Endocrinologia Diabetes Y Nutricion最新文献

英文中文

Multifocality of papillary thyroid carcinoma with low risk of recurrence: Prevalence, predictive markers, prognostic significance and initial surgical treatment 低复发风险的甲状腺乳头状癌的多灶性：患病率、预测指标、预后意义和初始手术治疗。

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-05-01 DOI: 10.1016/j.endien.2025.501545

Luis García Pascual , Carlos Puig-Jové , Andreu Simó-Servat , Lluís García-González

Background and objective

The impact of multifocality on the prognosis of patients with papillary thyroid cancer is relevant when considering the choice of initial surgical treatment by hemithyroidectomy or total thyroidectomy. The aim of the study is to determine the prevalence of multifocality in our setting, its predictive markers and the rates of persistence, recurrence and mortality associated with papillary thyroid cancer with a low risk of recurrence in order to infer the most appropriate initial surgical treatment.

Patients and method

Retrospective observational cross-sectional study of 85 total thyroidectomies.

Results

Prevalences: unifocal carcinoma: 68.2%; multifocal: 31.8%. Predictive markers of multifocality: multinodular ultrasound pattern (OR:17.069, 95% CI:2.989−97.454) and non-incidental finding (OR:7.569, 95% CI:2.363−24.242). In 66.6% of multifocal cases there was bilateral involvement, all of them had a bilateral multinodular ultrasound pattern. Multifocal cases received postoperative radioiodine more frequently (p < 0.001). During the follow-up of 95.5 ± 32.2 months there was one case of persistence and one of recurrence, both in the multifocal group (p:ns), at 12 and 71 months of follow-up. There was no mortality.

Conclusions

This is the first study in our country to estimate the prevalence of multifocality in papillary carcinoma with a low risk of recurrence and to show an excellent prognosis, with no differences compared to unifocal cases, considering that all cases have been treated with total thyroidectomy, but multifocal cases with radioiodine more frequently. Hemithyroidectomy could offer a similar prognosis to total thyroidectomy in cases with an ultrasound pattern of a single or unilateral multinodular nodule, but not in cases of bilateral multinodular thyroid.

背景与目的：多灶性对甲状腺乳头状癌患者预后的影响与选择甲状腺切除术或全甲状腺切除术的初始手术治疗相关。本研究的目的是确定在我们的环境中多灶性的患病率、其预测指标以及与低复发风险的甲状腺乳头状癌相关的持久性、复发率和死亡率，以便推断最合适的初始手术治疗。患者和方法：85例甲状腺全切除术的回顾性观察性横断面研究。结果：发病率：单灶性癌：68.2%；多病灶的:31.8%。多灶性的预测指标：多结节超声表现（OR:17.069, 95% CI:2.989-97.454）和非偶然发现（OR:7.569, 95% CI:2.363-24.242）。66.6%的多灶病例双侧受累，超声表现均为双侧多结节。结论：考虑到所有病例均行甲状腺全切除术，但多灶性病例放疗频率更高，这是我国首次对复发风险较低的乳头状癌中多灶性的患病率进行估计，且预后良好，与单灶性病例相比无差异。在超声表现为单侧或单侧多结节结节的病例中，半甲状腺切除术与全甲状腺切除术预后相似，但双侧甲状腺多结节病例则不然。

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引用次数: 0

Osteogenesis imperfecta type V: About a clinical case V型成骨不全症1例临床分析。

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-05-01 DOI: 10.1016/j.endien.2025.501544

María Fernanda Reinoso Gomezcoello , Isabel Pavón de Paz , Cristina Navea Aguilera , Belén Gil Fournier , Ana María Bueno Sanchez , Guadalupe Guijarro de Armas , María Merino Viveros , Jose Antonio Rosado Sierra , Paloma Iglesias Bolaños , María Durán Martínez

Osteogenesis imperfecta (OI) is a rare inherited connective tissue disorder. It is characterized by short stature, fragility and decreased bone mass, which leads to multiple and recurrent fractures after low-energy trauma, which generates susceptibility to long bone deformity and vertebral compression. There are several types of OI, with types I to IV, in which the COL1A1 and COL1A2 genes are affected, being the most frequent. In recent years, the discovery of new forms of OI has led to research into the pathways critical aspects of bone metabolism, with new genes involved being identified. The mutation in IFITM5 has been identified as the cause of OI type V, of autosomal dominant inheritance. OI type V has distinctive clinical features including the development of hypertrophic callus after fracture, early calcification of the interosseous membrane in the forearm, and the presence of hyperdense metaphyseal bands.

The case of a patient with a novo mutation in IFITM5 is presented.

成骨不全症是一种罕见的遗传性结缔组织疾病。其特点是身材矮小、脆弱、骨量减少，导致低能创伤后多发、复发性骨折，易发生长骨畸形和椎体受压。有几种类型的成骨不全，从I型到IV型，其中COL1A1和COL1A2基因受到影响，是最常见的。近年来，新形式的成骨不全的发现导致了对骨代谢关键方面的研究，并发现了新的相关基因。IFITM5突变已被确定为常染色体显性遗传的OI V型的原因。V型成骨不全具有独特的临床特征，包括骨折后肥厚性骨痂的发展，前臂骨间膜的早期钙化，以及存在高密度的干骺端带。在IFITM5患者的新突变的情况下提出。

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引用次数: 0

Transgender women and competitive sports: Considerations from Endocrinology 跨性别女性和竞技体育：来自内分泌学的考虑。

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.101539

Laura Cuadrado Clemente , María Miguélez González , Patricia Cabrera García , Mercedes Noval Font , Élida Alfaro Gandarillas , Marcelino Gómez Balaguer , Nieves Palacios Gil de Antuñano

Introduction

The participation of transgender women (TW) in high-level competitive sports increases every year, as does the interest of sports organizations in finding solutions that allow their inclusion without compromising the principle of equity governing high-level sports. However, the binary categorization of sports, influenced by the impact of sex hormone on physical performance, creates challenges for the inclusion of TW in the female category. This study aimed to understand the impact of gender-affirming hormone therapy (GAHT) on various athletic performance variables and to compare results with those obtained in cisgender populations.