Pub Date : 2025-12-16DOI: 10.1016/s2352-3018(25)00230-9
Mehrdad Khezri, Soheil Mehmandoost, Fatemeh Tavakoli, Saba Rouhani, Fatemeh Mehrabi, Elham Nourolahzadeh, Alireza Vassigh, Fardad Doroudi, Ali Akbar Haghdoost, Mohammad Karamouzian, Hamid Sharifi
{"title":"HIV prevalence, risk behaviours, and cascade of care among men who have sex with men in Iran: a nationwide, cross-sectional, biobehavioural survey","authors":"Mehrdad Khezri, Soheil Mehmandoost, Fatemeh Tavakoli, Saba Rouhani, Fatemeh Mehrabi, Elham Nourolahzadeh, Alireza Vassigh, Fardad Doroudi, Ali Akbar Haghdoost, Mohammad Karamouzian, Hamid Sharifi","doi":"10.1016/s2352-3018(25)00230-9","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00230-9","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"2 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/s2352-3018(25)00236-x
Laith J Abu-Raddad
{"title":"MSM and HIV in the Middle East and north Africa","authors":"Laith J Abu-Raddad","doi":"10.1016/s2352-3018(25)00236-x","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00236-x","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"65 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1016/s2352-3018(25)00358-3
Tony Kirby
{"title":"Cabotegravir injectable PrEP approved in England and Wales","authors":"Tony Kirby","doi":"10.1016/s2352-3018(25)00358-3","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00358-3","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"2 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-04DOI: 10.1016/s2352-3018(25)00357-1
Roger Pebody
{"title":"Peer support reshapes HIV care in London","authors":"Roger Pebody","doi":"10.1016/s2352-3018(25)00357-1","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00357-1","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"165 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1016/s2352-3018(25)00269-3
Jenell Stewart,Renee Heffron,Connie Celum
{"title":"HIV prevention for young African women is about choice.","authors":"Jenell Stewart,Renee Heffron,Connie Celum","doi":"10.1016/s2352-3018(25)00269-3","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00269-3","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"77 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-03DOI: 10.1016/s2352-3018(25)00229-2
Catherine Elizabeth Martin,Hlologelo Ramatsoma,Glory Chidumwa,Pelisa Nongena,Mosa Julia Letsielo,Alison Kutywayo,Nthabiseng Koloane,Sydney Ncube,Nhlanhla Mdluli,Cornelius Nattey,Saiqa Mullick
BACKGROUNDIntroduction of the dapivirine vaginal ring has paved the way for multimethod HIV pre-exposure prophylaxis (PrEP). We aimed to investigate PrEP method preference when offered within integrated, primary care HIV prevention.METHODSData are derived from an implementation science project assessing integration of PrEP as part of combination HIV prevention and sexual and reproductive health services. Eligible participants were women aged 18 years or older who were HIV-negative, and neither pregnant nor breastfeeding. Women were enrolled in a cohort offering ring and oral PrEP in six facilities and three mobile clinics in South Africa between August 2023 and April 2024. We describe PrEP method uptake and self-reported reasons for method choice at enrolment. We used log-binomial regression to estimate unadjusted risk ratios (RRs) and modified Poisson regression with robust variance to identify factors associated with ring uptake. On-time 1-month return among those initiating PrEP was described. Probabilities of PrEP interruption were estimated and the survival distribution explored using a Cox proportional hazards regression model.FINDINGSAmong 2325 women, 76·0% chose oral PrEP, 14·9% ring PrEP, and 9·0% no PrEP. Compared with women aged 18-24 years, those aged 25-34 years (adjusted RR [aRR]=3·01, 95% CI 2·36-3·84) and aged 35 years or older (3·49, 2·41-5·45) were more likely to select ring PrEP, as were those who had used oral PrEP previously (1·43, 1·11-1·85). Those with symptoms or signs of sexually transmitted infection (0·37, 0·19-0·72) or currently using oral PrEP (0·63, 0·49-0·82) were less likely to select rings. Women selected the method that felt safest, was easiest to use, and aligned to their individual lifestyles. On-time 1-month return among new PrEP initiations was higher in those initiating ring PrEP (46·5%, 95% CI 38·5-51·7) than in those starting oral PrEP (26·1%, 23·0-29·8), and PrEP interruptions were higher among those using oral PrEP than in those using ring PrEP (hazard ratio=2·2, 95% CI 1·60-3·00, p<0·0001).INTERPRETATIONChoice-based PrEP delivery allows women to select a formulation that aligns with their individual preferences and may improve PrEP use. Although there was a preference for oral PrEP compared with ring PrEP, on-time 1-month return was higher and PrEP interruptions lower among women choosing the ring.FUNDINGUnitaid.
{"title":"Uptake of dapivirine vaginal ring and oral pre-exposure prophylaxis among women accessing HIV prevention services in South Africa: a cohort study.","authors":"Catherine Elizabeth Martin,Hlologelo Ramatsoma,Glory Chidumwa,Pelisa Nongena,Mosa Julia Letsielo,Alison Kutywayo,Nthabiseng Koloane,Sydney Ncube,Nhlanhla Mdluli,Cornelius Nattey,Saiqa Mullick","doi":"10.1016/s2352-3018(25)00229-2","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00229-2","url":null,"abstract":"BACKGROUNDIntroduction of the dapivirine vaginal ring has paved the way for multimethod HIV pre-exposure prophylaxis (PrEP). We aimed to investigate PrEP method preference when offered within integrated, primary care HIV prevention.METHODSData are derived from an implementation science project assessing integration of PrEP as part of combination HIV prevention and sexual and reproductive health services. Eligible participants were women aged 18 years or older who were HIV-negative, and neither pregnant nor breastfeeding. Women were enrolled in a cohort offering ring and oral PrEP in six facilities and three mobile clinics in South Africa between August 2023 and April 2024. We describe PrEP method uptake and self-reported reasons for method choice at enrolment. We used log-binomial regression to estimate unadjusted risk ratios (RRs) and modified Poisson regression with robust variance to identify factors associated with ring uptake. On-time 1-month return among those initiating PrEP was described. Probabilities of PrEP interruption were estimated and the survival distribution explored using a Cox proportional hazards regression model.FINDINGSAmong 2325 women, 76·0% chose oral PrEP, 14·9% ring PrEP, and 9·0% no PrEP. Compared with women aged 18-24 years, those aged 25-34 years (adjusted RR [aRR]=3·01, 95% CI 2·36-3·84) and aged 35 years or older (3·49, 2·41-5·45) were more likely to select ring PrEP, as were those who had used oral PrEP previously (1·43, 1·11-1·85). Those with symptoms or signs of sexually transmitted infection (0·37, 0·19-0·72) or currently using oral PrEP (0·63, 0·49-0·82) were less likely to select rings. Women selected the method that felt safest, was easiest to use, and aligned to their individual lifestyles. On-time 1-month return among new PrEP initiations was higher in those initiating ring PrEP (46·5%, 95% CI 38·5-51·7) than in those starting oral PrEP (26·1%, 23·0-29·8), and PrEP interruptions were higher among those using oral PrEP than in those using ring PrEP (hazard ratio=2·2, 95% CI 1·60-3·00, p<0·0001).INTERPRETATIONChoice-based PrEP delivery allows women to select a formulation that aligns with their individual preferences and may improve PrEP use. Although there was a preference for oral PrEP compared with ring PrEP, on-time 1-month return was higher and PrEP interruptions lower among women choosing the ring.FUNDINGUnitaid.","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"158 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145689006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1016/s2352-3018(25)00296-6
Hasina Subedar, Nondumiso B Q Ncube, Herbert Kadama, Beatrice Matanje, Moses R Kamya, Celestine Mugambi, Peter Mudiope, Olawale Ajose, Sarah Y Jenkins, Uchechi C Roxo, Carmen Pérez Casas, Mitchell Warren, Anne-Isabelle Cameron, Ayesha Ismail, James Odek, Andrews Gunda, Lloyd Mulenga, Washington Ozituosauka, Sarah Hamm Rush, Maureen Luba, Deborah Hoege, Melody Sakala, Betha O Igbinosun, Jessica Burry, Sara M Allinder, Charles B Holmes
{"title":"Strengthening nationally led approaches to new product introduction for HIV prevention","authors":"Hasina Subedar, Nondumiso B Q Ncube, Herbert Kadama, Beatrice Matanje, Moses R Kamya, Celestine Mugambi, Peter Mudiope, Olawale Ajose, Sarah Y Jenkins, Uchechi C Roxo, Carmen Pérez Casas, Mitchell Warren, Anne-Isabelle Cameron, Ayesha Ismail, James Odek, Andrews Gunda, Lloyd Mulenga, Washington Ozituosauka, Sarah Hamm Rush, Maureen Luba, Deborah Hoege, Melody Sakala, Betha O Igbinosun, Jessica Burry, Sara M Allinder, Charles B Holmes","doi":"10.1016/s2352-3018(25)00296-6","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00296-6","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"1 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1016/s2352-3018(25)00271-1
Ima John-Dada, Lilian Otiso, Stephen Ayisi Addo, Grace Kumwenda, Raymond Yekeye, Stephen N Kiio, Chimwemwe Mablekisi, Chimika Phiri, Florence R Anam, Nina S Hasen, Barinaada Afirima, Lillian Mworeko, Anne-Isabelle Cameron, Simon Sikwese, Prosper F Njau, Yohane Kamgwira, Sarah N Konopka, Thato Farirai, Richard Chilongosi, Rosemary Mburu, James Odek, Alister Munthali, Gaetan Gatete, Nyanyiwe M Mbeye, Gisele Mujawamariya, Nellie Bristol, Sarah Mwale, Sara M Allinder, Betha O Igbinosun, Charles B Holmes, Solange L Baptiste
{"title":"Enhancing HIV prevention through systematic community engagement, learning, and response","authors":"Ima John-Dada, Lilian Otiso, Stephen Ayisi Addo, Grace Kumwenda, Raymond Yekeye, Stephen N Kiio, Chimwemwe Mablekisi, Chimika Phiri, Florence R Anam, Nina S Hasen, Barinaada Afirima, Lillian Mworeko, Anne-Isabelle Cameron, Simon Sikwese, Prosper F Njau, Yohane Kamgwira, Sarah N Konopka, Thato Farirai, Richard Chilongosi, Rosemary Mburu, James Odek, Alister Munthali, Gaetan Gatete, Nyanyiwe M Mbeye, Gisele Mujawamariya, Nellie Bristol, Sarah Mwale, Sara M Allinder, Betha O Igbinosun, Charles B Holmes, Solange L Baptiste","doi":"10.1016/s2352-3018(25)00271-1","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00271-1","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"1 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1016/s2352-3018(25)00270-x
Beatrice Matanje, Lillian Chunda, Lilian Otiso, Hasina Subedar, Mumbi Chola, Gallican N Rwibasira, David Chipanta, Ayesha Ismail, Uchechi C Roxo, Stephen Ayisi Addo, Erick K Mlanga, Hidayat B Yahaya, Ima John-Dada, Andrews Gunda, Florence R Anam, Priscah Wawire, Melody Sakala, Nyanyiwe M Mbeye, Betha O Igbinosun, Charles B Holmes, Kenneth Ngure
{"title":"Global HIV prevention is not on track: how a health systems approach can promote sustainable progress in African countries","authors":"Beatrice Matanje, Lillian Chunda, Lilian Otiso, Hasina Subedar, Mumbi Chola, Gallican N Rwibasira, David Chipanta, Ayesha Ismail, Uchechi C Roxo, Stephen Ayisi Addo, Erick K Mlanga, Hidayat B Yahaya, Ima John-Dada, Andrews Gunda, Florence R Anam, Priscah Wawire, Melody Sakala, Nyanyiwe M Mbeye, Betha O Igbinosun, Charles B Holmes, Kenneth Ngure","doi":"10.1016/s2352-3018(25)00270-x","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00270-x","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"26 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145658197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1016/s2352-3018(25)00355-8
Nittaya Phanuphak, Jakkrapatara Boonruang, Iskandar Azwa
{"title":"The future of HIV prevention in southeast Asia","authors":"Nittaya Phanuphak, Jakkrapatara Boonruang, Iskandar Azwa","doi":"10.1016/s2352-3018(25)00355-8","DOIUrl":"https://doi.org/10.1016/s2352-3018(25)00355-8","url":null,"abstract":"","PeriodicalId":48725,"journal":{"name":"Lancet Hiv","volume":"117 1","pages":""},"PeriodicalIF":16.1,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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