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Contemporary Surgical, Hybrid, and Transcatheter Approaches to the Dysfunctional Mitral Valve with Mitral Annular Calcification 二尖瓣功能不全合并二尖瓣环钙化的现代手术、混合和经导管入路。
IF 2.5 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-03 DOI: 10.1053/j.semtcvs.2025.01.008
Omar Toubat MD, PhD, Max Shin MD, Michael A. Catalano MD, Amit Iyengar MD, MSE, Pavan Atluri MD (Professor of Surgery)
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引用次数: 0
The Only Mitral Valve Repair Techniques That Everyone Ever Needs to Know 唯一的二尖瓣修复技术,每个人都需要知道。
IF 2.5 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-03 DOI: 10.1053/j.semtcvs.2025.02.003
Tarek Malas MD, Marc Gillinov MD
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引用次数: 0
Expert Opinion: What should Revascularization Trials that Inform the Guidelines Look Like? 专家意见:为指南提供信息的血管再通试验应该是什么样的?
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.08.005
Dawn S. Hui MD , Victor Dayan MD , David P. Taggart
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引用次数: 0
Minimally Invasive Coronary Artery Bypass Grafting is the Future: Pro 微创 CABG 是未来的趋势:专业
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.09.003
Marc Ruel MD, MPH , Michael E. Halkos MD, MSc
Coronary artery bypass grafting (CABG) remains one of the most commonly performed operations worldwide. However, most CABG operations performed today are as invasive —apart from saphenous vein harvesting— as they were 50 years ago. While heart valve operations have become less invasive, CABG faces formidable challenges in doing so. Valve surgery requires a single surgical exposure to the valve intervened on, but less invasive CABG necessitates multiple surgical exposures to harvest internal thoracic artery conduits, source their inflow plus that of other grafts, and expose each coronary target to be grafted —including anterior, lateral, posterior, and inferior vessels. In this article, we rationalize why we believe that conventional CABG remains unduly invasive, associated with morbidity and prolonged recovery, and why less invasive CABG in its many forms, which we describe, represents a safe, practical, diffusible, and less invasive alternative to sternotomy CABG. Centers of excellence in coronary artery surgery should dedicate resources and expertise to developing high-quality, safe, durable, and advanced forms of lesser invasive CABG.
冠状动脉旁路移植术(CABG)仍然是全球最常见的手术之一。然而,如今进行的大多数冠状动脉旁路移植手术(除大隐静脉采集外)与 50 年前一样具有创伤性。虽然心脏瓣膜手术的创伤性有所降低,但 CABG 手术在这方面却面临着巨大的挑战。瓣膜手术只需对所介入的瓣膜进行一次手术暴露,而创伤较小的 CABG 则需要进行多次手术暴露,以采集胸内动脉导管,获得其流入的血流和其他移植物的血流,并暴露每个需要移植的冠状动脉靶点,包括前方、侧方、后方和下方的血管。在这篇文章中,我们阐述了为什么我们认为传统的冠状动脉造影术仍然创伤过大、发病率高且恢复期长,以及为什么我们所描述的多种形式的微创冠状动脉造影术代表了一种安全、实用、可扩散且创伤较小的胸骨切开术冠状动脉造影术替代方案。卓越的冠状动脉外科中心应投入资源和专业技术,开发高质量、安全、持久和先进的微创 CABG。
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引用次数: 0
Systematic Review of Stereotactic Ablative Radiotherapy (SABR)/Stereotactic Body Radiation Therapy (SBRT) for Treatment of High-Risk Patients with Stage I Non-Small Cell Lung Cancer 立体定向消融放疗 (SABR)/ 立体定向体放射治疗 (SBRT) 用于治疗高风险 I 期非小细胞肺癌患者的系统性综述》(Systematic Review of Stereotactic Ablative Radiotherapy (SABR)/ Stereotactic Body Radiation Therapy (SBRT))。
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.10.005
Andrea Wolf MD, MPH , Billy W. Loo Jr, MD, PhD , Raymond H. Mak MD , Michael Liptay MD , Brian Pettiford MD , Gaetano Rocco MD , Michael Lanuti MD , Robert E. Merritt MD , Homa Keshavarz PhD , Robert D. Suh MD , Alessandro Brunelli MD , Gerard J. Criner MD , Peter J. Mazzone MD , Garrett Walsh MD , Q. Eileen Wafford MSt, MLIS , Sudish Murthy MD, PhD , M. Blair Marshall MD , Betty Tong MD , James Luketich MD , Matthew J. Schuchert MD , Scott J. Swanson MD, Co-Chair Writing Committee
Stereotactic ablative radiotherapy (SABR) has emerged as an alternative, non-surgical treatment for high-risk patients with stage I non-small cell lung cancer (NSCLC) with increased use over time. The American Association for Thoracic Surgery (AATS) Clinical Practice Standards Committee (CPSC) assembled an expert panel and conducted a systematic review of the literature evaluating the results of SABR, which is also referred to as stereotactic body radiation therapy (SBRT) or stereotactic radiosurgery (SRS), prior to developing treatment recommendations for high-risk patients with stage I NSCLC based on expert consensus. Publications detailing the findings of 16 prospective studies of SABR and 14 retrospective studies of SABR for the management of early-stage lung cancer in 54,697 patients were identified by systematic review of the literature with further review by members of our expert panel. Medical inoperability (93–95%) was the primary reason for utilizing SABR. The median rate of histologically confirmed cancer in treated patients was 67% (range 57–86%). In retrospective studies and prospective studies, the most common dosing regimens were 48–54 Gy in 3–5 fractions and 44–66 Gy in 3–5 fractions respectively. The median follow-up after SABR was 30 months (range 15–50). The complications, oncological results and quality of life after SABR in high-risk patients with early-stage NSCLC are summarized in this Expert Review article. Further prospective randomized trials are needed and are currently underway to compare outcomes after SABR with outcomes after sublobar resection to fully evaluate treatment options applicable this high-risk group of patients.
随着时间的推移,立体定向消融放射治疗(SABR)已成为高风险 I 期非小细胞肺癌(NSCLC)患者的一种替代性非手术疗法。美国胸外科协会(AATS)临床实践标准委员会(CPSC)组建了一个专家小组,对评估 SABR(也称为立体定向体放射治疗(SBRT)或立体定向放射外科(SRS))效果的文献进行了系统性回顾,然后根据专家共识为 I 期 NSCLC 高危患者制定了治疗建议。通过对文献进行系统性审查,并由我们的专家组成员进行进一步审查,我们确定了16篇关于SABR治疗早期肺癌的前瞻性研究和14篇关于SABR治疗早期肺癌的回顾性研究的文献,共54 697名患者接受了SABR治疗。医学上无法手术(93%-95%)是使用 SABR 的主要原因。在接受治疗的患者中,组织学确诊癌症的中位比例为 67%(范围为 57-86%)。在回顾性研究和前瞻性研究中,最常见的给药方案分别是 48-54 Gy,3-5 次分次给药和 44-66 Gy,3-5 次分次给药。SABR术后的中位随访时间为30个月(15-50个月)。本专家评论文章总结了早期NSCLC高危患者SABR术后的并发症、肿瘤治疗效果和生活质量。目前正在进行更多前瞻性随机试验,以比较SABR术后与球下切除术后的疗效,从而全面评估适用于这一高风险患者群体的治疗方案。
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引用次数: 0
CABG Should Be a Subspecialty CABG应该是一个亚专业。
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.12.003
Bob Kiaii MD , Bradley Taylor MD
Subspecialization in surgery is increasingly common and for great reasons. Over the past 20 years, there has been evidence in support of the link between subspecialization in the disciplines of orthopedic surgery, general, thoracic surgery, neurosurgery, and in interventional cardiology and better patient outcomes and technical advances in their respective fields. In addition, studies suggest that increased hospital and surgeon volume throughout surgery may lead to improved surgical outcomes. The degree of specialization has been shown to reduce operative mortality in a variety of procedures and highlights that the level of sophistication and fund of knowledge required within each area is so great that no one surgeon can “do it all” and do it well. Cardiac surgery has become more subspecialized; however, many still view coronary artery surgery as a generalist procedure. There is debate as to the relative contribution of hospital volume, surgeon volume, or degree of specialization on perioperative mortality following isolated coronary artery bypass grafting. In this paper, we will discuss the current data supporting the need for specialization in coronary surgery and present arguments in favor of further specialization in this field.
外科专科越来越普遍,这是有原因的。在过去的二十年中,有证据支持骨科、普通外科、胸外科、神经外科和介入心脏病学等学科的亚专业化与各自领域更好的患者预后和技术进步之间的联系。此外,研究表明,在整个手术过程中增加医院和外科医生的数量可能会导致手术结果的改善专业化程度已被证明可以降低各种手术的手术死亡率,并突出表明,每个领域所需要的复杂程度和知识基础是如此之高,以至于没有一个外科医生能够“样样精通”而且做得很好心脏手术已经变得更加专科化;然而,许多人仍然认为冠状动脉手术是一种全科手术关于医院规模、外科医生规模或专业化程度对孤立性冠状动脉搭桥术后围手术期死亡率的相对贡献存在争议。4-6在本文中,我们将讨论支持冠状动脉手术专业化需求的当前数据,并提出支持该领域进一步专业化的论点。
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引用次数: 0
New Directions in Coronary Revascularization for Refractory Angina: Gene Therapy and the Lizard Heart 难治性心绞痛冠状动脉血管重建的新方向:基因治疗和蜥蜴心脏
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.11.009
Ahmed H. Aly MD, PhD, Nahush A. Mokadam MD
Refractory angina is a debilitating disease with limited therapeutic options that is primarily caused by microvascular dysfunction and desertification. Toward addressing this unmet need, microvascular revascularization therapy has progressively evolved from the lizard heart–inspired transmyocardial revascularization to precisely inducing vascular endothelial growth factor with gene therapy. Gene therapy with adenoviral vehicles or naked modified ribonucleic acid is safe and shows early signs of clinical promise but has not yet been proven effective due to gaps in optimization.
难治性心绞痛是一种使人衰弱的疾病,其主要原因是微血管功能障碍和荒漠化,但治疗方法有限。为了满足这一尚未得到满足的需求,微血管再通疗法已从蜥蜴心脏启发的经心肌再通术逐步发展到利用基因疗法精确诱导血管内皮生长因子。使用腺病毒载体或裸体修饰核糖核酸进行基因治疗是安全的,并显示出临床前景的早期迹象,但由于在优化方面存在差距,其有效性尚未得到证实。
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引用次数: 0
The Importance of Pulmonary Nodule Features in the Selection of Treatment for the High-Risk Patient with Stage I Non-Small Cell Lung Cancer 肺结节特征在高风险I期非小细胞肺癌患者治疗选择中的重要性
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.10.003
Arjun Pennathur MD, Co-Chair Writing Committee , Michael Lanuti MD , Robert E. Merritt MD , Andrea Wolf MD, MPH , Homa Keshavarz PhD , Billy W. Loo Jr, MD, PhD , Robert D. Suh MD , Raymond H. Mak MD , Alessandro Brunelli MD , Gerard J. Criner MD , Peter J. Mazzone MD , Garrett Walsh MD , Michael Liptay MD , Q. Eileen Wafford MSt, MLIS , Sudish Murthy MD, PhD , M. Blair Marshall MD , Betty Tong MD , Brian Pettiford MD , Gaetano Rocco MD , James Luketich MD , Scott J. Swanson MD, Co-Chair Writing Committee
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引用次数: 0
Techniques and Results of Multiple Arterial Bypass Grafting: Towards More “Curative” Coronary Revascularizations 多支动脉旁路移植术的技术和结果:实现更具 "治疗性 "的冠状动脉血管重建术。
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.09.002
J. Scott Rankin MD , J. Hunter Mehaffey MD , Danny Chu MD , Richard Ramsingh MD , Abhishek Sharma MD , Vinay Badhwar MD , Faisal G. Bakaeen MD
Surgical coronary bypass has evolved continually, and most analyses currently favor performing coronary grafts with autologous living arterial conduits to obtain better long-term patencies and clinical outcomes. With bilateral internal mammary artery grafts and both radial arteries, 4 excellent arterial conduits exist for creating “all-arterial” revascularization in the majority of multivessel disease patients, including those with valve disorders. Using contemporary surgical techniques, it is possible to obtain greater than 95% overall early graft patencies that translate into better late outcomes, including improved survival, freedom from myocardial infarction, fewer percutaneous coronary interventions, and redo coronary bypass procedures. The overall goal is to revascularize the 2 most important coronary systems with internal mammary artery grafts, and the rest with radial arteries, depending on the anatomy, experience, and choice of the surgeon. Using highly validated management strategies, early postoperative complications, including the incidence of sternal infections, are extremely uncommon, and in many practices, multi-arterial grafts currently are used in the majority of multivessel patients, including those with concomitant valve disease. Because patencies and outcomes are significantly better than with saphenous vein bypass or percutaneous coronary interventions, referring physicians frequently favor multi-arterial bypass procedures as the primary therapy for patients with prognostically serious multivessel disease. Thus, coronary bypass using predominantly autologous arterial conduits should play an increasingly important role in the future management of severe coronary atherosclerosis.
冠状动脉搭桥手术不断发展,目前大多数分析都倾向于使用自体活体动脉导管进行冠状动脉移植,以获得更好的长期通畅性和临床疗效。通过双侧乳内动脉(IMA)移植物和双侧桡动脉(RA),有四种极佳的动脉导管可为大多数多血管疾病患者(包括瓣膜疾病患者)提供 "全动脉 "血运重建。利用现代外科技术,可以获得超过 95% 的早期移植物总通畅率,从而改善后期疗效,包括提高生存率、避免心肌梗死、减少经皮冠状动脉介入治疗(PCI)和重做冠状动脉搭桥手术。总体目标是使用 IMA 移植物对两个最重要的冠状动脉系统进行血管再通,并根据解剖结构、经验和外科医生的选择,使用 RA 对其余冠状动脉系统进行血管再通。采用经过高度验证的管理策略后,术后早期并发症(包括胸骨感染)的发生率极低,目前在许多临床实践中,多动脉移植物被用于大多数多血管患者,包括合并瓣膜疾病的患者。由于其通畅性和疗效明显优于大隐静脉搭桥或 PCI,转诊医生通常倾向于将多动脉搭桥术作为预后严重的多血管疾病患者的主要治疗方法。因此,主要使用自体动脉导管的冠状动脉搭桥术应在未来严重冠状动脉粥样硬化的治疗中扮演越来越重要的角色。
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引用次数: 0
Internal Thoracic Arteries Injuries During Harvesting: Mitigation and Management 采摘过程中的胸内动脉损伤:缓解和处理。
IF 2.6 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Pub Date : 2025-03-01 DOI: 10.1053/j.semtcvs.2024.08.006
Jules J. Bakhos MD, MSc, Gabriele M. Iacona MD, Marijan Koprivanac MD, Michael Z. Tong MD, Shinya Unai MD, Edward G. Soltesz MD, Haytham Elgharably MD, Faisal G. Bakaeen MD
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引用次数: 0
期刊
Seminars in Thoracic and Cardiovascular Surgery
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