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LONG-TERM PREDICTIVE VALUE OF BLEEDING ON PROBING IN PERI‑IMPLANTITIS DIAGNOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS 探诊出血在种植体周围炎诊断中的长期预测价值:系统回顾和荟萃分析
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-24 DOI: 10.1016/j.jebdp.2024.102034
Xinbo Yu , Xinyan Lin , Feng Wang, Yiqun Wu

Objective

This systematic review and meta-analysis aimed to evaluate the diagnostic value of bleeding on probing (BOP) for peri‑implantitis detection on implant- and patient-levels, as reported in prospective and retrospective studies with at least 5 years of follow-up.

Materials and Methods

A systematic search of 3 electronic databases was conducted and supplemented with a hand-search to identify clinical studies that reported the prevalence of peri‑implantitis and BOP after at least 5 years of functional loading. Random-effects meta-analyses were conducted to combine the proportions of peri‑implantitis among BOP positive implants and patients across studies. Heterogeneity was explored with subgroup analyses.

Results

5826 patients and 17,198 implants were included in this review. Definitions of peri‑implantitis varied between studies. Thirty studies were included for assessment. Implant-level meta-analysis was conducted in 24 studies and patient-level meta-analysis in 19 studies. Overall proportion of peri‑implantitis in BOP-positive implants was 26.5% (95% CI, 21.2 to 32.1) and 35.1% (95% CI, 27.4 to 43.1) in BOP-positive patients. Substantial heterogeneity was present, and prediction intervals were 5.2%-56% and 6.4%-71.5% at the implant- and patient-level, respectively.

Conclusion

Within the limitations, prevalence of peri‑implantitis was found to be around 1 third in both BOP-positive implants and patients. Prevalence varied between studies. Although a guiding clinical factor in the diagnosis of peri‑implantitis, clinicians should be aware of the significant false-positive rates of BOP.
材料和方法对 3 个电子数据库进行了系统性检索,并辅以人工检索,以确定报告了至少 5 年功能负荷后种植体周围炎和 BOP 患病率的临床研究。研究人员进行了随机效应荟萃分析,将 BOP 阳性种植体和患者中种植体周围炎的比例结合在一起。通过亚组分析探讨了异质性。不同研究对种植体周围炎的定义各不相同。共纳入 30 项研究进行评估。对 24 项研究进行了种植体层面的荟萃分析,对 19 项研究进行了患者层面的荟萃分析。BOP阳性种植体发生种植体周围炎的总体比例为26.5%(95% CI,21.2-32.1),BOP阳性患者发生种植体周围炎的总体比例为35.1%(95% CI,27.4-43.1)。在种植体和患者层面上,预测区间分别为5.2%-56%和6.4%-71.5%。结论在局限性研究中发现,BOP阳性种植体和患者的种植体周围炎发病率约为三分之一。不同研究的发病率各不相同。虽然 BOP 是诊断种植体周围炎的一个临床指导因素,但临床医生应该意识到 BOP 的假阳性率很高。
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引用次数: 0
Statement of Purpose/Levels of Evidence 目的声明/证据等级
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-20 DOI: 10.1016/S1532-3382(24)00066-6
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引用次数: 0
Information for Readers 读者信息
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-20 DOI: 10.1016/S1532-3382(24)00067-8
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引用次数: 0
Information for Authors 作者须知
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-20 DOI: 10.1016/S1532-3382(24)00068-X
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引用次数: 0
Levels of Evidence—Grading System 证据等级-分级系统
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-20 DOI: 10.1016/S1532-3382(24)00069-1
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引用次数: 0
Impact of Implant Design on Outcomes of Simultaneous Guided Bone Regeneration for Dehiscence Defects: A Systematic Review and Meta-Analysis 种植体设计对同时引导骨再生治疗开裂缺损结果的影响:系统回顾与元分析
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-08-16 DOI: 10.1016/j.jebdp.2024.102033
Bernadette Quah , Ali Sulaiman Al Yousef , Clement Wei Ming Lai , Raymond Chung Wen Wong , Ren Jie Jacob Chew

Objective

This systematic review and meta-analysis aimed to determine the implications of implant design on the outcomes of simultaneous guided bone regeneration (GBR) to correct dehiscence defects.

Methods

A structured search strategy was applied to MEDLINE (PubMed), Cochrane Library, and Embase, to identify prospective clinical trials involving implants with simultaneous GBR to correct dehiscence defects. Data regarding implant characteristics, GBR materials, as well as dehiscence defect dimensions at implant placement and surgical re-entry was collected. Meta-analyses were performed to estimate the pooled mean for (1) baseline dehiscence defect dimensions, (2) changes in defect dimensions at re-entry, and (3) prevalence of complete defect resolution.

Results

4298 unique records were identified, of which 21 studies with 680 implants were included. Despite having comparable baseline defect dimensions, greater height gains were achieved by implants with machined collars (MC) than noncollared (NC) implants (4.40 mm, 95% CI [3.70, 5.11] and 3.23 mm, 95% CI [2.72, 3.75] respectively), with significant subgroup differences (P < .01). Specifically, superior outcomes were observed for MC with space-maintaining geometries. However, there were no significant differences in the changes in defect width, prevalence of complete defect resolution, or the prevalence of postsurgical complication rates (P = .15, .54, and .18 respectively).

Conclusions

The regenerative outcomes of GBR were influenced by the implant design. Space-maintaining machined collars provide a tenting effect that improves vertical bone gain. While additional research is required to ascertain these findings and integrate choices regarding implant design into clinical decision-making, clinicians may consider replicating this effect to enhance treatment outcomes.
本系统综述和荟萃分析旨在确定种植体设计对同步引导骨再生(GBR)矫正开裂缺损结果的影响。方法在 MEDLINE (PubMed)、Cochrane Library 和 Embase 中采用结构化检索策略,以确定涉及种植体同步 GBR 矫正开裂缺损的前瞻性临床试验。收集了有关植入物特征、GBR 材料以及植入物植入和手术再入时的开裂缺损尺寸的数据。研究人员进行了 Meta 分析,以估算 (1) 基线开裂缺损尺寸、(2) 再次手术时缺损尺寸的变化以及 (3) 缺损完全愈合率的汇总平均值。尽管基线缺损尺寸相当,但与无领(NC)种植体(分别为 4.40 mm,95% CI [3.70,5.11] 和 3.23 mm,95% CI [2.72,3.75])相比,加工领(MC)种植体的高度增加幅度更大,亚组差异显著(P < .01)。具体而言,采用空间保持几何形状的 MC 治疗效果更佳。结论 GBR 的再生效果受植入物设计的影响。保持空间的机加工基台可提供帐篷效应,改善垂直骨增量。虽然还需要更多的研究来确定这些发现,并将有关种植体设计的选择纳入临床决策,但临床医生可以考虑复制这种效果,以提高治疗效果。
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引用次数: 0
CALCIUM PHOSPHATE GRAFTS COMBINED WITH GUIDED TISSUE REGENERATION IN THE TREATMENT OF PERIODONTAL BONY DEFECTS- A SYSTEMATIC REVIEW AND META-ANALYSIS 磷酸钙移植结合引导组织再生治疗牙周骨缺损--系统回顾和荟萃分析
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-07-25 DOI: 10.1016/j.jebdp.2024.102022
MONIREH KOUHI PhD , SABA YOUSEFI MSc , ZAHRA SADAT SAJADI-JAVAN Pharm D , ERFAN SADEGHI PhD , OMID SAVABI MD , MOHAMMADJAVAD SHIRANI DDS, MSc

Background

The objective of this systematic review is to assess the clinical outcomes of intrabony and furcation defects treated using a regenerative approach with calcium phosphate (CP) grafts combined plus guided tissue regeneration (GTR) membrane in comparison to open flap debridement (OFD).

Method

A review protocol was created under PRISMA checklist to find randomized clinical trials (RCTs) in English that compared CPs plus GTR with OFD in humans with intrabony and/or furcation defects. Both electronic and manual searches were conducted. The studied outcomes were probing pocket depth (PD) and clinical attachment level (CAL). To evaluate the treatment effect, a random effects model using restricted maximum likelihood method was performed to estimate the pooled effect size and corresponding 95% confidence interval. The quality assessment of the included studies was performed using Cochrane risk of bias tools version 5.1.0.

Results

Out of the 451 records identified, 7 studies were subjected to meta-analysis after discarding duplicates and excluding the studies that did not meet the inclusion criteria. While treated sites were intrabony defects in 5 papers, 2 studies focused on furcation defects. Based on the findings of the meta-analysis, the weighted mean difference (WMD) of 1.536 mm (95% CI −0.933 to 2.139) and 1.601 mm (95% CI −0.727 to 2.474) was obtained for CAL gain and PD reduction, respectively, in intrabony defects. The differences between CP grafts plus GTR groups and OFD groups for CAL gain and PD reduction were statistically significant. Similarly, for furcation defects, the application of CP grafts with GTR resulted in adjunctive advantages over OFD in terms of CAL gain (WMD of 1.807 mm; 95% CI 0.346-3.268), and PD reduction (WMD of 1.519 mm, 95% CI 1.215-4.253). The analysis on the limited number of study on furcation treatment revealed a statistically significant difference in CAL gain between CP grafts plus GTR groups and OFD groups, but a nonsignificant difference for PD reduction.

Conclusion

The results revealed that calcium phosphate grafts combined with GTR are superior to OFD in the healing of periodontal intrabony and furcation defects, considering the limitations of the present systematic review.
背景 本系统性综述的目的是评估采用磷酸钙(CP)移植物结合引导组织再生(GTR)膜的再生方法治疗骨内和毛缘缺损的临床疗效,并与开放皮瓣清创术(OFD)进行比较。方法 根据PRISMA检查表制定了综述方案,以寻找在骨内和/或毛缘缺损患者中比较磷酸钙移植物结合引导组织再生(GTR)膜与开放皮瓣清创术的英文随机临床试验(RCT)。该研究同时进行了电子和人工搜索。研究结果为探诊袋深度(PD)和临床附着水平(CAL)。为了评估治疗效果,我们使用限制性最大似然法建立了随机效应模型,以估计汇总效应大小和相应的 95% 置信区间。对纳入研究的质量评估采用 Cochrane 偏倚风险工具 5.1.0 版。结果在确定的 451 条记录中,有 7 项研究在剔除重复和不符合纳入标准的研究后进行了荟萃分析。其中 5 篇论文的治疗部位为牙槽窝内缺损,2 项研究的治疗部位为毛面缺损。根据荟萃分析的结果,骨内缺损的 CAL 增加和 PD 减少的加权平均差(WMD)分别为 1.536 毫米(95% CI -0.933 至 2.139)和 1.601 毫米(95% CI -0.727 至 2.474)。CP移植物加GTR组与OFD组在CAL增大和PD缩小方面的差异具有统计学意义。同样,对于毛面缺损,应用 CP 移植物加 GTR 比 OFD 在 CAL 增加(WMD 为 1.807 mm;95% CI 为 0.346-3.268)和 PD 减少(WMD 为 1.519 mm,95% CI 为 1.215-4.253)方面具有辅助优势。结论:考虑到本系统综述的局限性,研究结果表明,磷酸钙移植物联合 GTR 在牙周骨内和毛囊缺损的愈合方面优于 OFD。
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引用次数: 0
Adding calcium phosphate agents alongside fluorides may enhance caries prevention and remineralization, although evidence is limited 在添加氟化物的同时添加磷酸钙制剂可加强龋齿预防和再矿化,但证据有限
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-07-22 DOI: 10.1016/j.jebdp.2024.102024
Wei Lu (REVIEWERS), Huanhuan Zhang, Fang Hua

Article Title and Bibliographic Information

Effectiveness of Calcium Phosphate derivative agents on the prevention and remineralization of caries among children- A systematic review & meta-analysis of randomized controlled trials. Singal K, Sharda S, Gupta A, Malik VS, Singh M, Chauhan A, Agarwal A, Pradhan P, Singh M. J Evid Based Dent Pract. 2022; 22(3):101746.

Source of Funding

Indian Council of Medical Research.

Type of Study/Design

Systematic review with meta-analysis.

文章标题和参考文献信息磷酸钙衍生物制剂对儿童龋齿预防和再矿化的效果--随机对照试验的系统综述和荟萃分析。Singal K, Sharda S, Gupta A, Malik VS, Singh M, Chauhan A, Agarwal A, Pradhan P, Singh M. J Evid Based Dent Pract.2022; 22(3):101746.Funding SourceIndian Council of Medical Research.Type of Study/DesignSystematic review with meta-analysis.
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引用次数: 0
IMMEDIATE SINGLE IMPLANT PLACEMENT WITH FLAPLESS SURGERY MAY BETTER PRESERVE BUCCAL BONE THAN FLAP SURGERY, BUT CLINICAL SIGNIFICANCE IS UNCLEAR 与翻瓣手术相比,采用无瓣手术立即植入单个种植体可以更好地保护颊骨,但临床意义尚不明确。
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-07-22 DOI: 10.1016/j.jebdp.2024.102023
AHMED YASEEN ALQUTAIBI (REVIEWERS), HATEM Hazzaa HAMADALLAH, RADHWAN S. ALGABRI

Article Title and Bibliographic Information

Immediate implant placement with flap or flapless surgery: a systematic review and meta-analysis. Pitman J, Christiaens V, Callens J, Glibert M, Seyssens L, Blanco J, et al. J Clin Periodontol. 2023;50:755-64.

Source of Funding

The present study was funded by the authors and their institutions.

CONFLICT OF INTEREST

The authors have no actual or potential conflicts of interest.

Type of Study/Design

Systematic review and meta-analysis.

文章标题和参考文献信息翻瓣或无瓣手术即刻植入种植体:系统回顾和荟萃分析。Pitman J, Christiaens V, Callens J, Glibert M, Seyssens L, Blanco J, et al. J Clin Periodontol.2023;50:755-64.经费来源本研究由作者及其所在机构提供经费。利益冲突作者没有实际或潜在的利益冲突。
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引用次数: 0
IMPLANT-SUPPORTED DENTAL PROSTHESES MAY PRESERVE OROFACIAL HARD AND SOFT TISSUES 种植体支持的义齿可保护口面部软硬组织
IF 4.1 4区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-07-22 DOI: 10.1016/j.jebdp.2024.102025
KELVIN I. AFRASHTEHFAR (REVIEWERS), MUSAB H. SAEED, AL MOUTASSEM B.M. KHAIR, JONG-EUN KIM

Article Title and Bibliographic Information

De Souza AB, Papaspyridakos P, Weber HP, Vazouras K, Matarazzo F. Effect of dental implant therapy on the preservation of orofacial tissues: A systematic review and meta-analysis. Clin Oral Implants Res. 2023;34 Suppl 26:240-256. doi:10.1111/clr.14106. PMID: 37750525.

Source of Funding

No private or public funding was received for this research.

CONFLICT OF INTEREST

The authors declare that they have no competing interests.

Type of Study/Design

Systematic review (with meta-analysis).

文章标题和参考文献信息De Souza AB、Papaspyridakos P、Weber HP、Vazouras K、Matarazzo F.种植牙治疗对口腔组织保存的影响:系统综述和荟萃分析。2023;34 Suppl 26:240-256.DOI:10.1111/clr.14106.PMID:37750525.经费来源本研究未收到任何私人或公共资金.利益冲突作者声明无利益冲突.研究/设计类型系统综述(含荟萃分析).
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引用次数: 0
期刊
Journal of Evidence-Based Dental Practice
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