Endocrinologia Diabetes Y Nutricion最新文献

{"title":"The unavoidable decision for medical societies: Commercial drift or integrity","authors":"Ildefonso Hernández-Aguado , Elisa Chilet-Rosell","doi":"10.1016/j.endien.2025.501730","DOIUrl":"10.1016/j.endien.2025.501730","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501730"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish-eye disease. Altered HDL cholesterol metabolism and corneal involvement: A case report","authors":"Ana Álvarez ODogherty , Carmen Rodríguez Jiménez , Amaya Belanger-Quintana , Sonia Rodríguez Novoa , Francisco Arrieta Blanco","doi":"10.1016/j.endien.2025.501638","DOIUrl":"10.1016/j.endien.2025.501638","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501638"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The overweight and obesity landscape in Spain: Data from the Spanish cohort of the multi-country IMPACT-O study","authors":"Irene Breton ,&nbsp;Igotz Aranbarri ,&nbsp;Anastasia Lampropoulou ,&nbsp;Jennifer Redondo-Antón ,&nbsp;Javier Ágreda ,&nbsp;Atif Adam ,&nbsp;Esther Artime","doi":"10.1016/j.endien.2025.501643","DOIUrl":"10.1016/j.endien.2025.501643","url":null,"abstract":"<div><h3>Introduction</h3><div>The epIdeMiology landscape PAtient Care paThways of Obesity (IMPACT-O) study was a multi-country, retrospective cohort study that utilised healthcare databases to determine the landscape/impact of overweight and obesity. Here we describe the sociodemographic, clinical and treatment characteristics of adults with a first record of overweight/obesity or obesity in Spain between 2018 and 2022.</div></div><div><h3>Materials and methods</h3><div>The IQVIA longitudinal patient database in Spain was used to identify individuals with a first record of overweight/obesity, as determined by diagnosis codes and/or body mass index (BMI) measurements (overweight/obesity cohort: BMI ≥25<!--> <!-->kg/m²; obesity cohort: BMI ≥30<!--> <!-->kg/m²), in the years 2018–2022. Demographic and clinical parameters, including obesity-related complications (ORCs), as recorded by primary care providers and specialists contributing to the database, were described.</div></div><div><h3>Results</h3><div>The overweight/obesity cohort included 25,016 individuals, and the obesity cohort 13,441 individuals. Most individuals with overweight/obesity (60.1%) and obesity (63.6%) presented with ≥1 ORCs. The most frequent ORCs among people with obesity were hypertension (25.3%), dyslipidaemia (19.8%), anxiety (19.0%), osteoarthritis (14.3%), low-back pain (10.9%) and depression (10.9%). The proportion of individuals receiving pharmacological therapies with an effect on weight was &lt;1%. There were no records of lifestyle interventions or bariatric surgery in the database for this population.</div></div><div><h3>Conclusions</h3><div>This study highlights the high ORC burden at first documented diagnosis of overweight/obesity. Very few individuals with obesity in Spain receive pharmacological treatment with an effect on weight. Patient management could be improved by systematically recording all interventions in this population.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 10","pages":"Article 501643"},"PeriodicalIF":1.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145766123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taxonomic and functional characteristics of the gut microbiota in obesity: A systematic review","authors":"Cristina Mª Díaz Perdigones ,&nbsp;Daniel Hinojosa Nogueira ,&nbsp;Alba Rodríguez Muñoz ,&nbsp;Alba Subiri Verdugo ,&nbsp;Alberto Vilches-Pérez ,&nbsp;Virginia Mela ,&nbsp;Francisco J. Tinahones ,&nbsp;Isabel Moreno Indias","doi":"10.1016/j.endien.2025.501624","DOIUrl":"10.1016/j.endien.2025.501624","url":null,"abstract":"<div><div>Obesity is a growing public health problem. In recent decades, scientific evidence has linked gut microbiota to obesity. This systematic review summarizes current knowledge on the composition and functional differences in gut microbiota between individuals with obesity and those with normal weight. Following PRISMA 2020 recommendations, studies published in adult populations between January 2014 and May 2024 were reviewed. PubMed, Web of Science, and Scopus databases were searched for observational studies that had used advanced sequencing methods, such as 16S rRNA and shotgun metagenomics, to assess gut microbiota. The quality of these studies was also analyzed using the Newcastle-Ottawa scale. Our review of 16 studies shows a reduction in microbial diversity in individuals with obesity. In addition, a higher relative abundance of the phylum <em>Firmicutes</em>, <em>the families Enterobacteriaceae</em>, <em>Gemellaceae</em>, <em>Prevotellaceae</em>, <em>Streptococcaceae</em> and <em>Veillonellaceae</em>, as well as the genera <em>Blautia</em>, <em>Butyricimonas</em>, <em>Collinsella</em>, <em>Megamonas</em>, and <em>Streptococcus</em>, while beneficial bacteria such as the families <em>Porphyromonadaceae</em> and <em>Rikenellaceae</em>, and the genera <em>Bifidobacterium</em> spp<em>.</em> and <em>Faecalibacterium prausnitzii</em>, were depleted. Functional analysis showed a tendency to an increase in metabolic pathways associated with carbohydrate and lipid metabolism, with reduced pathways related to short-chain fatty acid production. Obesity is associated with altered gut microbiota composition and function. However, the variability across studies regarding population characteristics, dietary pattern, and sequencing techniques limits the comparability of findings. Future research should prioritize standardized methodologies and confounding factors to elucidate the role of the gut microbiome in obesity.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501624"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive summary. Screening, staging and follow-up of type 1 diabetes in preclinical stages: Consensus of the scientific societies SED, SEEN and SEEP","authors":"María Asunción Martínez-Brocca ,&nbsp;Virginia Bellido ,&nbsp;Roque Cardona-Hernandez ,&nbsp;Luis Castaño ,&nbsp;Ignacio Conget ,&nbsp;Alberto Fernández ,&nbsp;Ana Lucía Gómez Gila ,&nbsp;Isabel Leiva-Gea ,&nbsp;Dídac Mauricio","doi":"10.1016/j.endien.2025.501639","DOIUrl":"10.1016/j.endien.2025.501639","url":null,"abstract":"<div><div>Type 1 diabetes (T1D) is an autoimmune disease whose late diagnosis can lead to serious complications such as diabetic ketoacidosis, especially in children. The presence of specific autoantibodies allows for the identification of a presymptomatic phase, opening the door to screening strategies targeting populations at high genetic risk, such as first-degree relatives. This document presents the consensus recommendations of the Spanish Diabetes Society (SED), the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Society of Paediatric Endocrinology (SEEP) on the screening, staging and monitoring of T1D in preclinical stages. Early identification of the disease will enable a personalised approach to be established, promote health education and, eventually, consider therapeutic interventions that may delay progression to the symptomatic phase. This consensus seeks to establish a common framework for clinical action based on the available evidence, with clear recommendations for its proper implementation.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501639"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From COVID-19 telemedicine to artificial intelligence telemedicine","authors":"Ana Zugasti Murillo ,&nbsp;Juan José Gorgojo Martínez","doi":"10.1016/j.endien.2025.501595","DOIUrl":"10.1016/j.endien.2025.501595","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501595"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145309615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between fragmented QRS and left ventricular diastolic dysfunction in type 2 diabetes patients with or without microalbuminuria","authors":"Lili Wang ,&nbsp;Linjun Zheng ,&nbsp;Jiayu Hu ,&nbsp;Nongnong Zhao","doi":"10.1016/j.endien.2025.501623","DOIUrl":"10.1016/j.endien.2025.501623","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Cardiovascular disease (CVD) is the leading cause of death in patients with type 2 diabetes mellitus (T2DM), and left ventricular diastolic dysfunction (LVDD) is considered one of the earliest markers of myocardial dysfunction. Fragmented QRS (fQRS) and microalbuminuria (MAU) are important biomarkers of cardiac electrophysiological changes and CVD, but their relationship with LVDD in T2DM remains unclear. This study aims to explore the impact of fQRS and MAU on LVDD in T2DM patients and to analyze whether the association between fQRS and LVDD differs across varying MAU statuses.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A total of 374 patients with T2DM were ultimately enrolled in this study. Twelve-lead electrocardiography (ECG) and echocardiography were performed, and the patients’ baseline characteristics, laboratory results, and echocardiographic parameters were collected. Univariate and multivariate logistic regression analyses were conducted to assess the association between fQRS, MAU, and LVDD in T2DM patients. A stratified analysis was performed to examine the relationship between fQRS and LVDD across different MAU statuses.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The mean age of the T2DM patients was 57.19&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;12.47 years, and 62.57% were male. fQRS, MAU, and age were independent risk factors for LVDD in patients with T2DM. The risk of developing LVDD was 3.72 times higher in patients with fQRS compared to those without fQRS [95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;2.125–6.513, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001]. The risk of LVDD was 4.05 times higher in patients with MAU compared to those without MAU [95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;2.252–7.282, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001]. For each additional year of age, the risk of LVDD increased by 5.2% [95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;1.022–1.084, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.001]. Stratified analysis based on MAU status revealed that in patients without MAU, the association between fQRS and LVDD was stronger [OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;7.084, 95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;3.255–15.419, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001]. However, in patients with MAU, the relationship between fQRS and LVDD was no longer significant [OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;1.499, 95% CI&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.603–3.722, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.383].&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Our study found that both fQRS and MAU are independent risk factors for LVDD in patients with T2DM. The presence of fQRS increased the risk of LVDD by 3.72 times, while MAU increased the risk by 4.05 times. Stratified analysis further revealed that in patients without MAU, the association between fQRS and LVDD was significantly stronger (OR&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;7.084, &lt;em&gt;P&lt;/em&gt; &lt;!--&gt;&lt;&lt;!--&gt; &lt;!--&gt;0.0001), while in patients with MAU, this association was no longer significant (&lt;em&gt;P&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;0.383). These findings suggest that combining the detection of fQRS and MAU may provide valuab","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501623"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hemisoma in which the bioelectrical impedance vector analysis is performed has no influence on outcomes in patients receiving intravenous fluid therapy","authors":"Marina Jara Vidal,&nbsp;Andrés Ruiz de Assín Valverde,&nbsp;Marta Gallach Martínez,&nbsp;Noel Roig Marín,&nbsp;César Gonzalvo Díaz,&nbsp;Rosa Pilar Quílez Toboso,&nbsp;Lourdes García Blasco,&nbsp;Silvia Aznar Rodríguez,&nbsp;José Juan Lozano García,&nbsp;José Joaquín Alfaro Martínez","doi":"10.1016/j.endien.2025.501614","DOIUrl":"10.1016/j.endien.2025.501614","url":null,"abstract":"<div><h3>Introduction</h3><div>This study investigates the concordance of bioelectrical impedance vector analysis (BIVA) measurements in both hemisomes in patients receiving fluid therapy, since clinical practice suggests performing them in the hemisoma contralateral to that of its administration to avoid interferences.</div><div>The primary objective of this study was to evaluate the concordance of phase angle (PhA), resistance and reactance, both standardized by height (Rz/h, Xc/h) between the hemisoma where the patient is receiving iv fluids and the other one.</div></div><div><h3>Methods</h3><div>Clinical, prospective and descriptive study, which included 100 hospitalized patients with total parenteral nutrition (TPN) or other intravenous fluid therapy. BIVA measurements were taken in both hemisomes and analyzed by means of Bland–Altman plots, Passing–Block test and conditional method agreement trees (COAT).</div></div><div><h3>Results</h3><div>100 patients were included (57 men and 43 women), with an average age of 67.2<!--> <!-->±<!--> <!-->15.1 years. Univariate analysis using the Bland–Altman plot showed no concordance of PhA, Rz/h and Xc/h between both hemisomes in patients who received fluid therapy, but Passing–Block test showed no systematic or proportional differences between hemisomas and multivariate COAT analysis did not show that the specified covariates affected concordance.</div></div><div><h3>Conclusions</h3><div>No systematic or proportional differences between hemisomas in resistance and reactance has been demonstrated, suggesting the possibility of being able to perform the measurement independently of the side of fluid administration.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501614"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological crisis in tyrosinemia type 1: Essential roles of replacement therapy and nutrition in multidisciplinary management","authors":"David Sanchis-Pascual ,&nbsp;Agustín Ramos Prol ,&nbsp;María Argente Pla ,&nbsp;Cristina Montalbán Méndez ,&nbsp;Darío Lara Gálvez ,&nbsp;Carlos Folgado Bisbal ,&nbsp;Montserrat León Fábregas ,&nbsp;María Amparo Rubio Broseta ,&nbsp;Eva Gascó Santana ,&nbsp;Pilar Morillas-Amat ,&nbsp;Mónica García Peris ,&nbsp;Patricia Correcher Medina ,&nbsp;Juan Francisco Merino-Torres","doi":"10.1016/j.endien.2025.501534","DOIUrl":"10.1016/j.endien.2025.501534","url":null,"abstract":"<div><div>This is the case of a man with hepatorenal tyrosinemia type 1 (HT-1). Following the omission of his usual treatment with nitisinone and the withdrawal of dietary recommendations, the patient developed a severe neurological crisis requiring admission to the intensive care unit (ICU) due to profound diaphragmatic weakness. Despite the initial severity, appropriate management led to a favorable outcome and, eventually, weaning from mechanical ventilation. This case underscores the critical importance of a multidisciplinary approach in the management of inborn errors of metabolism, where nutritional therapy remains the cornerstone of treatment to prevent life-threatening complications.</div></div>","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501534"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxytocin in hypopituitarism: What do we know?","authors":"Anna Aulinas ,&nbsp;Elizabeth A. Lawson","doi":"10.1016/j.endien.2025.501637","DOIUrl":"10.1016/j.endien.2025.501637","url":null,"abstract":"","PeriodicalId":48650,"journal":{"name":"Endocrinologia Diabetes Y Nutricion","volume":"72 9","pages":"Article 501637"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145374547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}