Pub Date : 2025-12-01DOI: 10.1016/j.endien.2025.501646
Carmen Sánchez Blanco , Marina García Cancelo , Cristina González Martínez , Leire Cardo González , Marta Diéguez Felechosa
Introduction
Although former studies indicated that Asturias (Spain) is an iodine-sufficient region, preliminary data suggest this trend may be changing.
Objective
To determine the prevalence of iodine deficiency in pregnant women in Asturias.
Material and methods
We designed an observational, prospective, multicenter study. The urinary iodine concentration (UIC) of 371 pregnant women was analyzed between November 2021 and March 2023. Participants were recruited from the three central areas of the Principality of Asturias (Areas III, IV, and V). The project received approval from the Research Ethics Committee of the Principality of Asturias (RECPA).
Results
A total of 52% of pregnant women had urinary iodine levels indicative of iodine deficiency (< 150 μg/L). The average UIC in our cohort was 146 μg/L. We compared thyroid-stimulating hormone (TSH) levels between pregnant women with iodine deficiency and those with sufficient iodine, but found no statistically significant differences in TSH levels between the two groups. We also couldn't establish statistically significant links between iodine deficiency status and body mass index (BMI), number of previous births, nationality, or age. Furthermore, iodine deficiency did not show a significant link to obstetric complications such such as hypertension during pregnancy or premature birth.
Conclusions
These findings support the hypothesis of an increase in iodine deficiency during the first trimester of pregnancy in our population. This highlights the urgent need to review our supplementation strategies and nutritional education programs.
{"title":"Current status of iodisation in pregnant women in Asturias, Spain","authors":"Carmen Sánchez Blanco , Marina García Cancelo , Cristina González Martínez , Leire Cardo González , Marta Diéguez Felechosa","doi":"10.1016/j.endien.2025.501646","DOIUrl":"10.1016/j.endien.2025.501646","url":null,"abstract":"<div><h3>Introduction</h3><div>Although former studies indicated that Asturias (Spain) is an iodine-sufficient region, preliminary data suggest this trend may be changing.</div></div><div><h3>Objective</h3><div>To determine the prevalence of iodine deficiency in pregnant women in Asturias.</div></div><div><h3>Material and methods</h3><div>We designed an observational, prospective, multicenter study. The urinary iodine concentration (UIC) of 371 pregnant women was analyzed between November 2021 and March 2023. Participants were recruited from the three central areas of the Principality of Asturias (Areas III, IV, and V). The project received approval from the Research Ethics Committee of the Principality of Asturias (RECPA).</div></div><div><h3>Results</h3><div>A total of 52% of pregnant women had urinary iodine levels indicative of iodine deficiency (< 150 μg/L). The average UIC in our cohort was 146 μg/L. We compared thyroid-stimulating hormone (TSH) levels between pregnant women with iodine deficiency and those with sufficient iodine, but found no statistically significant differences in TSH levels between the two groups. We also couldn't establish statistically significant links between iodine deficiency status and body mass index (BMI), number of previous births, nationality, or age. Furthermore, iodine deficiency did not show a significant link to obstetric complications such such as hypertension during pregnancy or premature birth.</div></div><div><h3>Conclusions</h3><div>These findings support the hypothesis of an increase in iodine deficiency during the first trimester of pregnancy in our population. This highlights the urgent need to review our supplementation strategies and nutritional education programs.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501646"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.endien.2025.501643
Irene Breton , Igotz Aranbarri , Anastasia Lampropoulou , Jennifer Redondo-Antón , Javier Ágreda , Atif Adam , Esther Artime
Introduction
The epIdeMiology landscape PAtient Care paThways of Obesity (IMPACT-O) study was a multi-country, retrospective cohort study that utilised healthcare databases to determine the landscape/impact of overweight and obesity. Here we describe the sociodemographic, clinical and treatment characteristics of adults with a first record of overweight/obesity or obesity in Spain between 2018 and 2022.
Materials and methods
The IQVIA longitudinal patient database in Spain was used to identify individuals with a first record of overweight/obesity, as determined by diagnosis codes and/or body mass index (BMI) measurements (overweight/obesity cohort: BMI ≥25 kg/m2; obesity cohort: BMI ≥30 kg/m2), in the years 2018–2022. Demographic and clinical parameters, including obesity-related complications (ORCs), as recorded by primary care providers and specialists contributing to the database, were described.
Results
The overweight/obesity cohort included 25,016 individuals, and the obesity cohort 13,441 individuals. Most individuals with overweight/obesity (60.1%) and obesity (63.6%) presented with ≥1 ORCs. The most frequent ORCs among people with obesity were hypertension (25.3%), dyslipidaemia (19.8%), anxiety (19.0%), osteoarthritis (14.3%), low-back pain (10.9%) and depression (10.9%). The proportion of individuals receiving pharmacological therapies with an effect on weight was <1%. There were no records of lifestyle interventions or bariatric surgery in the database for this population.
Conclusions
This study highlights the high ORC burden at first documented diagnosis of overweight/obesity. Very few individuals with obesity in Spain receive pharmacological treatment with an effect on weight. Patient management could be improved by systematically recording all interventions in this population.
{"title":"The overweight and obesity landscape in Spain: Data from the Spanish cohort of the multi-country IMPACT-O study","authors":"Irene Breton , Igotz Aranbarri , Anastasia Lampropoulou , Jennifer Redondo-Antón , Javier Ágreda , Atif Adam , Esther Artime","doi":"10.1016/j.endien.2025.501643","DOIUrl":"10.1016/j.endien.2025.501643","url":null,"abstract":"<div><h3>Introduction</h3><div>The epIdeMiology landscape PAtient Care paThways of Obesity (IMPACT-O) study was a multi-country, retrospective cohort study that utilised healthcare databases to determine the landscape/impact of overweight and obesity. Here we describe the sociodemographic, clinical and treatment characteristics of adults with a first record of overweight/obesity or obesity in Spain between 2018 and 2022.</div></div><div><h3>Materials and methods</h3><div>The IQVIA longitudinal patient database in Spain was used to identify individuals with a first record of overweight/obesity, as determined by diagnosis codes and/or body mass index (BMI) measurements (overweight/obesity cohort: BMI ≥25<!--> <!-->kg/m<sup>2</sup>; obesity cohort: BMI ≥30<!--> <!-->kg/m<sup>2</sup>), in the years 2018–2022. Demographic and clinical parameters, including obesity-related complications (ORCs), as recorded by primary care providers and specialists contributing to the database, were described.</div></div><div><h3>Results</h3><div>The overweight/obesity cohort included 25,016 individuals, and the obesity cohort 13,441 individuals. Most individuals with overweight/obesity (60.1%) and obesity (63.6%) presented with ≥1 ORCs. The most frequent ORCs among people with obesity were hypertension (25.3%), dyslipidaemia (19.8%), anxiety (19.0%), osteoarthritis (14.3%), low-back pain (10.9%) and depression (10.9%). The proportion of individuals receiving pharmacological therapies with an effect on weight was <1%. There were no records of lifestyle interventions or bariatric surgery in the database for this population.</div></div><div><h3>Conclusions</h3><div>This study highlights the high ORC burden at first documented diagnosis of overweight/obesity. Very few individuals with obesity in Spain receive pharmacological treatment with an effect on weight. Patient management could be improved by systematically recording all interventions in this population.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501643"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1016/j.endien.2025.501624
Cristina Mª Díaz Perdigones , Daniel Hinojosa Nogueira , Alba Rodríguez Muñoz , Alba Subiri Verdugo , Alberto Vilches-Pérez , Virginia Mela , Francisco J. Tinahones , Isabel Moreno Indias
Obesity is a growing public health problem. In recent decades, scientific evidence has linked gut microbiota to obesity. This systematic review summarizes current knowledge on the composition and functional differences in gut microbiota between individuals with obesity and those with normal weight. Following PRISMA 2020 recommendations, studies published in adult populations between January 2014 and May 2024 were reviewed. PubMed, Web of Science, and Scopus databases were searched for observational studies that had used advanced sequencing methods, such as 16S rRNA and shotgun metagenomics, to assess gut microbiota. The quality of these studies was also analyzed using the Newcastle-Ottawa scale. Our review of 16 studies shows a reduction in microbial diversity in individuals with obesity. In addition, a higher relative abundance of the phylum Firmicutes, the families Enterobacteriaceae, Gemellaceae, Prevotellaceae, Streptococcaceae and Veillonellaceae, as well as the genera Blautia, Butyricimonas, Collinsella, Megamonas, and Streptococcus, while beneficial bacteria such as the families Porphyromonadaceae and Rikenellaceae, and the genera Bifidobacterium spp. and Faecalibacterium prausnitzii, were depleted. Functional analysis showed a tendency to an increase in metabolic pathways associated with carbohydrate and lipid metabolism, with reduced pathways related to short-chain fatty acid production. Obesity is associated with altered gut microbiota composition and function. However, the variability across studies regarding population characteristics, dietary pattern, and sequencing techniques limits the comparability of findings. Future research should prioritize standardized methodologies and confounding factors to elucidate the role of the gut microbiome in obesity.
肥胖是一个日益严重的公共健康问题。近几十年来，科学证据表明肠道微生物群与肥胖有关。这篇系统综述总结了目前关于肥胖个体和正常体重个体之间肠道微生物群组成和功能差异的知识。根据PRISMA 2020的建议，对2014年1月至2024年5月期间发表的成人研究进行了回顾。PubMed， Web of Science和Scopus数据库检索了使用先进测序方法（如16S rRNA和shotgun宏基因组学）评估肠道微生物群的观察性研究。这些研究的质量也用纽卡斯尔-渥太华量表进行了分析。我们对16项研究的回顾表明，肥胖个体的微生物多样性减少。此外，厚壁菌门、Enterobacteriaceae、Gemellaceae、Prevotellaceae、Streptococcaceae和Veillonellaceae以及Blautia属、Butyricimonas、Collinsella、Megamonas和Streptococcus等有益菌的相对丰度较高，而Porphyromonadaceae和Rikenellaceae、Bifidobacterium spp.和Faecalibacterium prausnitzii等有益菌的相对丰度则相对较少。功能分析显示，与碳水化合物和脂质代谢相关的代谢途径有增加的趋势，与短链脂肪酸产生相关的代谢途径减少。肥胖与肠道菌群组成和功能的改变有关。然而，关于人群特征、饮食模式和测序技术的研究差异限制了研究结果的可比性。未来的研究应优先考虑标准化的方法和混杂因素，以阐明肠道微生物群在肥胖中的作用。
{"title":"Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review","authors":"Cristina Mª Díaz Perdigones , Daniel Hinojosa Nogueira , Alba Rodríguez Muñoz , Alba Subiri Verdugo , Alberto Vilches-Pérez , Virginia Mela , Francisco J. Tinahones , Isabel Moreno Indias","doi":"10.1016/j.endien.2025.501624","DOIUrl":"10.1016/j.endien.2025.501624","url":null,"abstract":"<div><div>Obesity is a growing public health problem. In recent decades, scientific evidence has linked gut microbiota to obesity. This systematic review summarizes current knowledge on the composition and functional differences in gut microbiota between individuals with obesity and those with normal weight. Following PRISMA 2020 recommendations, studies published in adult populations between January 2014 and May 2024 were reviewed. PubMed, Web of Science, and Scopus databases were searched for observational studies that had used advanced sequencing methods, such as 16S rRNA and shotgun metagenomics, to assess gut microbiota. The quality of these studies was also analyzed using the Newcastle-Ottawa scale. Our review of 16 studies shows a reduction in microbial diversity in individuals with obesity. In addition, a higher relative abundance of the phylum <em>Firmicutes</em>, <em>the families Enterobacteriaceae</em>, <em>Gemellaceae</em>, <em>Prevotellaceae</em>, <em>Streptococcaceae</em> and <em>Veillonellaceae</em>, as well as the genera <em>Blautia</em>, <em>Butyricimonas</em>, <em>Collinsella</em>, <em>Megamonas</em>, and <em>Streptococcus</em>, while beneficial bacteria such as the families <em>Porphyromonadaceae</em> and <em>Rikenellaceae</em>, and the genera <em>Bifidobacterium</em> spp<em>.</em> and <em>Faecalibacterium prausnitzii</em>, were depleted. Functional analysis showed a tendency to an increase in metabolic pathways associated with carbohydrate and lipid metabolism, with reduced pathways related to short-chain fatty acid production. Obesity is associated with altered gut microbiota composition and function. However, the variability across studies regarding population characteristics, dietary pattern, and sequencing techniques limits the comparability of findings. Future research should prioritize standardized methodologies and confounding factors to elucidate the role of the gut microbiome in obesity.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501624"},"PeriodicalIF":1.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1016/j.endien.2025.501623
Lili Wang , Linjun Zheng , Jiayu Hu , Nongnong Zhao
Background
Cardiovascular disease (CVD) is the leading cause of death in patients with type 2 diabetes mellitus (T2DM), and left ventricular diastolic dysfunction (LVDD) is considered one of the earliest markers of myocardial dysfunction. Fragmented QRS (fQRS) and microalbuminuria (MAU) are important biomarkers of cardiac electrophysiological changes and CVD, but their relationship with LVDD in T2DM remains unclear. This study aims to explore the impact of fQRS and MAU on LVDD in T2DM patients and to analyze whether the association between fQRS and LVDD differs across varying MAU statuses.
Methods
A total of 374 patients with T2DM were ultimately enrolled in this study. Twelve-lead electrocardiography (ECG) and echocardiography were performed, and the patients’ baseline characteristics, laboratory results, and echocardiographic parameters were collected. Univariate and multivariate logistic regression analyses were conducted to assess the association between fQRS, MAU, and LVDD in T2DM patients. A stratified analysis was performed to examine the relationship between fQRS and LVDD across different MAU statuses.
Results
The mean age of the T2DM patients was 57.19 ± 12.47 years, and 62.57% were male. fQRS, MAU, and age were independent risk factors for LVDD in patients with T2DM. The risk of developing LVDD was 3.72 times higher in patients with fQRS compared to those without fQRS [95% CI = 2.125–6.513, P < 0.0001]. The risk of LVDD was 4.05 times higher in patients with MAU compared to those without MAU [95% CI = 2.252–7.282, P < 0.0001]. For each additional year of age, the risk of LVDD increased by 5.2% [95% CI = 1.022–1.084, P = 0.001]. Stratified analysis based on MAU status revealed that in patients without MAU, the association between fQRS and LVDD was stronger [OR = 7.084, 95% CI = 3.255–15.419, P < 0.0001]. However, in patients with MAU, the relationship between fQRS and LVDD was no longer significant [OR = 1.499, 95% CI = 0.603–3.722, P = 0.383].
Conclusions
Our study found that both fQRS and MAU are independent risk factors for LVDD in patients with T2DM. The presence of fQRS increased the risk of LVDD by 3.72 times, while MAU increased the risk by 4.05 times. Stratified analysis further revealed that in patients without MAU, the association between fQRS and LVDD was significantly stronger (OR = 7.084, P < 0.0001), while in patients with MAU, this association was no longer significant (P = 0.383). These findings suggest that combining the detection of fQRS and MAU may provide valuab
背景：心血管疾病（CVD）是2型糖尿病（T2DM）患者死亡的主要原因，而左室舒张功能障碍（LVDD）被认为是心肌功能障碍的最早标志之一。碎片化QRS （fQRS）和微量白蛋白尿（MAU）是心脏电生理变化和CVD的重要生物标志物，但它们与T2DM患者LVDD的关系尚不清楚。本研究旨在探讨fQRS和MAU对T2DM患者LVDD的影响，并分析fQRS与LVDD的相关性是否因MAU状态的不同而不同。方法共纳入374例T2DM患者。行十二导联心电图（ECG）和超声心动图，收集患者的基线特征、实验室结果和超声心动图参数。进行单因素和多因素logistic回归分析，评估T2DM患者fQRS、MAU和LVDD之间的关系。对不同MAU状态下fQRS和LVDD之间的关系进行了分层分析。结果T2DM患者平均年龄57.19±12.47岁，男性占62.57%。fQRS、MAU和年龄是T2DM患者LVDD的独立危险因素。fQRS患者发生LVDD的风险是无fQRS患者的3.72倍[95% CI = 2.125-6.513, P < 0.0001]。MAU患者发生LVDD的风险是无MAU患者的4.05倍[95% CI = 2.252-7.282, P < 0.0001]。每增加一岁，LVDD的风险增加5.2% [95% CI = 1.022-1.084, P = 0.001]。基于MAU状态的分层分析显示，在无MAU患者中，fQRS与LVDD的相关性更强[OR = 7.084, 95% CI = 3.255-15.419, P < 0.0001]。而在MAU患者中，fQRS与LVDD的关系不再显著[OR = 1.499, 95% CI = 0.603-3.722, P = 0.383]。结论本研究发现fQRS和MAU均为T2DM患者LVDD的独立危险因素。fQRS的存在使LVDD的风险增加了3.72倍，MAU的存在使LVDD的风险增加了4.05倍。分层分析进一步发现，在无MAU患者中，fQRS与LVDD的相关性显著增强（OR = 7.084, P < 0.0001），而在有MAU患者中，这种相关性不再显著（P = 0.383）。这些研究结果表明，fQRS和MAU的联合检测可能为T2DM患者心血管风险评估提供有价值的信息，有助于制定个性化的干预策略，最终改善患者预后。
{"title":"The association between fragmented QRS and left ventricular diastolic dysfunction in type 2 diabetes patients with or without microalbuminuria","authors":"Lili Wang , Linjun Zheng , Jiayu Hu , Nongnong Zhao","doi":"10.1016/j.endien.2025.501623","DOIUrl":"10.1016/j.endien.2025.501623","url":null,"abstract":"<div><h3>Background</h3><div>Cardiovascular disease (CVD) is the leading cause of death in patients with type 2 diabetes mellitus (T2DM), and left ventricular diastolic dysfunction (LVDD) is considered one of the earliest markers of myocardial dysfunction. Fragmented QRS (fQRS) and microalbuminuria (MAU) are important biomarkers of cardiac electrophysiological changes and CVD, but their relationship with LVDD in T2DM remains unclear. This study aims to explore the impact of fQRS and MAU on LVDD in T2DM patients and to analyze whether the association between fQRS and LVDD differs across varying MAU statuses.</div></div><div><h3>Methods</h3><div>A total of 374 patients with T2DM were ultimately enrolled in this study. Twelve-lead electrocardiography (ECG) and echocardiography were performed, and the patients’ baseline characteristics, laboratory results, and echocardiographic parameters were collected. Univariate and multivariate logistic regression analyses were conducted to assess the association between fQRS, MAU, and LVDD in T2DM patients. A stratified analysis was performed to examine the relationship between fQRS and LVDD across different MAU statuses.</div></div><div><h3>Results</h3><div>The mean age of the T2DM patients was 57.19<!--> <!-->±<!--> <!-->12.47 years, and 62.57% were male. fQRS, MAU, and age were independent risk factors for LVDD in patients with T2DM. The risk of developing LVDD was 3.72 times higher in patients with fQRS compared to those without fQRS [95% CI<!--> <!-->=<!--> <!-->2.125–6.513, <em>P</em> <!--><<!--> <!-->0.0001]. The risk of LVDD was 4.05 times higher in patients with MAU compared to those without MAU [95% CI<!--> <!-->=<!--> <!-->2.252–7.282, <em>P</em> <!--><<!--> <!-->0.0001]. For each additional year of age, the risk of LVDD increased by 5.2% [95% CI<!--> <!-->=<!--> <!-->1.022–1.084, <em>P</em> <!-->=<!--> <!-->0.001]. Stratified analysis based on MAU status revealed that in patients without MAU, the association between fQRS and LVDD was stronger [OR<!--> <!-->=<!--> <!-->7.084, 95% CI<!--> <!-->=<!--> <!-->3.255–15.419, <em>P</em> <!--><<!--> <!-->0.0001]. However, in patients with MAU, the relationship between fQRS and LVDD was no longer significant [OR<!--> <!-->=<!--> <!-->1.499, 95% CI<!--> <!-->=<!--> <!-->0.603–3.722, <em>P</em> <!-->=<!--> <!-->0.383].</div></div><div><h3>Conclusions</h3><div>Our study found that both fQRS and MAU are independent risk factors for LVDD in patients with T2DM. The presence of fQRS increased the risk of LVDD by 3.72 times, while MAU increased the risk by 4.05 times. Stratified analysis further revealed that in patients without MAU, the association between fQRS and LVDD was significantly stronger (OR<!--> <!-->=<!--> <!-->7.084, <em>P</em> <!--><<!--> <!-->0.0001), while in patients with MAU, this association was no longer significant (<em>P</em> <!-->=<!--> <!-->0.383). These findings suggest that combining the detection of fQRS and MAU may provide valuab","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501623"},"PeriodicalIF":1.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1016/j.endien.2025.501614
Marina Jara Vidal, Andrés Ruiz de Assín Valverde, Marta Gallach Martínez, Noel Roig Marín, César Gonzalvo Díaz, Rosa Pilar Quílez Toboso, Lourdes García Blasco, Silvia Aznar Rodríguez, José Juan Lozano García, José Joaquín Alfaro Martínez
Introduction
This study investigates the concordance of bioelectrical impedance vector analysis (BIVA) measurements in both hemisomes in patients receiving fluid therapy, since clinical practice suggests performing them in the hemisoma contralateral to that of its administration to avoid interferences.
The primary objective of this study was to evaluate the concordance of phase angle (PhA), resistance and reactance, both standardized by height (Rz/h, Xc/h) between the hemisoma where the patient is receiving iv fluids and the other one.
Methods
Clinical, prospective and descriptive study, which included 100 hospitalized patients with total parenteral nutrition (TPN) or other intravenous fluid therapy. BIVA measurements were taken in both hemisomes and analyzed by means of Bland–Altman plots, Passing–Block test and conditional method agreement trees (COAT).
Results
100 patients were included (57 men and 43 women), with an average age of 67.2 ± 15.1 years. Univariate analysis using the Bland–Altman plot showed no concordance of PhA, Rz/h and Xc/h between both hemisomes in patients who received fluid therapy, but Passing–Block test showed no systematic or proportional differences between hemisomas and multivariate COAT analysis did not show that the specified covariates affected concordance.
Conclusions
No systematic or proportional differences between hemisomas in resistance and reactance has been demonstrated, suggesting the possibility of being able to perform the measurement independently of the side of fluid administration.
{"title":"The hemisoma in which the bioelectrical impedance vector analysis is performed has no influence on outcomes in patients receiving intravenous fluid therapy","authors":"Marina Jara Vidal, Andrés Ruiz de Assín Valverde, Marta Gallach Martínez, Noel Roig Marín, César Gonzalvo Díaz, Rosa Pilar Quílez Toboso, Lourdes García Blasco, Silvia Aznar Rodríguez, José Juan Lozano García, José Joaquín Alfaro Martínez","doi":"10.1016/j.endien.2025.501614","DOIUrl":"10.1016/j.endien.2025.501614","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigates the concordance of bioelectrical impedance vector analysis (BIVA) measurements in both hemisomes in patients receiving fluid therapy, since clinical practice suggests performing them in the hemisoma contralateral to that of its administration to avoid interferences.</div><div>The primary objective of this study was to evaluate the concordance of phase angle (PhA), resistance and reactance, both standardized by height (Rz/h, Xc/h) between the hemisoma where the patient is receiving iv fluids and the other one.</div></div><div><h3>Methods</h3><div>Clinical, prospective and descriptive study, which included 100 hospitalized patients with total parenteral nutrition (TPN) or other intravenous fluid therapy. BIVA measurements were taken in both hemisomes and analyzed by means of Bland–Altman plots, Passing–Block test and conditional method agreement trees (COAT).</div></div><div><h3>Results</h3><div>100 patients were included (57 men and 43 women), with an average age of 67.2<!--> <!-->±<!--> <!-->15.1 years. Univariate analysis using the Bland–Altman plot showed no concordance of PhA, Rz/h and Xc/h between both hemisomes in patients who received fluid therapy, but Passing–Block test showed no systematic or proportional differences between hemisomas and multivariate COAT analysis did not show that the specified covariates affected concordance.</div></div><div><h3>Conclusions</h3><div>No systematic or proportional differences between hemisomas in resistance and reactance has been demonstrated, suggesting the possibility of being able to perform the measurement independently of the side of fluid administration.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501614"},"PeriodicalIF":1.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1016/j.endien.2025.501534
David Sanchis-Pascual , Agustín Ramos Prol , María Argente Pla , Cristina Montalbán Méndez , Darío Lara Gálvez , Carlos Folgado Bisbal , Montserrat León Fábregas , María Amparo Rubio Broseta , Eva Gascó Santana , Pilar Morillas-Amat , Mónica García Peris , Patricia Correcher Medina , Juan Francisco Merino-Torres
This is the case of a man with hepatorenal tyrosinemia type 1 (HT-1). Following the omission of his usual treatment with nitisinone and the withdrawal of dietary recommendations, the patient developed a severe neurological crisis requiring admission to the intensive care unit (ICU) due to profound diaphragmatic weakness. Despite the initial severity, appropriate management led to a favorable outcome and, eventually, weaning from mechanical ventilation. This case underscores the critical importance of a multidisciplinary approach in the management of inborn errors of metabolism, where nutritional therapy remains the cornerstone of treatment to prevent life-threatening complications.
{"title":"Neurological crisis in tyrosinemia type 1: Essential roles of replacement therapy and nutrition in multidisciplinary management","authors":"David Sanchis-Pascual , Agustín Ramos Prol , María Argente Pla , Cristina Montalbán Méndez , Darío Lara Gálvez , Carlos Folgado Bisbal , Montserrat León Fábregas , María Amparo Rubio Broseta , Eva Gascó Santana , Pilar Morillas-Amat , Mónica García Peris , Patricia Correcher Medina , Juan Francisco Merino-Torres","doi":"10.1016/j.endien.2025.501534","DOIUrl":"10.1016/j.endien.2025.501534","url":null,"abstract":"<div><div>This is the case of a man with hepatorenal tyrosinemia type 1 (HT-1). Following the omission of his usual treatment with nitisinone and the withdrawal of dietary recommendations, the patient developed a severe neurological crisis requiring admission to the intensive care unit (ICU) due to profound diaphragmatic weakness. Despite the initial severity, appropriate management led to a favorable outcome and, eventually, weaning from mechanical ventilation. This case underscores the critical importance of a multidisciplinary approach in the management of inborn errors of metabolism, where nutritional therapy remains the cornerstone of treatment to prevent life-threatening complications.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501534"},"PeriodicalIF":1.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1016/j.endien.2025.501629
Julieta Cigarroa-Durán , Gabriel López-Ramírez , Mirian Carolina Martínez-López , Itandehui Castro-Quezada , Arturo Ortega Soto , Orquidia G. Méndez-Flores
Introduction
Bitterness perception requires activation of the taste-receptor cells (TRCs) in the lingual papillae. The TAS2R38 specialist receptor (T2R family) is activated by thiol-urea chemicals, where 3 haplotype combinations are highly related to bitterness perception. Tasters (PAV/PAV) and non-tasters (AVI/AVI) represent the homozygous phenotypes, while the heterozygous combinations form the moderate tasters, who comprise approximately half of the population.
Material and methods
We determined the bitterness perception phenotype of 153 young adults, as they reacted to a phenylthiocarbamide (PTC) impregnated paper strip placed on their tongues. We measured their weight, height, waist and hip circumferences, total body fat and lean body mass. Mean and standard deviation is shown to express quantitative variables, Kruskal–Wallis test and Dunn's multiple comparison test was used, with 95% confidence intervals.
Results
PTC tasters comprised 27% of the study group, with non-tasters making up 18%. When analyzed by sex, 32% of women were PTC tasters vs 18% of men. Notably, for men, PTC tasters exhibited higher mean values across several body composition measures than non-tasters, including a BMI of 28 kg/m2 vs 24 kg/m2, a waist circumference of 94 cm vs 79 cm, a waist-to-height ratio of 0.54 vs 0.49, and a body fat percentage of 28% vs 15%. In contrast, women showed no significant differences in these measures based on their bitterness perception.
Conclusions
The distribution of perception groups and preponderance of female PTC tasters corresponds to previously reported data. Taster men had a body composition distant from healthy parameters and above the non-tasters values, yet not significant differences were found for female participants.
苦味感知需要激活舌乳头中的味觉受体细胞（TRCs）。TAS2R38特殊受体（T2R家族）被硫醇-尿素化学物质激活，其中3个单倍型组合与苦味感知高度相关。品尝者（PAV/PAV）和非品尝者（AVI/AVI）代表纯合表型，而杂合组合形成中等品尝者，约占人口的一半。材料和方法我们测定了153名年轻人的苦味感知表型，当他们对放在舌头上的浸渍了苯硫脲（PTC）的纸条做出反应时。我们测量了他们的体重、身高、腰围和臀围、全身脂肪和瘦体重。以均数和标准差表示定量变量，采用Kruskal-Wallis检验和Dunn’s多重比较检验，置信区间为95%。结果sptc品酒者占研究组的27%，非品酒者占18%。当按性别分析时，32%的女性是PTC品酒师，而男性是18%。值得注意的是，对于男性来说，PTC品酒师在几项身体成分测量中表现出比非品酒师更高的平均值，包括BMI为28 kg/m2 vs 24 kg/m2，腰围为94 cm vs 79 cm，腰高比为0.54 vs 0.49，体脂率为28% vs 15%。相比之下，女性在这些基于苦味感知的测量中没有显着差异。结论感知组的分布和女性味觉者的优势与先前报道的数据一致。品酒师男性的身体组成远离健康参数，高于非品酒师的值，但女性参与者没有发现显著差异。
{"title":"In young adult males, bitterness perception is associated with excess body mass and metabolic dysregulation","authors":"Julieta Cigarroa-Durán , Gabriel López-Ramírez , Mirian Carolina Martínez-López , Itandehui Castro-Quezada , Arturo Ortega Soto , Orquidia G. Méndez-Flores","doi":"10.1016/j.endien.2025.501629","DOIUrl":"10.1016/j.endien.2025.501629","url":null,"abstract":"<div><h3>Introduction</h3><div>Bitterness perception requires activation of the taste-receptor cells (TRCs) in the lingual papillae. The TAS2R38 specialist receptor (T2R family) is activated by thiol-urea chemicals, where 3 haplotype combinations are highly related to bitterness perception. Tasters (PAV/PAV) and non-tasters (AVI/AVI) represent the homozygous phenotypes, while the heterozygous combinations form the moderate tasters, who comprise approximately half of the population.</div></div><div><h3>Material and methods</h3><div>We determined the bitterness perception phenotype of 153 young adults, as they reacted to a phenylthiocarbamide (PTC) impregnated paper strip placed on their tongues. We measured their weight, height, waist and hip circumferences, total body fat and lean body mass. Mean and standard deviation is shown to express quantitative variables, Kruskal–Wallis test and Dunn's multiple comparison test was used, with 95% confidence intervals.</div></div><div><h3>Results</h3><div>PTC tasters comprised 27% of the study group, with non-tasters making up 18%. When analyzed by sex, 32% of women were PTC tasters vs 18% of men. Notably, for men, PTC tasters exhibited higher mean values across several body composition measures than non-tasters, including a BMI of 28<!--> <!-->kg/m<sup>2</sup> vs 24<!--> <!-->kg/m<sup>2</sup>, a waist circumference of 94<!--> <!-->cm vs 79<!--> <!-->cm, a waist-to-height ratio of 0.54 vs 0.49, and a body fat percentage of 28% vs 15%. In contrast, women showed no significant differences in these measures based on their bitterness perception.</div></div><div><h3>Conclusions</h3><div>The distribution of perception groups and preponderance of female PTC tasters corresponds to previously reported data. Taster men had a body composition distant from healthy parameters and above the non-tasters values, yet not significant differences were found for female participants.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501629"},"PeriodicalIF":1.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1016/j.endien.2025.501637
Anna Aulinas , Elizabeth A. Lawson
{"title":"Oxytocin in hypopituitarism: What do we know?","authors":"Anna Aulinas , Elizabeth A. Lawson","doi":"10.1016/j.endien.2025.501637","DOIUrl":"10.1016/j.endien.2025.501637","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501637"},"PeriodicalIF":1.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1016/j.endien.2025.501613
Alba Escolà-Rodríguez , Berta de Andrés , Tamara Hervis , Marina Rovira-Illamola
{"title":"Semaglutide-associated psychiatric disorders: A case report and literature review","authors":"Alba Escolà-Rodríguez , Berta de Andrés , Tamara Hervis , Marina Rovira-Illamola","doi":"10.1016/j.endien.2025.501613","DOIUrl":"10.1016/j.endien.2025.501613","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501613"},"PeriodicalIF":1.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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