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Investigating the Impact of Açai (Euterpe oleracea) on Lipid Profile: A Comprehensive Systematic Review and Meta-Analysis. 调查阿帕拉塞(欧洲甘蓝)对血脂的影响:一项全面的系统评价和荟萃分析。
IF 3.6 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-02-17 DOI: 10.1111/nbu.12735
Bruno Moreira Candeloro, Túlio H B Bitencourt, Sergio F R Elias, Maria Clara Rauli, Isabela B Brandão, Sandra Maria Barbalho, David M Garner, Rodrigo D Raimundo, Andrey A Porto, Vitor E Valenti

Conditions such as obesity and cardiovascular diseases represent significant global public health challenges, driven by their increasing prevalence and profound effects on morbidity and mortality. Dyslipidemia, defined by abnormal lipid concentrations, performs a pivotal role in the onset of cardiovascular diseases, especially atherosclerosis. Dietary strategies and other nonpharmacological interventions are crucial for the management of dyslipidemia. Açaí (Euterpe oleracea), a fruit native to the Amazon, is recognised for its antioxidant properties and potential impact on lipid metabolism. This systematic review and meta-analysis aimed to assess the impact of açaí consumption on lipid profile markers. A systematic search was performed across several databases, including MEDLINE/PubMed, EMBASE, Web of Science and Scopus. We included non-randomised, randomised, no blind, blind and control trials involving adult participants who received açaí in any form. The outcome measures included triglycerides, total cholesterol, LDL-c and HDL-c. The screening of studies and data extraction were independently conducted by four reviewers. The risk of bias was evaluated using the Cochrane Risk of Bias tool, and meta-analyses were completed where applicable. Out of 188 identified studies, 8 met the inclusion criteria. Meta-analysis of 411 participants displayed no significant effect of açaí on LDL-c (MD = 6.06 mg/dL 95% CI: -0.03, 12.48, p = 0.06), HDL-c (MD = 0.30 mg/dL 95% CI: -1.54, 2.13, p = 0.75), total cholesterol (MD = 2.94 mg/dL 95% CI: -6.44, 12.31, p = 0.54) and triglycerides (MD = 2.05 mg/dL 95% CI: 1.79, 2.28, p = 0.59). Additionally, açaí consumption was related to a significant reduction in total lipids (MD = -9.80 g, 95% CI: -13.94 to -5.66, p < 0.001). GRADE evaluation pointed to low/very low certainty of evidence. Açaí consumption may lessen total lipid levels, but no significant effect was noted for cholesterol parameters and triglycerides. Further trials with more demanding research methodologies are required to clarify the effects of açaí on lipid profiles. Trial Registration: CRD42024549531.

肥胖和心血管疾病等疾病的流行率不断上升,对发病率和死亡率产生深远影响,构成了重大的全球公共卫生挑战。血脂异常,由脂质浓度异常定义,在心血管疾病,特别是动脉粥样硬化的发病中起着关键作用。饮食策略和其他非药物干预对血脂异常的管理至关重要。Açaí (Euterpe oleracea),一种原产于亚马逊的水果,因其抗氧化特性和对脂质代谢的潜在影响而被认可。本系统综述和荟萃分析旨在评估açaí消费对血脂指标的影响。在MEDLINE/PubMed、EMBASE、Web of Science和Scopus等多个数据库中进行系统检索。我们纳入了非随机、随机、无盲、盲和对照试验,这些试验涉及以任何形式接受açaí治疗的成年参与者。结果测量包括甘油三酯、总胆固醇、LDL-c和HDL-c。研究筛选和数据提取由四位审稿人独立进行。使用Cochrane偏倚风险工具评估偏倚风险,并在适用的情况下完成meta分析。在188项确定的研究中,有8项符合纳入标准。411名参与者的荟萃分析显示açaí对LDL-c (MD = 6.06 mg/dL 95% CI: -0.03, 12.48, p = 0.06)、HDL-c (MD = 0.30 mg/dL 95% CI: -1.54, 2.13, p = 0.75)、总胆固醇(MD = 2.94 mg/dL 95% CI: -6.44, 12.31, p = 0.54)和甘油三酯(MD = 2.05 mg/dL 95% CI: 1.79, 2.28, p = 0.59)没有显著影响。此外,açaí的摄入与总脂质的显著降低有关(MD = -9.80 g, 95% CI: -13.94至-5.66,p
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引用次数: 0
Knowledge and Perceptions of Supplemental Nutrition Assistance Program-Eligible Purchases: A Survey of US Midwestern College Students. 补充营养援助计划合格购买的知识和观念:一项对美国中西部大学生的调查。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-02-17 DOI: 10.1111/nbu.70002
Matthew Chrisman, Matthew J Landry, Seth Klobodu, Dylan Bailey

Little is known regarding the intrastudent barriers to accessing and utilising the Supplemental Nutrition Assistance Program (SNAP). To examine college students' knowledge of allowable items and perception of what items should be allowed for purchase with (SNAP) benefits, particularly by food security status and enrolment in SNAP in the past 12 months, a cross-sectional, online survey was conducted among 844 college students from nine higher education institutions in a single Midwestern state. Many students were unaware that certain food items were already covered by SNAP, leading them to express a desire for these items to be included. Additionally, there were misconceptions about the eligibility of nonfood items for purchase using SNAP benefits. Beyond traditional food items, students highly desired the inclusion of necessities such as toiletries and cooking equipment. Improved outreach and educational campaigns could be developed to clarify the eligible items and scope of the programme, enabling students to make informed decisions about their SNAP benefit usage.

关于学生访问和利用补充营养援助计划(SNAP)的障碍知之甚少。为了检查大学生对允许购买的物品的知识和对应该允许购买(SNAP)福利的物品的看法,特别是通过过去12个月的食品安全状况和SNAP的注册情况,对来自中西部一个州的9所高等教育机构的844名大学生进行了横断面在线调查。许多学生不知道SNAP已经涵盖了某些食品,这导致他们表达了将这些食品包括在内的愿望。此外,人们对使用SNAP福利购买非食品物品的资格存在误解。除了传统的食品外,学生们还非常希望包括洗漱用品和烹饪设备等必需品。可以开展改进的外展和教育活动,以澄清项目的合格项目和范围,使学生能够对其SNAP福利的使用做出明智的决定。
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引用次数: 0
Ultra-Processed Foods Marketed in Türkiye: An Analysis of Nutritional Quality and Packaging Sustainability. 在日本销售的超加工食品:营养质量和包装可持续性分析。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-03-12 DOI: 10.1111/nbu.70005
Hilal Şimşek, Armineh Rajabi, Büşra Öztürk, Aslı Uçar

This study aimed to evaluate the nutritional profile and packaging recycling status of ultra-processed foods (UPFs) sold in chain markets across Türkiye. In this regard, the nutritional quality and recyclability status of the packages of UPFs, as defined by NOVA, sold in five major supermarket chains across Türkiye were examined. The energy and nutrient content displayed on UPF labels were analysed, and their nutritional profiles considered using the Nutri-Score algorithm. The study also documented the frequency of recycling symbols on the packaging. Of the 1365 UPFs examined across 13 categories, 61.6% were identified as having an unhealthy nutritional profile (Nutri-Score Grades D and E), whereas only 16% were classified as healthy (Grades A and B). Categories predominantly containing unhealthy products included milk and dairy, sauces and dressings, frozen and dehydrated meals, processed meats, along with various snacks and desserts like salty and sweet snacks, candies, chocolates and ice cream. Notably, candies, chocolates, and salty and sweet snacks were identified as the most energy-dense UPF categories. In terms of packaging, 84.4% of UPFs used at least one recycling symbol, 55.3% of these used plastic material and 38.2% used the Green Dot symbol. The results of the study may guide UPF nutrient profile reformulations and contribute to epidemiological studies analysing the relationship between UPF consumption and public health. Furthermore, these results highlight the necessity for more defined national regulations on the recycling of food packaging within the context of food system sustainability.

本研究旨在评估 rkiye连锁市场销售的超加工食品(upf)的营养概况和包装回收状况。在这方面,研究人员检查了全国五大连锁超市销售的由NOVA定义的upf包装的营养质量和可回收性状况。分析UPF标签上显示的能量和营养含量,并使用nutrition - score算法考虑其营养概况。该研究还记录了包装上回收标志的频率。在13个类别的1365个upf中,61.6%被确定为具有不健康的营养状况(营养评分等级D和E),而只有16%被归类为健康(等级A和B)。主要含有不健康产品的类别包括牛奶和乳制品、酱汁和调味品、冷冻和脱水食品、加工肉类,以及各种零食和甜点,如咸点心和甜食、糖果、巧克力和冰淇淋。值得注意的是,糖果、巧克力、咸味和甜味零食被确定为能量密度最高的UPF类别。在包装方面,84.4%的upf使用至少一个回收标志,其中55.3%使用塑料材料,38.2%使用绿点标志。这项研究的结果可以指导UPF营养成分的重新配制,并有助于分析UPF消费与公众健康之间关系的流行病学研究。此外,这些结果强调了在食品系统可持续性的背景下,对食品包装回收制定更明确的国家法规的必要性。
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引用次数: 0
Diet, Physical Activity and Depression: Does Gastrointestinal Health Help Explain the Relationship Between Lifestyle Factors and Depression? 饮食、体育活动与抑郁症:胃肠道健康是否有助于解释生活方式因素与抑郁症之间的关系?
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-03-04 DOI: 10.1111/nbu.12734
Deili Sinimeri, Caroline Childs, Dennis Golm

Lifestyle factors such as diet and physical activity are involved in the development and maintenance of depression, but the mechanism by which these factors influence mental health remains unclear. The aim of this study was to investigate whether gastrointestinal health helps explain some of the relationship between these lifestyle factors and depression. The study used a cross-sectional design to compare dietary intake, physical activity and gastrointestinal health in three groups, healthy (n = 235), lifetime depression (n = 161) and current depression (n = 86). Dietary intake was measured by the Fruit And Vegetable VAriety index, N-3 PUFA Food Frequency Questionnaire and Prebiotic and Probiotic Food Frequency Questionnaire. Analysis of variance, Pearson correlations and Hayes PROCESS macro mediation analysis were used to compare the groups and examine the relationships. Physical activity and gastrointestinal health differed significantly between the groups with no differences in overall fruit and vegetable, omega-3 and probiotic food intake. Bootstrapped correlations showed that higher fruit and vegetable and omega-3 intake were associated with lower gastrointestinal symptom and depression scores, but effects were weak. Furthermore, higher occurrence of gastrointestinal symptoms was moderately associated with higher depression scores. Results from a series of exploratory mediation analyses suggested that gastrointestinal symptoms mediated the relationship between lifestyle factors and depression status. These data indicate that the effects of lifestyle factors on depression might partly work through the gastrointestinal system. The findings of this study help further understand the mechanisms between dietary intake and physical activity, and depression and can inform future longitudinal and experimental studies.

饮食和体育活动等生活方式因素与抑郁症的发展和维持有关,但这些因素影响心理健康的机制尚不清楚。这项研究的目的是调查胃肠道健康是否有助于解释这些生活方式因素与抑郁症之间的一些关系。该研究采用了横断面设计,比较了健康(n = 235)、终生抑郁(n = 161)和当前抑郁(n = 86)三组的饮食摄入量、体育活动和胃肠道健康状况。膳食摄入量采用果蔬品种指数、N-3 PUFA食物频率问卷和益生元和益生菌食物频率问卷进行测定。采用方差分析、Pearson相关分析和Hayes PROCESS宏观中介分析进行组间比较和关系检验。两组之间的身体活动和胃肠道健康状况存在显著差异,但在水果和蔬菜、omega-3和益生菌食物的总体摄入量方面没有差异。自举相关性显示,摄入较多的水果、蔬菜和omega-3脂肪酸与较低的胃肠道症状和抑郁评分相关,但效果较弱。此外,胃肠道症状的高发生率与高抑郁评分有中度相关性。一系列探索性中介分析结果表明,胃肠道症状在生活方式因素与抑郁状态之间起中介作用。这些数据表明,生活方式因素对抑郁症的影响可能部分通过胃肠道系统起作用。这项研究的发现有助于进一步了解饮食摄入、身体活动和抑郁症之间的机制,并可以为未来的纵向和实验研究提供信息。
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引用次数: 0
Ultra Processed Food Consumption in Children and Adolescents: Main Food Group Contributors and Associations With Weight Status. 儿童和青少年的超加工食品消费:主要食物组贡献者及其与体重状况的关系。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1111/nbu.70001
Evgenia Petridi, Emmanuella Magriplis, Kalliopi Karatzi, Evelina Charidemou, Elena Philippou, Antonis Zampelas

Consumption of ultra-processed foods (UPFs) is thought to play an important role in the development of childhood obesity worldwide. The aim of this study was to assess the main food groups contributing to UPF consumption and their association with weight status. Following exclusion of children with implausible intakes and misreporters, the final sample included 443 of 484 eligible (children and adolescents aged 2-18 years old) (91.5%), from the Hellenic National Nutrition and Health Survey (HNNHS). UPF items reported in 24-h recalls were identified according to the NOVA4 system and the proportion of their contribution to the daily energy intake was calculated. Main UPF food contributors were derived for the total population and by weight status. The association between weight status and UPF intake for the main contributors was examined using generalised linear models. The average percentage of total daily energy provided by UPFs was 39.8%. Four major food groups were found to contribute > 10% of total UPF intake: ready-to-eat/heat dishes (36.2%), sweet grain products (21.4%), savoury snacks (15.4%) and sweets (12.9%). These provided 86% of the total UPF intake, with no significant differences between children's weight status. There was also no significant association between the total percentage of energy as UPF and obesity. The relatively high contribution of UPFs, however, to children's daily energy intake in Greece emphasises the need for public food awareness campaigns for health promotion. Evaluation of the contribution of different food groups and not only of total UPF intake is also important.

超加工食品(upf)的消费被认为在全球儿童肥胖的发展中起着重要作用。本研究的目的是评估导致UPF消费的主要食物组及其与体重状况的关系。在排除摄入不合理和错误报告的儿童后,最终样本包括来自希腊国家营养与健康调查(HNNHS)的484名合格儿童(2-18岁的儿童和青少年)中的443名(91.5%)。根据NOVA4系统确定24小时召回报告的UPF项目,并计算其对每日能量摄入的贡献比例。根据总人口和体重状况得出了UPF的主要食物贡献者。使用广义线性模型检查了主要贡献者的体重状况与UPF摄入量之间的关系。upf每天提供的总能量的平均百分比为39.8%。四类主要食物占UPF总摄入量的10%:即食/热菜(36.2%)、甜谷物产品(21.4%)、咸味小吃(15.4%)和糖果(12.9%)。这些提供了总UPF摄入量的86%,儿童体重状况之间没有显着差异。能量的总百分比作为UPF和肥胖之间也没有显著的联系。然而,普遍膳食津贴对希腊儿童每日能量摄入的贡献相对较高,这突出表明需要开展公众食品意识运动,以促进健康。评估不同食物组的贡献,而不仅仅是UPF总摄入量也很重要。
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引用次数: 0
Consumption and Greenhouse Gas Emissions Impacts of Population-Wide Adoption of Dietary Guidelines in China. 中国全民膳食指南的消费和温室气体排放影响
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-04-18 DOI: 10.1111/nbu.70008
Sabina Crowe, Rosemary Green, Christian Reynolds, Bhavani Shankar

This paper uses an optimisation model to quantify the necessary food consumption adjustments for Chinese diets to fulfil the requirements in the health-based Chinese Dietary Guidelines (CDG) or WHO dietary guidelines. We further aim to determine whether adopting these guidelines could lead to lower levels of greenhouse gas emissions (GHGE) while maintaining diet affordability. Modelling outcomes under the CDG and WHO scenarios differ significantly from nutritional, GHGE and diet affordability perspectives: relative to observed eating patterns, diets following the WHO guidelines are equally emissions intensive, while diets consistent with the CDG recommendations are less sustainable. Further optimisations imposing significant reductions in GHGE indicate important environmental and nutritional co-benefits can be achieved through the WHO guidelines, while maintaining diet affordability. In the WHO scenario, the maximum diet-related GHGE reduction policymakers could aim for is 30%, since above this threshold, recommended diets would deviate considerably from observed patterns. The CDG model with a 20% emissions reduction does not converge for 64% of the initial data set, casting doubt on the affordability and compatibility of the CDG with China's decarbonisation goal. We recommend that future versions of the CDG be reformulated to closer align with WHO advice and explicitly include environmental considerations.

本文采用优化模型,量化了中国饮食需要的食物消费调整,以满足以健康为基础的中国膳食指南(CDG)或世界卫生组织膳食指南的要求。我们进一步的目的是确定采用这些指南是否可以在保持饮食负担能力的同时降低温室气体排放水平。从营养、温室气体排放和饮食负担能力的角度来看,CDG和世卫组织情景下的建模结果存在显著差异:相对于观察到的饮食模式,遵循世卫组织指南的饮食同样是排放密集型的,而符合CDG建议的饮食则不太可持续。实施温室气体显著减少的进一步优化表明,通过世卫组织指南可以实现重要的环境和营养协同效益,同时保持饮食的可负担性。在世卫组织的设想中,与饮食有关的温室气体减排的最大目标是30%,因为超过这个阈值,推荐的饮食将大大偏离观察到的模式。减排20%的CDG模型在64%的初始数据集上没有收敛,这使人们对CDG与中国脱碳目标的可负担性和兼容性产生了怀疑。我们建议重新制定未来版本的可持续发展目标,以更加符合世卫组织的建议,并明确纳入环境考虑因素。
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引用次数: 0
Portion Estimation, Satiety Perception and Energy Intake Following Different Breakfast Portion Sizes in Healthy Adults. 健康成年人不同份量早餐的份量估计、饱腹感和能量摄入。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-02-05 DOI: 10.1111/nbu.12733
Kinga Kwiecien, Lourdes Santos-Merx, Tarsem Sahota, Helen Coulthard, Mariasole Da Boit

Expected satiety is a key element in predicting meal portion size and food consumption; however, how this can be affected by different breakfast portion sizes is unknown. The study examined the impact of different breakfast portions on satiety, portion size, and energy intake and comprised an online survey and an experimental intervention. Sixteen adults (9 women, BMI: 24.9 ± 4.3 kg/m2) rated images of three portion sizes (small, standard, large) of the same breakfast using an ordinal scale. Subsequently, they were asked to self-prepare and consume ad libitum the three breakfast portions in a randomised order on different days and to complete a food diary. Satiety and portion size perception were re-measured upon consumption of each breakfast. For both the visual image and breakfast consumption, the small breakfast portion was rated as the smallest and least filling, while the large portion was rated as the largest and most filling (p < 0.05). When consuming the small breakfast, participants reported being hungrier and less full between breakfast and lunch (p < 0.05) and had a higher energy intake from lunch onward, due to more snacking (p < 0.05). However, the total daily energy intake was not different among the three breakfast portion sizes. Individuals seemed accustomed to predicting satiety and portion size from images. The consumption of the small breakfast was judged as not filling enough and was accompanied by a higher energy intake via energy-dense snacks. Based on these preliminary findings, breakfast size reduction may lead to unhealthy compensatory energy intake by snacking on energy-dense foods.

预期饱腹感是预测餐量和食物消耗量的关键因素;然而,这是如何影响不同的早餐份量是未知的。该研究考察了不同早餐分量对饱腹感、份量大小和能量摄入的影响,并包括在线调查和实验干预。16名成年人(9名女性,BMI: 24.9±4.3 kg/m2)使用顺序量表对同一份早餐的三种份量(小、标准、大)的图像进行评分。随后,他们被要求在不同的日子里按随机顺序自行准备和随意食用这三种早餐,并完成一份食物日记。在每顿早餐的消费中重新测量饱腹感和分量感知。在视觉形象和早餐消费方面,小份早餐被评为最小和最不饱腹,而大份早餐被评为最大和最饱腹(p
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引用次数: 0
Health Impact Database Development for Sweeteners and Sweetness Enhancers: The SWEET Project. 甜味剂和增甜剂的健康影响数据库开发:SWEET项目。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-04-03 DOI: 10.1111/nbu.70006
Corey E Scott, Nikoleta Stamataki, Joanne A Harrold, Anne Raben, Jason C G Halford

Sweeteners and sweetness enhancers (S&SEs) are ingredients used in foods and beverages to reduce sugar while providing the sweetness of sugar with little to no calories. Although S&SEs have global regulatory approval and acceptance, questions remain regarding their overall safety and efficacy. Information on the effects of S&SEs in regard to health and efficacy can be found in randomised controlled trials (RCTs) that exist in peer-reviewed literature. With the large number of RCT publications on various S&SEs, a need exists to organise and collect each of the published studies in a useful database. Currently, a database containing human clinical information on S&SEs does not exist and so The SWEET project has created a publicly available and comprehensive Health Impact Database that includes available human clinical information on sweeteners. This paper describes the process and development of a database that collects comprehensive information on published human clinical studies evaluating S&SEs between the years January 2000 and September 2024. Ovid Medline was used to search for RCT publications from the year 2000 to 2024. The search produced 1538 publications, of which 257 complied with the predetermined eligibility criteria. There was a large variability in the number of studies that fit the inclusion criteria. For example, some S&SEs had numerous studies (i.e., sucralose, n = 63 eligible publications) and some S&SEs had no publications that fit the criteria (aspartame-acesulfame K salt and neohesperidine DC). The Health Impact Database is located at https://sweetproject.eu/HIdatabase and is contained in Microsoft Excel spreadsheets which are organised by health impact criteria. This database will be a useful tool for researchers as it provides comprehensive information on human clinical studies on S&SEs that can be leveraged as a general resource and for systematic reviews and meta-analyses.

甜味剂和甜味增强剂(S&SE)是食品和饮料中用来减少糖分的成分,在提供糖的甜味的同时几乎不含热量。尽管甜味剂和增甜剂已获得全球监管机构的批准和认可,但有关其整体安全性和功效的问题依然存在。有关 S&SE 对健康和功效影响的信息,可在同行评审文献中的随机对照试验(RCT)中找到。由于有关各种 S&SE 的随机对照试验出版物数量庞大,因此有必要将已发表的每项研究整理并收集到一个有用的数据库中。目前,还没有一个包含有关 S&SE 的人体临床信息的数据库,因此 SWEET 项目创建了一个公开、全面的健康影响数据库,其中包括有关甜味剂的现有人体临床信息。本文介绍了该数据库的开发过程,该数据库收集了 2000 年 1 月至 2024 年 9 月期间已发表的评估 S&SE 的人体临床研究的全面信息。我们使用 Ovid Medline 搜索 2000 年至 2024 年期间的 RCT 出版物。搜索结果显示有 1538 篇出版物,其中 257 篇符合预定的资格标准。符合纳入标准的研究数量差异很大。例如,有些 S&SE 有大量研究(如三氯蔗糖,n = 63 份符合条件的出版物),而有些 S&SE 则没有符合标准的出版物(天冬酰胺-安赛蜜 K 盐和新橙皮苷 DC)。健康影响数据库位于 https://sweetproject.eu/HIdatabase,包含在按健康影响标准组织的 Microsoft Excel 电子表格中。该数据库将成为研究人员的有用工具,因为它提供了有关 S&SE 人类临床研究的全面信息,可作为一般资源加以利用,也可用于系统综述和荟萃分析。
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引用次数: 0
Interaction of Genetics and Dietary Patterns Scored by the High Healthy Eating Index in Hyperhomocysteinaemia Influencing Cardiovascular Disease Risk. 高同型半胱氨酸血症与高健康饮食指数评分饮食模式的相互作用影响心血管疾病风险
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-06-01 Epub Date: 2025-04-17 DOI: 10.1111/nbu.70007
Sunmin Park, Suna Kang

Hyperhomocysteinaemia has been associated with increased cardiovascular disease (CVD) risk, but the complex interplay between genetic determinants and modifiable lifestyle factors in modulating homocysteine (HC) levels remains incompletely understood. We aimed to investigate the aetiology of hyperhomocysteinaemia by examining the interactions between genetic predisposition, dietary patterns and other lifestyle factors and their potential associations with metabolic syndrome (MetS) and CVD risk. Cross-sectional analysis from the Korean Genome and Epidemiology Study, a hospital-based cohort conducted by the Korean Centers for Disease Control and Prevention from 2012 to 2016. Korean adults (n = 62 743, aged 40-79 years) were categorised into Low-HC (n = 53 450) and High-HC (n = 9293) groups based on a 15 μM serum homocysteine cutoff. Demographic, anthropometric and biochemical data were analysed. Genome-wide association and gene-environment interaction models explored genetic variants influencing hyperhomocysteinaemia and their interplay with lifestyle factors, including nutrient intake. Multivariable logistic regression assessed associations between hyperhomocysteinaemia and metabolic/CVD risks, adjusting for covariates. Genetic variant-environment interaction analyses identified genetic determinants and their interactions with diet/lifestyle. The High-HC group exhibited an elevated MetS risk. Hyperhomocysteinaemia was correlated with liver damage, inflammation and CVD risks. Low vitamin B12 intake (< 5.4 μg/day) showed a stronger association with hyperhomocysteinaemia than low folate intake (< 350 μg/day), with combined deficiencies exacerbating hyperhomocysteinaemia. An inverse relationship was observed between hyperhomocysteinaemia and healthy eating indices like Asian balanced and plant-based diets. Variants in MTHFR, NOX4, PLOD1, MIIP, PAX6 and CBS genes, involved in methionine/cysteine metabolism, exhibited differential expression in skeletal muscle, liver and adipose tissues. High polygenic risk scores interacted with poor diet quality, excess energy intake, a high glycemic index, smoking and heavy alcohol consumption to contribute to hyperhomocysteinaemia. In conclusion, these findings elucidate the complex interplay between genetics, diet and lifestyle in modulating homocysteine levels, providing insights for personalised nutrition strategies to mitigate CVD risk.

高同型半胱氨酸血症与心血管疾病(CVD)风险增加有关,但遗传决定因素和可改变的生活方式因素在调节同型半胱氨酸(HC)水平中的复杂相互作用仍未完全了解。我们旨在通过研究遗传易感性、饮食模式和其他生活方式因素之间的相互作用及其与代谢综合征(MetS)和心血管疾病风险的潜在关联来研究高同型半胱氨酸血症的病因。韩国疾病管理本部从2012年到2016年进行的以医院为基础的队列研究“韩国基因组和流行病学研究”的横断面分析。根据15 μM的血清同型半胱氨酸截止值,将韩国成年人(n = 62 743,年龄40-79岁)分为低hc组(n = 53 450)和高hc组(n = 9293)。对人口统计学、人体测量学和生化数据进行分析。全基因组关联和基因环境相互作用模型探讨了影响高同型半胱氨酸血症的遗传变异及其与生活方式因素(包括营养摄入)的相互作用。多变量逻辑回归评估了高同型半胱氨酸血症与代谢/心血管疾病风险之间的关联,并对协变量进行了调整。遗传变异-环境相互作用分析确定了遗传决定因素及其与饮食/生活方式的相互作用。高hc组表现出较高的MetS风险。高同型半胱氨酸血症与肝损害、炎症和心血管疾病风险相关。维生素B12摄入量低(
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引用次数: 0
Do Athletes Cook? A Systematic Scoping Review of Culinary Nutrition in Athletes. 运动员会做饭吗?运动员烹饪营养的系统范围审查。
IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS Pub Date : 2025-05-07 DOI: 10.1111/nbu.70012
Rachael Camp, Oliver C Witard, Michèle Renard, Ciarán Ó Catháin, Fiona Lavelle

Applied sports nutrition is fundamental to athlete health, performance and training adaptation; hence, culinary skills are paramount to meet physiological demands. With the decline in domestic cooking, culinary nutrition has emerged as a priority for research and education. However, limited information exists regarding culinary research in athletes. The aim of this scoping review was to collate, map and overview the current body of literature regarding culinary nutrition in athletes while also identifying existing knowledge gaps. The PRISMA-ScR guidelines were used. Five electronic databases were searched in March 2023. Data extraction was conducted using a custom form. A critical appraisal was undertaken, data were charted in narrative and numerical format, and thematic analysis was conducted mapping relationships between studies and identifying knowledge gaps. Seven primary research studies were included, two qualitative and five quantitative study designs, with only one randomised controlled trial. Four studies were conducted in North America and four studies included athletes from multiple sports. Delivery, content and duration of interventions varied, with limited detail provided in most studies. All intervention studies included a practical culinary element. The use of validated measurement tools was limited. One study received a positive rating in the critical appraisal. Culinary nutrition research in athletes is grossly limited and warrants further investigation. Specifically, a focus on methodological issues is required to improve the quality of evidence, with the inclusion of well-designed studies, use of validated measurement tools, implementation of clear theoretical frameworks and clear intervention descriptions to assist in strengthening the culinary nutrition research field.

应用运动营养是运动员健康、表现和训练适应的基础;因此,烹饪技巧是最重要的,以满足生理需求。随着家庭烹饪的减少,烹饪营养已经成为研究和教育的重点。然而,关于运动员烹饪研究的信息有限。这一范围审查的目的是整理,地图和概述有关运动员烹饪营养的现有文献,同时也确定现有的知识差距。采用PRISMA-ScR指南。在2023年3月检索了5个电子数据库。使用自定义表单进行数据提取。进行了批判性评价,以叙述和数字格式绘制了数据图表,并进行了专题分析,绘制了研究之间的关系并确定了知识差距。纳入了七项主要研究,两项定性研究和五项定量研究设计,只有一项随机对照试验。四项研究在北美进行,其中四项研究包括来自多个项目的运动员。干预的方式、内容和持续时间各不相同,大多数研究提供的细节有限。所有的干预研究都包括一个实用的烹饪元素。有效测量工具的使用受到限制。一项研究在批判性评价中获得了积极的评价。运动员的烹饪营养研究非常有限,需要进一步调查。具体而言,需要关注方法学问题,以提高证据的质量,包括设计良好的研究,使用经过验证的测量工具,实施明确的理论框架和明确的干预描述,以帮助加强烹饪营养研究领域。
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引用次数: 0
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Nutrition Bulletin
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