Endocrinologia Diabetes Y Nutricion最新文献

英文中文

Transgender women and competitive sports: Considerations from Endocrinology

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.101539

Laura Cuadrado Clemente , María Miguélez González , Patricia Cabrera García , Mercedes Noval Font , Élida Alfaro Gandarillas , Marcelino Gómez Balaguer , Nieves Palacios Gil de Antuñano

Introduction

The participation of transgender women (TW) in high-level competitive sports increases every year, as does the interest of sports organizations in finding solutions that allow their inclusion without compromising the principle of equity governing high-level sports. However, the binary categorization of sports, influenced by the impact of sex hormone on physical performance, creates challenges for the inclusion of TW in the female category. This study aimed to understand the impact of gender-affirming hormone therapy (GAHT) on various athletic performance variables and to compare results with those obtained in cisgender populations.

Methods

Review of cross-sectional and longitudinal studies that included TW (preferably athletes) undergoing GAHT.

Results

Significant decreases in hematocrit, total serum testosterone, lean body mass, strength, and muscle area were observed after 12 mo of GAHT, with increases in fat mass. Grip strength was higher in TW compared to cisgender females (CW) in the long term. TW showed better performance in sports involving the upper body.

Conclusions

At least 2 years of postpubertal GAHT are necessary to achieve a significant reduction in the effects of male hormones on various physiological parameters. The scientific evidence regarding the impact of GAHT on physical performance is insufficient. Long-term studies are needed, incorporating new biomarkers and morphofunctional parameters, to allow for comparisons of athletic performance across different disciplines between TW and CW.

导言：变性妇女（TW）参与高水平竞技体育运动的人数逐年增加，体育组织也希望找到既能让她们参与进来，又不损害高水平体育运动公平原则的解决方案。然而，受性激素对身体表现的影响，体育运动的二元分类对将 TW 纳入女性类别造成了挑战。本研究旨在了解性别确认激素疗法（GAHT）对各种运动表现变量的影响，并将结果与在顺性别人群中获得的结果进行比较：方法：回顾包括接受 GAHT 治疗的 TW（最好是运动员）的横断面和纵向研究：结果：接受 GAHT 12 个月后，观察到血细胞比容、血清总睾酮、瘦体重、力量和肌肉面积显著下降，脂肪量增加。与同性女性（CW）相比，TW 的握力在长期内更高。TW在涉及上半身的运动中表现更好：结论：要显著降低雄性激素对各种生理参数的影响，青春期后的 GAHT 至少需要 2 年的时间。GAHT 对身体表现影响的科学证据尚不充分。需要结合新的生物标志物和形态功能参数进行长期研究，以便对 TW 和 CW 在不同项目中的运动表现进行比较。

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引用次数: 0

Trans and cis women in sport: Citius, altius, fortius, sed aequitas

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.501547

Óscar Moreno-Perez , Inés Modrego-Pardo

引用次数: 0

Clinical characteristics and management of type 2 diabetes in primary care in Spain. SED2 Study

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.501543

Violeta Antonio-Arques , Berta Fernandez Camins , Bogdan Vlacho , Joan Barrot , Jorge Navarro Pérez , Edelmiro Menéndez Torre , Didac Mauricio , Josep Franch-Nadal

Introduction

Type 2 diabetes mellitus (DM2) is a prevalent chronic disease with major complications. Primary care (PC) plays a crucial role in the management of this disease.

Objectives

To evaluate the organization and resources available in PC for the care of patients with DM2 in Spain.

Material and methods

Descriptive, cross-sectional, observational study in 65 health centers (HC) selected by opportunistic sampling. Data were collected through a structured survey.

Results

Half of the HCs have a diabetes referent, two thirds have specific protocols and almost 90% involve nurses in diabetes education. Access to non-mydriatic retinography is limited (38.5%) and its interpretation varies. Diabetic foot examination is mainly performed by nurses (47.7%) and there is the possibility of referral to vascular surgery or specialized units in most cases. The most frequent analytical tests are the HbA1c every 6 mo (67.7%). 63.1% of the HCs can perform telematic consultations to hospital specialists and most of them have access to patients’ medical records at the hospital. Significant variations are observed in some aspects between autonomous communities.

Conclusions

Care for patients with DM2 in PC in Spain is uneven and presents opportunities for improvement. Comprehensive diabetes care in PC needs to be strengthened, including the training of professionals, the implementation of protocols and the provision of adequate resources. Measures are needed to reduce variations in care between autonomous communities.

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引用次数: 0

Alterations in MORC2 gene and DIGFAN syndrome: A rare cause of short stature MORC2 基因的改变与 DIGFAN 综合征：导致身材矮小的罕见病因

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.101537

Enrique Palomo Atance , Prado Sánchez Ruiz , Elena Reyzábal Ereño , Paola Sánchez Tudela , Laura Acero García de la Santa

引用次数: 0

Combined adalimumab and etonogestrel/ethinylestradiol therapy associated with hypertriglyceridemia-induced pancreatitis in a young woman with hidradenitis suppurativa

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.101536

Darko Siuka , Matej Rakusa

引用次数: 0

Deciphering deleterious missense variants in the MC4R gene in the pathogenesis of obesity

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-04-01 DOI: 10.1016/j.endien.2025.501559

Meriem El Fessikh , Hanaa Skhoun , Zohra Ouzzif , Jamila El Baghdadi

The MC4R gene plays a critical role in regulating food intake, making it an important model for studying genetic mutations that impact the protein function. This study aimed to identify the most deleterious functional and structural variants in individuals with obesity by analyzing SNPs from the NCBI dbSNP database and selecting pathogenic variants from ClinVar. Bioinformatics tools were employed to predict deleterious SNPs, and conservation analysis was performed using ConSurf. Stability predictions were made with MUpro, I-Mutant2.0, and iStable. The 3D structure of the MC4R protein was examined using YASARA view. A total of 20 out of 348 missense mutations were associated with obesity. Fifteen of these variants were predicted to be the most deleterious. Eight variants located in conserved regions were found to significantly reduce protein stability and cause structural changes (S58C, E61K, N62S, I69R, D90N, R165Q, P299H, and I316S), indicating their potential as obesity biomarkers and therapeutic targets.

引用次数: 0

Hyperglycemia-related risk factors in enteral nutrition in non-critically ill patients

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.101534

Esther Delgado-García , Juan José López-Gómez , Rebeca Jiménez-Sahagún , Emilia Gómez-Hoyos , Ana Ortolá-Buigues , Paloma Pérez-López , Beatriz Torres-Torres , Daniel A. De Luis-Román

Introduction

Carbohydrate metabolism can change in hospitalized patients due to stress, or the use of enteral nutrition (EN). The aim of this study was to determine the risk factors triggering these changes.

Material and Methods

We conducted a retrospective observational study in non-diabetic patients with low levels of stress on EN. Five groups were categorized based on changes to the metabolism of hydrocarbons produced before or after EN: plasma glycemia prior to EN >126 mg/dL (stress hyperglycemia – SH) (35.1%); plasma glycaemia prior to EN <126 mg/dL (non-HE) (64.89%). Hyperglycemia with EN (HyperEN): at least, two capillary blood glucose readings >140 mg/dL or 1 >180 mg/dL during EN (71%); non-HyperEN: capillary blood glucose readings with EN <140 mg/dL (29%).

Results

A total of 131 patients were included (45.8% men) with a median age of 81 (71–87) years. A total of 52 patients exceeded 180 mg/dL at one measurement, and 24 patients required insulin detemir with a median of 16 (12–27) IU per day. Risk factors for HyperEN were identified as patient age (OR, 1.186; 95% CI, 1.051–1.341; p < 0.01) and duration of nutritional treatment (OR, 1.320; 95% CI, 1.086–1.605; p < 0.01).

Conclusions

Our study shows a high prevalence of carbohydrate metabolism disorders in hospitalized patients on total EN, with age and duration of nutritional treatment being the main risk factors.

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引用次数: 0

Short bowel syndrome and d-lactic acidosis: A case report with supplemental home parenteral nutrition and teduglutide

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.101535

Elena Carrillo-López, Maria Sara Tapia-Sanchiz, Sara Jiménez-Blanco, Begoña Molina-Baena

d-Lactic acidosis is an uncommon cause of acidosis that occurs in patients with short bowel syndrome (SBS). Reduced intestinal absorption surface leads to carbohydrate malabsorption, fermented by abnormal colonic bacterial flora, resulting in elevated d-lactate levels. It should be suspected in SBS patients who exhibit typical neurological symptoms without other apparent causes, along with metabolic acidosis with normal l-lactate levels. Treatment involves correcting acidosis and managing bacterial overgrowth with non-absorbable antibiotics.

This report presents a case of a patient on teduglutide for SBS who experienced an episode of d-lactic acidosis. To date, there are no documented cases in the literature of similar episodes in adult patients undergoing therapy with GLP2 analogs.

引用次数: 0

New drugs in pituitary diseases

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.501546

Fernando Cordido , Pedro Iglesias

引用次数: 0

Recommendations of the Spanish Society of Endocrinology and Nutrition (SEEN) on “what not to do” in clinical practice

IF 1.8 4区医学 Q4 ENDOCRINOLOGY & METABOLISM

Endocrinologia Diabetes Y Nutricion

Pub Date : 2025-03-01 DOI: 10.1016/j.endien.2025.101531

Juan José Díez , Emma Anda , Irene Bretón , Cintia González-Blanco , María Miguélez , Ana Zugasti , Alberto Fernández , on behalf of the Sociedad Española de Endocrinología y Nutrición

Quality healthcare should be grounded on clinical practice with the highest benefit-risk ratio and cost-effectiveness according to the available scientific evidence. The overuse of unproven diagnostic or therapeutic procedures is common in our setting and leads to increased healthcare spending and even iatrogenic harm. Previous cost-effectiveness initiatives have proposed identifying diagnostic and therapeutic measures that are better 'not done' in certain clinical contexts under the lens of the available scientific evidence. In this regard, the Spanish Society of Endocrinology and Nutrition (SEEN) has compiled a series of 'not-to-do' recommendations from its various working groups. These recommendations cover common clinical situations classified into the following thematic areas: diabetes, nutrition, pituitary gland, neuroendocrine tumors, thyroid, and hormone replacement therapy in postmenopausal women.

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引用次数: 0

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