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The future of HIV prevention in southeast Asia 东南亚艾滋病毒预防的未来
IF 16.1 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-02 DOI: 10.1016/s2352-3018(25)00355-8
Nittaya Phanuphak, Jakkrapatara Boonruang, Iskandar Azwa
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引用次数: 0
HIV-related outcomes among migrants living in Europe compared with the general population: a systematic review and meta-analysis. 生活在欧洲的移民与一般人群的hiv相关结果的比较:系统回顾和荟萃分析。
IF 13 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI: 10.1016/S2352-3018(25)00301-7
Francesco Vladimiro Segala, Francesco Di Gennaro, Luisa Frallonardo, Elda De Vita, Valentina Petralia, Vitalba Sapienza, Stefano Di Gregorio, Mariangela Cormio, Roberta Novara, Giuseppina Rizzo, Mario Barbagallo, Nicola Veronese, Annalisa Saracino

Background: Compared with the general population, international migrants arriving in Europe face severe socioeconomic challenges that result in higher HIV prevalence and limited access to health care, potentially leading to negative outcomes. In this systematic review and meta-analysis, we aimed to investigate the incidence of HIV-related outcomes among international migrants arriving in Europe compared with the incidence among the general population.

Methods: We did a systematic review and meta-analysis to identify studies investigating HIV-related outcomes in migrants and the general population living with HIV in Europe. Six authors (EDV, VP, VS, SDG, MC, and RN) independently searched PubMed, Scopus, and Web of Science from database inception until July 22, 2023 (with an update on March 3, 2024), then screened titles and abstracts of all potentially eligible articles. Studies were included if they were observational studies; investigated clinical, virological, or immunological outcomes in migrants living with HIV; were conducted in Europe; had at least one control group of non-migrants living in a European country; and were in English. Titles and abstracts were screened for eligibility followed by a full-text assessment by two authors (EDV, VP, VS, SDG, MC, or RN). Data were extracted from articles using a structured Redcap form. Primary outcomes of our systematic review were (1) mortality, (2) AIDS-defining condition, (3) combined outcome of AIDS or death, (4) treatment discontinuation, (5) rate of loss to follow-up, (6) virological failure, and (7) immunological failure. Data were reported as relative risks (RRs) or odds ratios with their 95% CIs. The study is registered with PROSPERO, CRD42024501191.

Findings: Of the 1316 articles identified (1297 in the initial search and 19 in the updated search), 18 were included in our systematic review, consisting of 104 597 participants who were followed up for a mean of 86·6 months. The meta-analysis, adjusted for potential confounders, showed that migrants present similar mortality risk (RR 0·88, 95% CI 0·75-1·04), but higher risk for AIDS-defining conditions (1·21, 1·11-1·31), treatment discontinuation (2·39, 1·49-3·29), loss to follow-up (2·53, 1·41-4·53), and virological failure (1·93, 1·34-2·52) compared with the general population. Subanalyses for WHO regions showed that risk was driven mainly by migrants from the African region.

Interpretation: Compared with the non-migrant population, migrants living in Europe with HIV face higher risks for progression to AIDS, loss to follow-up, treatment discontinuation, and virological failure. Interventions aimed to improve HIV care among migrants living in Europe are urgently needed.

Funding: None.

背景:与一般人口相比,抵达欧洲的国际移民面临严峻的社会经济挑战,导致艾滋病毒感染率较高,获得保健的机会有限,可能导致负面后果。在这项系统回顾和荟萃分析中,我们旨在调查抵达欧洲的国际移民与普通人群中艾滋病相关结果的发生率。方法:我们进行了系统回顾和荟萃分析,以确定调查欧洲移民和普通艾滋病毒感染者中艾滋病毒相关结果的研究。6位作者(EDV, VP, VS, SDG, MC和RN)从数据库建立到2023年7月22日(2024年3月3日更新)独立搜索PubMed, Scopus和Web of Science,然后筛选所有可能符合条件的文章的标题和摘要。观察性研究也包括在内;调查携带艾滋病毒的移民的临床、病毒学或免疫学结果;是在欧洲进行的;至少有一个非移民控制组居住在欧洲国家;都是用英语写的。对标题和摘要进行筛选,然后由两位作者(EDV、VP、VS、SDG、MC或RN)进行全文评估。使用结构化的Redcap表格从文章中提取数据。我们系统评价的主要结局是(1)死亡率,(2)艾滋病定义条件,(3)艾滋病或死亡的综合结局,(4)停止治疗,(5)失去随访的比率,(6)病毒学失败,(7)免疫失败。数据以相对危险度(rr)或95% ci的比值比报告。该研究已注册为PROSPERO, CRD42024501191。结果:在纳入的1316篇文献中(初始检索1297篇,更新检索19篇),有18篇纳入我们的系统综述,共纳入104597名参与者,随访时间平均为86.6个月。对潜在混杂因素进行调整后的荟萃分析显示,与普通人群相比,移民具有相似的死亡风险(RR 0.88, 95% CI 0.75 - 1.04),但在艾滋病定义条件(1.21,1.11 - 1.31)、治疗中断(2.39,1.49 - 3.29)、随访缺失(2.53,1.41 - 1.53)和病毒学失败(1.93,1.34 - 2.52)方面的风险更高。对世卫组织各区域的亚分析表明,风险主要是由来自非洲区域的移民造成的。解释:与非移民人群相比,生活在欧洲的携带艾滋病毒的移民面临着更高的发展为艾滋病、失去随访、停止治疗和病毒学失败的风险。迫切需要采取干预措施,改善生活在欧洲的移民的艾滋病毒护理。资金:没有。
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引用次数: 0
Correction to Lancet HIV 2025; 12: e473-84. 《柳叶刀HIV 2025》修正;12: e473 - 84。
IF 13 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 Epub Date: 2025-07-01 DOI: 10.1016/S2352-3018(25)00191-2
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引用次数: 0
Correction to Lancet HIV 2025; 12: e473-84. 《柳叶刀HIV 2025》修正;12: e473 - 84。
IF 13 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 Epub Date: 2025-09-25 DOI: 10.1016/S2352-3018(25)00297-8
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引用次数: 0
Correction to Lancet HIV 2024; 11: e793-94. 《柳叶刀HIV 2024》修正;11: e793 - 94。
IF 13 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI: 10.1016/S2352-3018(25)00298-X
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引用次数: 0
Correction to Lancet HIV 2024; 11: e31-41. 《柳叶刀HIV 2024》修正;11: e31-41。
IF 13 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 Epub Date: 2025-03-16 DOI: 10.1016/S2352-3018(25)00075-X
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引用次数: 0
Fixed-dose combination bictegravir–emtricitabine–tenofovir alafenamide twice-daily for treatment of HIV during rifampicin-based tuberculosis treatment (INSIGHT Study): a phase 2b, open-label, randomised non-comparative trial 每日两次的比替格拉韦-恩曲他滨-替诺福韦阿拉那胺固定剂量联合治疗在基于利福平的结核病治疗期间治疗HIV (INSIGHT研究):一项2b期、开放标签、随机、非比较试验
IF 16.1 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 DOI: 10.1016/s2352-3018(25)00200-0
Anushka Naidoo, Kogieleum Naidoo, Marothi P Letsoalo, Roeland E Wasmann, Gillian Dorse, Rubeshan Perumal, Mahomed-Yunus S Moosa, Emmanuella C Osuala, Resha Boodhram, Benjamin Chimukangara, Lubbe Wiesner, Dennis Israelski, Paolo Denti, James F Rooney, Kelly E Dooley, Anushka Naidoo, Kelly E. Dooley, Kogieleum Naidoo, Gillian Dorse, Rubeshan Perumal, Resha Boodhram, Busisiwe Ntsalaze, Samiksha Byroo, Ellisha Francis, Anokhee Leela, Rosemary Gray, Bhavna Maharaj, Nompumelelo Zungu, Phindile Msomi, Claudia Shozi, Radhamoney Narasimmulu, Nokuzola Cwazibe, Rajesperi Venter, Saras Pather, Nokwanda Depargo, Silindile Tenza, Patience Mbatha, Marothi P. Letsoalo, Mxolisi Mahlangu, Natasha Samsunder, Zanele Mchunu, Avanthi Moodley-Reddy, Lungile Maphumulo, Adejumoke Abiose, Emmanuella C. Osuala
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引用次数: 0
Correction to Lancet HIV 2025; published online March 26. https://doi.org/10.1016/S2352-3018(25)00074-8. 《柳叶刀HIV 2025》修正;3月26日在网上发表。https://doi.org/10.1016/s2352 - 3018(25) 00074 - 8。
IF 13 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 Epub Date: 2025-04-01 DOI: 10.1016/S2352-3018(25)00095-5
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引用次数: 0
The clock is ticking for UNAIDS. 联合国艾滋病规划署的时间紧迫。
IF 16.1 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 DOI: 10.1016/s2352-3018(25)00331-5
The Lancet Hiv
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引用次数: 0
Correction to Lancet HIV 2025; 12: e638-48. 《柳叶刀HIV 2025》修正;12: e638-48。
IF 13 1区 医学 Q1 IMMUNOLOGY Pub Date : 2025-12-01 Epub Date: 2025-08-27 DOI: 10.1016/S2352-3018(25)00240-1
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引用次数: 0
期刊
Lancet Hiv
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