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Medizinische Genetik最新文献

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Die GfH-Juniorakademie 2023 – #GfHJAK23 @schlossbuchenau 2023 年 GfH 青少年学院 - #GfHJAK23 @schlossbuchenau
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2058
I. Krey, Simone Ahting, A. Forstner, Maria Korte, R. Meyer, F. Schnabel, Daniel Pieh, Maike Karnstedt
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引用次数: 0
Ein Geburtstagsgruß für Hans-Hilger Ropers 为汉斯-希尔格-罗珀斯送上生日祝福
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2067
T. Wienker
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引用次数: 0
Nachruf Prof. Dr. med. Michael Speicher 讣告 迈克尔-施佩歇博士教授
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2063
Sarah Verheyen, Ellen Heitzer, J. Geigl
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引用次数: 0
Nachruf Prof. Dr. med. Wilko Weichert 威尔科-魏切特博士教授的讣告
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2047
B. Schlegelberger
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引用次数: 0
Tagungsbericht SSIEM Jahrestagung vom 29.08.2023 bis 01.09.2023 in Jerusalem 会议报告 SSIEM 年会,2023 年 8 月 29 日至 2023 年 9 月 1 日,耶路撒冷
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2044
L. D. Schlieben
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引用次数: 0
Liquid biopsies and those three little words: finding the perfect match for the MTB 液体活检和这三个小词:为山地车寻找完美匹配
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2064
A. Wahida, L. Buschhorn
Abstract Monitoring ctDNA by liquid biopsies seems to represent the perfect match for precision oncology and its cornerstone clinical framework: the molecular tumour board (MTB). Detecting and scrutinising the success of targeted therapies or tracking and, for that matter, addressing the therapy with the evolutive nature of a tumour are some of the main advancements one considers to be important for the MTB. One challenge is correlating the estimated allele frequency of each identified genetic alteration determined by analysing the ctDNA sequencing results and matching these with the range of suitable drugs, which may limit the simultaneous treatment of all tumour variations. This limitation arises because a new biopsy would typically be required to evaluate the response to treatment. As a result, evaluating the success of MTB recommendations relies on traditional staging methods, highlighting an existing diagnostic gap. Thus, optimising liquid biopsy technology could enhance the efficacy of MTB treatment recommendations and ensuing tailored therapies. Herein, we discuss the prospect of ctDNA analyses in the molecular tumour board.
摘要 通过液体活检监测ctDNA似乎是精准肿瘤学及其基础临床框架--分子肿瘤委员会(MTB)的完美结合。检测和检查靶向治疗的成功与否,或跟踪并根据肿瘤的演变特性来解决治疗问题,是人们认为对 MTB 非常重要的一些主要进展。一个挑战是如何将通过分析 ctDNA 测序结果确定的每个已识别基因变异的估计等位基因频率与适合的药物范围相匹配,这可能会限制对所有肿瘤变异的同时治疗。出现这种限制的原因是,通常需要进行新的活检来评估治疗反应。因此,评估 MTB 建议的成功与否依赖于传统的分期方法,凸显了现有的诊断差距。因此,优化液体活检技术可以提高 MTB 治疗建议的疗效,并随之提供量身定制的疗法。在此,我们将讨论ctDNA分析在肿瘤分子分期中的应用前景。
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引用次数: 0
Nachruf Prof. Dr. rer. nat. Jeanette Erdmann 讣告 Jeanette Erdmann 博士教授
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2046
M. Nöthen, Malte Spielmann
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引用次数: 0
Frank-Majewski-Preisträgerin 2023 2023 年弗兰克-马耶夫斯基奖获得者
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2052
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引用次数: 0
Tagungsbericht Kongress für Kinder- und Jugendmedizin 20. bis 23. September 2023 in Hamburg 会议报告 2023 年 9 月 20 日至 23 日在汉堡举行的儿科和青少年医学大会
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2051
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引用次数: 0
Akademie Humangenetik 人类遗传学学会
IF 1.1 4区 生物学 Q4 Medicine Pub Date : 2023-11-29 DOI: 10.1515/medgen-2023-2053
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引用次数: 0
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Medizinische Genetik
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