The present study investigated the chemopreventive potential of geraniol by monitoring the tumor incidence and analyzing the status of early response gene, signalling pathways (NF-kB, CREB, cyclic AMP, RAS-MAPK, ERK1/2, p38, PI3K/AKT, PTEN) and also clarifying the significance of DNA methylation alteration during endometrial carcinogenesis type I and type II cells (HEC-155/180, HEC-1A). These genes communicate through a signalling cascade by adding phosphate group to neighboring proteins and this will eventually activate and translocate. This shows that an integrated computational approach combined with biological knowledge could identify expression signatures as potential diagnostic biomarkers common to multiple tumors.
本研究通过监测肿瘤发病率，分析早期反应基因、信号通路（NF-kB、CREB、环磷酸腺苷、RAS-MAPK、ERK1/2、p38、PI3K/AKT、PTEN）的状态，以及明确 I 型和 II 型子宫内膜癌变细胞（HEC-155/180、HEC-1A）DNA 甲基化改变的意义，研究了香叶醇的化学预防潜力。这些基因通过向邻近蛋白添加磷酸基团的信号级联进行交流，最终激活并转移。这表明，结合生物学知识的综合计算方法可以确定表达特征，作为多种肿瘤共同的潜在诊断生物标志物。
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