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2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-08-01 DOI: 10.1016/s2589-5974(23)00174-0
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引用次数: 0
Nanomachines in living matters: the soft-robot cytochrome P450 生物中的纳米机器:软体机器人细胞色素P450
IF 15.7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-08-01 DOI: 10.1016/j.trechm.2023.07.002
S. Shaik, K. Dubey
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引用次数: 0
Advisory Board and Contents 咨询委员会及内容
2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-08-01 DOI: 10.1016/s2589-5974(23)00171-5
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引用次数: 0
Interphasial engineering for Ni-rich NMC cathode materials 富镍NMC正极材料的相间工程
IF 15.7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-08-01 DOI: 10.1016/j.trechm.2023.08.002
Zulipiya Shadike, Yiming Chen, E. Hu, Junliang Zhang, Xiao-Qing Yang
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引用次数: 0
Bioactive molecules from lignin via homogeneous and heterogeneous catalytic pathways 木质素的生物活性分子通过均相和非均相催化途径
IF 15.7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-08-01 DOI: 10.1016/j.trechm.2023.08.001
Mengying Liu, Zhuohua Sun, Saravanakumar Elangovan
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引用次数: 0
New functionality of electrode materials with highly concentrated electrolytes 高浓度电解质电极材料的新功能
IF 15.7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-08-01 DOI: 10.1016/j.trechm.2023.07.003
Yosuke Ugata, N. Yabuuchi
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引用次数: 1
Discovery, Function, and Engineering of Graspetides. 草履虫的发现、功能和工程学。
IF 14 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-08-01 Epub Date: 2023-04-30 DOI: 10.1016/j.trechm.2023.04.003
Brian Choi, A James Link

Graspetides are a class of RiPPs (ribosomally synthesized and post-translationally modified peptides) defined by the presence of ester or amide side chain-side chain linkages resulting in peptide macrocycles. The graspetide name comes from the ATP-grasp enzymes that install the side chain-side chain linkages. This review covers the early, activity-based isolation of the first graspetides, marinostatins and microviridins, as well as the key genomics-driven experiments that established graspetide as RiPPs. The mechanism and structure of graspetide-associated ATP-grasp enzymes is discussed. Genome mining methods to discover new graspetides as well as the analytical techniques used to determine the linkages in graspetides are described. Extant knowledge on the bioactivity of graspetides as protease inhibitors is reviewed. Further chemical modifications to graspetides as well graspetide engineering studies are also described. We conclude with several suggestions about future directions of graspetide research.

Graspetides是一类RiPPs（核糖体合成并翻译后修饰的肽），其特征是存在酯或酰胺侧链-侧链连接，从而形成肽大环。抓取肽的名称来自于安装侧链-侧链连接的 ATP 抓取酶。这篇综述涵盖了早期基于活性分离出的首批胰凝乳肽、马林诺司他汀类和微病毒素，以及确定胰凝乳肽为 RiPPs 的关键基因组学驱动实验。还讨论了与抓药相关的 ATP 抓药酶的机制和结构。介绍了发现新grantetides的基因组挖掘方法，以及用于确定grantetides中联系的分析技术。综述了作为蛋白酶抑制剂的抓地力的生物活性方面的现有知识。此外，还介绍了对抓地力苷的进一步化学修饰以及抓地力苷工程学研究。最后，我们就grgretide 研究的未来方向提出了一些建议。
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引用次数: 0
Biocompatible reactions: advances in kinetic target-guided synthesis 生物相容性反应:动力学靶标导向合成的研究进展
IF 15.7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-07-01 DOI: 10.1016/j.trechm.2023.06.002
P. Parvatkar, Alicia Wagner, Roman Manetsch
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引用次数: 0
Celebrating Our Good ‘Four’-tune 庆祝我们的好“四”调
IF 15.7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-07-01 DOI: 10.1016/j.trechm.2023.07.001
J. Pancholi
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引用次数: 0
C–N and C–S bond formation by cytochrome P450 enzymes 细胞色素P450酶形成C–N和C–S键
IF 15.7 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Trends in Chemistry
Pub Date : 2023-07-01 DOI: 10.1016/j.trechm.2023.04.008
Richiro Ushimaru, I. Abe
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引用次数: 1
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