Respiratory Medicine and Research最新文献_第5页

French translation and linguistic validation of four questionnaires relevant to psychological interventions targeting persistent dyspnea: The Breathlessness catastrophizing questionnaire, the breathlessness beliefs questionnaire, the COPD self-efficacy scale, and the three-domain interoceptive sensations questionnaire. 针对持续性呼吸困难的心理干预相关问卷：呼吸困难灾难化问卷、呼吸困难信念问卷、COPD自我效能量表和三域内感受问卷的法语翻译和语言验证。

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-08-23 DOI: 10.1016/j.resmer.2025.101202

Sophie Lavault , Nicolas Roche , Capucine Morélot-Panzini , Christian Straus , Thomas Similowski

Background

Psychological interventions such as medical hypnosis, cognitive-behavioral therapy (CBT), and mindfulness-based techniques are emerging as promising tools in the management of persistent dyspnea. Their integration into clinical practice, however, is limited by the scarcity of validated outcome measures in non-English languages.

Objectives

This study aimed to provide linguistically validated French versions of four questionnaires selected for their potential relevance in assessing the psychological and perceptual dimensions of dyspnea: the Breathlessness Catastrophizing Questionnaire (BCQ), the Breathlessness Beliefs Questionnaire (BBQ), the COPD Self-Efficacy Scale (CSES), and the Three-Domain Interoceptive Sensations Questionnaire (THISQ).

Methods

Questionnaire selection was based on constructs likely to be modulated by psychological interventions: catastrophic thinking, maladaptive beliefs, self-efficacy, and interoception. Translation and linguistic validation followed internationally accepted forward–backward methodology, in collaboration with a specialized agency. Reconciliation was performed through iterative review by subject-matter experts until full consensus was achieved.

Results

French versions of all four questionnaires were successfully produced. Specific challenges arose regarding the translation of key constructs (e.g., “catastrophizing,” “belief,” “self-efficacy”), leading to the proposal of dual titling strategies to balance semantic precision and user acceptability.

Conclusion

These French-language instruments address a practical need for culturally and linguistically appropriate tools in the assessment of psychological dimensions of dyspnea. While developed with medical hypnosis in mind, they may prove equally valuable in research and clinical practice involving other psychological interventions. Psychometric validation in French-speaking populations is warranted.

心理干预，如医学催眠、认知行为疗法（CBT）和基于正念的技术正在成为治疗持续性呼吸困难的有前途的工具。然而，它们与临床实践的结合受到非英语语言验证结果测量的缺乏的限制。目的本研究旨在提供法语版本的问卷，以评估呼吸困难的心理和知觉维度：呼吸困难灾难问卷（BCQ），呼吸困难信念问卷（BBQ）， COPD自我效能量表（CSES）和三域内感受问卷（THISQ）。方法问卷选择基于可能被心理干预调节的构念：灾难性思维、适应不良信念、自我效能感和内感受。在一个专门机构的合作下，翻译和语言验证遵循国际上接受的前向后方法。协调是通过主题专家的反复审查进行的，直到达成完全的共识。结果四份问卷的法文版本均制作成功。在翻译关键构念（如“灾难化”、“信念”、“自我效能”）方面出现了具体的挑战，导致提出了双重标题策略，以平衡语义精度和用户可接受性。结论这些法语仪器在评估呼吸困难的心理维度时满足了文化和语言上适当的工具的实际需要。虽然是在医学催眠的基础上发展起来的，但在涉及其他心理干预的研究和临床实践中，它们可能被证明同样有价值。在法语人群中进行心理测量验证是必要的。

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引用次数: 0

Association between neutrophil extracellular traps in bronchoalveolar lavage fluid and severity of drug-induced lung injury 支气管肺泡灌洗液中性粒细胞胞外陷阱与药物性肺损伤严重程度的关系

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-08-05 DOI: 10.1016/j.resmer.2025.101195

Genki Inui , Miki Takata , Yoshihiro Funaki , Aditya Sri Listyoko , Miyu Nishigami , Hiroyuki Tanaka , Hiroki Ishikawa , Hiroki Kohno , Tomoya Harada , Ryota Okazaki , Masato Morita , Akira Yamasaki

Background

Neutrophil extracellular traps (NETs) play a pivotal role in early immune responses and are implicated in various respiratory diseases, such as acute respiratory distress syndrome (ARDS). A correlation between NETs in bronchoalveolar lavage fluid (BALF) and the severity of ARDS has been reported. NETs are also associated with drug-induced organ disorders. However, the relationship between drug-induced lung injury (DLI) and NETs remains unclear. This study aimed to establish and substantiate this relationship.

Methods

We conducted a retrospective observational study. We extracted DLI cases in which BAL was performed at Tottori university hospital. Based on the need for glucocorticoid treatment, patients were classified into the “moderate severity or above” group (PaO₂ < 80 mmHg) and “mild” group (PaO₂ ≧ 80 mmHg). We examined myeloperoxidase, neutrophil elastase, and double-strand-DNA levels in BALFs, and examined their association with clinical findings and severity, with non-parametric Mann-Whitney U test.

Results

We studied 46 patients with DLI. The “moderate severity or above” group had 32 patients, while the “mild” group had 14 patients, and NETs in BALF were significantly higher in the former group. Three cases showed a diffuse alveolar damage (DAD) pattern on high-resolution computed tomography (HRCT), with significantly higher NET levels that those with non-DAD patterns.

Conclusion

In DLI, NETs in BALF were found to be related with disease severity and the presence of DAD patterns in HRCT images. Measuring NETs in BALF offer potential utility in guiding future treatment selection and aiding the differential diagnosis of clinical phenotypes.

中性粒细胞胞外陷阱（NETs）在早期免疫反应中起关键作用，并与多种呼吸系统疾病有关，如急性呼吸窘迫综合征（ARDS）。支气管肺泡灌洗液（BALF）中的NETs与ARDS严重程度之间存在相关性。NETs还与药物引起的器官疾病有关。然而，药物性肺损伤（DLI）与NETs之间的关系尚不清楚。本研究旨在建立和证实这种关系。方法采用回顾性观察性研究。我们提取了在鸟取大学医院行BAL的DLI病例。根据患者是否需要糖皮质激素治疗，将患者分为“中度及以上”组（PaO2≧80 mmHg）和“轻度”组（PaO2≧80 mmHg）。我们检测了balf中的髓过氧化物酶、中性粒细胞弹性酶和双链dna水平，并通过非参数Mann-Whitney U检验检验了它们与临床表现和严重程度的关系。结果对46例DLI患者进行了研究。“中度及以上”组32例，“轻度”组14例，前者BALF NETs明显高于后者。3例高分辨率计算机断层扫描（HRCT）显示弥漫性肺泡损伤（DAD）模式，其NET水平明显高于非DAD模式。结论在DLI中，发现BALF的NETs与疾病严重程度和HRCT图像中DAD模式的存在有关。测量BALF中的NETs在指导未来的治疗选择和帮助临床表型的鉴别诊断方面具有潜在的效用。

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引用次数: 0

Editorial – "Lung ultrasound and community-acquired pneumonia: from complementary tool to clinical game-changer" 社论-《肺部超声和社区获得性肺炎：从辅助工具到临床游戏规则改变者》

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-08-30 DOI: 10.1016/j.resmer.2025.101203

Luigi Vetrugno , Damiano D’Ardes , Cristian Deana , Daniele Guerino Biasucci , Andrea Boccatonda

Community-acquired pneumonia (CAP) remains a major global health concern, traditionally diagnosed through chest X-ray (CXR). However, lung ultrasound (LUS) is increasingly emerging as a transformative tool in both diagnosis and management. Evidence from recent meta-analyses reveals that LUS outperforms CXR in sensitivity and rivals it in specificity, with pooled diagnostic accuracies exceeding 90 %. Unlike CXR, LUS is radiation-free, cost-effective, and ideal for bedside use, making it particularly valuable in emergency departments, intensive care units, pediatric and geriatric populations, and resource-limited settings. In children, LUS spares radiation exposure, while in elderly patients, contrast-enhanced ultrasound improves diagnostic specificity. Beyond diagnosis, LUS enables dynamic monitoring, prognostic scoring (e.g., LUS score, CPIS-PLUS), and supports treatment decisions such as ventilator weaning and antibiotic stewardship. Recent applications during the COVID-19 pandemic have demonstrated its effectiveness in triage and outcome prediction. Despite challenges such as operator dependency and reduced penetration for deep lesions, technological advances—particularly artificial intelligence and handheld devices—are mitigating these limitations. Deep learning models now interpret LUS images with high accuracy, enhancing reproducibility and accessibility for general practitioners. In low- and middle-income countries, LUS serves as a crucial diagnostic bridge, improving access and reducing reliance on costly imaging modalities. As training programs and standardized scoring systems evolve, LUS is becoming a frontline tool rather than a supplementary option. Its integration into clinical practice promises to reshape pneumonia care through rapid, accurate, and scalable diagnostics. In light of these advancements, LUS is not just complementary to radiography—it is redefining the diagnostic landscape of pneumonia.

社区获得性肺炎（CAP）仍然是一个主要的全球卫生问题，传统上是通过胸部x射线（CXR）诊断的。然而，肺超声（LUS）越来越多地成为诊断和管理的变革性工具。来自最近荟萃分析的证据显示，LUS在敏感性上优于CXR，在特异性上优于CXR，合并诊断准确率超过90% %。与CXR不同，LUS无辐射，具有成本效益，是床边使用的理想选择，因此在急诊科、重症监护病房、儿科和老年人群以及资源有限的环境中特别有价值。在儿童中，LUS可以避免辐射暴露，而在老年患者中，造影增强超声可以提高诊断特异性。除了诊断之外，LUS还支持动态监测、预后评分（例如，LUS评分、CPIS-PLUS），并支持治疗决策，如呼吸机脱机和抗生素管理。最近在COVID-19大流行期间的应用已经证明了它在分类和结果预测方面的有效性。尽管存在操作员依赖性和深度病变穿透减少等挑战，但技术进步（尤其是人工智能和手持设备）正在缓解这些限制。深度学习模型现在以高精度解释LUS图像，增强了全科医生的再现性和可访问性。在低收入和中等收入国家，LUS是一个重要的诊断桥梁，改善了获取途径并减少了对昂贵成像方式的依赖。随着培训项目和标准化评分系统的发展，LUS正在成为一线工具，而不是补充选项。将其整合到临床实践中，有望通过快速、准确和可扩展的诊断重塑肺炎护理。鉴于这些进步，LUS不仅仅是对x线摄影的补充，它正在重新定义肺炎的诊断前景。

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引用次数: 0

Prognostic value of the mini nutritional assessment short-form and SpO₂/FiO₂ ratio at admission for in-hospital mortality in patients with interstitial lung disease 迷你营养评估简表和入院时SpO₂/FiO₂比值对间质性肺疾病患者住院死亡率的预后价值

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-11-12 DOI: 10.1016/j.resmer.2025.101222

Mayuko Ishiwari, Yuta Kono, Yuki Togashi, Kenichi Kobayashi, Ryota Kikuchi, Mariko Kogami, Shinji Abe

Background

Hospitalization of patients with interstitial lung disease (ILD) is a poor prognostic factor. Simple and rapid biomarkers at the time of admission of hospitalized ILD patients are needed. The aim of this study was to investigate prognostic biomarkers in hospitalized patients with ILD.

Methods

A total of 95 consecutive hospitalized patients aged ≥ 65 years with ILD were retrospectively enrolled from April 2022 to December 2024 at Tokyo Medical University Hospital, Tokyo, Japan. Clinical and laboratory parameters at admission were retrospectively collected, and risk factors for in-hospital mortality were evaluated.

Results

The median age was 77 years (IQR: 72–83), and 62 patients (65.0 %) were male. Sixty-nine patients (73.0 %) were ex-smokers. Thirty patients (31.5 %) died during hospitalization, with a median time to death of 19 days (IQR: 10–28). Univariable analysis revealed that a low SpO₂/FiO₂ (S/F) ratio (<419) (p = 0.0003), high neutrophil-to-lymphocyte ratio (NLR) (≥6.5) (p = 0.0003), Glasgow Prognostic Score (GPS) 2 (p = 0.0383), and low Mini Nutritional Assessment Short-Form (MNA-SF) score (<11) (p = 0.0007) were significantly associated with in-hospital mortality of hospitalized patients with ILD. In the multivariable analysis, S/F ratio (p = 0.0116) and low MNA-SF score (p = 0.0289) had a significant effect on the prognosis of hospitalized patients with ILD.

Conclusions

Nutritional risk assessed by the MNA-SF, together with oxygenation status measured by the S/F ratio, could serve as valuable and readily available prognostic biomarkers for hospitalized patients with ILD.

背景：间质性肺疾病（ILD）患者住院是预后不良的因素。住院ILD患者入院时需要简单快速的生物标志物。本研究的目的是研究ILD住院患者的预后生物标志物。方法：回顾性纳入日本东京医科大学医院2022年4月至2024年12月95例年龄≥65岁的ILD连续住院患者。回顾性收集入院时的临床和实验室参数，并评估住院死亡率的危险因素。结果：中位年龄77岁（IQR: 72 ~ 83），男性62例（65.0%）。69例（73.0%）为戒烟者。30例（31.5%）患者在住院期间死亡，中位死亡时间为19天（IQR: 10-28）。单变量分析显示，低SpO2/FiO2 （S/F）比率(结论：MNA-SF评估的营养风险，以及S/F比率测量的氧合状态，可以作为住院ILD患者有价值且易于获得的预后生物标志物。

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引用次数: 0

Real-world treatment patterns, healthcare resource utilization, and healthcare costs in patients in the United States with metastatic non-small cell cancer receiving second or subsequent line systemic anticancer therapy 美国转移性非小细胞癌患者接受二线或后续全身抗癌治疗的现实世界治疗模式、医疗资源利用和医疗成本

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-07-31 DOI: 10.1016/j.resmer.2025.101197

Divyan Chopra , Ihtisham Sultan , David M. Waterhouse , Alexander Lonshteyn , Thomas E. Delea , Björn Stollenwerk

Background

This study assessed real-world treatment patterns, healthcare resource utilization, and healthcare costs in the US adults with metastatic non-small cell lung cancer (NSCLC) receiving second or later line (2L+) treatment for non-actionable alterations.

Methods

Adults with metastatic NSCLC who received 2L+ treatment for non-actionable alterations from January 1, 2020, to March 31, 2023, were identified using the US Optum deidentified Clinformatics® database. Patients were continuously enrolled in health plans for ≥180 days before NSCLC diagnosis until ≥30 days after receiving treatment.

Results

5310 patients met the inclusion criteria and received 2L+ treatments (7010). Median age was 73 years; 86% were insured by Medicare Advantage. Commonly used 2L+ treatments were mono or dual immunotherapy (IO) without chemotherapy (CT) (43.2%) and IO plus platinum-based CT (PBCT) (13.4%). Median treatment duration and time to next treatment were 3.8 months and 6.0 months respectively and were low for CT without IO. Healthcare resource utilization was mainly attributed to outpatient visits (mean: 5.09 per-patient per-month [PPPM]) and were highest for CT without IO. Patients receiving CT without IOs also had the highest rates of inpatient and emergency utilization. Mean total healthcare costs were $27,105 PPPM with hospitalization costs being highest for CT without IO.

Conclusions

In the treatment of 2L+ metastatic NSCLC, chemotherapy without IO was associated with poor treatment duration, high inpatient, emergency care utilization, and substantial economic burden. These results highlight the need for more efficacious, safe and cost-efficient treatment options in the 2L+ setting.

本研究评估了美国成年转移性非小细胞肺癌（NSCLC）患者接受二线或二线以上（2L+）治疗的现实世界治疗模式、医疗资源利用和医疗费用。方法：在2020年1月1日至2023年3月31日期间接受2L+治疗的非可操作改变的转移性NSCLC成人患者，使用US Optum deidentified Clinformatics®数据库进行鉴定。患者在NSCLC诊断前≥180天连续参加健康计划，直到接受治疗后≥30天。结果5310例患者符合纳入标准，接受2L+治疗（7010例）。中位年龄73岁；86%的人参加了医疗保险优惠计划。常用的2L+治疗方法为单或双免疫治疗（IO）不加化疗（CT）（43.2%）和IO加铂基CT (PBCT)（13.4%）。中位治疗持续时间为3.8个月，到下一次治疗的时间为6.0个月，CT无IO组较低。医疗资源利用主要归因于门诊就诊（平均：5.09 /患者/月[PPPM]）， CT未进行IO的利用率最高。接受CT治疗而不进行IOs的患者住院和急诊使用率也最高。平均总医疗费用为27,105美元，住院费用最高的是CT而非IO。结论在2L+转移性非小细胞肺癌的治疗中，化疗无IO治疗时间短，住院率高，急诊使用率高，经济负担大。这些结果强调了在2L+环境中需要更有效、更安全和更具成本效益的治疗方案。

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引用次数: 0

MUC5B polymorphism and post COVID-19 lung abnormalities on chest CT-scan MUC5B多态性与胸部ct扫描新冠肺炎后肺部异常

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-09-17 DOI: 10.1016/j.resmer.2025.101207

Celestie Yaacoub , Coralie Tardivon , Jean Dib , Spyridon Prountzos , Joe Yazbeck , Elvira-Markela Antonogiannaki , Ibrahima Ba , Christina Kontopoulou , Pinelopi Kazakou , Lykourgos Kolilekas , Anastasia Antoniadou , Bruno Crestani , Spyros A. Papiris , Effrosyni D. Manali , Quentin Philippot , Antoine Khalil , Cedric Laouenan , Raphael Borie , Marie-Pierre Debray , on behalf of the French COVID cohort study group

引用次数: 0

Analysis of exhaled breath and serum markers following a single bout of exercise in COPD patients - a case-control study. 慢性阻塞性肺病患者单次运动后呼气和血清标志物的分析-一项病例对照研究。

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-07-23 DOI: 10.1016/j.resmer.2025.101193

Rembert Koczulla, Tobias Boeselt, Albrecht Sitte Zoellner, Rainer Gloeckl, Daniela Kroll, Inga Jarosch, Tessa Schneeberger, Julia Held, Sabina Janciauskiene

引用次数: 0

Six-minute walking distance is a robust predictor of mortality in stable chronic obstructive pulmonary disease without major comorbidities 6分钟步行距离是无主要合并症的稳定型慢性阻塞性肺疾病死亡率的可靠预测因子。

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-10-03 DOI: 10.1016/j.resmer.2025.101214

Brede Kvisvik , Ingunn Skjørten , Janne Mykland , Torbjørn Omland , Morten Nissen Melsom , Sjur Humerfelt , Kjetil Steine

Background

Most patients with COPD are examined with specific pulmonary function tests and blood samples in addition to six-minute walking distance (6MWD), while few are examined by echocardiography and even fewer by invasive right heart catheterization (RHC). However, the relative prognostic value of these indices of disease remains to be defined.

Aim

We aimed in the present study to identify predictors of mortality in a cohort of COPD patients who had undergone comprehensive testing of pulmonary function, echocardiography and RHC.

Material and methods

The study included 97 outpatients with stable COPD in GOLD stages I-IV, after excluding three patients receiving a lung transplant. All patients underwent preinclusion screening where patients with left ventricular disease and other major comorbidities were excluded. Spirometry, blood tests, 6MWD and echocardiography of right and left heart were carried out, and RHC was performed at rest.

Results

During a mean follow-up of 7.6 ± 0.6 years, 44 patients died. Pulmonary hypertension was diagnosed in 32 patients (33 %) and was associated with mortality (p = 0.029). 6MWD, right ventricular tricuspid annular plane systolic excursion and myocardial performance index, mean pulmonary artery pressure, pulmonary vascular resistance, arterial oxygen tension, forced expiratory volume in one second, and oxygen uptake were all associated with mortality. However, 6MWD was the only significant variable in the multivariable Cox regression model (p = 0.001).

Conclusions

6MWD was the most robust prognostic determinant of mortality in a stable COPD population free of major comorbidities.

背景：大多数COPD患者除了6分钟步行距离（6MWD）外，还接受特定的肺功能检查和血液样本检查，而很少接受超声心动图检查，更少接受有创右心导管（RHC）检查。然而，这些疾病指标的相对预后价值仍有待确定。目的：在本研究中，我们旨在确定经过肺功能、超声心动图和RHC综合检查的COPD患者队列的死亡率预测因素。材料和方法：该研究包括97例GOLD期I-IV期稳定COPD门诊患者，排除了3例接受肺移植的患者。所有患者均接受纳入前筛查，排除左心室疾病和其他主要合并症患者。进行肺活量测定、血液检查、6MWD及左右心超声心动图检查，静息时进行RHC检查。结果：平均随访7.6±0.6年，44例患者死亡。32例（33%）患者被诊断为肺动脉高压，并与死亡率相关（p = 0.029）。6MWD、右心室三尖瓣环平面收缩偏移及心肌表现指数、平均肺动脉压、肺血管阻力、动脉氧张力、1秒用力呼气量、摄氧量均与死亡率相关。然而，在多变量Cox回归模型中，6MWD是唯一显著变量（p = 0.001）。结论：在无主要合并症的稳定COPD人群中，6MWD是最可靠的死亡率预后决定因素。

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引用次数: 0

Early mobilization and functional outcomes in cystic fibrosis patients after lung transplantation: A single-center retrospective study 肺移植后囊性纤维化患者的早期活动和功能结局：一项单中心回顾性研究

IF 2.2 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-05-29 DOI: 10.1016/j.resmer.2025.101184

Matthieu Reffienna , Jeremy Roussel , Gabor Kalman , Mathilde Labro , Charles Cerf , François Parquin

Background

Rehabilitation has been shown to enhance patient performance before and after lung transplantation, but limited data exist on its role during the immediate post-transplant phase in critical care units.

Methods

We conducted a single-center retrospective study. All adult patients who underwent bilateral transplantation for cystic fibrosis were included. Patients were followed from admission to discharge from critical care. All rehabilitation sessions were recorded. We aimed to evaluate the relationship between the amount of mobilization performed by the patient in critical care, and functional performance at discharge.

Results

We included 36 patients (21 males) with a median age of 29 years (IQR: 24.5–35.0) and a median critical care length of stay of 15 days (12.5–20). Patients performed a total of 388 sessions of rehabilitation. Out-of-bed mobilization started at a median of post-operative day 2.5 (IQR: 1.0–4.5), with the first walking session at day 3 (IQR: 2.0–4.5). A strong correlation was found between daily walking distance and functional performance, as measured by the 6-minute walk test, with a Pearson correlation coefficient of 0.70 (95 % CI: 0.48–0.84).

Conclusions

After lung transplantation for cystic fibrosis, early initiated rehabilitation in critical care is feasible and can improve patients' functional performance. These findings are promising, but require validation in other lung transplant populations.

康复已被证明可以提高患者在肺移植前后的表现，但关于其在重症监护病房移植后立即阶段的作用的数据有限。方法采用单中心回顾性研究。所有因囊性纤维化而接受双侧移植的成年患者均被纳入研究。随访患者从入院到出院。所有的康复疗程都被记录下来。我们的目的是评估重症监护患者的活动量与出院时的功能表现之间的关系。结果纳入36例患者（男性21例），中位年龄29岁（IQR: 24.5-35.0），中位重症监护住院时间15天（12.5-20）。患者总共进行了388次康复治疗。术后中位2.5天开始床下活动（IQR: 1.0-4.5），第3天开始第一次行走（IQR: 2.0-4.5）。通过6分钟步行测试，发现每日步行距离与功能表现之间存在很强的相关性，Pearson相关系数为0.70 （95% CI: 0.48-0.84）。结论囊性纤维化肺移植术后危重监护早期康复是可行的，可提高患者的功能表现。这些发现很有希望，但需要在其他肺移植人群中进行验证。

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引用次数: 0

Use of complementary medicines and self-medication practices in cystic fibrosis – MUCAUTOMED study 囊性纤维化患者补充药物和自我药疗的应用MUCAUTOMED研究

IF 1.8 4区医学 Q3 RESPIRATORY SYSTEM

Respiratory Medicine and Research

Pub Date : 2025-11-01 Epub Date: 2025-06-16 DOI: 10.1016/j.resmer.2025.101186

Sophie Lemagner , Isabelle Récoché , Frédéric Eyvrard , Remy Chambault , Marie Mittaine , Marlène Murris

Background

Cystic fibrosis (CF) patients often undergo treatment with CFTR modulators, which have demonstrated high efficacy but also potential involvement in drug interactions. Inquiries regarding the risks of drug interactions with complementary and alternative medicine products (CAMp) and self-medication drugs have become frequent among patients and prescribers at Toulouse University Hospital. Currently, there is lack of literature on these practices within CF patients, particularly in France, and more so since the advent of CFTR modulators.

Methods

This observational monocentric study (MUCAUTOMED) aimed to characterize and quantify the prevalence of CAMp utilization among CF patients under our hospital's care. A secondary objective was to assess and describe the prevalence of self-medication practices. Surveys were administered to outpatients during visits from January 10 to June 6, 2022.

Results

Out of 171 included patients, responses from 64 adults and 69 children were analyzed (response rate 133/171 = 77.8 %). CAMp usage was reported by 56.3 % of adults and 46.4 % of children. Most patients use CAMp for enhancing wellness, addressing digestive concerns, and managing respiratory issues. Remarkably, 71.4 % of participants were unaware of potential drug interactions with CAMp, and 48.9 % initiated such use without consulting healthcare professionals. Notably, a significant correlation between CAMp utilization and self-medication was identified within the pediatric population.

Conclusion

Our investigation underscores a notably high prevalence of CAMp use among the CF population. Given these findings, it is imperative to routinely discuss CAMp utilization and self-medication practices when initiating CFTR modulator therapy. A multidisciplinary approach is recommended to address potential interactions that may impact overdosing and underdosing, ensuring patients and families are informed of associated risks.

Registration number 2021-A02593-38.

囊性纤维化（CF）患者通常接受CFTR调节剂治疗，CFTR调节剂已证明具有较高的疗效，但也可能涉及药物相互作用。图卢兹大学医院的病人和处方者经常询问药物与补充和替代药物产品（CAMp）和自我药疗药物相互作用的风险。目前，在CF患者中缺乏这些实践的文献，特别是在法国，自CFTR调节剂出现以来更是如此。方法本观察性单中心研究（MUCAUTOMED）旨在描述和量化我院CF患者CAMp使用率。第二个目的是评估和描述自我药疗实践的流行程度。对2022年1月10日至6月6日就诊的门诊患者进行调查。结果在171例纳入的患者中，分析了64例成人和69例儿童的反应（有效率133/171 = 77.8%）。56.3%的成年人和46.4%的儿童使用CAMp。大多数患者使用CAMp来增强健康，解决消化问题和管理呼吸问题。值得注意的是，71.4%的参与者不知道潜在的药物与CAMp的相互作用，48.9%的人在没有咨询医疗保健专业人员的情况下开始使用CAMp。值得注意的是，在儿科人群中发现了CAMp使用与自我用药之间的显著相关性。结论：我们的调查强调了CF人群中CAMp使用的显著高流行率。鉴于这些发现，在开始CFTR调节剂治疗时，常规讨论CAMp的使用和自我用药实践是必要的。建议采用多学科方法来解决可能影响过量和剂量不足的潜在相互作用，确保患者和家属了解相关风险。注册号2021-A02593-38。

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引用次数: 0