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Organising pneumonia following amivantamab treatment: a case report 阿米万他单抗治疗后组织性肺炎1例报告
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2025-11-09 DOI: 10.1016/j.resmer.2025.101227
Gaspard Naulleau , Lise Matton , Ioana Hutuca , Xavier Fremand , Florence Jeny , Boris Duchemann
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引用次数: 0
Screening for an underlying myeloproliferative neoplasm in patients with chronic thromboembolic pulmonary hypertension 慢性血栓栓塞性肺动脉高压患者潜在骨髓增生性肿瘤的筛查
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2025-12-10 DOI: 10.1016/j.resmer.2025.101235
Stephen E. Langabeer
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引用次数: 0
Impact of having pulmonary embolism response team (PERT) on outcome of pulmonary embolism: A systematic review and meta-analysis 肺栓塞反应小组(PERT)对肺栓塞预后的影响:一项系统回顾和荟萃分析。
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2025-12-11 DOI: 10.1016/j.resmer.2025.101245
Sagun Dawadi , Dhan Bahadur Shrestha , Prakash Raj Oli , Raj Kumar Thapa , Jurgen Shtembari , Amit Bhandari , Daniel H. Katz

Introduction

Pulmonary embolism (PE) continues to pose a significant challenge in clinical practice. Selecting the optimal management approach is complicated by conflicting societal guidelines, which can hinder the care team's ability to deliver effective therapies in timely fashion. To address this complexity, the Pulmonary Embolism Response Team (PERT) was introduced in 2012. This study evaluates the effectiveness of PERT and explores its integration as a standard of care for PE management.

Methods

A systematic search of databases was conducted from inception to April 2024. Relevant references were identified and imported for analysis. Statistical evaluation was performed using RevMan Web, using odds ratios (OR) for dichotomous outcomes and mean differences (MD) for continuous outcomes.

Results

The analysis included 23 studies, comprising 15,621 patients in two groups: patient managed by PERT, n=5,555 and patient managed with standard treatment without PERT, n=10,066. The use of PERT significantly lowered odds of 30-day or in-hospital mortality (OR 0.76, CI 0.59-0.99) but significantly increased the utilization of advanced therapeutic strategies (OR 3.45, CI 1.95-6.09). Although PERT demonstrated favorable odds for reduced major bleeding events and earlier achievement of therapeutic anticoagulation but could not achive statistcal significance. Also, while PERT was associated with higher odds of ICU admission (OR 2.41, CI 1.33-4.34)but significantly reduced the length of ICU stay (MD -0.67, CI -1.28 to -0.05).

Conclusion

PERT implementation has been associated with reduced mortality, shorter ICU stays, at cost of higher utilization of advanced therapies. However, given that most studies are observational, these findings should be interpreted cautiously, and higher-quality research is needed to establish definitive benefit.
肺栓塞(PE)在临床实践中仍然是一个重大挑战。选择最佳的管理方法是复杂的矛盾的社会准则,这可能会阻碍护理团队的能力提供有效的治疗及时。为了解决这种复杂性,肺栓塞反应小组(PERT)于2012年成立。本研究评估了PERT的有效性,并探讨了其作为体育管理护理标准的整合。方法:系统检索自成立至2024年4月的数据库。识别并导入相关参考文献进行分析。使用RevMan Web进行统计评价,二分结果使用比值比(OR),连续结果使用平均差异(MD)。结果:该分析包括23项研究,包括15,621例患者,分为两组:采用PERT治疗的患者,n=5,555,以及采用不采用PERT治疗的标准治疗的患者,n=10,066。PERT的使用显著降低了30天或住院死亡率(or 0.76, CI 0.59-0.99),但显著增加了先进治疗策略的使用(or 3.45, CI 1.95-6.09)。虽然PERT在减少大出血事件和早期实现治疗性抗凝方面表现出有利的优势,但不能达到统计学意义。此外,虽然PERT与较高的ICU住院几率(OR 2.41, CI 1.33-4.34)相关,但显著缩短了ICU住院时间(MD -0.67, CI -1.28至-0.05)。结论:PERT的实施与降低死亡率,缩短ICU住院时间,以更高的先进治疗利用率为代价。然而,考虑到大多数研究是观察性的,这些发现应该谨慎解释,需要更高质量的研究来确定确切的益处。
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引用次数: 0
Frailty in COPD hospitalized patients: Associated factors from a multicentre cohort study COPD住院患者的虚弱:来自多中心队列研究的相关因素
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2025-12-15 DOI: 10.1016/j.resmer.2025.101239
Cristóbal Esteban , María Gascón , Eva Tabernero , Patricia Sobradillo , Monica Rayón , Ignacio García-Talavera , Amaia Aramburu , Leyre Chasco , José M. Quintana , the ReEPOC-REDISSEC group

Objective

The aim of the study was to determine the association between frailty and hospitalizations, mid-term mortality and medical readmissions, and to evaluate the relationship between frailty and other variables, such as dependence, anxiety, depression and health-related quality of life in a cohort of COPD patients after admission due to exacerbation (eCOPD).

Methods

Prospective observational cohort study conducted across nine Spanish hospitals. Patients were recruited consecutively. Variables relating to the patients' clinical baseline status were recorded, including the Tilburg Frailty Indicator (TFI), EuroQol EQ-5D, the COPD Assessment Test (CAT), Yale Physical Activity Survey (YPAS); the mMRC Dyspnea Scale, Hospital Anxiety and Depression Scale (HAD), and the Duke-UNC scale.

Results

1638 COPD patients were studied, with a mean age of 72.4 (SD 10.3), 77 % male, mean FEV1 49.4 % (SD 19.2), median Charlson index 2; mean CAT 21.3 (SD 9.1). In the multivariate analysis, the variables independently associated with frailty were older age, female sex, comorbidities, health-related quality of life, dyspnea, dependence, anxiety, depression, and physical activity. Multivariable survival regression analysis identified TFI, sex, and previous hospitalizations as predictors of one-year mortality. These variables, together with comorbidities, were associated with the risk of readmission due to any medical condition during the 1-year follow-up.

Conclusions

Frailty was associated with admission due to eCOPD and to the number of hospitalizations. In COPD, a single hospitalization should be considered a warning sign for frailty. Variables such as dependence, anxiety, depression and HRQoL were independent predictors of frailty. Additionally, frailty was associated with mortality and medical readmissions in the following year.
目的本研究的目的是确定虚弱与住院、中期死亡率和再入院之间的关系,并评估因急性加重(eCOPD)入院的COPD患者队列中虚弱与其他变量(如依赖、焦虑、抑郁和健康相关生活质量)之间的关系。方法在西班牙9家医院进行前瞻性观察队列研究。患者被连续招募。记录与患者临床基线状态相关的变量,包括Tilburg衰弱指标(TFI)、EuroQol EQ-5D、COPD评估测试(CAT)、Yale Physical Activity Survey (YPAS);mMRC呼吸困难量表、医院焦虑抑郁量表(HAD)和Duke-UNC量表。结果共纳入COPD患者1638例,平均年龄72.4岁(SD 10.3),男性77%,平均FEV1 49.4% (SD 19.2),中位Charlson指数2;平均CAT 21.3 (SD 9.1)。在多变量分析中,与虚弱独立相关的变量为年龄较大、女性、合并症、健康相关生活质量、呼吸困难、依赖性、焦虑、抑郁和体力活动。多变量生存回归分析确定TFI、性别和既往住院是一年死亡率的预测因子。在1年随访期间,这些变量以及合并症与任何医疗状况导致的再入院风险相关。结论慢性阻塞性肺病患者的虚弱程度与住院次数有关。在慢性阻塞性肺病中,一次住院治疗应被视为虚弱的警告信号。依赖性、焦虑、抑郁和HRQoL等变量是虚弱的独立预测因子。此外,虚弱与次年的死亡率和再入院率有关。
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引用次数: 0
Bioactive peptides in therapeutic α1-Antitrypsin preparations modulate neutrophil chemokine receptors: Implications for augmentation therapy 治疗性α - 1抗胰蛋白酶制剂中的生物活性肽调节中性粒细胞趋化因子受体:增强治疗的意义
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2026-01-09 DOI: 10.1016/j.resmer.2026.101249
Julia Held , Jing Liu , Friedemann R. Börner , Michael Kiehntopf , Sabine Wrenger , Sabina Janciauskiene
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引用次数: 0
Chronic myelomonocytic leukaemia occurring in patients with pulmonary Langerhans cell histiocytosis: A common progenitor? 肺朗格汉斯细胞组织细胞增多症患者发生的慢性髓单细胞白血病:共同的祖细胞?
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2025-11-19 DOI: 10.1016/j.resmer.2025.101221
Pierre Thoré, Sérine Chaibi, Matthieu Duchmann, Raphaël Itzykson, Amira Benattia, Abdellatif Tazi
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引用次数: 0
BAP-1 in the diagnosis of malignant pleural mesothelioma BAP-1在恶性胸膜间皮瘤中的诊断价值。
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2025-11-28 DOI: 10.1016/j.resmer.2025.101231
Irene Sansano , Ana Vázquez , Oscar Persiva , Marc Simó , Leire Sánchez , Pilar Montoya , Carme Dinarès , Carmen Alemán

Background

The diagnosis of malignant pleural mesothelioma (MPM) can be challenging for clinicians and pathologists.

Patients and methods

This study included all patients diagnosed with pleural mesothelioma between October 2013 and April 2024. Clinical data, history of asbestos exposure, pleural fluid analysis, chest-X-ray, thoracic computed tomography and positron emission tomography findings, video-assisted thoracic surgery report, pleural fluid cytology and pleural biopsy results were included. Loss of BRCA1-associated protein 1 (BAP1) nuclear staining was examined in cytologies and biopsies.

Results

Forty-one patients were diagnosed with pleural mesothelioma, 35 epithelioid, 5 sarcomatoid and 1 biphasic. The diagnosis was established after the first sample in 30 patients, while a second one was necessary in 11 patients. BAP1 loss in pleural cytology and histology was not always consistent. Sixteen patients showed loss of BAP1 expression in cytology. Among these, 10 patients also presented BAP1 loss in pleural histology, whereas 5 patients with BAP1 loss in histology did not show BAP1 loss in cytology. Additionally, two patients initially diagnosed with idiopathic pleural effusion and 3 patients diagnosed with benign pleural effusion due to asbestos showed BAP1 loss and were later diagnosed with MPM during follow-up.

Conclusion

MPM remains difficult to diagnose. Performing BAP1 immunohistochemistry in patients with an undiagnosed pleural effusion or a history of asbestos exposure can aid in identifying those with mesothelioma.
背景:恶性胸膜间皮瘤(MPM)的诊断对临床医生和病理学家来说是具有挑战性的。患者和方法:本研究纳入2013年10月至2024年4月期间诊断为胸膜间皮瘤的所有患者。包括临床资料、石棉接触史、胸膜液分析、胸部x线、胸部计算机断层扫描和正电子发射断层扫描结果、胸腔镜手术报告、胸膜液细胞学检查和胸膜活检结果。细胞学和活组织检查brca1相关蛋白1 (BAP1)核染色缺失。结果:胸膜间皮瘤41例,上皮样瘤35例,肉瘤样瘤5例,双相瘤1例。30名患者在第一次取样后确诊,11名患者需要进行第二次取样。胸膜细胞学和组织学的BAP1缺失并不总是一致的。16例患者细胞学显示BAP1表达缺失。其中10例患者胸膜组织学上也出现BAP1丢失,5例组织学上BAP1丢失的患者细胞学上未出现BAP1丢失。另外,2例最初诊断为特发性胸腔积液的患者和3例诊断为石棉所致良性胸腔积液的患者均出现BAP1丢失,并在随访中被诊断为MPM。结论:MPM仍然难以诊断。对未确诊胸腔积液或石棉暴露史的患者进行BAP1免疫组化检查有助于间皮瘤患者的鉴别。
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引用次数: 0
Response to the comment of Yu Tian et al. on “Increasing sleep apnoea burden in the elderly in Finland from 1996 to 2018: A national registry study” 对于田等人关于“1996 - 2018年芬兰老年人睡眠呼吸暂停负担增加:一项国家登记研究”的评论的回应
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2025-11-14 DOI: 10.1016/j.resmer.2025.101226
Hannele Hasala, Tiina Mattila, Hanna-Riikka Kreivi, Heidi Avellan-Hietanen, Tuula Vasankari, Fredrik Herse, Riikka-Leena Leskelä, Sanna Toppila-Salmi, Marina Erhola, Tuija Jääskeläinen, Tari Haahtela
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引用次数: 0
Reporting of data on participant ethnicity and socioeconomic status in high impact respiratory journals: a targeted literature review 高影响力呼吸期刊中参与者种族和社会经济地位的数据报告:一项有针对性的文献综述
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2026-01-11 DOI: 10.1016/j.resmer.2026.101250
Ishani Kenny , Caitlin Meechan , Georgia Hopley , Rachel Snow , Arjun Menon , Diana David , Natasha Manuelpillai , Obada Katan , Keir E J Philip

Background

Demographic data, including ethnicity/race and socioeconomic status (SES), of research participants is required for interpretation and application of findings. The International Committee of Medical Journal Editors recommend inclusion of representative populations in studies, and to provide relevant demographic information, but they are not prescriptive in their recommendations. This study aimed to assess the reporting of ethnicity/race and SES in high-impact respiratory journals.

Method

The ten most recent research articles (to 18/10/24) from the top 10 respiratory journals (using h5-index), were selected and reviewed by two researchers independently. Data was collected on reporting of key demographic data, including age, sex/gender, ethnicity/race and SES.

Results

100 research articles were included. 43 contained demographic information on ethnicity/race, 10 on SES, 100 on age and 99 on sex/gender. Median reporting of ethnicity/race was 4/10 per journal (range 2–8), and only 5 studies acknowledged this as a limitation. The Lancet Respiratory Medicine, in which 8/10 articles contained ethnicity/race data and 1 of the remaining articles acknowledged the lack as a limitation, is the only journal to explicitly recommend inclusion of ethnicity/race or an explanation for lack of reporting. No journals recommended inclusion of SES data with globally poor reporting; a median of 1/10 articles per journal reported SES (range 0–2).

Conclusion

Reporting of ethnicity/race and SES in high impact respiratory journals is poor despite both being linked to health disparities. Explicit guidelines may improve reporting of key demographic data which would improve research interpretation and application.
研究背景需要研究参与者的人口统计数据,包括民族/种族和社会经济地位(SES),以解释和应用研究结果。国际医学杂志编辑委员会建议在研究中纳入有代表性的人群,并提供相关的人口统计信息,但他们的建议并没有规定。本研究旨在评估在高影响力的呼吸学期刊上关于种族/种族和社会经济地位的报道。方法选取国内外十大呼吸科学期刊(h5指数)中最近发表的10篇(至18/10/24)的研究论文,由2位研究者进行独立评审。数据收集于主要人口统计数据的报告,包括年龄、性别/性别、民族/种族和社会经济地位。结果共纳入100篇研究论文。43项载有族裔/种族的人口资料,10项载有社会经济地位资料,100项载有年龄资料,99项载有性别/性别资料。种族/种族报告的中位数为每份期刊4/10(范围2-8),只有5项研究承认这是一个局限性。《柳叶刀呼吸医学》是唯一明确建议纳入种族/种族或解释缺乏报告的期刊,其中8/10篇文章包含种族/种族数据,其余1篇文章承认缺乏种族/种族数据是一种限制。没有期刊建议纳入全球报告较差的SES数据;每本期刊报告SES的文章中位数为1/10(范围0-2)。结论:尽管民族/种族和社会经济地位与健康差异有关,但在高影响力呼吸期刊上的报道却很少。明确的指导方针可以改进关键人口数据的报告,从而改进研究的解释和应用。
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引用次数: 0
Radiologist-reported tension features on x-ray are not associated with physiological instability in ED patients with primary spontaneous pneumothorax 放射科医生报告的x线张力特征与原发性自发性气胸ED患者的生理不稳定无关
IF 1.8 4区 医学 Q3 RESPIRATORY SYSTEM Pub Date : 2026-05-01 Epub Date: 2026-01-09 DOI: 10.1016/j.resmer.2026.101247
Anne-Maree Kelly, Marsalina Heritrenggi, Matthew Birdsey, Samuel Peat
{"title":"Radiologist-reported tension features on x-ray are not associated with physiological instability in ED patients with primary spontaneous pneumothorax","authors":"Anne-Maree Kelly,&nbsp;Marsalina Heritrenggi,&nbsp;Matthew Birdsey,&nbsp;Samuel Peat","doi":"10.1016/j.resmer.2026.101247","DOIUrl":"10.1016/j.resmer.2026.101247","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"89 ","pages":"Article 101247"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Respiratory Medicine and Research
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