterogeneity is revealed. Morphological changes in the exocrine pancreas of the raccoon dog puppies should be considered as a compensatory-adaptive reaction of the organism.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135701020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article presents the results on the study of lipid and carbohydrate metabolism in sows in different periods of the reproductive cycle (after weaning, gestation, lactation) on an industrial pig-breeding complex. It was found that in the animals predisposed to postpartum pathology, compared with clinically healthy sows, a high level of glucose was established with a reduced content of lactate and pyruvate, indicating a pronounced intensity of gluconeogenesis. Lipid metabolism has been characterized by a reduced concentration of cholesterol and triglycerides which occurs in case of functional disorders of the liver and the manifestation of inflammatory processes. The revealed changes in carbohydrate and lipid metabolism in sows at different periods of the reproductive cycle can be used to assess the level of energy metabolism.
{"title":"STATE OF LIPID AND CARBOHYDRATE METABOLISM IN SOWS IN DIFFERENT PERIODS OF THE REPRODUCTIVE CYCLE IN CASE OF THE POSTPARTUM PATHOLOGY","authors":"A.G. Shakhov, L.Yu. Sashnina, V.N. Kotsarev, G.G. Chusova, G.V. Nikonenko","doi":"10.52368/2078-0109-2023-59-2-87-92","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-87-92","url":null,"abstract":"The article presents the results on the study of lipid and carbohydrate metabolism in sows in different periods of the reproductive cycle (after weaning, gestation, lactation) on an industrial pig-breeding complex. It was found that in the animals predisposed to postpartum pathology, compared with clinically healthy sows, a high level of glucose was established with a reduced content of lactate and pyruvate, indicating a pronounced intensity of gluconeogenesis. Lipid metabolism has been characterized by a reduced concentration of cholesterol and triglycerides which occurs in case of functional disorders of the liver and the manifestation of inflammatory processes. The revealed changes in carbohydrate and lipid metabolism in sows at different periods of the reproductive cycle can be used to assess the level of energy metabolism.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"165 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135845376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52368/2078-0109-2023-59-2-46-50
V.N. Osipova, I.M. Revyakin
The article presents studies on the concentration of trace elements in the coat hair of cattle. They reflect the amount of copper, manganese and zinc in the hair coat of cattle under the influence of seasonality, type of maintenance, topographical area of the animal's body. Based on the results, it can be concluded that, in contrast to the factor of the topographic site, the seasonality and type of maintenance possess a pronounced impact on the concentrations of the studied trace elements in the hair coat. And the variability within the studied groups emphasizes the individuality of the accumulation of trace elements by every individual animal. This reflects the multifunctionality of the hair coat, which consists not only in performing the thermoregulatory function, but also in reflecting the mineral status of the animal's body.
{"title":"CONCENTRATON OF ZINC, MANGANESE, COPPER IN THE COAT HAIR OF CATTLE DEPENDING ON MAINTENANCE CONDITIONS, SEASONALITY AND TOPOGRAPHY","authors":"V.N. Osipova, I.M. Revyakin","doi":"10.52368/2078-0109-2023-59-2-46-50","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-46-50","url":null,"abstract":"The article presents studies on the concentration of trace elements in the coat hair of cattle. They reflect the amount of copper, manganese and zinc in the hair coat of cattle under the influence of seasonality, type of maintenance, topographical area of the animal's body. Based on the results, it can be concluded that, in contrast to the factor of the topographic site, the seasonality and type of maintenance possess a pronounced impact on the concentrations of the studied trace elements in the hair coat. And the variability within the studied groups emphasizes the individuality of the accumulation of trace elements by every individual animal. This reflects the multifunctionality of the hair coat, which consists not only in performing the thermoregulatory function, but also in reflecting the mineral status of the animal's body.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135748978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52368/2078-0109-2023-59-2-99-103
A.T. Zaseev, M.P. Semenenko
The article presents the results of the use of osprey as a non-traditional feed additive for its inclusion in the diets of cattle. The experiment was carried out on the basis of the breeding farm “Berezka” of the Alagir district of the North Ossetia-Alania on clinically healthy dry cows, formed into 2 groups (n=20). In the diets of cows of both groups, a cellulose-containing additive from the osprey in the amount of 9.5 kg was used, while the animals of the second group were additionally fed with dolomite (calcium carbonate) in the amount of 50.0 g. Under production conditions, the influence of a diet with the inclusion of an osprey on the physiological parameters of the body of cows and the biochemical homeostasis of blood was studied. It has been determined that the use of the additive does not have a negative effect on the body of pregnant cows, but according to some indicators of protein metabolism, it even exhibits an exchange-stimulating effect, characterized by a quantitative increase in the amount of free amino acids. At the same time, the inclusion of dolomite in the diet improves the nutritional value of the diet.
{"title":"USE OF NON-TRADITIONAL CELLULOSE-CONTAINING ADDITIVES IN COWS' DIETS AS AN ALTERNATIVE TO REDUCING THE TECHNOGENIC LOAD ON THE ENVIRONMENT","authors":"A.T. Zaseev, M.P. Semenenko","doi":"10.52368/2078-0109-2023-59-2-99-103","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-99-103","url":null,"abstract":"The article presents the results of the use of osprey as a non-traditional feed additive for its inclusion in the diets of cattle. The experiment was carried out on the basis of the breeding farm “Berezka” of the Alagir district of the North Ossetia-Alania on clinically healthy dry cows, formed into 2 groups (n=20). In the diets of cows of both groups, a cellulose-containing additive from the osprey in the amount of 9.5 kg was used, while the animals of the second group were additionally fed with dolomite (calcium carbonate) in the amount of 50.0 g. Under production conditions, the influence of a diet with the inclusion of an osprey on the physiological parameters of the body of cows and the biochemical homeostasis of blood was studied. It has been determined that the use of the additive does not have a negative effect on the body of pregnant cows, but according to some indicators of protein metabolism, it even exhibits an exchange-stimulating effect, characterized by a quantitative increase in the amount of free amino acids. At the same time, the inclusion of dolomite in the diet improves the nutritional value of the diet.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135955474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lameness is widespread in dairy cattle herds all over the world. Up to 25% of highly productive cows of the herd can go lame at the same time, which causes significant damage, mainly affecting dairy productivity, and leads to financial losses. The findings make clearly visible the picture of a decrease in cases of interdigital dermatitis when using hoof baths. In the experimental group, the identified cases of Mortellaro disease had a mild form of M1, which were easily treated with bandages containing powder with zinc oxide, boric acid, acetylsalicylic acid, Egocin 20 (1:1:1:0,5). The resulting powder was applied with a bandage and fixed on the hoof with a special hoof cloth tape. After a double change of dressings with an interval of 3 days, regeneration of the skin and disappearance of clinical signs of the disease were observed. In the control group, the detected cases were in the stage from M1 to M3. The nature of the diseases was medium, with a three-time change of the therapeutic dressing, the recovery time for sick cows was 9 days.
{"title":"HOOF BATHS IN THE SYSTEM OF MEASURES TO ENSURE THE HEALTH OF THE HOOVES OF COWS","authors":"V.G. Tyurin, N.V. Rodionova, V.G. Semenov, N.I. Kosyaev, D.A. Patorov, R.M. Alekseev, C.K. Avylov, Е.А. Kapitonova","doi":"10.52368/2078-0109-2023-59-2-77-83","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-77-83","url":null,"abstract":"Lameness is widespread in dairy cattle herds all over the world. Up to 25% of highly productive cows of the herd can go lame at the same time, which causes significant damage, mainly affecting dairy productivity, and leads to financial losses. The findings make clearly visible the picture of a decrease in cases of interdigital dermatitis when using hoof baths. In the experimental group, the identified cases of Mortellaro disease had a mild form of M1, which were easily treated with bandages containing powder with zinc oxide, boric acid, acetylsalicylic acid, Egocin 20 (1:1:1:0,5). The resulting powder was applied with a bandage and fixed on the hoof with a special hoof cloth tape. After a double change of dressings with an interval of 3 days, regeneration of the skin and disappearance of clinical signs of the disease were observed. In the control group, the detected cases were in the stage from M1 to M3. The nature of the diseases was medium, with a three-time change of the therapeutic dressing, the recovery time for sick cows was 9 days.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135839424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52368/2078-0109-2023-59-2-73-77
L.V. Sysa, S.A. Sysa
The article describes the effectiveness of preventive use of dry blood plasma in calves' diets, ways to increase total protein, contributing to increased resistance. When plasma was used in the calves' diet, it was noted that the animals were mobile, active, appetite was expressed, a low percentage of morbidity was established (3-4%), weight gain was better (by 10-15%), mortality was not observed. In the control group, no special changes were observed from the moment of the experiment, some animals were sedentary, there was a decrease in appetite, the percentage of morbidity (8-12%).
{"title":"STUDY OF THE EFFECTIVENESS OF THE USE OF DRY BLOOD PLASMA IN CALVES' DIETS","authors":"L.V. Sysa, S.A. Sysa","doi":"10.52368/2078-0109-2023-59-2-73-77","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-73-77","url":null,"abstract":"The article describes the effectiveness of preventive use of dry blood plasma in calves' diets, ways to increase total protein, contributing to increased resistance. When plasma was used in the calves' diet, it was noted that the animals were mobile, active, appetite was expressed, a low percentage of morbidity was established (3-4%), weight gain was better (by 10-15%), mortality was not observed. In the control group, no special changes were observed from the moment of the experiment, some animals were sedentary, there was a decrease in appetite, the percentage of morbidity (8-12%).","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article presents the data on the expression level of the pro-inflammatory cytokine interleukin-1 (IL-1) in piglets 3-5 days of age diseased with colibacteriosis, against the background of the use of the species-specific drug Prostimul, containing recombinant type 1 cytokine, vitamins A, E and C, in comparison with antibacterial drug Quinocol Plus. The analysis of the obtained data has shown that the drug Prostimul suppresses the expression of IL-1β by 70 times, and Quinocol Plus – by 6.5 times. This fact indicates the prospect of using the drug to reduce the development of an inflammatory reaction in case of colibacteriosis in newborn piglets. When analyzing hematological blood indicators, a decrease in the number of stab neutrophils was revealed against the background of the use of Prostimul and Quinocol Plus. The analysis of leukocyte indices of blood intoxication has indicated that against the background of the use of the drug Prostimul this indicator decreases by 4.9 times, and Quinocol Plus – by 5.6 times, respectively.
本文报道了在使用含有重组1型细胞因子和维生素A、E、C的物种特异性药物prostimull的情况下，3-5日龄大肠杆菌病仔猪中促炎细胞因子白细胞介素-1 (IL-1)的表达水平，并与抗菌药物喹诺醇Plus进行了比较。结果表明，prostimulus对IL-1β表达的抑制作用为70倍，对Quinocol Plus -的抑制作用为6.5倍。这一事实表明，在新生仔猪大肠杆菌病的情况下，使用该药物减少炎症反应的发展前景。在分析血液学血液指标时，在使用prostil和Quinocol Plus的背景下，发现刺伤中性粒细胞数量减少。血液中毒白细胞指标分析表明，在使用prostil药物的背景下，该指标分别下降了4.9倍和5.6倍。
{"title":"EFFECT OF THE SPECIES-SPECIFIC DRUG PROSTIMUL ON THE LEVEL OF IL-1 GENE EXPRESSION IN NEWBORN PIGLETS WITH COLIBACTERIOSIS","authors":"V.V. Strebkova, M.Yu. Syromyatnikov, N.V. Pasko, N.A. Khokhlova, N.A. Strelnikov, E.V. Mikhaylov","doi":"10.52368/2078-0109-2023-59-2-60-65","DOIUrl":"https://doi.org/10.52368/2078-0109-2023-59-2-60-65","url":null,"abstract":"The article presents the data on the expression level of the pro-inflammatory cytokine interleukin-1 (IL-1) in piglets 3-5 days of age diseased with colibacteriosis, against the background of the use of the species-specific drug Prostimul, containing recombinant type 1 cytokine, vitamins A, E and C, in comparison with antibacterial drug Quinocol Plus. The analysis of the obtained data has shown that the drug Prostimul suppresses the expression of IL-1β by 70 times, and Quinocol Plus – by 6.5 times. This fact indicates the prospect of using the drug to reduce the development of an inflammatory reaction in case of colibacteriosis in newborn piglets. When analyzing hematological blood indicators, a decrease in the number of stab neutrophils was revealed against the background of the use of Prostimul and Quinocol Plus. The analysis of leukocyte indices of blood intoxication has indicated that against the background of the use of the drug Prostimul this indicator decreases by 4.9 times, and Quinocol Plus – by 5.6 times, respectively.","PeriodicalId":477320,"journal":{"name":"Učenye zapiski učreždeniâ obrazovaniâ \"Vitebskaâ orderna \"Znak početa\" gosudarstvennaâ akademiâ veterinarnoj mediciny\"","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135800268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.52368/2078-0109-2023-59-2-38-41
E.V. Mikhaylov, O.S. Drozhzhin, V.V. Shipilov, N.N. Ivanova
The protection of fishery waters from pollution caused by toxicants is one of the urgent problems in the development of fisheries. The article presents the results of studying the dynamics of the content of heavy metals in the pond water of a fish farm in the Voronezh region. A significant decrease in the concentration of iron, copper, zinc, and manganese in the spring-summer period compared with the autumn-winter period was established. The most dramatic changes in the concentration are typical of copper and zinc. It was shown that the content of heavy metals in pond water exceeded the maximum permissible concentrations for fishery water bodies throughout the year, the smallest exceedance was noted in the spring and summer periods. The data obtained indicate the need for regular monitoring and maintenance of the required level of heavy metals in water bodies to ensure the normal physiological state of hydrobionts.
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