Respiratory Medicine and Research最新文献

{"title":"Real-world treatment patterns, healthcare resource utilization, and healthcare costs in patients in the United States with metastatic non-small cell cancer receiving second or subsequent line systemic anticancer therapy","authors":"Divyan Chopra ,&nbsp;Ihtisham Sultan ,&nbsp;David M. Waterhouse ,&nbsp;Alexander Lonshteyn ,&nbsp;Thomas E. Delea ,&nbsp;Björn Stollenwerk","doi":"10.1016/j.resmer.2025.101197","DOIUrl":"10.1016/j.resmer.2025.101197","url":null,"abstract":"<div><h3>Background</h3><div>This study assessed real-world treatment patterns, healthcare resource utilization, and healthcare costs in the US adults with metastatic non-small cell lung cancer (NSCLC) receiving second or later line (2L+) treatment for non-actionable alterations.</div></div><div><h3>Methods</h3><div>Adults with metastatic NSCLC who received 2L+ treatment for non-actionable alterations from January 1, 2020, to March 31, 2023, were identified using the US Optum deidentified Clinformatics® database. Patients were continuously enrolled in health plans for ≥180 days before NSCLC diagnosis until ≥30 days after receiving treatment.</div></div><div><h3>Results</h3><div>5310 patients met the inclusion criteria and received 2L+ treatments (7010). Median age was 73 years; 86% were insured by Medicare Advantage. Commonly used 2L+ treatments were mono or dual immunotherapy (IO) without chemotherapy (CT) (43.2%) and IO plus platinum-based CT (PBCT) (13.4%). Median treatment duration and time to next treatment were 3.8 months and 6.0 months respectively and were low for CT without IO. Healthcare resource utilization was mainly attributed to outpatient visits (mean: 5.09 per-patient per-month [PPPM]) and were highest for CT without IO. Patients receiving CT without IOs also had the highest rates of inpatient and emergency utilization. Mean total healthcare costs were $27,105 PPPM with hospitalization costs being highest for CT without IO.</div></div><div><h3>Conclusions</h3><div>In the treatment of 2L+ metastatic NSCLC, chemotherapy without IO was associated with poor treatment duration, high inpatient, emergency care utilization, and substantial economic burden. These results highlight the need for more efficacious, safe and cost-efficient treatment options in the 2L+ setting.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101197"},"PeriodicalIF":1.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144829713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm dysfunction evaluated by electroneuromyography in patients with interstitial lung disease (ILD), risks factors and impact on mortality: a retrospective observational study","authors":"Jules Milesi ,&nbsp;Sophie Ng Wing Tin ,&nbsp;Thomas Gille ,&nbsp;Hilario Nunes ,&nbsp;Simon Chauveau ,&nbsp;Carole Planès ,&nbsp;Guillaume Robbe ,&nbsp;Yurdagül Uzunhan ,&nbsp;Lucile Sesé","doi":"10.1016/j.resmer.2025.101196","DOIUrl":"10.1016/j.resmer.2025.101196","url":null,"abstract":"<div><h3>Introduction</h3><div>Diaphragmatic dysfunction (DD) plays a significant role in dyspnea, quality of life, and prognosis in various respiratory diseases. However, its characterization in Interstitial Lung Diseases (ILDs) remains limited. This study aimed to characterize ILD patients with probable DD using diaphragmatic electroneuromyography (dENMG) and analysis of the diaphragm's compound muscle action potential (CMAP), and to determine predictive factors of DD and its prognostic impact.</div></div><div><h3>Methods</h3><div>A retrospective monocentric study was conducted in our center, including all consecutive ILD patients who underwent diaphragm evaluation with ENMG between May 2018 and September 2023. Clinical data, dENMG, and other assessments were collected. Association between abnormal diaphragm’s CMAP and ILD characteristics were analyzed using logistic regression. Survival was analyzed using Kaplan-Meier curves and cox model adjusted for age and sex.</div></div><div><h3>Results</h3><div>Between May 2018 and September 2023, thirty-seven ILD patients underwent an dENMG for suspected DD. Connective Tissue Disease-associated ILD (CTD-ILD) [28 (76 %)] was the most common ILD-subtype. Thirteen (35 %) had a DD according to dENMG. Patients with DD were predominantly older males, had a higher prevalence of coronary artery disease (CAD), and had less non-specific interstitial pneumonia (NSIP) pattern compared to patients without DD. The prognosis appeared to be worse in the DD group, with reduced survival [mean 29.3 (± 17.2) <em>p</em> = 0.04 vs 31.3 months (± 18.3)].</div></div><div><h3>Discussion</h3><div>In a French referral center for ILDs, suspicion of associated DD concerned only a small proportion of ILD patients, mainly with CTD-ILD. Among those, only a third had DD suspected by a dENMG and abnormal diaphragm’s CMAP. DD appears to be associated with unfavorable outcomes, although further research with larger cohorts is warranted.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101196"},"PeriodicalIF":1.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chest mechanics after endoscopic lung volume reduction: Comparison between responders and non-responders based on dynamic hyperinflation","authors":"Olivier Taton ,&nbsp;Silvia Perez-Bogerd ,&nbsp;Alain Van Muylem ,&nbsp;Pierre Alain Gevenois ,&nbsp;Olivier Van Hove ,&nbsp;Benjamin Bondue ,&nbsp;Emmeline Brenard ,&nbsp;Dimitri Leduc","doi":"10.1016/j.resmer.2025.101194","DOIUrl":"10.1016/j.resmer.2025.101194","url":null,"abstract":"<div><h3>Background</h3><div>Endobronchial lung volume reduction (ELVR) improves lung function, exercise capacity, and quality of life in case of severe emphysema. Nevertheless, not all patients are improved by ELVR including those with substantially decreased lung volume. We tested the hypothesis that unilateral volume loss could impact differently both responders and non-responders.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 20 patients, classified as 13 responders and 7 non-responders based on inspiratory capacity increase ≥200 ml at isotime. We compared changes in lung volume, diaphragm shape and strength, mediastinal shift, lung function, exercise capacity, and quality of life before and three months after ELVR.</div></div><div><h3>Results</h3><div>Compared to non-responders, responders showed a more improved diaphragm strength (4 vs<em>.</em> 2 cmH₂O, <em>p</em> = 0.0318) and shape in both sides (non-treated side total area: +42 (7–54) cm², <em>p</em> = 0.0079, non-treated side zone of apposition: +26 (18–52) cm², <em>p</em> = 0.0270). Responders had a larger mediastinal shift than non-responders (13 vs<em>.</em> 3 degrees, <em>p</em> = 0.0039) with significant positive correlations between mediastinal shift and improvements in lung function (FEV₁: <em>r</em> = 0.48, <em>p</em> = 0.0365), exercise capacity (6MWD: <em>r</em> = 0.78, <em>p</em> &lt; 0.0001, inspiratory capacity: <em>r</em> = 0.48, <em>p</em> = 0.0365), and quality of life (CAT: <em>r</em>=-0.58, <em>p</em> = 0.0096).</div></div><div><h3>Conclusions</h3><div>Dynamic hyperinflation responders present a larger mediastinal shift than non-responders. This shift could be a marker of improved diaphragm shape and strength in both treated and non-treated sides.</div></div><div><h3>Clinical trial registration</h3><div>NCT05799352</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101194"},"PeriodicalIF":1.8,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid and extensive calcification of pulmonary arteries","authors":"Sahbi Guezara ,&nbsp;Vincent Cottin ,&nbsp;Giulia Francese ,&nbsp;Mohamed Bakloul ,&nbsp;Sara Boccalini ,&nbsp;Ségolène Turquier","doi":"10.1016/j.resmer.2025.101189","DOIUrl":"10.1016/j.resmer.2025.101189","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101189"},"PeriodicalIF":1.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-synthetase syndrome: A focus on interstitial lung disease as a diagnostic criteria","authors":"Jessica A. Peterson ,&nbsp;Caroline Cook ,&nbsp;Hanzhi Gao ,&nbsp;Raju Reddy ,&nbsp;Bruno Hochhegger ,&nbsp;Diana Gomez-Manjarres ,&nbsp;Faye Pais","doi":"10.1016/j.resmer.2025.101190","DOIUrl":"10.1016/j.resmer.2025.101190","url":null,"abstract":"<div><h3>Background</h3><div>Anti-synthetase syndrome (ASyS) is an autoimmune disorder with clinical manifestations that often include interstitial lung disease (ILD), myositis, and arthritis. Although it shares features with other idiopathic inflammatory myopathies, ILD is more prevalent and often more severe in this syndrome. The aim of this study was to compare Connors and Solomon diagnostic criteria for ASyS and investigated whether the presence of no additional symptoms, one additional symptom, or two or more symptoms, in addition to ILD and relevant antibodies, would indicate a worse prognosis.</div></div><div><h3>Methods</h3><div>This retrospective single-center study examined patients who were previously diagnosed with ASyS based on Connors or Solomon criteria and were further categorized using the 273rd ENMC International workshop criteria and post-hoc. The patients were then stratified based upon how many “defining” signs and symptoms that they had in addition to ILD and antibodies. Demographic characteristics, pulmonary function tests (PFT), chest CT’s—along with clinical outcomes were assessed.</div></div><div><h3>Results</h3><div>No differences in demographic factors and PFT’s were found between those who were diagnosed using Solomons versus Connors criteria. No differences in demographic, PFT’s and chest CT’s between those with ILD and antibodies only, with 1 additional criteria, and with 2+ additional criteria groups, although those with two or more additional criteria had a longer duration since diagnosis.</div></div><div><h3>Discussion</h3><div>Key findings from the study suggest that there are no differences in diagnostic outcomes, therapeutic interventions, or mortality rates when using different criteria to diagnose ASyS. This study suggests a reevaluation of diagnostic criteria for ASyS to prioritize ILD and relevant antibodies rather than a focus of additional criteria, supporting the new ASyS defining criteria from 273rd ENMC International Workshop (2024).</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101190"},"PeriodicalIF":2.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging respiratory challenges in space and long-duration missions","authors":"Benjamin Pequignot ,&nbsp;Seamus Thierry ,&nbsp;G Kim Prisk ,&nbsp;Mickael Lescroart","doi":"10.1016/j.resmer.2025.101188","DOIUrl":"10.1016/j.resmer.2025.101188","url":null,"abstract":"","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101188"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144711500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of complementary medicines and self-medication practices in cystic fibrosis – MUCAUTOMED study","authors":"Sophie Lemagner ,&nbsp;Isabelle Récoché ,&nbsp;Frédéric Eyvrard ,&nbsp;Remy Chambault ,&nbsp;Marie Mittaine ,&nbsp;Marlène Murris","doi":"10.1016/j.resmer.2025.101186","DOIUrl":"10.1016/j.resmer.2025.101186","url":null,"abstract":"<div><h3>Background</h3><div>Cystic fibrosis (CF) patients often undergo treatment with CFTR modulators, which have demonstrated high efficacy but also potential involvement in drug interactions. Inquiries regarding the risks of drug interactions with complementary and alternative medicine products (CAMp) and self-medication drugs have become frequent among patients and prescribers at Toulouse University Hospital. Currently, there is lack of literature on these practices within CF patients, particularly in France, and more so since the advent of CFTR modulators.</div></div><div><h3>Methods</h3><div>This observational monocentric study (MUCAUTOMED) aimed to characterize and quantify the prevalence of CAMp utilization among CF patients under our hospital's care. A secondary objective was to assess and describe the prevalence of self-medication practices. Surveys were administered to outpatients during visits from January 10 to June 6, 2022.</div></div><div><h3>Results</h3><div>Out of 171 included patients, responses from 64 adults and 69 children were analyzed (response rate 133/171 = 77.8 %). CAMp usage was reported by 56.3 % of adults and 46.4 % of children. Most patients use CAMp for enhancing wellness, addressing digestive concerns, and managing respiratory issues. Remarkably, 71.4 % of participants were unaware of potential drug interactions with CAMp, and 48.9 % initiated such use without consulting healthcare professionals. Notably, a significant correlation between CAMp utilization and self-medication was identified within the pediatric population.</div></div><div><h3>Conclusion</h3><div>Our investigation underscores a notably high prevalence of CAMp use among the CF population. Given these findings, it is imperative to routinely discuss CAMp utilization and self-medication practices when initiating CFTR modulator therapy. A multidisciplinary approach is recommended to address potential interactions that may impact overdosing and underdosing, ensuring patients and families are informed of associated risks.</div><div>Registration number 2021-A02593-38.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101186"},"PeriodicalIF":1.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of hemi-cannula in patients with high risk of recannulation in an intermediate respiratory care unit. A descriptive analysis and study of the predictor variables of the use of posterior non-invasive mechanical ventilation","authors":"Sergio Lopez-Ruz,&nbsp;Alba Fernández-Boza,&nbsp;Maria Andrea Jaimes-Castaño,&nbsp;Carlos Carrera-Cueva,&nbsp;Belen Muñoz-Sánchez,&nbsp;Emilio Garcia-Díaz,&nbsp;Demetrio González-Vergara,&nbsp;Javier Toral-Marin,&nbsp;Maria Barca-Hernando","doi":"10.1016/j.resmer.2025.101185","DOIUrl":"10.1016/j.resmer.2025.101185","url":null,"abstract":"<div><h3>Background</h3><div>Information about the decannulation process in patients with high risk of recannulation is limited. However, devices such as the hemi-cannula, which maintain airway permeability for a controlled period, may enhance the safety of this process.</div></div><div><h3>Aims</h3><div>Describe and analyze the variables in the decannulation process of patients with high risk of recannulation, who have used a hemi-cannula and correlate these variables with the posterior need for Non-Invasive Mechanical Ventilation (NIMV).</div></div><div><h3>Methods</h3><div>Unicentric study analyzing a retrospective cohort of consecutive patients admitted to the Intermediate Respiratory Care Unit (IRCU) to continue the decannulation process from April 2022 to April 2024. Sociodemographic and clinical variables were described and analyzed. SPSS software was used to analyze the data with T student for independent data and Chi-square with Fischer correction.</div></div><div><h3>Results</h3><div>The final cohort included 19 patients, whom most of them had no previous respiratory pathology, but a 47.4 % had some cardiovascular risk factors. All of the patients had polyneuropathy at the admission to the IRCU. No 30-day mortality was observed in any patient. The recannulation rate was 10.5 %. 21 % of the patients required subsequent NIMV. Statistical significance at the analysis of the correlation between the mean number of days of Invasive Mechanical Ventilation (IMV) and the need for subsequent NIMV was found. However, there was not with the remaining variables.</div></div><div><h3>Conclusions</h3><div>The use of devices such as the hemi-cannula can enhance safety during the complex decannulation process in patients with high risk of recannulation, reducing the likelihood of reintubation or readmission to the Intensive Care Unit (ICU).</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101185"},"PeriodicalIF":2.2,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does occupational exposure affect the surgical management of patients with non-small cell lung cancer? A single-center retrospective experience","authors":"Matthieu Thumerel ,&nbsp;Camille Carles ,&nbsp;Hugues Begueret ,&nbsp;Quentin Thomas ,&nbsp;Jacques Jougon ,&nbsp;Carine Audoin ,&nbsp;Jean-François Bernaudin ,&nbsp;Patrick Brochard ,&nbsp;Yaniss Belaroussi","doi":"10.1016/j.resmer.2025.101183","DOIUrl":"10.1016/j.resmer.2025.101183","url":null,"abstract":"<div><h3>Objective</h3><div>Non-small-cell lung cancer (NSCLC) remains a major public health concern, with tobacco and environmental exposures to carcinogens (such as asbestos, radon, and silica) recognized as major risk factors. This study investigates the impact of occupational exposure, particularly to crystalline silica on peri‑ and postoperative outcomes in patients undergoing surgery for NSCLC.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 251 patients who underwent lobectomy or segmentectomy between 2018 and 2021, with occupational exposure data collected postoperatively.</div></div><div><h3>Results</h3><div>Our findings suggest that patients with occupational exposure, particularly to silica, asbestos, or multiple carcinogens, have more complex surgical courses, including longer operative times, higher rates of conversion from minimally invasive to open surgery, and increased postoperative complications (Clavien-Dindo grade II or higher). Preoperative lymph node staging was less accurate in exposed patients, in part because of inflammatory changes such as fibro-hyaline lesions, which can cause false-positive PET/CT findings.</div></div><div><h3>Conclusions</h3><div>The study highlights the need for tailored surgical strategies and accurate lymph node staging in exposed individuals. Future research should focus on prospective studies to refine perioperative management and explore the biological mechanisms driving these complications.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101183"},"PeriodicalIF":2.2,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should segmentectomy indications be extended to NSCLC smaller than 3 cm without lymph node involvement? A retrospective single-center study","authors":"Damien Leveque ,&nbsp;Soufiane Lebal ,&nbsp;Tristan Goudou ,&nbsp;Mihaela Giol ,&nbsp;Denis Debrosse ,&nbsp;Marielle LE Roux ,&nbsp;Thérésa Khalife-Hocquemiller ,&nbsp;Anna Vayssette ,&nbsp;Juliette Camuset ,&nbsp;Alexandra Rousseau ,&nbsp;Jalal Assouad ,&nbsp;Harry Etienne","doi":"10.1016/j.resmer.2025.101179","DOIUrl":"10.1016/j.resmer.2025.101179","url":null,"abstract":"<div><h3>Introduction</h3><div>Surgical resection remains the standard treatment for stage IA non-small cell lung cancers (NSCLC). The dual objective of this study is to compare long-term outcomes of lobectomies and segmentectomies for stage IA NSCLC and to identify prognostic factors for resected stage IA NSCLC.</div></div><div><h3>Materials and Methods</h3><div>This is a retrospective monocentric study including patients diagnosed with NSCLC smaller than 3 cm, without lymph node involvement, from November 2015 to November 2021. The primary endpoint was event-free survival (EFS), defined as time from surgery to recurrence or all-cause death. Secondary endpoints included overall survival, recurrence-free survival, and short-term postoperative outcomes (length of stay, drainage duration, 30-day mortality, and postoperative complications). Prognostic factors were analyzed using multivariate Cox regression adjusted for variables identified in univariate analysis.</div></div><div><h3>Results</h3><div>A total of 457 patients underwent surgery for stage cIA NSCLC during the 11study period. Of these, 176 (38.5 %) had a segmentectomy, and 281 (61.5 %) underwent lobectomy. Among patients with cT1N0 tumors, the 5-year event-free survival did not significantly differ between the segmentectomy and lobectomy groups (adjusted HR = 0.59 (0.32; 1.08), <em>p</em> = 0.086), with 5-year event-free rates of 75.0 % and 83.0 %, respectively (<em>p</em> = 0.054). Multivariate analysis revealed an association between nodule type (solid vs. ground-glass or mixed) and event-free survival (death and/or recurrence) ([adjusted HR =2.07 (1.17–3.66), <em>p</em> = 0.01)]. Vascular and/or lymphatic invasion is associated with a decrease in event-free survival (recurrence or death) [adjusted HR = 2.25 (1.29; 3.92), <em>p</em> = 0.004]. Conversion from segmentectomy to lobectomy occurred in 6 patients (3.4 %), and they were included in the lobectomy group for analysis.</div></div><div><h3>Conclusion</h3><div>For patients with clinical stage cIA NSCLC, segmentectomy appears to offer comparable oncologic outcomes to lobectomy. Tumor characteristics, including radiological appearance and histological factors, should be carefully considered when selecting the appropriate surgical strategy. Prospective multicenter studies are needed to confirm these findings.</div></div>","PeriodicalId":48479,"journal":{"name":"Respiratory Medicine and Research","volume":"88 ","pages":"Article 101179"},"PeriodicalIF":2.2,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}