Aim: Hip fractures in older adults often result in decreased mobility and independence. This study aimed to identify critical balance skills that distinguish different activity levels following fracture, using sub-items of the Berg Balance Scale (BBS).
Methods: This retrospective cross-sectional study analyzed the medical records of 252 older adults (mean age 79.8 ± 8.8 years) with hip fractures. Participants were classified into Independent (n = 90), House-bound (n = 92), and Chair-bound (n = 70) groups based on the Japanese Bedriddenness Rank (BR). Decision tree analysis was performed using BBS sub-items as predictors of activity level.
Results: Key discriminators between activity levels were identified: "360° Turning" and "Sit to Stand" differentiated the Independent from the House-bound groups, while "Reaching Forward While Standing" and "Standing Unsupported" distinguished the House-bound from Chair-bound groups. Model accuracy was 81.9% (AUC 0.894) for Independent vs House-bound and 83.3% (AUC 0.910) for House-bound vs Chair-bound groups.
Discussion: Our results offer a novel, evidence-based approach to tailoring rehabilitation strategies for hip fracture patients. By focusing on these critical balance skills, patient functional outcomes may improve, ultimately enhancing quality of life in older adults following hip fracture.
{"title":"Identifying Key Balance Skills Predicting Functional Independence After Hip Fracture: A Decision Tree Analysis of Berg Balance Scale Sub-items.","authors":"Hiroaki Yoshida, Yasuhide Nakayama, Kenji Higuchi, Masahiro Abo","doi":"10.1177/21514593251403434","DOIUrl":"10.1177/21514593251403434","url":null,"abstract":"<p><strong>Aim: </strong>Hip fractures in older adults often result in decreased mobility and independence. This study aimed to identify critical balance skills that distinguish different activity levels following fracture, using sub-items of the Berg Balance Scale (BBS).</p><p><strong>Methods: </strong>This retrospective cross-sectional study analyzed the medical records of 252 older adults (mean age 79.8 ± 8.8 years) with hip fractures. Participants were classified into Independent (<i>n</i> = 90), House-bound (<i>n</i> = 92), and Chair-bound (<i>n</i> = 70) groups based on the Japanese Bedriddenness Rank (BR). Decision tree analysis was performed using BBS sub-items as predictors of activity level.</p><p><strong>Results: </strong>Key discriminators between activity levels were identified: \"360° Turning\" and \"Sit to Stand\" differentiated the Independent from the House-bound groups, while \"Reaching Forward While Standing\" and \"Standing Unsupported\" distinguished the House-bound from Chair-bound groups. Model accuracy was 81.9% (AUC 0.894) for Independent vs House-bound and 83.3% (AUC 0.910) for House-bound vs Chair-bound groups.</p><p><strong>Discussion: </strong>Our results offer a novel, evidence-based approach to tailoring rehabilitation strategies for hip fracture patients. By focusing on these critical balance skills, patient functional outcomes may improve, ultimately enhancing quality of life in older adults following hip fracture.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251403434"},"PeriodicalIF":1.6,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25eCollection Date: 2025-01-01DOI: 10.1177/21514593251403400
Sun Hwan Choi, Myeong Gu Lee, Yoon Je Cho, Young Soo Chun, Kee Hyung Rhyu
Introduction: Prophylactic surgery for symptomatic incomplete atypical femoral fractures (SIAFFs) has demonstrated favorable outcomes. However, concerns remain regarding surgical intervention for a fracture that has not yet completed. This retrospective study aimed to evaluate the efficacy of conservative treatment using teriparatide (TPTD) as a conservative treatment for SIAFF.
Methods: This retrospective study reviewed 30 cases with SIAFF who underwent conservative treatment between November 2012 and September 2019. The diagnosis of SIAFF was based on the criteria established by the Task Force of the American Society for Bone and Mineral Research(ASBMR). The treatment protocol included (1) discontinuation of bisphosphonates, (2) use of 2 crutches or a four-point walker, (3) daily subcutaneous TPTD injection until pain subsided, and (4) monthly radiographic follow-up. Radiographs and bone scans were used to assess bone union, and follow-up continued for up to 2 years from protocol initiation. Comparisons between the successful and failed treatment groups were performed using the Student's t-test for continuous variables and Fisher's exact test for categorical variables.
Results: The mean age was 72.6 years (range, 55-87) and all patients were female. 13 cases involved the diaphyseal region and 17 involved the subtrochanteric region. The average duration of TPTD treatment was 6.5 months (range, 3-12), and the average follow-up was 45.5 months (range, 19-84) after the final injection. The mean SIAFF severity score was 9.5 (range, 7-11). Symptom-free bone union was achieved in 23 of 30 cases (76.7%). Five cases (4 with worsening pain, 1 with radiographic progression) underwent prophylactic intramedullary nailing, and 2 cases progressed to complete fracture and were treated with intramedullary nailing.
Conclusion: The result of this study suggests that the conservative treatment with teriparatide injection may be a potentially effective option for patients with SIAFF.
{"title":"Conservative Treatment With Teriparatide for Symptomatic Incomplete Atypical Femoral Fractures: A Retrospective Observational Study.","authors":"Sun Hwan Choi, Myeong Gu Lee, Yoon Je Cho, Young Soo Chun, Kee Hyung Rhyu","doi":"10.1177/21514593251403400","DOIUrl":"https://doi.org/10.1177/21514593251403400","url":null,"abstract":"<p><strong>Introduction: </strong>Prophylactic surgery for symptomatic incomplete atypical femoral fractures (SIAFFs) has demonstrated favorable outcomes. However, concerns remain regarding surgical intervention for a fracture that has not yet completed. This retrospective study aimed to evaluate the efficacy of conservative treatment using teriparatide (TPTD) as a conservative treatment for SIAFF.</p><p><strong>Methods: </strong>This retrospective study reviewed 30 cases with SIAFF who underwent conservative treatment between November 2012 and September 2019. The diagnosis of SIAFF was based on the criteria established by the Task Force of the American Society for Bone and Mineral Research(ASBMR). The treatment protocol included (1) discontinuation of bisphosphonates, (2) use of 2 crutches or a four-point walker, (3) daily subcutaneous TPTD injection until pain subsided, and (4) monthly radiographic follow-up. Radiographs and bone scans were used to assess bone union, and follow-up continued for up to 2 years from protocol initiation. Comparisons between the successful and failed treatment groups were performed using the Student's t-test for continuous variables and Fisher's exact test for categorical variables.</p><p><strong>Results: </strong>The mean age was 72.6 years (range, 55-87) and all patients were female. 13 cases involved the diaphyseal region and 17 involved the subtrochanteric region. The average duration of TPTD treatment was 6.5 months (range, 3-12), and the average follow-up was 45.5 months (range, 19-84) after the final injection. The mean SIAFF severity score was 9.5 (range, 7-11). Symptom-free bone union was achieved in 23 of 30 cases (76.7%). Five cases (4 with worsening pain, 1 with radiographic progression) underwent prophylactic intramedullary nailing, and 2 cases progressed to complete fracture and were treated with intramedullary nailing.</p><p><strong>Conclusion: </strong>The result of this study suggests that the conservative treatment with teriparatide injection may be a potentially effective option for patients with SIAFF.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251403400"},"PeriodicalIF":1.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12647540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: Post-acute care (PAC) plays a key role in recovery following hip fractures. The aim of the study is to examine the factors affecting the achievement of the minimal important change (MIC) in older patients with hip fractures.
Methods: This retrospective cohort study included 228 patients who underwent surgical interventions for hip fractures and received subsequent PAC between 2020 and 2021. Data on demographics, medical history, and lifestyle habits were collected. Outcomes were measured using the Barthel Index, Numeric Rating Scale (NRS), and Harris Hip Score (HHS). Univariate and multivariate regression analyses were conducted to identify predictors of achieving the MIC.
Results: After treatment, significant improvements were observed in the Barthel Index (from 41.45 to 65.15, P < 0.001), NRS (from 5.03 to 2.52, P < 0.001), and HHS (from 29.35 to 63.68, P < 0.005). The MIC for the Barthel Index, NRS, and HHS were determined to be 6.20, 0.92, and 6.69, respectively. Dementia (odds ratio [OR] = 3.77, 95% confidence interval [CI] = 1.51-9.44, P = 0.005), age above 80 years (OR = 2.80, 95% CI = 1.15-6.84, P = 0.024), and heart failure (OR = 4.21, 95% CI = 1.34-13.23, P = 0.014) served as significant predictors of failure to achieve the MIC with the Barthel Index. For HHS, Diabetes mellitus was the only significant predictor of failure to achieve the MIC (OR = 4.32, 95% CI = 1.00-18.62, P = 0.050).
Conclusions: This study highlights major improvements in the Barthel Index, NRS, and HHS among older patients receiving PAC after hip fractures, along with a quantifiable MIC. Dementia is a robust predictor of failure to achieve the MIC with the Barthel Index, and advanced age, heart failure, and diabetes mellitus are key factors for optimizing recovery.
目的:急性期后护理(PAC)在髋部骨折后的康复中起着关键作用。本研究的目的是探讨影响老年髋部骨折患者实现最小重要改变(MIC)的因素。方法:这项回顾性队列研究包括228例在2020年至2021年间接受髋部骨折手术干预并随后接受PAC的患者。收集了人口统计、病史和生活习惯方面的数据。结果采用Barthel指数、数字评定量表(NRS)和Harris髋关节评分(HHS)进行测量。进行单因素和多因素回归分析,以确定实现MIC的预测因素。结果:治疗后Barthel指数(由41.45改善至65.15,P < 0.001)、NRS(由5.03改善至2.52,P < 0.001)、HHS(由29.35改善至63.68,P < 0.005)均有显著改善。Barthel指数、NRS和HHS的MIC分别为6.20、0.92和6.69。痴呆(优势比[OR] = 3.77, 95%可信区间[CI] = 1.51-9.44, P = 0.005)、80岁以上年龄(OR = 2.80, 95% CI = 1.15-6.84, P = 0.024)和心力衰竭(OR = 4.21, 95% CI = 1.34-13.23, P = 0.014)是Barthel指数未能达到MIC的重要预测因素。对于HHS,糖尿病是未能达到MIC的唯一显著预测因子(OR = 4.32, 95% CI = 1.00-18.62, P = 0.050)。结论:本研究强调了髋部骨折后接受PAC的老年患者在Barthel指数、NRS和HHS方面的主要改善,以及可量化的MIC。痴呆是Barthel指数(MIC)达到失败的可靠预测指标,高龄、心力衰竭和糖尿病是优化恢复的关键因素。
{"title":"Evaluating Barriers to Achieving the Minimal Important Change in Older Patients With Hip Fractures After Post-Acute Care.","authors":"Yueh Chen, Fa-Chuan Kuan, Chih-Kai Hong, Wei-Ren Su, Hsiu-Hua Li, Gui-Ying Liu, Kai-Lan Hsu","doi":"10.1177/21514593251403425","DOIUrl":"https://doi.org/10.1177/21514593251403425","url":null,"abstract":"<p><strong>Purpose: </strong>Post-acute care (PAC) plays a key role in recovery following hip fractures. The aim of the study is to examine the factors affecting the achievement of the minimal important change (MIC) in older patients with hip fractures.</p><p><strong>Methods: </strong>This retrospective cohort study included 228 patients who underwent surgical interventions for hip fractures and received subsequent PAC between 2020 and 2021. Data on demographics, medical history, and lifestyle habits were collected. Outcomes were measured using the Barthel Index, Numeric Rating Scale (NRS), and Harris Hip Score (HHS). Univariate and multivariate regression analyses were conducted to identify predictors of achieving the MIC.</p><p><strong>Results: </strong>After treatment, significant improvements were observed in the Barthel Index (from 41.45 to 65.15, <i>P</i> < 0.001), NRS (from 5.03 to 2.52, <i>P</i> < 0.001), and HHS (from 29.35 to 63.68, <i>P</i> < 0.005). The MIC for the Barthel Index, NRS, and HHS were determined to be 6.20, 0.92, and 6.69, respectively. Dementia (odds ratio [OR] = 3.77, 95% confidence interval [CI] = 1.51-9.44, <i>P</i> = 0.005), age above 80 years (OR = 2.80, 95% CI = 1.15-6.84, <i>P</i> = 0.024), and heart failure (OR = 4.21, 95% CI = 1.34-13.23, <i>P</i> = 0.014) served as significant predictors of failure to achieve the MIC with the Barthel Index. For HHS, Diabetes mellitus was the only significant predictor of failure to achieve the MIC (OR = 4.32, 95% CI = 1.00-18.62, <i>P</i> = 0.050).</p><p><strong>Conclusions: </strong>This study highlights major improvements in the Barthel Index, NRS, and HHS among older patients receiving PAC after hip fractures, along with a quantifiable MIC. Dementia is a robust predictor of failure to achieve the MIC with the Barthel Index, and advanced age, heart failure, and diabetes mellitus are key factors for optimizing recovery.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251403425"},"PeriodicalIF":1.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12647561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145641310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: To evaluate the clinical efficacy of PFNA in treating intertrochanteric fractures in super-elderly patients.
Methods: This study included patients aged over 90 years admitted to the orthopedic department of our hospital with intertrochanteric fractures between January 2021 and December 2023. The patients were categorized into two groups: the surgical group, which received treatment with PFNA, and the conservative group, which underwent tibial tubercle skeletal traction. PSM was additionally applied to control for confounding biases. Comparisons were conducted between the two groups concerning VAS scores at 1 week and 3 months post-admission, fracture healing time, complication rates, HHS, and SF-36 at the final follow-up, as well as 1-year survival rates.
Results: A total of 112 patients were enrolled, including 36 in the surgical group and 76 in the conservative group. After performing 1:1 PSM on baseline characteristics such as gender, age, BMI, bone density, Evans-Jensen classification, ASA grade, and CCI, 32 pairs of data were obtained, with 32 patients in the surgical group and 32 in the conservative group. Follow-up results indicated that the surgical group experienced faster pain relief, shorter fracture healing times, and lower incidence rates of most complications. Additionally, the HHS and SF-36 scores at the final follow-up were higher in the surgical group, and the one-year survival rate was also greater than that of the conservative group (P < 0.05).
Conclusion: For super-elderly patients with relatively good physical conditions who suffer from intertrochanteric fractures, the use of PFNA fixation, compared to conservative treatment, can achieve better limb function, a lower incidence of complications, and a higher survival rate.
{"title":"Comparative Outcomes of Proximal Femoral Nail Antirotation Versus Conservative Treatment in Super-Elderly Patients With Intertrochanteric Fractures.","authors":"Xiang Yu, Dong-Mei Li, Xiao-Kai Li, Hai-Jian Lu, Rong-Guang Ao, Bing-Li Liu","doi":"10.1177/21514593251398378","DOIUrl":"10.1177/21514593251398378","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the clinical efficacy of PFNA in treating intertrochanteric fractures in super-elderly patients.</p><p><strong>Methods: </strong>This study included patients aged over 90 years admitted to the orthopedic department of our hospital with intertrochanteric fractures between January 2021 and December 2023. The patients were categorized into two groups: the surgical group, which received treatment with PFNA, and the conservative group, which underwent tibial tubercle skeletal traction. PSM was additionally applied to control for confounding biases. Comparisons were conducted between the two groups concerning VAS scores at 1 week and 3 months post-admission, fracture healing time, complication rates, HHS, and SF-36 at the final follow-up, as well as 1-year survival rates.</p><p><strong>Results: </strong>A total of 112 patients were enrolled, including 36 in the surgical group and 76 in the conservative group. After performing 1:1 PSM on baseline characteristics such as gender, age, BMI, bone density, Evans-Jensen classification, ASA grade, and CCI, 32 pairs of data were obtained, with 32 patients in the surgical group and 32 in the conservative group. Follow-up results indicated that the surgical group experienced faster pain relief, shorter fracture healing times, and lower incidence rates of most complications. Additionally, the HHS and SF-36 scores at the final follow-up were higher in the surgical group, and the one-year survival rate was also greater than that of the conservative group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>For super-elderly patients with relatively good physical conditions who suffer from intertrochanteric fractures, the use of PFNA fixation, compared to conservative treatment, can achieve better limb function, a lower incidence of complications, and a higher survival rate.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251398378"},"PeriodicalIF":1.6,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12605874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: To evaluate the incidence rate of urinary tract infection (UTI) and postoperative urinary retention (POUR) in the initial indwelling urinary catheter (IIC) and intraoperative indwelling urinary catheter (IOC) groups of hip fracture patients who had undergone either fracture fixation or hemiarthroplasty operation within 48 hours.
Methods: Between June 2023 and October 2024, 110 patients who met the eligible criteria were enrolled in this study. We prospectively randomized all patients into the IOC (n = 55) and IIC (n = 55) groups. The postoperative incidence of UTI and POUR was compared between the two groups and evaluated 24 h postoperatively.
Results: The incidence of UTI was significantly higher in the IIC group (23.6%) than in the IOC group (9.1%) (P = .039). However, the incidence of POUR was not significantly different between the groups (16.4% vs 9.1%; P = .252).
Conclusion: For hip fracture patients undergoing early surgery within 48 h, intraoperative urinary catheterization significantly reduced the incidence of POUR, while the incidence of UTI did not differ significantly between the groups.
研究背景:评价术后48小时内行骨折固定或半关节置换术的髋部骨折患者初始留置导尿管组(IIC)和术中留置导尿管组(IOC)尿路感染(UTI)和术后尿潴留(POUR)的发生率。方法:2023年6月至2024年10月,110例符合条件的患者入组研究。我们前瞻性地将所有患者随机分为IOC组(n = 55)和IIC组(n = 55)。比较两组患者术后尿路感染和POUR发生率,并于术后24 h进行评估。结果:IIC组尿路感染发生率(23.6%)明显高于IOC组(9.1%)(P = 0.039)。然而,两组间POUR的发生率无显著差异(16.4% vs 9.1%; P = 0.252)。结论:对于早期手术48 h内的髋部骨折患者,术中导尿可显著降低POUR的发生率,而组间尿路感染的发生率无显著差异。
{"title":"Comparison of Urinary Tract Infection and Postoperative Urinary Retention Between Preoperative and Intraoperative Indwelling Urinary Catheterization in Hip Fracture Patients Undergoing Early Surgery: A Randomized Controlled Trial.","authors":"Pacharapol Natee, Ittiwat Onklin, Natthapong Hongku","doi":"10.1177/21514593251397788","DOIUrl":"10.1177/21514593251397788","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the incidence rate of urinary tract infection (UTI) and postoperative urinary retention (POUR) in the initial indwelling urinary catheter (IIC) and intraoperative indwelling urinary catheter (IOC) groups of hip fracture patients who had undergone either fracture fixation or hemiarthroplasty operation within 48 hours.</p><p><strong>Methods: </strong>Between June 2023 and October 2024, 110 patients who met the eligible criteria were enrolled in this study. We prospectively randomized all patients into the IOC (<i>n</i> = 55) and IIC (<i>n</i> = 55) groups. The postoperative incidence of UTI and POUR was compared between the two groups and evaluated 24 h postoperatively.</p><p><strong>Results: </strong>The incidence of UTI was significantly higher in the IIC group (23.6%) than in the IOC group (9.1%) (<i>P</i> = .039). However, the incidence of POUR was not significantly different between the groups (16.4% vs 9.1%; <i>P</i> = .252).</p><p><strong>Conclusion: </strong>For hip fracture patients undergoing early surgery within 48 h, intraoperative urinary catheterization significantly reduced the incidence of POUR, while the incidence of UTI did not differ significantly between the groups.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251397788"},"PeriodicalIF":1.6,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12605899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145514092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-01eCollection Date: 2025-01-01DOI: 10.1177/21514593251386766
Kelsey Brown, Austin T Gregg, Mary M Morcos, Jacob S Borgida, Jordan O Gasho, Emma Kerimo, Robert K Wagner, WuQiang Fan, Thuan Ly
Objectives: To explore the impact of race, language, and socioeconomic status on vitamin D screening and osteoporosis treatment after operative management of proximal femur fractures.
Methods: Design: Retrospective cohort. Setting: Level I, II, and III Trauma Centers within an overarching institutional organization. Patient Selection Criteria: Patients greater than 65 years of age who underwent operative treatment for a proximal femur fracture between January 2020 and June 2023. Outcome Measures and Comparisons: Primary outcomes were rates of vitamin D screening and osteoporosis treatment. Secondary outcomes were rates of geriatric and endocrinology consultation during admission. Primary and secondary outcomes were compared by race, language, and socioeconomic status (Area of Deprivation Index [ADI]). ADI was recorded at the state level (0 to 10) using the ADI mapping tool with higher ADI indicating more socioeconomic disadvantage.
Results: In total, 1149 patients were included (primary English-speaking: 89.2%, White: 90.3%, with intertrochanteric hip fractures: 76.6%). There were no differences in vitamin D screening or osteoporosis treatment observed between racial, language, or socioeconomic groups (P > 0.05). While non-English speakers were more likely to get an endocrine consult (OR 1.98, 95% CI 1.29-3.04, P = 0.002), Black patients or those with a higher ADI were less likely to receive endocrine consults (OR 0.30, 95% CI 0.11-0.81, P = 0.018 and OR 0.69, 95% CI 0.50-0.90, P = 0.008, respectively).
Conclusions: Black patients or those from higher area of deprivation neighborhoods were less likely to receive endocrine consults. Geriatric and endocrine consults increased the odds of obtaining vitamin D screening and osteoporosis treatment. Despite this finding, race, language, and socioeconomic status did not impact vitamin D screening or osteoporosis treatment after proximal femur fracture. The discrepancies in consultation based on non-clinical factors emphasize the importance of interdepartmental collaboration to optimize standardized osteoporosis treatment after proximal femur fracture and highlight disparities in osteoporosis care.
Level of evidence: Therapeutic Level III.
目的:探讨种族、语言和社会经济状况对股骨近端骨折术后维生素D筛查和骨质疏松症治疗的影响。方法:设计:回顾性队列。环境:一级,二级和三级创伤中心在一个总体机构组织。患者选择标准:年龄大于65岁,在2020年1月至2023年6月期间因股骨近端骨折接受手术治疗的患者。结果测量和比较:主要结果是维生素D筛查率和骨质疏松症治疗。次要结果是入院时的老年和内分泌咨询率。主要和次要结果按种族、语言和社会经济地位(剥夺面积指数[ADI])进行比较。使用ADI绘图工具在州一级(0至10)记录ADI, ADI越高表明社会经济劣势越大。结果:共纳入1149例患者(母语为英语的占89.2%,白人占90.3%,股骨粗隆间髋部骨折占76.6%)。在种族、语言或社会经济群体之间,维生素D筛查或骨质疏松症治疗没有差异(P < 0.05)。非英语人士更有可能接受内分泌咨询(OR 1.98, 95% CI 1.29-3.04, P = 0.002),黑人患者或ADI较高的患者更不可能接受内分泌咨询(OR 0.30, 95% CI 0.11-0.81, P = 0.018; OR 0.69, 95% CI 0.50-0.90, P = 0.008)。结论:黑人患者或来自贫困程度较高社区的患者接受内分泌咨询的可能性较低。老年和内分泌咨询增加了获得维生素D筛查和骨质疏松症治疗的几率。尽管有这一发现,种族、语言和社会经济地位对股骨近端骨折后的维生素D筛查或骨质疏松症治疗没有影响。基于非临床因素的咨询差异强调了跨部门合作优化股骨近端骨折后骨质疏松规范化治疗的重要性,并突出了骨质疏松护理的差异。证据等级:治疗性III级。
{"title":"Exploring the Impact of Race, Language, Socioeconomics, and Medical Management on Osteoporosis Workup and Treatment After Proximal Femur Fractures.","authors":"Kelsey Brown, Austin T Gregg, Mary M Morcos, Jacob S Borgida, Jordan O Gasho, Emma Kerimo, Robert K Wagner, WuQiang Fan, Thuan Ly","doi":"10.1177/21514593251386766","DOIUrl":"10.1177/21514593251386766","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the impact of race, language, and socioeconomic status on vitamin D screening and osteoporosis treatment after operative management of proximal femur fractures.</p><p><strong>Methods: </strong><i>Design</i>: Retrospective cohort. <i>Setting</i>: Level I, II, and III Trauma Centers within an overarching institutional organization. <i>Patient Selection Criteria</i>: Patients greater than 65 years of age who underwent operative treatment for a proximal femur fracture between January 2020 and June 2023. <i>Outcome Measures and Comparisons</i>: Primary outcomes were rates of vitamin D screening and osteoporosis treatment. Secondary outcomes were rates of geriatric and endocrinology consultation during admission. Primary and secondary outcomes were compared by race, language, and socioeconomic status (Area of Deprivation Index [ADI]). ADI was recorded at the state level (0 to 10) using the ADI mapping tool with higher ADI indicating more socioeconomic disadvantage.</p><p><strong>Results: </strong>In total, 1149 patients were included (primary English-speaking: 89.2%, White: 90.3%, with intertrochanteric hip fractures: 76.6%). There were no differences in vitamin D screening or osteoporosis treatment observed between racial, language, or socioeconomic groups (<i>P</i> > 0.05)<b>.</b> While non-English speakers were more likely to get an endocrine consult (OR 1.98, 95% CI 1.29-3.04, <i>P</i> = 0.002), Black patients or those with a higher ADI were less likely to receive endocrine consults (OR 0.30, 95% CI 0.11-0.81, <i>P</i> = 0.018 and OR 0.69, 95% CI 0.50-0.90, <i>P</i> = 0.008, respectively).</p><p><strong>Conclusions: </strong>Black patients or those from higher area of deprivation neighborhoods were less likely to receive endocrine consults. Geriatric and endocrine consults increased the odds of obtaining vitamin D screening and osteoporosis treatment. Despite this finding, race, language, and socioeconomic status did not impact vitamin D screening or osteoporosis treatment after proximal femur fracture. The discrepancies in consultation based on non-clinical factors emphasize the importance of interdepartmental collaboration to optimize standardized osteoporosis treatment after proximal femur fracture and highlight disparities in osteoporosis care.</p><p><strong>Level of evidence: </strong>Therapeutic Level III.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251386766"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12580514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-25eCollection Date: 2025-01-01DOI: 10.1177/21514593251366227
Michael Akodu, Diviya Rajesh, Amy Steele, Naing Aung, Cancan Zhang, Michael McTague, Catherine DesRoches, John Wixted, Kiran Agarwal-Harding, Paul Appleton, Edward Rodriguez, Karen Chahal, Daniele Olveczky
Introduction: Hip fractures are common among older adults; and while urgent fracture fixation is recommended, it is often weighed against preoperative optimization needs. Previous studies have reported conflicting findings on the association between time to surgery and mortality risk. In this study, we investigated the association between surgical timing and mortality. We also explored the relationship between time to surgery and secondary outcomes, including length of stay and hospital readmission.
Methods: We conducted a retrospective cross-sectional study of 967 adults aged 65 who underwent hip fracture repair between 2018 and 2023. Time to surgery (in days) was the primary exposure. Multivariable Cox proportional hazards models were used to assess associations with 30-day, 90-day, and 365-day mortality. Firth penalized logistic regression was used to examine associations with secondary outcomes, including length of stay >7 days and 30-day readmission.
Results: For 30-day, 90-day, and 365-day mortality, each additional day of delay in surgery was associated with an increased risk of mortality, with adjusted hazard ratios (HR) of 1.15 (95% CI [1.02, 1.30], P = .02), 1.13 (95% CI [1.02, 1.26], P = .02), and 1.09 (95% CI [1.01, 1.19], P = .03), respectively. Similarly, each additional day of delay was associated with an increased risk of a length of stay >7 days and readmission within 30 days of discharge, with adjusted odds ratios (OR) of 2.26 (95% CI [1.89, 2.74]) and 1.16 (95% CI [1.05, 1.29]), respectively.
Conclusion: Delaying surgery in older adults increases the risk of mortality, along with a potential elevated risk of prolonged hospital stays and readmission. We recommend that, when safe, surgery should be performed promptly for these patients.
髋部骨折在老年人中很常见;虽然推荐紧急骨折固定,但通常要权衡术前优化的需要。先前的研究报告了关于手术时间与死亡风险之间关系的相互矛盾的发现。在这项研究中,我们调查了手术时机与死亡率之间的关系。我们还探讨了手术时间与次要结果之间的关系,包括住院时间和再入院时间。方法:我们对2018年至2023年间接受髋部骨折修复的967名年龄≥65岁的成年人进行了回顾性横断面研究。手术时间(以天为单位)是主要暴露。多变量Cox比例风险模型用于评估与30天、90天和365天死亡率的关系。Firth惩罚逻辑回归用于检查与次要结局的关联,包括住院时间(7天)和再入院时间(30天)。结果:对于30天、90天和365天的死亡率,每延迟一天手术与死亡风险增加相关,校正风险比(HR)分别为1.15 (95% CI [1.02, 1.30], P = 0.02)、1.13 (95% CI [1.02, 1.26], P = 0.02)和1.09 (95% CI [1.01, 1.19], P = 0.03)。同样,每多延迟一天,住院时间延长7天和出院后30天内再入院的风险增加,调整后的优势比(OR)分别为2.26 (95% CI[1.89, 2.74])和1.16 (95% CI[1.05, 1.29])。结论:老年人延迟手术会增加死亡风险,同时延长住院时间和再入院的潜在风险也会增加。我们建议,在安全的情况下,对这些患者应及时进行手术。
{"title":"Is the Timing of Surgery Associated With the Risk of Mortality Among Older Adults Undergoing Operative Hip Fracture Repair?","authors":"Michael Akodu, Diviya Rajesh, Amy Steele, Naing Aung, Cancan Zhang, Michael McTague, Catherine DesRoches, John Wixted, Kiran Agarwal-Harding, Paul Appleton, Edward Rodriguez, Karen Chahal, Daniele Olveczky","doi":"10.1177/21514593251366227","DOIUrl":"10.1177/21514593251366227","url":null,"abstract":"<p><strong>Introduction: </strong>Hip fractures are common among older adults; and while urgent fracture fixation is recommended, it is often weighed against preoperative optimization needs. Previous studies have reported conflicting findings on the association between time to surgery and mortality risk. In this study, we investigated the association between surgical timing and mortality. We also explored the relationship between time to surgery and secondary outcomes, including length of stay and hospital readmission.</p><p><strong>Methods: </strong>We conducted a retrospective cross-sectional study of 967 adults aged <math><mrow><mo>≥</mo></mrow> </math> 65 who underwent hip fracture repair between 2018 and 2023. Time to surgery (in days) was the primary exposure. Multivariable Cox proportional hazards models were used to assess associations with 30-day, 90-day, and 365-day mortality. Firth penalized logistic regression was used to examine associations with secondary outcomes, including length of stay >7 days and 30-day readmission.</p><p><strong>Results: </strong>For 30-day, 90-day, and 365-day mortality, each additional day of delay in surgery was associated with an increased risk of mortality, with adjusted hazard ratios (HR) of 1.15 (95% CI [1.02, 1.30], <i>P</i> = .02), 1.13 (95% CI [1.02, 1.26], <i>P</i> = .02), and 1.09 (95% CI [1.01, 1.19], <i>P</i> = .03), respectively. Similarly, each additional day of delay was associated with an increased risk of a length of stay >7 days and readmission within 30 days of discharge, with adjusted odds ratios (OR) of 2.26 (95% CI [1.89, 2.74]) and 1.16 (95% CI [1.05, 1.29]), respectively.</p><p><strong>Conclusion: </strong>Delaying surgery in older adults increases the risk of mortality, along with a potential elevated risk of prolonged hospital stays and readmission. We recommend that, when safe, surgery should be performed promptly for these patients.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251366227"},"PeriodicalIF":1.6,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12572600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-25eCollection Date: 2025-01-01DOI: 10.1177/21514593251392692
Hannah Grimmett, Arsalaan Sayyed, Victor Koltenyuk, Aruni Areti, Hikmat R Chmait, Nithin Gupta, Mitchell Gray, William Young, Tyler K Williamson, Chance Moore, Frank A Buttacavoli
Background: Frailty is an established risk factor for adverse outcomes following total joint arthroplasty, including higher rates of prosthetic joint infection (PJI), reoperation rates, and readmission, which may be greater in the setting of revision. The purpose of this study is to compare the association of frailty indices with mortality and complications following septic revision arthroplasty.
Methods: A query from The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) was performed for adult patients undergoing revision total knee or hip arthroplasty between 2015 and 2020, which records perioperative data (30 days postoperatively) for over 700 centers nationwide. PJI cases without revision arthroplasty were excluded. The RAI-rev and mFI-5 frailty scores were calculated for each patient. Outcomes included major complications, mortality, non-home discharge (NHD), DVT, readmission within 30 days, wound complications, pulmonary complications, cardiac complications, and postoperative infection. T-test and binary logistic regression assessed associations with frailty scores and outcomes. Predictability was evaluated through multivariate regression analysis, and its discriminative accuracy was measured using receiver operating curve (ROC) analysis and C-statistics.
Results: A total of 4395 patients were included (median age: 66 [IQR 59-73]). Within the cohort, 46.44% were female and 38.02% exhibited NHD. RAI-rev demonstrated increased association compared to mFI-5 with mortality (OR: 1.20 vs 1.10, CI: 95%) and NHD (OR: 1.15 vs 1.05, CI: 95%). RAI-Rev demonstrated significantly superior discriminatory accuracy when compared to mFI-5 for NHD (Cs: 0.670 vs 0.602, P < 0.001) and mortality (Cs: 0.795 vs 0.574, P < 0.001).
Conclusions: Frailty may have a distinct association with mortality and NHD following septic rTJA, especially when assessed by the revised Risk Analysis Index. This understanding is important to educate the patient and their family and provide insight into the necessary resources and surveillance needed to manage frail patients undergoing septic revision total joint arthroplasty.
背景:虚弱是全关节置换术后不良结果的一个确定的危险因素,包括更高的假体关节感染(PJI)率、再手术率和再入院率,在翻修的情况下可能会更高。本研究的目的是比较虚弱指数与脓毒性关节置换术后死亡率和并发症的关系。方法:从美国外科医师学会国家手术质量改进计划(NSQIP)中查询2015年至2020年间接受翻修性全膝关节或髋关节置换术的成人患者,记录全国700多家中心的围手术期数据(术后30天)。未进行翻修关节置换术的PJI病例被排除。计算每位患者的RAI-rev和mFI-5衰弱评分。结果包括主要并发症、死亡率、非家庭出院(NHD)、DVT、30天内再入院、伤口并发症、肺部并发症、心脏并发症和术后感染。t检验和二元逻辑回归评估了衰弱评分和结果之间的关联。通过多元回归分析评估其可预测性,并采用受试者工作曲线(ROC)分析和c统计量测量其判别精度。结果:共纳入4395例患者(中位年龄:66岁[IQR 59-73])。在队列中,46.44%为女性,38.02%为NHD。与mFI-5相比,RAI-rev与死亡率(OR: 1.20 vs 1.10, CI: 95%)和NHD (OR: 1.15 vs 1.05, CI: 95%)的相关性增加。与mFI-5相比,RAI-Rev对NHD (Cs: 0.670 vs 0.602, P < 0.001)和死亡率(Cs: 0.795 vs 0.574, P < 0.001)的区分准确性显著优于mFI-5。结论:虚弱可能与败血症性rTJA后的死亡率和NHD有明显的关联,特别是当使用修订的风险分析指数进行评估时。这一认识对于教育患者及其家属,并提供必要的资源和监测,以管理虚弱的患者进行脓毒性翻修全关节置换术是重要的。
{"title":"Comparative Analysis of Frailty Indices on Complication Risk Following Septic Revision Total Hip and Knee Arthroplasty.","authors":"Hannah Grimmett, Arsalaan Sayyed, Victor Koltenyuk, Aruni Areti, Hikmat R Chmait, Nithin Gupta, Mitchell Gray, William Young, Tyler K Williamson, Chance Moore, Frank A Buttacavoli","doi":"10.1177/21514593251392692","DOIUrl":"10.1177/21514593251392692","url":null,"abstract":"<p><strong>Background: </strong>Frailty is an established risk factor for adverse outcomes following total joint arthroplasty, including higher rates of prosthetic joint infection (PJI), reoperation rates, and readmission, which may be greater in the setting of revision. The purpose of this study is to compare the association of frailty indices with mortality and complications following septic revision arthroplasty.</p><p><strong>Methods: </strong>A query from The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) was performed for adult patients undergoing revision total knee or hip arthroplasty between 2015 and 2020, which records perioperative data (30 days postoperatively) for over 700 centers nationwide. PJI cases without revision arthroplasty were excluded. The RAI-rev and mFI-5 frailty scores were calculated for each patient. Outcomes included major complications, mortality, non-home discharge (NHD), DVT, readmission within 30 days, wound complications, pulmonary complications, cardiac complications, and postoperative infection. T-test and binary logistic regression assessed associations with frailty scores and outcomes. Predictability was evaluated through multivariate regression analysis, and its discriminative accuracy was measured using receiver operating curve (ROC) analysis and C-statistics.</p><p><strong>Results: </strong>A total of 4395 patients were included (median age: 66 [IQR 59-73]). Within the cohort, 46.44% were female and 38.02% exhibited NHD. RAI-rev demonstrated increased association compared to mFI-5 with mortality (OR: 1.20 vs 1.10, CI: 95%) and NHD (OR: 1.15 vs 1.05, CI: 95%). RAI-Rev demonstrated significantly superior discriminatory accuracy when compared to mFI-5 for NHD (Cs: 0.670 vs 0.602, <i>P</i> < 0.001) and mortality (Cs: 0.795 vs 0.574, <i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>Frailty may have a distinct association with mortality and NHD following septic rTJA, especially when assessed by the revised Risk Analysis Index. This understanding is important to educate the patient and their family and provide insight into the necessary resources and surveillance needed to manage frail patients undergoing septic revision total joint arthroplasty.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251392692"},"PeriodicalIF":1.6,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12572601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-25eCollection Date: 2025-01-01DOI: 10.1177/21514593251389810
Jack Twomey-Kozak, John Lewis Atwater, Kenneth Adam Taylor, Malcolm DeBaun, Christian Alexander Pean
Purpose: To examine five-year trends in 30-day readmission and length of stay (LOS) among the geriatric population after surgical fixation for hip fracture in a large database model.
Methods: Patients ≥ 65 years of age in the American College of Surgeons National Surgical Quality Improvement Program Targeted Hip Fracture (ACS-NSQIP THF) were identified using Current Procedural Terminology (CPT®) codes 27 236, 27 244, 27 245 for intramedullary nailing or Open Reduction and Internal Fixation (ORIF) of fractures involving the femoral head, neck, peritrochanteric, intertrochanteric, and subtrochanteric regions. The primary outcome was incidence of ≥1 30-day hospital readmission and secondary outcome was total hospital length of stay in trend analysis.
Results: Overall, there were 64 794 patients who met inclusion criteria, of which 7.85% (95% CI: 7.64% to 8.05%) were readmitted within 30 days of hip fracture surgical fixation. The proportion of patients with ≥1 30-day readmission were presented over time and Cochran-Armitage Trend Testing indicated a statistically significant decreasing trend in the 30-day readmission incidence from 2016-2021 (P < 0.0001). The mean absolute change in incidence from year-to-year was -0.24% (mean relative change, 0.97) and the total absolute difference in incidence from 2016 to 2021 was -1.20% (relative difference, 0.85). LOS data were missing for 1048 cases (1.62%). Mean and median length of stay data was similar across all years.
Conclusion: The probability of having ≥1 30-day readmission decreased 0.85-times from 2016 to 2021, with a statistically significant downward trend over time. There were no meaningful changes in length of stay. Healthcare providers, policymakers, and stakeholders can utilize these findings to implement initiatives that enhance value-based care in hip fracture management and benchmark institutional metrics, ultimately improving patient outcomes and optimizing healthcare resources.
{"title":"Are We Getting Better? Trends in 30-Day Readmission and Length of Stay Following Hip Fracture Surgery Among Older Adults: A Five-Year ACS-NSQIP Analysis.","authors":"Jack Twomey-Kozak, John Lewis Atwater, Kenneth Adam Taylor, Malcolm DeBaun, Christian Alexander Pean","doi":"10.1177/21514593251389810","DOIUrl":"10.1177/21514593251389810","url":null,"abstract":"<p><strong>Purpose: </strong>To examine five-year trends in 30-day readmission and length of stay (LOS) among the geriatric population after surgical fixation for hip fracture in a large database model.</p><p><strong>Methods: </strong>Patients ≥ 65 years of age in the American College of Surgeons National Surgical Quality Improvement Program Targeted Hip Fracture (ACS-NSQIP THF) were identified using Current Procedural Terminology (CPT®) codes 27 236, 27 244, 27 245 for intramedullary nailing or Open Reduction and Internal Fixation (ORIF) of fractures involving the femoral head, neck, peritrochanteric, intertrochanteric, and subtrochanteric regions. The primary outcome was incidence of ≥1 30-day hospital readmission and secondary outcome was total hospital length of stay in trend analysis.</p><p><strong>Results: </strong>Overall, there were 64 794 patients who met inclusion criteria, of which 7.85% (95% CI: 7.64% to 8.05%) were readmitted within 30 days of hip fracture surgical fixation. The proportion of patients with ≥1 30-day readmission were presented over time and Cochran-Armitage Trend Testing indicated a statistically significant decreasing trend in the 30-day readmission incidence from 2016-2021 (<i>P</i> < 0.0001). The mean absolute change in incidence from year-to-year was -0.24% (mean relative change, 0.97) and the total absolute difference in incidence from 2016 to 2021 was -1.20% (relative difference, 0.85). LOS data were missing for 1048 cases (1.62%). Mean and median length of stay data was similar across all years.</p><p><strong>Conclusion: </strong>The probability of having ≥1 30-day readmission decreased 0.85-times from 2016 to 2021, with a statistically significant downward trend over time. There were no meaningful changes in length of stay. Healthcare providers, policymakers, and stakeholders can utilize these findings to implement initiatives that enhance value-based care in hip fracture management and benchmark institutional metrics, ultimately improving patient outcomes and optimizing healthcare resources.</p>","PeriodicalId":48568,"journal":{"name":"Geriatric Orthopaedic Surgery & Rehabilitation","volume":"16 ","pages":"21514593251389810"},"PeriodicalIF":1.6,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12572606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}